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The map label for this gene is zraR [H]

Identifier: 74316516

GI number: 74316516

Start: 517334

End: 518845

Strand: Reverse

Name: zraR [H]

Synonym: Tbd_0498

Alternate gene names: 74316516

Gene position: 518845-517334 (Counterclockwise)

Preceding gene: 74316518

Following gene: 74316515

Centisome position: 17.83

GC content: 67.53

Gene sequence:

>1512_bases
ATGTCCTACACTTTGTGGATGGCGGCAGCGCCCGTCGGAGGCCCCGGGCGCGGCTCACATCGCGGCCGGGCCGATGCGCG
GTCGCGGTGCATCGTCATTCCGAGAGGAGACAGAATGGCTTGGGTTGAGCGGGACGTCGTCGCGTTGGTCGACGACTGCG
TGCACGGCGAGATTCATCGGTTTCTCTGCGCGGAGGGCTGGCGCGTGCATCGCGCGACGGGGCTTCAGGACCTCGCGAAG
CAGCTTCAAGGCCATACCTTCCACGCCGGTCTGGTGCAACTTCAGCGCGCCGGCAACAACCGTCTCTTCGAGCTCGTGGG
CCGGCAGCGGTCCCTGCAATGGATCGCGCTGTCCGACCCGGCTTTCTGGCGGCCCGGCCCCCAGCATCGCAACTTTCTCG
CCGGCGTCTACGACTTCCATTCCCTGCCGGTCGACAGCCAGCGGCTCGCGATCTCGCTCGGTCATGCCTGGGGCAAGGGG
CAGCTGCTCCAGCACCCGGAGGCGCCGTTCGAGACCCTCGAGGAATACGGCATCGTCGGCAGCAGCCCGGCAATGCTGAG
CTTCGCTCACATGCTGCGCAAGGCGAGCAAGACCGACGCACCGGTACTGATCGCCGGCGAGAGCGGAACCGGCAAGGAAC
TCGCCGCACGCGCGATCCACGATATGTCTTCGCGTGCGCGAAAACCCTTCGTCGCGGTCAACTGCGGGGCGCTTCCTCCC
CATCTGATCCAGAGCGAACTGTTCGGCCACGAGAAGGGCGCGTTCACCGGCGCTCACCAGCGCAAGATCGGCCGCATCGA
AGCGGCCGACGGCGGCACGCTCTTCCTCGACGAGATCGCCGACCTGCCGCTCAGCCTGCAGGCCAATCTGCTGCGCGTGC
TGCAGGACAAGGTGATCGAGCGCCTGGGGTCGACGCAGTCGGTGCAGCTCGACATCCGCGTCCTTGCCGCATCGCACGTC
GACCTACTGGACGCCGTGGCGAAAGACCTGTTCCGCGAAGACCTCTACTACCGGCTCAACGTCGTCAAACTCGTCGTCCC
GCCGCTGCGCGACCGGCACGGCGACATCGAGCTGCTCGCGCAGGCGCTGCTCGACAAGTTTTCATGGGAGACGCTCGGCA
AGGTCAAGGGCTTCAGCCAGCAGGCGCTGCGCGCGATGAACCAGTACGCGTGGCCGGGCAACGTCCGCGAGATGGTCAAC
CGCATCCGGCAGGGCATCATCATGGCCGAACACCCCTATCTGACGCCGGAGGATCTTGGAATGGAAAGACGCGCCGCCTG
CGCACCGGGCCTCACGCTCGACGGCGCGCGCGCCAAGGCCGAAGCCGATGCGATCCGCTCGGCCCTGCGCCGCTGCCAGC
ACAACGTCTCGGAAGCCGCCCGCGAGCTCGGCGTCTCGCGCGCGACGATGTACCGCCTGCTCGAACGCCACGCCCTGATC
GGGCCCTCTCTTCGCGCGACGCCACCCGAAGCGCTGCACACGCTCGCGGGAGCCACGGAACGCAACGCCTGA

Upstream 100 bases:

>100_bases
CGGTGCTTCATGCTTGCATGAAACCCATGGACAGGCAAGGCAGGAGGCGCCGCGTCCGGCGAACCAGTGACAGGGCCTGC
CTACCGACCGCCCGCAGCCG

Downstream 100 bases:

>100_bases
GCGGGCGCGCCGCGACGCCCCGCCGAGTGGCTCCGGCCGCGGCCGATTCGCTCGGACATCCTGGCCGTAGGGCCGACTTC
CCAAGTCACGTTAAGATACG

Product: Fis family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 503; Mature: 502

Protein sequence:

>503_residues
MSYTLWMAAAPVGGPGRGSHRGRADARSRCIVIPRGDRMAWVERDVVALVDDCVHGEIHRFLCAEGWRVHRATGLQDLAK
QLQGHTFHAGLVQLQRAGNNRLFELVGRQRSLQWIALSDPAFWRPGPQHRNFLAGVYDFHSLPVDSQRLAISLGHAWGKG
QLLQHPEAPFETLEEYGIVGSSPAMLSFAHMLRKASKTDAPVLIAGESGTGKELAARAIHDMSSRARKPFVAVNCGALPP
HLIQSELFGHEKGAFTGAHQRKIGRIEAADGGTLFLDEIADLPLSLQANLLRVLQDKVIERLGSTQSVQLDIRVLAASHV
DLLDAVAKDLFREDLYYRLNVVKLVVPPLRDRHGDIELLAQALLDKFSWETLGKVKGFSQQALRAMNQYAWPGNVREMVN
RIRQGIIMAEHPYLTPEDLGMERRAACAPGLTLDGARAKAEADAIRSALRRCQHNVSEAARELGVSRATMYRLLERHALI
GPSLRATPPEALHTLAGATERNA

Sequences:

>Translated_503_residues
MSYTLWMAAAPVGGPGRGSHRGRADARSRCIVIPRGDRMAWVERDVVALVDDCVHGEIHRFLCAEGWRVHRATGLQDLAK
QLQGHTFHAGLVQLQRAGNNRLFELVGRQRSLQWIALSDPAFWRPGPQHRNFLAGVYDFHSLPVDSQRLAISLGHAWGKG
QLLQHPEAPFETLEEYGIVGSSPAMLSFAHMLRKASKTDAPVLIAGESGTGKELAARAIHDMSSRARKPFVAVNCGALPP
HLIQSELFGHEKGAFTGAHQRKIGRIEAADGGTLFLDEIADLPLSLQANLLRVLQDKVIERLGSTQSVQLDIRVLAASHV
DLLDAVAKDLFREDLYYRLNVVKLVVPPLRDRHGDIELLAQALLDKFSWETLGKVKGFSQQALRAMNQYAWPGNVREMVN
RIRQGIIMAEHPYLTPEDLGMERRAACAPGLTLDGARAKAEADAIRSALRRCQHNVSEAARELGVSRATMYRLLERHALI
GPSLRATPPEALHTLAGATERNA
>Mature_502_residues
SYTLWMAAAPVGGPGRGSHRGRADARSRCIVIPRGDRMAWVERDVVALVDDCVHGEIHRFLCAEGWRVHRATGLQDLAKQ
LQGHTFHAGLVQLQRAGNNRLFELVGRQRSLQWIALSDPAFWRPGPQHRNFLAGVYDFHSLPVDSQRLAISLGHAWGKGQ
LLQHPEAPFETLEEYGIVGSSPAMLSFAHMLRKASKTDAPVLIAGESGTGKELAARAIHDMSSRARKPFVAVNCGALPPH
LIQSELFGHEKGAFTGAHQRKIGRIEAADGGTLFLDEIADLPLSLQANLLRVLQDKVIERLGSTQSVQLDIRVLAASHVD
LLDAVAKDLFREDLYYRLNVVKLVVPPLRDRHGDIELLAQALLDKFSWETLGKVKGFSQQALRAMNQYAWPGNVREMVNR
IRQGIIMAEHPYLTPEDLGMERRAACAPGLTLDGARAKAEADAIRSALRRCQHNVSEAARELGVSRATMYRLLERHALIG
PSLRATPPEALHTLAGATERNA

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=438, Percent_Identity=37.4429223744292, Blast_Score=270, Evalue=2e-73,
Organism=Escherichia coli, GI1788905, Length=347, Percent_Identity=43.5158501440922, Blast_Score=265, Evalue=7e-72,
Organism=Escherichia coli, GI1788550, Length=357, Percent_Identity=42.0168067226891, Blast_Score=263, Evalue=1e-71,
Organism=Escherichia coli, GI87082117, Length=275, Percent_Identity=45.8181818181818, Blast_Score=232, Evalue=4e-62,
Organism=Escherichia coli, GI1789087, Length=349, Percent_Identity=39.8280802292264, Blast_Score=231, Evalue=8e-62,
Organism=Escherichia coli, GI1790299, Length=371, Percent_Identity=38.2749326145553, Blast_Score=228, Evalue=8e-61,
Organism=Escherichia coli, GI1789233, Length=324, Percent_Identity=40.1234567901235, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI87082152, Length=332, Percent_Identity=40.3614457831325, Blast_Score=218, Evalue=9e-58,
Organism=Escherichia coli, GI87081872, Length=319, Percent_Identity=36.9905956112853, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI1786524, Length=314, Percent_Identity=40.1273885350318, Blast_Score=198, Evalue=5e-52,
Organism=Escherichia coli, GI1787583, Length=308, Percent_Identity=35.7142857142857, Blast_Score=185, Evalue=5e-48,
Organism=Escherichia coli, GI87081858, Length=303, Percent_Identity=31.3531353135314, Blast_Score=146, Evalue=4e-36,
Organism=Escherichia coli, GI1789828, Length=232, Percent_Identity=37.0689655172414, Blast_Score=132, Evalue=7e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 55475; Mature: 55344

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYTLWMAAAPVGGPGRGSHRGRADARSRCIVIPRGDRMAWVERDVVALVDDCVHGEIHR
CCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCEEHHHHHHHHHHHHHHHHHHHH
FLCAEGWRVHRATGLQDLAKQLQGHTFHAGLVQLQRAGNNRLFELVGRQRSLQWIALSDP
HHHHCCCEEHHHCCHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHCCCCCEEEEEECCC
AFWRPGPQHRNFLAGVYDFHSLPVDSQRLAISLGHAWGKGQLLQHPEAPFETLEEYGIVG
CCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHCCCCC
SSPAMLSFAHMLRKASKTDAPVLIAGESGTGKELAARAIHDMSSRARKPFVAVNCGALPP
CCHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCH
HLIQSELFGHEKGAFTGAHQRKIGRIEAADGGTLFLDEIADLPLSLQANLLRVLQDKVIE
HHHHHHHHCCCCCCCCCHHHHHCCCEEECCCCEEEHHHHHCCCCHHHHHHHHHHHHHHHH
RLGSTQSVQLDIRVLAASHVDLLDAVAKDLFREDLYYRLNVVKLVVPPLRDRHGDIELLA
HHCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHH
QALLDKFSWETLGKVKGFSQQALRAMNQYAWPGNVREMVNRIRQGIIMAEHPYLTPEDLG
HHHHHHHCHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCEEEECCCCCCHHHCC
MERRAACAPGLTLDGARAKAEADAIRSALRRCQHNVSEAARELGVSRATMYRLLERHALI
CHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHC
GPSLRATPPEALHTLAGATERNA
CCCCCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SYTLWMAAAPVGGPGRGSHRGRADARSRCIVIPRGDRMAWVERDVVALVDDCVHGEIHR
CEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCEEHHHHHHHHHHHHHHHHHHHH
FLCAEGWRVHRATGLQDLAKQLQGHTFHAGLVQLQRAGNNRLFELVGRQRSLQWIALSDP
HHHHCCCEEHHHCCHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHCCCCCEEEEEECCC
AFWRPGPQHRNFLAGVYDFHSLPVDSQRLAISLGHAWGKGQLLQHPEAPFETLEEYGIVG
CCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHCCCCC
SSPAMLSFAHMLRKASKTDAPVLIAGESGTGKELAARAIHDMSSRARKPFVAVNCGALPP
CCHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCH
HLIQSELFGHEKGAFTGAHQRKIGRIEAADGGTLFLDEIADLPLSLQANLLRVLQDKVIE
HHHHHHHHCCCCCCCCCHHHHHCCCEEECCCCEEEHHHHHCCCCHHHHHHHHHHHHHHHH
RLGSTQSVQLDIRVLAASHVDLLDAVAKDLFREDLYYRLNVVKLVVPPLRDRHGDIELLA
HHCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHH
QALLDKFSWETLGKVKGFSQQALRAMNQYAWPGNVREMVNRIRQGIIMAEHPYLTPEDLG
HHHHHHHCHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCEEEECCCCCCHHHCC
MERRAACAPGLTLDGARAKAEADAIRSALRRCQHNVSEAARELGVSRATMYRLLERHALI
CHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHC
GPSLRATPPEALHTLAGATERNA
CCCCCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11243806 [H]