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The map label for this gene is engA

Identifier: 74316616

GI number: 74316616

Start: 626825

End: 628234

Strand: Direct

Name: engA

Synonym: Tbd_0598

Alternate gene names: 74316616

Gene position: 626825-628234 (Clockwise)

Preceding gene: 74316615

Following gene: 74316619

Centisome position: 21.54

GC content: 66.45

Gene sequence:

>1410_bases
ATGCTTCCCACTCTGGTTCTTGTCGGACGCCCGAACGTCGGCAAGTCCACGCTCTTCAATCGCCTGACCGGCACCCGCGA
CGCGCTCGTCCATGACCTGCCGGGCATGACGCGCGACCGCCACTACGGTCGCGGCCGCATCGGCGGCAAGCCCTATCTCG
TGGTCGACACGGGCGGTCTCGAACCGGTCGTCAAGGATGGCATCCTGGCCGAGATGGCGCGCCAGACGCTGCAGGCCATC
GACGAAGCCGACGCGATCATCTTCATGGTCGACGCGCGCGCCGGCGTGACCCCGCAGGACAAGGTCATCGCCGACCGACT
GCGCCGCGTGACGTCGCCGGTCCTGCTCGCGGTCAACAAGGCCGAAGGCATGAATCGCGCCGTGGTGACCGCCGAGTTCC
ACGAACTCGGCCTCGGCGAGCCGCTCGCGATCTCGGGCGCGCACGGCGACGGCATCGCCGACCTCGTGGCCGAGGCGCTG
GCGCCCTTCCCCGAAGAGGAAGAGGCGAGCGACGATTTCGGCGTGCCCAAGATCGCGCTGGTCGGCCGACCCAACGTCGG
CAAGTCGACGCTCGTCAACGCGCTGGTCGGCGCGGAGCGCGTGATCGCCTTCGACCAGCCGGGAACGACGCGCGACTCGA
TCTACGTCGACTTCGAGCGGGGCGGCAAGCCCTATGTCCTCATCGACACCGCGGGCGTCCGTCGCCGCGGCAAGGTGTTC
GAGACCGTGGAAAAATTCTCGGTCATCAAGACCCTGCAGGCGATTGAGGACGCCAACGTCGTGGTGCTCGTGCTCGACGC
GCGCGAGAACATTTCCGAGCAGGACGCGCATCTCGCGGGCTTCGTGCTCGAAACCGGGCGCGCGCTGGTCGTCGCGATCA
ACAAGTGGGACGGTCTCTCGGCCGAACAGCGCGACGACGTCAAGCGCGACATCGGACGCAAGCTCGCTTTCCTCGACTTT
GCGCGCTTCAATTACATCTCTGCGCTCAAGGCGAAGGGCCTGGAGAACCTGCTCAAGGATATCGAGGCCGCACACGCCGC
GGCCTTCATCAAGCTGTCGACGCCCAAGCTCACGCGCGTGCTCGAAATGGCCGTCGAACAGCATGCGCCGCCGAAGAACG
GGCTGTTCCGTCCGAAGCCGCGCTACGCGCATCAGGGCGGCAAGAACCCACCCGTCATCGTGCTGCACGGCAACGCGCTC
GAAGGGCTGCGCGACGACTACAAGCGCTATCTCGAAAGCAGCTTCCGCAAGGCGTTCAAGCTGCAGGGCACGCCGCTCCG
AATCCAGATCAAGGAGGACGAGGGCAAGAATCCGTTCGAAGGCAAGAAGCGCGCGCCGCTCAGCGAAAGCGAGGCGACGC
GGATGCGGCGCAAGAAGCGCGTACGGCGCAAGGTCTACGGCGCCGACTGA

Upstream 100 bases:

>100_bases
CGCGGTGCAGACGAGCGACGGCAGCGTCGTCGCGTTCAGGCTGCAATAGCGAGGTTCACACGGCCGCCGGTGCGCCGGCC
GGCATGCTACAAGGACAGCC

Downstream 100 bases:

>100_bases
ACGCCGTCAGCGCTGGCGGGCCGGGGCGCAGCCGTGCTCAGGCTCAGTCCAGCCAACGCACTAGGTAAAACAGCCTGAAC
CCTTCGGACGAGCGCGACGG

Product: GTP-binding protein EngA

Products: NA

Alternate protein names: GTP-binding protein EngA

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MLPTLVLVGRPNVGKSTLFNRLTGTRDALVHDLPGMTRDRHYGRGRIGGKPYLVVDTGGLEPVVKDGILAEMARQTLQAI
DEADAIIFMVDARAGVTPQDKVIADRLRRVTSPVLLAVNKAEGMNRAVVTAEFHELGLGEPLAISGAHGDGIADLVAEAL
APFPEEEEASDDFGVPKIALVGRPNVGKSTLVNALVGAERVIAFDQPGTTRDSIYVDFERGGKPYVLIDTAGVRRRGKVF
ETVEKFSVIKTLQAIEDANVVVLVLDARENISEQDAHLAGFVLETGRALVVAINKWDGLSAEQRDDVKRDIGRKLAFLDF
ARFNYISALKAKGLENLLKDIEAAHAAAFIKLSTPKLTRVLEMAVEQHAPPKNGLFRPKPRYAHQGGKNPPVIVLHGNAL
EGLRDDYKRYLESSFRKAFKLQGTPLRIQIKEDEGKNPFEGKKRAPLSESEATRMRRKKRVRRKVYGAD

Sequences:

>Translated_469_residues
MLPTLVLVGRPNVGKSTLFNRLTGTRDALVHDLPGMTRDRHYGRGRIGGKPYLVVDTGGLEPVVKDGILAEMARQTLQAI
DEADAIIFMVDARAGVTPQDKVIADRLRRVTSPVLLAVNKAEGMNRAVVTAEFHELGLGEPLAISGAHGDGIADLVAEAL
APFPEEEEASDDFGVPKIALVGRPNVGKSTLVNALVGAERVIAFDQPGTTRDSIYVDFERGGKPYVLIDTAGVRRRGKVF
ETVEKFSVIKTLQAIEDANVVVLVLDARENISEQDAHLAGFVLETGRALVVAINKWDGLSAEQRDDVKRDIGRKLAFLDF
ARFNYISALKAKGLENLLKDIEAAHAAAFIKLSTPKLTRVLEMAVEQHAPPKNGLFRPKPRYAHQGGKNPPVIVLHGNAL
EGLRDDYKRYLESSFRKAFKLQGTPLRIQIKEDEGKNPFEGKKRAPLSESEATRMRRKKRVRRKVYGAD
>Mature_469_residues
MLPTLVLVGRPNVGKSTLFNRLTGTRDALVHDLPGMTRDRHYGRGRIGGKPYLVVDTGGLEPVVKDGILAEMARQTLQAI
DEADAIIFMVDARAGVTPQDKVIADRLRRVTSPVLLAVNKAEGMNRAVVTAEFHELGLGEPLAISGAHGDGIADLVAEAL
APFPEEEEASDDFGVPKIALVGRPNVGKSTLVNALVGAERVIAFDQPGTTRDSIYVDFERGGKPYVLIDTAGVRRRGKVF
ETVEKFSVIKTLQAIEDANVVVLVLDARENISEQDAHLAGFVLETGRALVVAINKWDGLSAEQRDDVKRDIGRKLAFLDF
ARFNYISALKAKGLENLLKDIEAAHAAAFIKLSTPKLTRVLEMAVEQHAPPKNGLFRPKPRYAHQGGKNPPVIVLHGNAL
EGLRDDYKRYLESSFRKAFKLQGTPLRIQIKEDEGKNPFEGKKRAPLSESEATRMRRKKRVRRKVYGAD

Specific function: GTPase that plays an essential role in the late steps of ribosome biogenesis

COG id: COG1160

COG function: function code R; Predicted GTPases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH-like domain

Homologues:

Organism=Escherichia coli, GI87082120, Length=493, Percent_Identity=50.709939148073, Blast_Score=482, Evalue=1e-137,
Organism=Escherichia coli, GI1788919, Length=174, Percent_Identity=31.6091954022989, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI2367268, Length=90, Percent_Identity=41.1111111111111, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323665, Length=175, Percent_Identity=28, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DER_THIDA (Q3SL66)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_314356.1
- HSSP:   O57939
- ProteinModelPortal:   Q3SL66
- SMR:   Q3SL66
- STRING:   Q3SL66
- GeneID:   3673708
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_0598
- NMPDR:   fig|292415.3.peg.443
- eggNOG:   COG1160
- HOGENOM:   HBG592135
- OMA:   TRDRTYQ
- PhylomeDB:   Q3SL66
- ProtClustDB:   PRK00093
- BioCyc:   TDEN292415:TBD_0598-MONOMER
- GO:   GO:0005622
- HAMAP:   MF_00195
- InterPro:   IPR003593
- InterPro:   IPR016484
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PIRSF:   PIRSF006485
- PRINTS:   PR00326
- SMART:   SM00382
- TIGRFAMs:   TIGR03594
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01926 MMR_HSR1

EC number: NA

Molecular weight: Translated: 51482; Mature: 51482

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPTLVLVGRPNVGKSTLFNRLTGTRDALVHDLPGMTRDRHYGRGRIGGKPYLVVDTGGL
CCCCEEEEECCCCCHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCC
EPVVKDGILAEMARQTLQAIDEADAIIFMVDARAGVTPQDKVIADRLRRVTSPVLLAVNK
CHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEEC
AEGMNRAVVTAEFHELGLGEPLAISGAHGDGIADLVAEALAPFPEEEEASDDFGVPKIAL
CCCCCEEEEEEEHHHCCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEE
VGRPNVGKSTLVNALVGAERVIAFDQPGTTRDSIYVDFERGGKPYVLIDTAGVRRRGKVF
ECCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCHHH
ETVEKFSVIKTLQAIEDANVVVLVLDARENISEQDAHLAGFVLETGRALVVAINKWDGLS
HHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHEECCCEEEEEEECCCCCC
AEQRDDVKRDIGRKLAFLDFARFNYISALKAKGLENLLKDIEAAHAAAFIKLSTPKLTRV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHH
LEMAVEQHAPPKNGLFRPKPRYAHQGGKNPPVIVLHGNALEGLRDDYKRYLESSFRKAFK
HHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHH
LQGTPLRIQIKEDEGKNPFEGKKRAPLSESEATRMRRKKRVRRKVYGAD
CCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLPTLVLVGRPNVGKSTLFNRLTGTRDALVHDLPGMTRDRHYGRGRIGGKPYLVVDTGGL
CCCCEEEEECCCCCHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCC
EPVVKDGILAEMARQTLQAIDEADAIIFMVDARAGVTPQDKVIADRLRRVTSPVLLAVNK
CHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEEC
AEGMNRAVVTAEFHELGLGEPLAISGAHGDGIADLVAEALAPFPEEEEASDDFGVPKIAL
CCCCCEEEEEEEHHHCCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEE
VGRPNVGKSTLVNALVGAERVIAFDQPGTTRDSIYVDFERGGKPYVLIDTAGVRRRGKVF
ECCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCHHH
ETVEKFSVIKTLQAIEDANVVVLVLDARENISEQDAHLAGFVLETGRALVVAINKWDGLS
HHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHEECCCEEEEEEECCCCCC
AEQRDDVKRDIGRKLAFLDFARFNYISALKAKGLENLLKDIEAAHAAAFIKLSTPKLTRV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHH
LEMAVEQHAPPKNGLFRPKPRYAHQGGKNPPVIVLHGNALEGLRDDYKRYLESSFRKAFK
HHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHH
LQGTPLRIQIKEDEGKNPFEGKKRAPLSESEATRMRRKKRVRRKVYGAD
CCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA