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The map label for this gene is prs [H]

Identifier: 74316405

GI number: 74316405

Start: 415528

End: 416478

Strand: Direct

Name: prs [H]

Synonym: Tbd_0387

Alternate gene names: 74316405

Gene position: 415528-416478 (Clockwise)

Preceding gene: 74316404

Following gene: 74316406

Centisome position: 14.28

GC content: 63.93

Gene sequence:

>951_bases
GTGTCCATAGACAATCTGATGGTGTTCAGTGGGAACGCGAACCCGCGTTTGGCCAGCGACGTGGTGCGCCATCTCAATAT
CCATCTCGGGCGCGCGACCGTTTCGCGCTTCTCGGACGGCGAGGTCATGGTCGAAATCCTCGAGAACGTGCGCGGCAAGG
ACGTCTTCGTCCTGCAGTCGACCTGCCAGCCGACCAACGACACCCTGATGGAGGTGATGGTCATGGTCGACGCGCTCAAG
CGCGCCTCGGCTGCACGCATCACCGCGGCCATCCCGTATTACGGCTACGCGCGCCAGGACCGGCGCACGCGGTCGGCGCG
TGTCGCGATCACGGCCAAGGTCGTCGCCAACATGCTGCAGGGCGCCGGGGTCGATCGCCTGCTGACGATGGACCTGCACT
CGGACCAGATTCAGGGCTTTTTCGACATTCCGGTCGACAACATCTACTCGAGCCCGATCCTGCTGGGCGACATCTGGAAG
CGCAACCACCCGAACCTCATGGTGGTCTCGCCCGACGTCGGTGGCGTGGTACGGGCCCGCGCGATCGCGAAGCGCCTCGA
ATGCGATCTGGCGATCATCGACAAGCGCCGCCCCAAGCCCAACGTCGCGAAGGTCATGCACATCATCGGCGACGTCAAGG
ACCGCACCTGCATCATCATGGATGACATGGTCGACACGGCGAACACGCTGTGCGAGGCGGCCAGTGCGCTCAAGGAACAT
GGTGCGCAGAAGGTCATGGCCTATTGCACCCACGCCGTGCTGTCGGGCAGCGCGGCCGAGCGCGTCACCAACTCGGCGCT
CGATGAGCTCGTCGTGACCGACACGATCCCGCTGCGCGACGACGCGCGGGCGTGCAAGAAGATCCGGCAATTGTCGGTGG
CTGAGCTGCTCGCGGAAACGATCCGCCGCATCAGCAACGAGGATTCCGTCAGTTCGCTCTTCATCGAATAG

Upstream 100 bases:

>100_bases
TCGTAGGTTCGATCCCTACCTCCCCAGCCAGATAGAGCGAACAGCCGCCCGGTGGCGGCTGTTTTTGTTGTGTCGGACCA
GCCGAAAGCCGGAGACTCGC

Downstream 100 bases:

>100_bases
CGAAGTGGAATGCCCCTGGTCGCGGGGGCTCAACCATGCGTCGGCGCGCATCGCCGATGCATCATCAGGCAGTCATTGAG
GAGAAGTTTCATGGAAATCG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MSIDNLMVFSGNANPRLASDVVRHLNIHLGRATVSRFSDGEVMVEILENVRGKDVFVLQSTCQPTNDTLMEVMVMVDALK
RASAARITAAIPYYGYARQDRRTRSARVAITAKVVANMLQGAGVDRLLTMDLHSDQIQGFFDIPVDNIYSSPILLGDIWK
RNHPNLMVVSPDVGGVVRARAIAKRLECDLAIIDKRRPKPNVAKVMHIIGDVKDRTCIIMDDMVDTANTLCEAASALKEH
GAQKVMAYCTHAVLSGSAAERVTNSALDELVVTDTIPLRDDARACKKIRQLSVAELLAETIRRISNEDSVSSLFIE

Sequences:

>Translated_316_residues
MSIDNLMVFSGNANPRLASDVVRHLNIHLGRATVSRFSDGEVMVEILENVRGKDVFVLQSTCQPTNDTLMEVMVMVDALK
RASAARITAAIPYYGYARQDRRTRSARVAITAKVVANMLQGAGVDRLLTMDLHSDQIQGFFDIPVDNIYSSPILLGDIWK
RNHPNLMVVSPDVGGVVRARAIAKRLECDLAIIDKRRPKPNVAKVMHIIGDVKDRTCIIMDDMVDTANTLCEAASALKEH
GAQKVMAYCTHAVLSGSAAERVTNSALDELVVTDTIPLRDDARACKKIRQLSVAELLAETIRRISNEDSVSSLFIE
>Mature_315_residues
SIDNLMVFSGNANPRLASDVVRHLNIHLGRATVSRFSDGEVMVEILENVRGKDVFVLQSTCQPTNDTLMEVMVMVDALKR
ASAARITAAIPYYGYARQDRRTRSARVAITAKVVANMLQGAGVDRLLTMDLHSDQIQGFFDIPVDNIYSSPILLGDIWKR
NHPNLMVVSPDVGGVVRARAIAKRLECDLAIIDKRRPKPNVAKVMHIIGDVKDRTCIIMDDMVDTANTLCEAASALKEHG
AQKVMAYCTHAVLSGSAAERVTNSALDELVVTDTIPLRDDARACKKIRQLSVAELLAETIRRISNEDSVSSLFIE

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=314, Percent_Identity=47.7707006369427, Blast_Score=299, Evalue=2e-81,
Organism=Homo sapiens, GI84875539, Length=316, Percent_Identity=47.1518987341772, Blast_Score=298, Evalue=5e-81,
Organism=Homo sapiens, GI4506127, Length=314, Percent_Identity=47.4522292993631, Blast_Score=297, Evalue=7e-81,
Organism=Homo sapiens, GI28557709, Length=314, Percent_Identity=46.8152866242038, Blast_Score=289, Evalue=2e-78,
Organism=Homo sapiens, GI4506133, Length=346, Percent_Identity=36.1271676300578, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI194018537, Length=342, Percent_Identity=35.9649122807018, Blast_Score=198, Evalue=6e-51,
Organism=Homo sapiens, GI310128524, Length=149, Percent_Identity=33.5570469798658, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI310115209, Length=149, Percent_Identity=33.5570469798658, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI310118259, Length=149, Percent_Identity=33.5570469798658, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI310119946, Length=149, Percent_Identity=33.5570469798658, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1787458, Length=311, Percent_Identity=62.7009646302251, Blast_Score=410, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI25149168, Length=313, Percent_Identity=45.6869009584665, Blast_Score=289, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI17554702, Length=313, Percent_Identity=45.6869009584665, Blast_Score=288, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI71989924, Length=317, Percent_Identity=45.1104100946372, Blast_Score=287, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI17554704, Length=310, Percent_Identity=45.8064516129032, Blast_Score=286, Evalue=8e-78,
Organism=Caenorhabditis elegans, GI17570245, Length=340, Percent_Identity=35.2941176470588, Blast_Score=199, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6319403, Length=318, Percent_Identity=43.3962264150943, Blast_Score=267, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6321776, Length=316, Percent_Identity=43.0379746835443, Blast_Score=260, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6320946, Length=317, Percent_Identity=42.2712933753943, Blast_Score=260, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6322667, Length=198, Percent_Identity=40.9090909090909, Blast_Score=147, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6324511, Length=109, Percent_Identity=39.4495412844037, Blast_Score=102, Evalue=8e-23,
Organism=Drosophila melanogaster, GI21355239, Length=313, Percent_Identity=48.8817891373802, Blast_Score=293, Evalue=1e-79,
Organism=Drosophila melanogaster, GI45551540, Length=335, Percent_Identity=45.6716417910448, Blast_Score=283, Evalue=9e-77,
Organism=Drosophila melanogaster, GI24651458, Length=358, Percent_Identity=34.3575418994413, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24651456, Length=358, Percent_Identity=34.3575418994413, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI281362873, Length=358, Percent_Identity=34.3575418994413, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24651454, Length=358, Percent_Identity=34.3575418994413, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24651462, Length=377, Percent_Identity=31.8302387267904, Blast_Score=195, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24651464, Length=377, Percent_Identity=31.8302387267904, Blast_Score=195, Evalue=3e-50,
Organism=Drosophila melanogaster, GI45552010, Length=377, Percent_Identity=31.8302387267904, Blast_Score=195, Evalue=3e-50,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34771; Mature: 34639

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIDNLMVFSGNANPRLASDVVRHLNIHLGRATVSRFSDGEVMVEILENVRGKDVFVLQS
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEC
TCQPTNDTLMEVMVMVDALKRASAARITAAIPYYGYARQDRRTRSARVAITAKVVANMLQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GAGVDRLLTMDLHSDQIQGFFDIPVDNIYSSPILLGDIWKRNHPNLMVVSPDVGGVVRAR
CCCCCCEEEECCCHHHCCEEEECCHHHHCCCCEEEHHHHCCCCCCEEEECCCCCHHHHHH
AIAKRLECDLAIIDKRRPKPNVAKVMHIIGDVKDRTCIIMDDMVDTANTLCEAASALKEH
HHHHHHHCCEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
GAQKVMAYCTHAVLSGSAAERVTNSALDELVVTDTIPLRDDARACKKIRQLSVAELLAET
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
IRRISNEDSVSSLFIE
HHHHCCCCCHHHHCCC
>Mature Secondary Structure 
SIDNLMVFSGNANPRLASDVVRHLNIHLGRATVSRFSDGEVMVEILENVRGKDVFVLQS
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEC
TCQPTNDTLMEVMVMVDALKRASAARITAAIPYYGYARQDRRTRSARVAITAKVVANMLQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GAGVDRLLTMDLHSDQIQGFFDIPVDNIYSSPILLGDIWKRNHPNLMVVSPDVGGVVRAR
CCCCCCEEEECCCHHHCCEEEECCHHHHCCCCEEEHHHHCCCCCCEEEECCCCCHHHHHH
AIAKRLECDLAIIDKRRPKPNVAKVMHIIGDVKDRTCIIMDDMVDTANTLCEAASALKEH
HHHHHHHCCEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
GAQKVMAYCTHAVLSGSAAERVTNSALDELVVTDTIPLRDDARACKKIRQLSVAELLAET
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
IRRISNEDSVSSLFIE
HHHHCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]