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The map label for this gene is ntpA [H]

Identifier: 74316462

GI number: 74316462

Start: 464671

End: 465111

Strand: Direct

Name: ntpA [H]

Synonym: Tbd_0444

Alternate gene names: 74316462

Gene position: 464671-465111 (Clockwise)

Preceding gene: 74316461

Following gene: 74316463

Centisome position: 15.97

GC content: 65.08

Gene sequence:

>441_bases
GTGACGCCGCACAAGATTCCCGTTTCGGTACTCGTCGTCATCTACACGGTCGACGGCGAGGTCTTGCTGCTCGAACGCGC
GGACGCGCCCGGTTTCTGGCAATCGGTGACGGGTTCGCAGGATGAAGGCGAAACGCTGGAACAGACCGCGATCCGGGAAG
TGCGCGAAGAAACCGGGCTCGATGCCGCACAGTTCGAGTTGAGTCCGTGGGACATCGAAACCCGCTTCGAGATCTACGAA
CGCTGGCGCCACCGTTACGCGCCGGGCGTGACGCACAACACCGAGCACGTGTTCGGGCTGCGGCTGCCGTCGCGCCTGCC
GGTGGTACTGGCGCCGCAGGAGCACCTGCGCTATCTGTGGTTGCCGTGGCCGCGCGCTGCGGAACGCTGCTTTTCGCCTA
GCAACGCAGCCGCGATTCGGCTCGTCCCCAGGCGCCTATAA

Upstream 100 bases:

>100_bases
AACATACCGAGGACGCGGCACGCCACCCGGGTAAGCATCCGAACGTGGACCGCCTGGTCGATATCCTCAAGACGGGCGTT
CCGCTCGCGGCCCGCGTGAT

Downstream 100 bases:

>100_bases
TTCCGGCATGAGCCAAGCGCTGCACATCGCGAGCTACAACATCCACAAGGGCATGTCGCAATTCAACCGCCGCCTGATGG
TGCACGAGTTGCGCGACCGC

Product: dATP pyrophosphohydrolase

Products: dAMP; pyrophosphate [C]

Alternate protein names: dATP pyrophosphohydrolase [H]

Number of amino acids: Translated: 146; Mature: 145

Protein sequence:

>146_residues
MTPHKIPVSVLVVIYTVDGEVLLLERADAPGFWQSVTGSQDEGETLEQTAIREVREETGLDAAQFELSPWDIETRFEIYE
RWRHRYAPGVTHNTEHVFGLRLPSRLPVVLAPQEHLRYLWLPWPRAAERCFSPSNAAAIRLVPRRL

Sequences:

>Translated_146_residues
MTPHKIPVSVLVVIYTVDGEVLLLERADAPGFWQSVTGSQDEGETLEQTAIREVREETGLDAAQFELSPWDIETRFEIYE
RWRHRYAPGVTHNTEHVFGLRLPSRLPVVLAPQEHLRYLWLPWPRAAERCFSPSNAAAIRLVPRRL
>Mature_145_residues
TPHKIPVSVLVVIYTVDGEVLLLERADAPGFWQSVTGSQDEGETLEQTAIREVREETGLDAAQFELSPWDIETRFEIYER
WRHRYAPGVTHNTEHVFGLRLPSRLPVVLAPQEHLRYLWLPWPRAAERCFSPSNAAAIRLVPRRL

Specific function: Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788172, Length=139, Percent_Identity=51.7985611510791, Blast_Score=121, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003564
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 16825; Mature: 16694

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPHKIPVSVLVVIYTVDGEVLLLERADAPGFWQSVTGSQDEGETLEQTAIREVREETGL
CCCCCCCCEEEEEEEECCCCEEEEEECCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHCC
DAAQFELSPWDIETRFEIYERWRHRYAPGVTHNTEHVFGLRLPSRLPVVLAPQEHLRYLW
CEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEEECHHHCEEEE
LPWPRAAERCFSPSNAAAIRLVPRRL
CCCCHHHHHHCCCCCCEEEEEECCCC
>Mature Secondary Structure 
TPHKIPVSVLVVIYTVDGEVLLLERADAPGFWQSVTGSQDEGETLEQTAIREVREETGL
CCCCCCCEEEEEEEECCCCEEEEEECCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHCC
DAAQFELSPWDIETRFEIYERWRHRYAPGVTHNTEHVFGLRLPSRLPVVLAPQEHLRYLW
CEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEEECHHHCEEEE
LPWPRAAERCFSPSNAAAIRLVPRRL
CCCCHHHHHHCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: deoxy-ATP; H2O [C]

Specific reaction: deoxy-ATP + H2O = dAMP + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]