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The map label for this gene is yggW [H]

Identifier: 74316497

GI number: 74316497

Start: 500960

End: 502138

Strand: Direct

Name: yggW [H]

Synonym: Tbd_0479

Alternate gene names: 74316497

Gene position: 500960-502138 (Clockwise)

Preceding gene: 74316496

Following gene: 74316498

Centisome position: 17.22

GC content: 67.26

Gene sequence:

>1179_bases
TTGGCTGACGCCGTCGTTCGCGTCGCGGGGCGCGGGCTCACGGTCCCGCCGCCGCTGTCGCTCTACATCCACCTGCCGTG
GTGCGTGAAGAAGTGCCCGTATTGCGACTTCAATTCCCACGCCGCGGAAGGCATCCCCGAAGCTGCCTACGTCGACGCCT
TGCGGGCCGACCTCGAGCACGCGCTGCCCGACATCTGGGGCCGCAAGATCCACACGGTGTTTTTCGGCGGCGGCACGCCG
AGCCTGTTCTCGGCCGAGGGCATCGACCGGATTCTCGCCACAGTGCGCACGCTGACGCCACTGGTGCCCGGCGCGGAAAT
CACGCTCGAGGCGAATCCGGGCACCATCGAAGCGGCAAAGTTCGCCGGCTTTCGTGAGGCCGGAATTACGCGAGTCTCGC
TGGGCATCCAGAGCTTCGATCCGCGCCATCTCAAGGCGCTCGGGCGCATCCACGACGGGACCGAGGCGCGCCGCGCAGCC
GAGCTTGCGGCCACGCATTTCGATACTTTCAATCTCGACCTGATGTACGCGCTGCCCGGGCAGACGCTCGCCGAAGCGCT
CGCCGATGTCGACGCGGCGCTCGCTTTTCAGCCGCCGCATCTGTCGGCCTATCACCTCACGCTCGAGCCCAACACGCCGT
TCGGCCACGCCGCCCCGCCCAACCTGCCCGACGACGACCTCGCCGCCGACATGCAGCTCGCGATCGGGGCGCGGTTGATC
GACGCCGGCATGCAGCACTACGAAACCTCCGCGTATGCGAAGCCCGGCCACGCCGGTCGTCACAACCTCAACTACTGGCA
GTTCGGCGACTACCTCGGGATCGGTGCCGGCGCGCATTCCAAGTTGAGCTTCCACGACCGCATCGTACGCCAGATGCGCA
CCAAGCATCCGCAGCAGTACATGACGGCCGTACACGGCGGCGCCCACGTCGCCGACACGCGCGCCCTCACGCGCAACGAC
CTGCCCTTCGAGTTCATGATGAACGCCTTGCGCCTCACCGAAGGCGTGCCGGCTGAGTTGTTCGAGTTGCGTACGGGGTT
GCCGCTCAACGTATGTGCCGCCGCGCTCGCACAGGCGCGCGCGAAGGGCTTGCTCGGGGTCGAGCTCGGCCGCCTCGAGC
CGACGCTGCAGGGTCAGCGCTTCCTCAACGACCTGCTGGAATTGTTTCTGCCCGCTTGA

Upstream 100 bases:

>100_bases
AAAACCGGCGCCGAGCTCGACGAGGACGTCAAGAATGCAGTCAGCCACCGCGGCCAGGCGCTGCGCGACCTCGTCGACAA
GCTCAAGCGCCTGAAGCGGC

Downstream 100 bases:

>100_bases
CGCGCTTTCGCGGCCGCCTGCGACGTGATCCTGCCTTGGGGGGCGTCGCGCCGGCGCTGCGGACATCGAGGCCGGGCAAA
AGACGCGCCCCTGCCGCGGT

Product: coproporphyrinogen III oxidase

Products: Protoporphyrinogen IX; CO2; H2O

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MADAVVRVAGRGLTVPPPLSLYIHLPWCVKKCPYCDFNSHAAEGIPEAAYVDALRADLEHALPDIWGRKIHTVFFGGGTP
SLFSAEGIDRILATVRTLTPLVPGAEITLEANPGTIEAAKFAGFREAGITRVSLGIQSFDPRHLKALGRIHDGTEARRAA
ELAATHFDTFNLDLMYALPGQTLAEALADVDAALAFQPPHLSAYHLTLEPNTPFGHAAPPNLPDDDLAADMQLAIGARLI
DAGMQHYETSAYAKPGHAGRHNLNYWQFGDYLGIGAGAHSKLSFHDRIVRQMRTKHPQQYMTAVHGGAHVADTRALTRND
LPFEFMMNALRLTEGVPAELFELRTGLPLNVCAAALAQARAKGLLGVELGRLEPTLQGQRFLNDLLELFLPA

Sequences:

>Translated_392_residues
MADAVVRVAGRGLTVPPPLSLYIHLPWCVKKCPYCDFNSHAAEGIPEAAYVDALRADLEHALPDIWGRKIHTVFFGGGTP
SLFSAEGIDRILATVRTLTPLVPGAEITLEANPGTIEAAKFAGFREAGITRVSLGIQSFDPRHLKALGRIHDGTEARRAA
ELAATHFDTFNLDLMYALPGQTLAEALADVDAALAFQPPHLSAYHLTLEPNTPFGHAAPPNLPDDDLAADMQLAIGARLI
DAGMQHYETSAYAKPGHAGRHNLNYWQFGDYLGIGAGAHSKLSFHDRIVRQMRTKHPQQYMTAVHGGAHVADTRALTRND
LPFEFMMNALRLTEGVPAELFELRTGLPLNVCAAALAQARAKGLLGVELGRLEPTLQGQRFLNDLLELFLPA
>Mature_391_residues
ADAVVRVAGRGLTVPPPLSLYIHLPWCVKKCPYCDFNSHAAEGIPEAAYVDALRADLEHALPDIWGRKIHTVFFGGGTPS
LFSAEGIDRILATVRTLTPLVPGAEITLEANPGTIEAAKFAGFREAGITRVSLGIQSFDPRHLKALGRIHDGTEARRAAE
LAATHFDTFNLDLMYALPGQTLAEALADVDAALAFQPPHLSAYHLTLEPNTPFGHAAPPNLPDDDLAADMQLAIGARLID
AGMQHYETSAYAKPGHAGRHNLNYWQFGDYLGIGAGAHSKLSFHDRIVRQMRTKHPQQYMTAVHGGAHVADTRALTRNDL
PFEFMMNALRLTEGVPAELFELRTGLPLNVCAAALAQARAKGLLGVELGRLEPTLQGQRFLNDLLELFLPA

Specific function: Unknown

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=294, Percent_Identity=37.0748299319728, Blast_Score=175, Evalue=8e-44,
Organism=Escherichia coli, GI1789325, Length=377, Percent_Identity=51.1936339522546, Blast_Score=363, Evalue=1e-102,
Organism=Escherichia coli, GI87082341, Length=325, Percent_Identity=27.6923076923077, Blast_Score=105, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: 1.3.3.3

Molecular weight: Translated: 42504; Mature: 42373

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADAVVRVAGRGLTVPPPLSLYIHLPWCVKKCPYCDFNSHAAEGIPEAAYVDALRADLEH
CCCCEEEECCCCCCCCCCCEEEEECCHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHHHH
ALPDIWGRKIHTVFFGGGTPSLFSAEGIDRILATVRTLTPLVPGAEITLEANPGTIEAAK
HHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEHHH
FAGFREAGITRVSLGIQSFDPRHLKALGRIHDGTEARRAAELAATHFDTFNLDLMYALPG
HCCHHHHCCEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCC
QTLAEALADVDAALAFQPPHLSAYHLTLEPNTPFGHAAPPNLPDDDLAADMQLAIGARLI
HHHHHHHHHHHHHHEECCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
DAGMQHYETSAYAKPGHAGRHNLNYWQFGDYLGIGAGAHSKLSFHDRIVRQMRTKHPQQY
HHHHHHHHCCCCCCCCCCCCCCCCCEECCCEEEECCCCCCCCHHHHHHHHHHHHCCHHHH
MTAVHGGAHVADTRALTRNDLPFEFMMNALRLTEGVPAELFELRTGLPLNVCAAALAQAR
HHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHH
AKGLLGVELGRLEPTLQGQRFLNDLLELFLPA
HCCCEEEECCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ADAVVRVAGRGLTVPPPLSLYIHLPWCVKKCPYCDFNSHAAEGIPEAAYVDALRADLEH
CCCEEEECCCCCCCCCCCEEEEECCHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHHHH
ALPDIWGRKIHTVFFGGGTPSLFSAEGIDRILATVRTLTPLVPGAEITLEANPGTIEAAK
HHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEHHH
FAGFREAGITRVSLGIQSFDPRHLKALGRIHDGTEARRAAELAATHFDTFNLDLMYALPG
HCCHHHHCCEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCC
QTLAEALADVDAALAFQPPHLSAYHLTLEPNTPFGHAAPPNLPDDDLAADMQLAIGARLI
HHHHHHHHHHHHHHEECCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
DAGMQHYETSAYAKPGHAGRHNLNYWQFGDYLGIGAGAHSKLSFHDRIVRQMRTKHPQQY
HHHHHHHHCCCCCCCCCCCCCCCCCEECCCEEEECCCCCCCCHHHHHHHHHHHHCCHHHH
MTAVHGGAHVADTRALTRNDLPFEFMMNALRLTEGVPAELFELRTGLPLNVCAAALAQAR
HHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHH
AKGLLGVELGRLEPTLQGQRFLNDLLELFLPA
HCCCEEEECCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coproporphyrinogen III; O2; H+

Specific reaction: coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]