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The map label for this gene is ctaB

Identifier: 74316353

GI number: 74316353

Start: 355177

End: 356073

Strand: Direct

Name: ctaB

Synonym: Tbd_0335

Alternate gene names: 74316353

Gene position: 355177-356073 (Clockwise)

Preceding gene: 74316352

Following gene: 74316354

Centisome position: 12.21

GC content: 66.11

Gene sequence:

>897_bases
ATGGAGTCCTTGATGATCCAGGGCGCCGCGTGTCGCTGCCAGCAGTTCCTCGCCCTGTGCAAGCTGCGTGTGGTGAGCCT
GATCGTGTTCACGGCCGTGATCGGGATGTTTCTGGCGGTGCCGGCCTGGCCGAGTTGGACCACGATCTGGGCCGGGACTC
TCGGAATCGGGCTCGTCGCGAGCGCCGCGGCCGCGTTCAACTGCCTGATCGAGCAGAAAATCGACGCCGTCATGGCGCGC
ACCCGCGCGCGCCCGTTGCCGCGAGGCGAACTGACCGGCACACAGACGCTCGTGTTCGCCGGCGTGCTCGGCGGAAGCGG
TCTGCTTCTGCTCCATACCGTCGTCAATCCGCTCACGATGTGGCTGACGCTCGCGACCTTCGTCGGCTACGCGGTGATCT
ATACGGTTCTTCTCAAGCCCGCGACGCCGCAGAACATCGTCATCGGAGGCGCCTCGGGCGCGATGCCGCCGGTGCTCGGC
TGGGCTGCGGCGACCGGGGAGATTCACCACGACGCCTTGCTGCTCTTTCTCATCATCTTCGCCTGGACGCCGCCGCATTT
CTGGGCGCTGGCGCTGTATCGGCGCGAGGAATACGCGAGGGCCGGACTGCCGATGCTCCCGGTCACGCACGGCGAGGCCT
ATACGCGCCTGCATGTCCTGCTCTACACGCTGCTGCTGCTCGCCGTGAGTCTGCTGCCGGTCGGCACCGGGATGGCCGGC
GCCCTCTACCTCGTCGGCGCGGTCCTGCTGGGAGCGCGTTTCATCCAGTACGGCTGGGCGCTCCACCGCGAATACAGTGA
CGCGCTGGCGCGCCGGACCTTCCGGTATTCGATCTGGTATCTTGCCGCCTTGTTCGCGATCATGTTGCTCGACCACTATT
TCCCGATACCGGTATGA

Upstream 100 bases:

>100_bases
CTGAGTCTGCCGCTGGGCCTCGCGGTCGCCCATAACACGGGCGCAGCGCTGCTGCTTGCAGCCGTTGTGTTGTTGAATTA
TCGCTTGAGGGGGAAATGAC

Downstream 100 bases:

>100_bases
TTTTTATGAGGATTTAAGCAATCTCTGGATATTCGGACAAGATTGTTTTATATTGTGCTTCTTCAATTGATCGTTGGGGC
ACGTATGATCCTCTCGCGAA

Product: protoheme IX farnesyltransferase

Products: heme O; pyrophosphate [C]

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MESLMIQGAACRCQQFLALCKLRVVSLIVFTAVIGMFLAVPAWPSWTTIWAGTLGIGLVASAAAAFNCLIEQKIDAVMAR
TRARPLPRGELTGTQTLVFAGVLGGSGLLLLHTVVNPLTMWLTLATFVGYAVIYTVLLKPATPQNIVIGGASGAMPPVLG
WAAATGEIHHDALLLFLIIFAWTPPHFWALALYRREEYARAGLPMLPVTHGEAYTRLHVLLYTLLLLAVSLLPVGTGMAG
ALYLVGAVLLGARFIQYGWALHREYSDALARRTFRYSIWYLAALFAIMLLDHYFPIPV

Sequences:

>Translated_298_residues
MESLMIQGAACRCQQFLALCKLRVVSLIVFTAVIGMFLAVPAWPSWTTIWAGTLGIGLVASAAAAFNCLIEQKIDAVMAR
TRARPLPRGELTGTQTLVFAGVLGGSGLLLLHTVVNPLTMWLTLATFVGYAVIYTVLLKPATPQNIVIGGASGAMPPVLG
WAAATGEIHHDALLLFLIIFAWTPPHFWALALYRREEYARAGLPMLPVTHGEAYTRLHVLLYTLLLLAVSLLPVGTGMAG
ALYLVGAVLLGARFIQYGWALHREYSDALARRTFRYSIWYLAALFAIMLLDHYFPIPV
>Mature_298_residues
MESLMIQGAACRCQQFLALCKLRVVSLIVFTAVIGMFLAVPAWPSWTTIWAGTLGIGLVASAAAAFNCLIEQKIDAVMAR
TRARPLPRGELTGTQTLVFAGVLGGSGLLLLHTVVNPLTMWLTLATFVGYAVIYTVLLKPATPQNIVIGGASGAMPPVLG
WAAATGEIHHDALLLFLIIFAWTPPHFWALALYRREEYARAGLPMLPVTHGEAYTRLHVLLYTLLLLAVSLLPVGTGMAG
ALYLVGAVLLGARFIQYGWALHREYSDALARRTFRYSIWYLAALFAIMLLDHYFPIPV

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=192, Percent_Identity=38.5416666666667, Blast_Score=115, Evalue=5e-26,
Organism=Escherichia coli, GI1786631, Length=283, Percent_Identity=31.4487632508834, Blast_Score=139, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71998235, Length=283, Percent_Identity=30.7420494699647, Blast_Score=104, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6325085, Length=213, Percent_Identity=32.8638497652582, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI19921064, Length=287, Percent_Identity=32.7526132404181, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_THIDA (Q3SLW5)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_314093.1
- STRING:   Q3SLW5
- GeneID:   3672121
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_0335
- NMPDR:   fig|292415.3.peg.602
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   MALTEEW
- PhylomeDB:   Q3SLW5
- ProtClustDB:   PRK04375
- BioCyc:   TDEN292415:TBD_0335-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.- [C]

Molecular weight: Translated: 32450; Mature: 32450

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1fcbc758)-; HASH(0x1e0eccc8)-; HASH(0x1fbe3fa8)-; HASH(0x1fc608dc)-; HASH(0x1e57ae68)-; HASH(0x1fe37f94)-; HASH(0x2031b1a0)-; HASH(0x1e59549c)-;

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESLMIQGAACRCQQFLALCKLRVVSLIVFTAVIGMFLAVPAWPSWTTIWAGTLGIGLVA
CCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
SAAAAFNCLIEQKIDAVMARTRARPLPRGELTGTQTLVFAGVLGGSGLLLLHTVVNPLTM
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
WLTLATFVGYAVIYTVLLKPATPQNIVIGGASGAMPPVLGWAAATGEIHHDALLLFLIIF
HHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHH
AWTPPHFWALALYRREEYARAGLPMLPVTHGEAYTRLHVLLYTLLLLAVSLLPVGTGMAG
HCCCHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
ALYLVGAVLLGARFIQYGWALHREYSDALARRTFRYSIWYLAALFAIMLLDHYFPIPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
>Mature Secondary Structure
MESLMIQGAACRCQQFLALCKLRVVSLIVFTAVIGMFLAVPAWPSWTTIWAGTLGIGLVA
CCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
SAAAAFNCLIEQKIDAVMARTRARPLPRGELTGTQTLVFAGVLGGSGLLLLHTVVNPLTM
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
WLTLATFVGYAVIYTVLLKPATPQNIVIGGASGAMPPVLGWAAATGEIHHDALLLFLIIF
HHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHH
AWTPPHFWALALYRREEYARAGLPMLPVTHGEAYTRLHVLLYTLLLLAVSLLPVGTGMAG
HCCCHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
ALYLVGAVLLGARFIQYGWALHREYSDALARRTFRYSIWYLAALFAIMLLDHYFPIPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: protoheme; farnesyl-PP [C]

Specific reaction: protoheme + farnesyl-PP = heme O + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA