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The map label for this gene is yggV [C]

Identifier: 74316496

GI number: 74316496

Start: 500368

End: 500967

Strand: Direct

Name: yggV [C]

Synonym: Tbd_0478

Alternate gene names: 74316496

Gene position: 500368-500967 (Clockwise)

Preceding gene: 74316495

Following gene: 74316497

Centisome position: 17.2

GC content: 66.17

Gene sequence:

>600_bases
ATGAGCAAGATCGTCATCGCGTCCGGCAATCCCGGCAAGCTGCGCGAAATCGCGCGCATCCTCGCGCCGCTCGAGATCGA
AGCGGTGCCGCAGTCGGATTTCGACGTGCCGGACTGCCCCGAGCCGCATGTCACCTTCGTCGAGAACTGTCTTGCCAAGG
CGCGTCACGCGAGCAGGCACAGCGGCCTGCCGGCGCTCGCCGACGACTCCGGCATCTGCGTCGAGGCACTCGGCGGCGCG
CCGGGCGTGTTCTCGGCGCGCTACGCCGGCGAGCCCAAGTCGGATGCGCGCAACAACGAGAAACTCATCGCCGACCTGAA
GGGCAAGTCCAATCGGCGCGCGCATTACACCTGCGTCATGGTCTACGTGCGGCATCCCGACGACCCTGAGCCGGTGATCG
CCGAAGGCCGCTGGTACGGTGAGATCATCGACACCCCGCGTGGCGAGAAGGGCTTCGGCTACGACCCGTATTTCCTTGTC
CCAGAATTCGGCAAAACCGGCGCCGAGCTCGACGAGGACGTCAAGAATGCAGTCAGCCACCGCGGCCAGGCGCTGCGCGA
CCTCGTCGACAAGCTCAAGCGCCTGAAGCGGCTTGGCTGA

Upstream 100 bases:

>100_bases
GCGTGGCGTTTTCGCGCACCACCCTCGAAGCCTTGCTCGACCTGGCCACGGCCGGCATCGCGCAGATCAGCGCGGAACAG
GTCAGGACACTGGGGCAGCC

Downstream 100 bases:

>100_bases
CGCCGTCGTTCGCGTCGCGGGGCGCGGGCTCACGGTCCCGCCGCCGCTGTCGCTCTACATCCACCTGCCGTGGTGCGTGA
AGAAGTGCCCGTATTGCGAC

Product: putative deoxyribonucleotide triphosphate pyrophosphatase

Products: NA

Alternate protein names: Nucleoside triphosphate phosphohydrolase; NTPase [H]

Number of amino acids: Translated: 199; Mature: 198

Protein sequence:

>199_residues
MSKIVIASGNPGKLREIARILAPLEIEAVPQSDFDVPDCPEPHVTFVENCLAKARHASRHSGLPALADDSGICVEALGGA
PGVFSARYAGEPKSDARNNEKLIADLKGKSNRRAHYTCVMVYVRHPDDPEPVIAEGRWYGEIIDTPRGEKGFGYDPYFLV
PEFGKTGAELDEDVKNAVSHRGQALRDLVDKLKRLKRLG

Sequences:

>Translated_199_residues
MSKIVIASGNPGKLREIARILAPLEIEAVPQSDFDVPDCPEPHVTFVENCLAKARHASRHSGLPALADDSGICVEALGGA
PGVFSARYAGEPKSDARNNEKLIADLKGKSNRRAHYTCVMVYVRHPDDPEPVIAEGRWYGEIIDTPRGEKGFGYDPYFLV
PEFGKTGAELDEDVKNAVSHRGQALRDLVDKLKRLKRLG
>Mature_198_residues
SKIVIASGNPGKLREIARILAPLEIEAVPQSDFDVPDCPEPHVTFVENCLAKARHASRHSGLPALADDSGICVEALGGAP
GVFSARYAGEPKSDARNNEKLIADLKGKSNRRAHYTCVMVYVRHPDDPEPVIAEGRWYGEIIDTPRGEKGFGYDPYFLVP
EFGKTGAELDEDVKNAVSHRGQALRDLVDKLKRLKRLG

Specific function: Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions [H]

COG id: COG0127

COG function: function code F; Xanthosine triphosphate pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAM1 NTPase family [H]

Homologues:

Organism=Homo sapiens, GI15626999, Length=195, Percent_Identity=32.3076923076923, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI31657144, Length=159, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=5e-12,
Organism=Escherichia coli, GI1789324, Length=195, Percent_Identity=49.2307692307692, Blast_Score=206, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI17556833, Length=189, Percent_Identity=33.3333333333333, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI19920712, Length=199, Percent_Identity=32.6633165829146, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002637
- InterPro:   IPR020922 [H]

Pfam domain/function: PF01725 Ham1p_like [H]

EC number: =3.6.1.15 [H]

Molecular weight: Translated: 21787; Mature: 21656

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIVIASGNPGKLREIARILAPLEIEAVPQSDFDVPDCPEPHVTFVENCLAKARHASRH
CCEEEEECCCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
SGLPALADDSGICVEALGGAPGVFSARYAGEPKSDARNNEKLIADLKGKSNRRAHYTCVM
CCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEEE
VYVRHPDDPEPVIAEGRWYGEIIDTPRGEKGFGYDPYFLVPEFGKTGAELDEDVKNAVSH
EEEECCCCCCCEEECCEEEEHHHCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHH
RGQALRDLVDKLKRLKRLG
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKIVIASGNPGKLREIARILAPLEIEAVPQSDFDVPDCPEPHVTFVENCLAKARHASRH
CEEEEECCCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
SGLPALADDSGICVEALGGAPGVFSARYAGEPKSDARNNEKLIADLKGKSNRRAHYTCVM
CCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEEE
VYVRHPDDPEPVIAEGRWYGEIIDTPRGEKGFGYDPYFLVPEFGKTGAELDEDVKNAVSH
EEEECCCCCCCEEECCEEEEHHHCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHH
RGQALRDLVDKLKRLKRLG
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]