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The map label for this gene is pth

Identifier: 74316407

GI number: 74316407

Start: 417213

End: 417821

Strand: Direct

Name: pth

Synonym: Tbd_0389

Alternate gene names: 74316407

Gene position: 417213-417821 (Clockwise)

Preceding gene: 74316406

Following gene: 74316408

Centisome position: 14.34

GC content: 66.83

Gene sequence:

>609_bases
ATGACAGCGCCCAGTCTTGCCCCGCCGCGCCTGATCGTCGGCCTCGGTAATCCGGGGCGCGACTACGAAGAAACCCGGCA
CAATGCCGGGTTTTGGTTTTGCGCGCGCCTCGCGCAGGCCTGGGGTGCCGCGCTCGCGCACGAGTCGCGATTCCACGGCA
TCGTTGGCAGGCACGGCACGCGCTGGATGCTATTGCCACAGACCTTCATGAACCGCTCCGGACAGGCGGTCGGCGCGCTC
GCGCGCTTTCATCGCATCGCGCCGGCCGAGATTCTGGTGGTGCACGACGAACTCGATATTCCGCCCGGACAGCTGCGCCT
CAAGTTCGGCGGCGGCATGGGCGGGCACAACGGCCTCAAGGACATCACCGCGCATCTCGGCACCCAGGACTACTGGCGTT
TGCGCATCGGCATCGGGCATCCGGGCGACCGCAGCGAGGTCGTCAACTACGTGCTGAAGCCGCCGCGGCGCGAGGAGCAG
GCCGACATCGACGCCGCGATCGAGCGTGCGCTCGGACTCCTTCCCCTGATCGAAAAGGGCGAGTGGAACGCCGCGACCCA
GCGCGCCAACAGCAAACCTGCATCACCCAAATCCCAGGAAACCCCATGA

Upstream 100 bases:

>100_bases
TCGCCGTGATCCACGCGCCGAAGGGCGGGGTCGAAGAAACGCCGGCGGCACCTGCGGCCTGACGGGCCTGCGCATCCCCT
CGCGGGATGCGCACCTCTGC

Downstream 100 bases:

>100_bases
GCCTCAAATGCGGCATCGTTGGCTTGCCCAACGTCGGAAAATCCACCCTGTTCAACGCGCTGACCCAGGCGGGCATCGCG
GCGGAAAACTACCCGTTCTG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 202; Mature: 201

Protein sequence:

>202_residues
MTAPSLAPPRLIVGLGNPGRDYEETRHNAGFWFCARLAQAWGAALAHESRFHGIVGRHGTRWMLLPQTFMNRSGQAVGAL
ARFHRIAPAEILVVHDELDIPPGQLRLKFGGGMGGHNGLKDITAHLGTQDYWRLRIGIGHPGDRSEVVNYVLKPPRREEQ
ADIDAAIERALGLLPLIEKGEWNAATQRANSKPASPKSQETP

Sequences:

>Translated_202_residues
MTAPSLAPPRLIVGLGNPGRDYEETRHNAGFWFCARLAQAWGAALAHESRFHGIVGRHGTRWMLLPQTFMNRSGQAVGAL
ARFHRIAPAEILVVHDELDIPPGQLRLKFGGGMGGHNGLKDITAHLGTQDYWRLRIGIGHPGDRSEVVNYVLKPPRREEQ
ADIDAAIERALGLLPLIEKGEWNAATQRANSKPASPKSQETP
>Mature_201_residues
TAPSLAPPRLIVGLGNPGRDYEETRHNAGFWFCARLAQAWGAALAHESRFHGIVGRHGTRWMLLPQTFMNRSGQAVGALA
RFHRIAPAEILVVHDELDIPPGQLRLKFGGGMGGHNGLKDITAHLGTQDYWRLRIGIGHPGDRSEVVNYVLKPPRREEQA
DIDAAIERALGLLPLIEKGEWNAATQRANSKPASPKSQETP

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=170, Percent_Identity=33.5294117647059, Blast_Score=82, Evalue=3e-16,
Organism=Escherichia coli, GI1787455, Length=167, Percent_Identity=55.0898203592814, Blast_Score=153, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_THIDA (Q3SLR3)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_314147.1
- ProteinModelPortal:   Q3SLR3
- SMR:   Q3SLR3
- STRING:   Q3SLR3
- GeneID:   3671652
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_0389
- NMPDR:   fig|292415.3.peg.783
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   SHAGHNG
- PhylomeDB:   Q3SLR3
- ProtClustDB:   PRK05426
- BioCyc:   TDEN292415:TBD_0389-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 22182; Mature: 22050

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPSLAPPRLIVGLGNPGRDYEETRHNAGFWFCARLAQAWGAALAHESRFHGIVGRHGT
CCCCCCCCCEEEEECCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RWMLLPQTFMNRSGQAVGALARFHRIAPAEILVVHDELDIPPGQLRLKFGGGMGGHNGLK
EEEEECHHHCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCHH
DITAHLGTQDYWRLRIGIGHPGDRSEVVNYVLKPPRREEQADIDAAIERALGLLPLIEKG
HHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCC
EWNAATQRANSKPASPKSQETP
CCCHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TAPSLAPPRLIVGLGNPGRDYEETRHNAGFWFCARLAQAWGAALAHESRFHGIVGRHGT
CCCCCCCCEEEEECCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RWMLLPQTFMNRSGQAVGALARFHRIAPAEILVVHDELDIPPGQLRLKFGGGMGGHNGLK
EEEEECHHHCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCHH
DITAHLGTQDYWRLRIGIGHPGDRSEVVNYVLKPPRREEQADIDAAIERALGLLPLIEKG
HHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCC
EWNAATQRANSKPASPKSQETP
CCCHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA