Click here to switch to the map view.

The map label for this gene is rnr [H]

Identifier: 74316626

GI number: 74316626

Start: 636269

End: 638545

Strand: Direct

Name: rnr [H]

Synonym: Tbd_0608

Alternate gene names: 74316626

Gene position: 636269-638545 (Clockwise)

Preceding gene: 74316625

Following gene: 74316627

Centisome position: 21.87

GC content: 64.78

Gene sequence:

>2277_bases
ATGTCTTCCAGTAAATCACGCAGCCGCGGCGCGAAACACCAGGTCCCCGCGATCCGTCTCGCCGATCCGTTCTATGCGCG
CGAAACCGAGCGCTACGAATCACCGCTTCCGAGCCGCGAGTACATCCTGCAACTGCTGAGCGACGCGGGCTGCCCGCTCG
ACGTCGACGCGTTCGCCGAACAGCTCCAGATCACCGAAGCCGAGCGCGACTTGTTCCAGCGCCGTCTCGGCGCGATGCAG
CGCGACGGCCAGCTGATGCTGAACCGCAAGCGCCAGCTCTGCCTGCCCGACAAGCTCGATCTGATCAAGGGCCGCGTCGA
GGGTCACCCTGACGGCTTCGGCTTCGTCGTTCCCGAGGAAGGCGGCGACGACCTCTTCCTCTCGCCCAAGGAAATGCATC
GCGTGCTGCACGGCGACAAGGTGCTCGTGCGCGTCGCCGGCTTCGACCGCCGCGGGCGGCGCGAGGCCAAGATCGTCGAG
GTGCTCGAGCACGTCAACAAATTCGTCGTCGGCCGTTACTACCTCGAGGGCGGGGTCGGCTTCCTGATCGCCGAAAACCG
CCGTATCAACCAGGACATCCTGGTGCCGCCCGAAAACGCGGGGAACGCCAAGTCCGGCCAGGTGGTGACGGTCGAGATCG
TCAGCCAGCCCGGCGCGCACAACGAGGCCGTCGGCCGGGTCACCGAAGTGCTCGGCAGTTTCACCGGCCCCGGCATGGAA
ATCGAGATCGCGTTGCGCAAGCACGATCTGCCCTACGTCTTCCCACCCGAGGTCGAAGCGCAGGCGTCGAAGTTGCCGAA
CAAGGTGCTGAAAAAGGATCTTGCCGGGCGCGAGGACATCCGCCAGCTGCCGCTCGTCACGATCGACGGCGAGACCGCCC
GCGACTTCGATGACGCCGTCTACTGCGAACCGCTCGGGCGCAGCGGCTACCGCCTGGTCGTCGCGATCGCCGATGTCAGC
CATTACGTTCATCCGCGCGACGCGCTCGACAGCGAGGGCTTCAACCGCGGCAACTCGGTCTACTTCCCGCGCCGCGTCAT
TCCGATGCTGCCCGAGGCGCTGTCGAACGGCCTGTGCTCGCTCAACCCCGAGGTCGACCGCCTGTCGATGGTCTGCGACA
TGCGCATCACGACCGCCGGCAACATCAAGGAATACCGCTTCTATCCGGCGGTCATCCATTCGCACGCGCGCCTGACCTAC
AACCAGGTGTGGGACTGGCTCTCCGGCGCTGCCAAGCCGGAAAAGAAACACGCCGCGCTGATGCCGCACCTCGAAGCGCT
CGACAAACTGTTCCGCACGCTGCTCAAGGCGCGCGCCAAGCGCGGCGCGATCGATTTCGGCTCGACCGAGACGCAGATCG
TTTTCGACGACAACGGCAAGATCAAGGAGATCGTGCCGGTGATCCGCAACGATGCCCATCGCATCATCGAGGAATGCATG
CTTGCGGCCAACGTCTGCGCGTCTGACTTCCTGCACGAGAACAAGCAGCCCGCCCTGTTCCGCGTGCACGAGGGGCCGAC
GCCCGAAAAGCTGACTGCGCTGCGCGGCTTTCTGGCGGAATTCGGTCTCGATCTCGGCGGCGGCGACAAGCCACACGCCA
AGGATTACGCCGCGCTGCTCGAAAACATCAAGGACCGGCCGGACCACGGCCTGCTGCAGACCGTCATGCTGCGCTCGCTC
AGGCAGGCGATCTACAGCCCCGACAACAAGGGCCACTTCGGCCTGGCCTACGAGGCCTACACCCATTTCACCTCGCCGAT
CCGGCGCTATCCTGACCTGCTGGTGCACCGTGGCATCAAGGCCGTGCTCAACGGCGAGAAACTGCCGGCCAAGGGCCTCG
CGGAAATCGGCGCCCACTGCTCGATGACCGAACGCCGCGCCGACGACGCGACGCGCGACGTCGACGCCTGGCTCAAGACC
TACTTCATGCAGGACCGCATCGGCGACGAATACGACGGCACCGTCAGCGCGGTGACGAGCTTCGGCATGTTCGTCGCGAT
CGACGAGATTTTCATCGAGGGCCTCGTCCACGTCTCGGAGCTCGGCCAGGATTACTTCCACTACGACCAGGCCAAGCACA
TGATGCTCGGCGAACGGACCGGAAAAAGATATCGGCTCGGCGACCGCGTGCGCATCAAGGTGATGCGCGCCGACATCGAG
ACCAGCAAGATCGACTTCAGCCTCGTCGAGACGATCGAGACTGCGACCCAGCCCGAGGAGAGCGTCGCGCCGAAGAAGAA
ACGCAGCAAGACACGCGGCGGCGGCAAGAAGAAATGA

Upstream 100 bases:

>100_bases
GCCACCGCTAGGACCTGAACCTAGTGCGTCTACCAATTCCGCCATCTGGGCATGAAGGCGCGCATTTTAGAGAGCCATAA
ATCAATTGTCAACGAAGAAG

Downstream 100 bases:

>100_bases
GCGAGAAGCCTGCCGAAAGACTCATCTACGGTTTCCATGCCGTGCTCGCCCGGCTCCGGCACGATCCGGCGGGCGTGCTC
GAAATCTACCTCGATCTCAC

Product: RNAse R

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 758; Mature: 757

Protein sequence:

>758_residues
MSSSKSRSRGAKHQVPAIRLADPFYARETERYESPLPSREYILQLLSDAGCPLDVDAFAEQLQITEAERDLFQRRLGAMQ
RDGQLMLNRKRQLCLPDKLDLIKGRVEGHPDGFGFVVPEEGGDDLFLSPKEMHRVLHGDKVLVRVAGFDRRGRREAKIVE
VLEHVNKFVVGRYYLEGGVGFLIAENRRINQDILVPPENAGNAKSGQVVTVEIVSQPGAHNEAVGRVTEVLGSFTGPGME
IEIALRKHDLPYVFPPEVEAQASKLPNKVLKKDLAGREDIRQLPLVTIDGETARDFDDAVYCEPLGRSGYRLVVAIADVS
HYVHPRDALDSEGFNRGNSVYFPRRVIPMLPEALSNGLCSLNPEVDRLSMVCDMRITTAGNIKEYRFYPAVIHSHARLTY
NQVWDWLSGAAKPEKKHAALMPHLEALDKLFRTLLKARAKRGAIDFGSTETQIVFDDNGKIKEIVPVIRNDAHRIIEECM
LAANVCASDFLHENKQPALFRVHEGPTPEKLTALRGFLAEFGLDLGGGDKPHAKDYAALLENIKDRPDHGLLQTVMLRSL
RQAIYSPDNKGHFGLAYEAYTHFTSPIRRYPDLLVHRGIKAVLNGEKLPAKGLAEIGAHCSMTERRADDATRDVDAWLKT
YFMQDRIGDEYDGTVSAVTSFGMFVAIDEIFIEGLVHVSELGQDYFHYDQAKHMMLGERTGKRYRLGDRVRIKVMRADIE
TSKIDFSLVETIETATQPEESVAPKKKRSKTRGGGKKK

Sequences:

>Translated_758_residues
MSSSKSRSRGAKHQVPAIRLADPFYARETERYESPLPSREYILQLLSDAGCPLDVDAFAEQLQITEAERDLFQRRLGAMQ
RDGQLMLNRKRQLCLPDKLDLIKGRVEGHPDGFGFVVPEEGGDDLFLSPKEMHRVLHGDKVLVRVAGFDRRGRREAKIVE
VLEHVNKFVVGRYYLEGGVGFLIAENRRINQDILVPPENAGNAKSGQVVTVEIVSQPGAHNEAVGRVTEVLGSFTGPGME
IEIALRKHDLPYVFPPEVEAQASKLPNKVLKKDLAGREDIRQLPLVTIDGETARDFDDAVYCEPLGRSGYRLVVAIADVS
HYVHPRDALDSEGFNRGNSVYFPRRVIPMLPEALSNGLCSLNPEVDRLSMVCDMRITTAGNIKEYRFYPAVIHSHARLTY
NQVWDWLSGAAKPEKKHAALMPHLEALDKLFRTLLKARAKRGAIDFGSTETQIVFDDNGKIKEIVPVIRNDAHRIIEECM
LAANVCASDFLHENKQPALFRVHEGPTPEKLTALRGFLAEFGLDLGGGDKPHAKDYAALLENIKDRPDHGLLQTVMLRSL
RQAIYSPDNKGHFGLAYEAYTHFTSPIRRYPDLLVHRGIKAVLNGEKLPAKGLAEIGAHCSMTERRADDATRDVDAWLKT
YFMQDRIGDEYDGTVSAVTSFGMFVAIDEIFIEGLVHVSELGQDYFHYDQAKHMMLGERTGKRYRLGDRVRIKVMRADIE
TSKIDFSLVETIETATQPEESVAPKKKRSKTRGGGKKK
>Mature_757_residues
SSSKSRSRGAKHQVPAIRLADPFYARETERYESPLPSREYILQLLSDAGCPLDVDAFAEQLQITEAERDLFQRRLGAMQR
DGQLMLNRKRQLCLPDKLDLIKGRVEGHPDGFGFVVPEEGGDDLFLSPKEMHRVLHGDKVLVRVAGFDRRGRREAKIVEV
LEHVNKFVVGRYYLEGGVGFLIAENRRINQDILVPPENAGNAKSGQVVTVEIVSQPGAHNEAVGRVTEVLGSFTGPGMEI
EIALRKHDLPYVFPPEVEAQASKLPNKVLKKDLAGREDIRQLPLVTIDGETARDFDDAVYCEPLGRSGYRLVVAIADVSH
YVHPRDALDSEGFNRGNSVYFPRRVIPMLPEALSNGLCSLNPEVDRLSMVCDMRITTAGNIKEYRFYPAVIHSHARLTYN
QVWDWLSGAAKPEKKHAALMPHLEALDKLFRTLLKARAKRGAIDFGSTETQIVFDDNGKIKEIVPVIRNDAHRIIEECML
AANVCASDFLHENKQPALFRVHEGPTPEKLTALRGFLAEFGLDLGGGDKPHAKDYAALLENIKDRPDHGLLQTVMLRSLR
QAIYSPDNKGHFGLAYEAYTHFTSPIRRYPDLLVHRGIKAVLNGEKLPAKGLAEIGAHCSMTERRADDATRDVDAWLKTY
FMQDRIGDEYDGTVSAVTSFGMFVAIDEIFIEGLVHVSELGQDYFHYDQAKHMMLGERTGKRYRLGDRVRIKVMRADIET
SKIDFSLVETIETATQPEESVAPKKKRSKTRGGGKKK

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=550, Percent_Identity=29.8181818181818, Blast_Score=201, Evalue=3e-51,
Organism=Homo sapiens, GI190014625, Length=550, Percent_Identity=29.8181818181818, Blast_Score=200, Evalue=5e-51,
Organism=Homo sapiens, GI134288890, Length=442, Percent_Identity=28.2805429864253, Blast_Score=155, Evalue=2e-37,
Organism=Homo sapiens, GI19115966, Length=517, Percent_Identity=27.6595744680851, Blast_Score=150, Evalue=4e-36,
Organism=Homo sapiens, GI219521928, Length=517, Percent_Identity=27.6595744680851, Blast_Score=150, Evalue=6e-36,
Organism=Homo sapiens, GI156105695, Length=456, Percent_Identity=24.5614035087719, Blast_Score=78, Evalue=4e-14,
Organism=Homo sapiens, GI156105693, Length=457, Percent_Identity=24.507658643326, Blast_Score=77, Evalue=7e-14,
Organism=Escherichia coli, GI87082383, Length=725, Percent_Identity=51.1724137931034, Blast_Score=764, Evalue=0.0,
Organism=Escherichia coli, GI1787542, Length=593, Percent_Identity=27.318718381113, Blast_Score=191, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI212645896, Length=440, Percent_Identity=31.5909090909091, Blast_Score=180, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17553506, Length=472, Percent_Identity=28.1779661016949, Blast_Score=155, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6324552, Length=509, Percent_Identity=29.2730844793713, Blast_Score=164, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6320499, Length=586, Percent_Identity=21.6723549488055, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323943, Length=351, Percent_Identity=25.0712250712251, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24649634, Length=573, Percent_Identity=27.5741710296684, Blast_Score=184, Evalue=3e-46,
Organism=Drosophila melanogaster, GI19922976, Length=370, Percent_Identity=31.3513513513514, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24654597, Length=370, Percent_Identity=31.3513513513514, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24654592, Length=370, Percent_Identity=31.3513513513514, Blast_Score=147, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 85007; Mature: 84876

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSKSRSRGAKHQVPAIRLADPFYARETERYESPLPSREYILQLLSDAGCPLDVDAFAE
CCCCCCHHCCCCCCCCEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHH
QLQITEAERDLFQRRLGAMQRDGQLMLNRKRQLCLPDKLDLIKGRVEGHPDGFGFVVPEE
HHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCEEEECCC
GGDDLFLSPKEMHRVLHGDKVLVRVAGFDRRGRREAKIVEVLEHVNKFVVGRYYLEGGVG
CCCCCEECHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCEE
FLIAENRRINQDILVPPENAGNAKSGQVVTVEIVSQPGAHNEAVGRVTEVLGSFTGPGME
EEEECCCCCCCCCEECCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEE
IEIALRKHDLPYVFPPEVEAQASKLPNKVLKKDLAGREDIRQLPLVTIDGETARDFDDAV
EEEEEEECCCCEECCCCCHHHHHHCCHHHHHHHCCCHHHHHHCCEEEECCCCCCCCCCCE
YCEPLGRSGYRLVVAIADVSHYVHPRDALDSEGFNRGNSVYFPRRVIPMLPEALSNGLCS
EECCCCCCCCEEEEEEECHHHHCCCCHHCCCCCCCCCCCEECCHHHHHHHHHHHCCCCCC
LNPEVDRLSMVCDMRITTAGNIKEYRFYPAVIHSHARLTYNQVWDWLSGAAKPEKKHAAL
CCCCHHHHHHHHCEEEECCCCCHHHEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
MPHLEALDKLFRTLLKARAKRGAIDFGSTETQIVFDDNGKIKEIVPVIRNDAHRIIEECM
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHCHHHHHHHHHH
LAANVCASDFLHENKQPALFRVHEGPTPEKLTALRGFLAEFGLDLGGGDKPHAKDYAALL
HHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
ENIKDRPDHGLLQTVMLRSLRQAIYSPDNKGHFGLAYEAYTHFTSPIRRYPDLLVHRGIK
HHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
AVLNGEKLPAKGLAEIGAHCSMTERRADDATRDVDAWLKTYFMQDRIGDEYDGTVSAVTS
HHHCCCCCCCHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
FGMFVAIDEIFIEGLVHVSELGQDYFHYDQAKHMMLGERTGKRYRLGDRVRIKVMRADIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCEEEEEEEECCC
TSKIDFSLVETIETATQPEESVAPKKKRSKTRGGGKKK
CHHCHHHHHHHHHHHCCCHHHCCCCHHHHHCCCCCCCC
>Mature Secondary Structure 
SSSKSRSRGAKHQVPAIRLADPFYARETERYESPLPSREYILQLLSDAGCPLDVDAFAE
CCCCCHHCCCCCCCCEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHH
QLQITEAERDLFQRRLGAMQRDGQLMLNRKRQLCLPDKLDLIKGRVEGHPDGFGFVVPEE
HHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCEEEECCC
GGDDLFLSPKEMHRVLHGDKVLVRVAGFDRRGRREAKIVEVLEHVNKFVVGRYYLEGGVG
CCCCCEECHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCEE
FLIAENRRINQDILVPPENAGNAKSGQVVTVEIVSQPGAHNEAVGRVTEVLGSFTGPGME
EEEECCCCCCCCCEECCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEE
IEIALRKHDLPYVFPPEVEAQASKLPNKVLKKDLAGREDIRQLPLVTIDGETARDFDDAV
EEEEEEECCCCEECCCCCHHHHHHCCHHHHHHHCCCHHHHHHCCEEEECCCCCCCCCCCE
YCEPLGRSGYRLVVAIADVSHYVHPRDALDSEGFNRGNSVYFPRRVIPMLPEALSNGLCS
EECCCCCCCCEEEEEEECHHHHCCCCHHCCCCCCCCCCCEECCHHHHHHHHHHHCCCCCC
LNPEVDRLSMVCDMRITTAGNIKEYRFYPAVIHSHARLTYNQVWDWLSGAAKPEKKHAAL
CCCCHHHHHHHHCEEEECCCCCHHHEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
MPHLEALDKLFRTLLKARAKRGAIDFGSTETQIVFDDNGKIKEIVPVIRNDAHRIIEECM
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHCHHHHHHHHHH
LAANVCASDFLHENKQPALFRVHEGPTPEKLTALRGFLAEFGLDLGGGDKPHAKDYAALL
HHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
ENIKDRPDHGLLQTVMLRSLRQAIYSPDNKGHFGLAYEAYTHFTSPIRRYPDLLVHRGIK
HHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
AVLNGEKLPAKGLAEIGAHCSMTERRADDATRDVDAWLKTYFMQDRIGDEYDGTVSAVTS
HHHCCCCCCCHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
FGMFVAIDEIFIEGLVHVSELGQDYFHYDQAKHMMLGERTGKRYRLGDRVRIKVMRADIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCEEEEEEEECCC
TSKIDFSLVETIETATQPEESVAPKKKRSKTRGGGKKK
CHHCHHHHHHHHHHHCCCHHHCCCCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]