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The map label for this gene is apaH

Identifier: 74316186

GI number: 74316186

Start: 182154

End: 182975

Strand: Direct

Name: apaH

Synonym: Tbd_0168

Alternate gene names: 74316186

Gene position: 182154-182975 (Clockwise)

Preceding gene: 74316182

Following gene: 74316206

Centisome position: 6.26

GC content: 70.32

Gene sequence:

>822_bases
ATGCCTACCTATGCCATCGGTGACATTCAGGGTTGCCACGAGCCCTTGCTGCGCCTGCTCGACGTCGTCCGTTTCGACGC
GGCTTCCGACCGCCTGTGGTTCGTCGGCGACCTGGTCAACCGCGGGCCCGATTCGCTCGAAACGCTGCGTTTCATCCGCG
GCCTCGGCGACGCCGCCGTGTGCGTGCTCGGAAACCATGACCTGCACCTGATCGCGCTTGCCGCCGGCCACGGCCGGGCG
CACAAGGGCGATACGCTCGACGCGGTACTGGCGGCGCCCGACCGGGACGAGCTGCTCGGCTGGCTGCGGCGGCAGAAGCT
GGCGTGGCGCGAGGGCGACTGGCTCATGGTGCACGCGGGCGTGCTGCCGGGCTGGACGGCGGACGAGGTCATGCGTCACG
CGGCGGAGGCCGAGGCCGTGCTCGCGGGCGCCCACTATCGCGACTTTCTCGCGCAGATGTACGGCAACGCACCGGTCGCC
TGGGACGACGGGCTCGAAGGCGTCGAACGCCTGCGCGTCATCGTCAACGCCTTCACGCGCCTGCGCTACTGTTCGGCGGC
CGGCGAGATGGAATTCCACCATAAAGGCGCGCCCGGCACGCAGCCGTCGGGCTGGCTGCCCTGGTTCGACGTGCCGGCGC
GCAAGAGCGCGGATCTTGCCGTCGTCTTCGGCCACTGGTCGACGCTCGGCCTCGTCAACCGCGACGACCTGATCGCGCTC
GATACGGGCTGTCTGTGGGGCGGGGCGCTGAGCGCCGTCAGGCTCGAGGATCGGCAGGTGTTCGCGGTGAAGTGCCGTCA
GGCGCGGTCGCCGACGGGCTGA

Upstream 100 bases:

>100_bases
AAACAGACGGATCAGCGGTTTCATGGCGCGGGTGTCGCGAGAGGTTGAAGCGGGGGCGCTATGATGGCGAATCGAACCAG
CGCGAAGACCCGTATTTTAT

Downstream 100 bases:

>100_bases
CGCCAAGCAGGTCGGCAACGGCGCGCTCGGCCTGCGCGGCGAGTTCGCGGCGATGGCCGTCGGGCGCGATCGGTTCGCCG
AACTGGAGCTCGGCGACGAG

Product: diadenosine tetraphosphatase

Products: NA

Alternate protein names: Ap4A hydrolase; Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase; Diadenosine tetraphosphatase

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MPTYAIGDIQGCHEPLLRLLDVVRFDAASDRLWFVGDLVNRGPDSLETLRFIRGLGDAAVCVLGNHDLHLIALAAGHGRA
HKGDTLDAVLAAPDRDELLGWLRRQKLAWREGDWLMVHAGVLPGWTADEVMRHAAEAEAVLAGAHYRDFLAQMYGNAPVA
WDDGLEGVERLRVIVNAFTRLRYCSAAGEMEFHHKGAPGTQPSGWLPWFDVPARKSADLAVVFGHWSTLGLVNRDDLIAL
DTGCLWGGALSAVRLEDRQVFAVKCRQARSPTG

Sequences:

>Translated_273_residues
MPTYAIGDIQGCHEPLLRLLDVVRFDAASDRLWFVGDLVNRGPDSLETLRFIRGLGDAAVCVLGNHDLHLIALAAGHGRA
HKGDTLDAVLAAPDRDELLGWLRRQKLAWREGDWLMVHAGVLPGWTADEVMRHAAEAEAVLAGAHYRDFLAQMYGNAPVA
WDDGLEGVERLRVIVNAFTRLRYCSAAGEMEFHHKGAPGTQPSGWLPWFDVPARKSADLAVVFGHWSTLGLVNRDDLIAL
DTGCLWGGALSAVRLEDRQVFAVKCRQARSPTG
>Mature_272_residues
PTYAIGDIQGCHEPLLRLLDVVRFDAASDRLWFVGDLVNRGPDSLETLRFIRGLGDAAVCVLGNHDLHLIALAAGHGRAH
KGDTLDAVLAAPDRDELLGWLRRQKLAWREGDWLMVHAGVLPGWTADEVMRHAAEAEAVLAGAHYRDFLAQMYGNAPVAW
DDGLEGVERLRVIVNAFTRLRYCSAAGEMEFHHKGAPGTQPSGWLPWFDVPARKSADLAVVFGHWSTLGLVNRDDLIALD
TGCLWGGALSAVRLEDRQVFAVKCRQARSPTG

Specific function: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Ap4A hydrolase family

Homologues:

Organism=Escherichia coli, GI1786234, Length=264, Percent_Identity=45.8333333333333, Blast_Score=240, Evalue=6e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APAH_THIDA (Q3SMC6)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_313926.1
- ProteinModelPortal:   Q3SMC6
- SMR:   Q3SMC6
- STRING:   Q3SMC6
- GeneID:   3673614
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_0168
- NMPDR:   fig|292415.3.peg.78
- eggNOG:   COG0639
- HOGENOM:   HBG724457
- OMA:   LVFGHWA
- PhylomeDB:   Q3SMC6
- ProtClustDB:   PRK00166
- BioCyc:   TDEN292415:TBD_0168-MONOMER
- HAMAP:   MF_00199
- InterPro:   IPR004617
- InterPro:   IPR004843
- InterPro:   IPR006186
- PANTHER:   PTHR11668
- PIRSF:   PIRSF000903
- TIGRFAMs:   TIGR00668

Pfam domain/function: PF00149 Metallophos

EC number: =3.6.1.41

Molecular weight: Translated: 29958; Mature: 29827

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTYAIGDIQGCHEPLLRLLDVVRFDAASDRLWFVGDLVNRGPDSLETLRFIRGLGDAAV
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHCCCCHHHHHHHHHCCCCEEE
CVLGNHDLHLIALAAGHGRAHKGDTLDAVLAAPDRDELLGWLRRQKLAWREGDWLMVHAG
EEECCCCEEEEEEEECCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHCEECCCEEEEECC
VLPGWTADEVMRHAAEAEAVLAGAHYRDFLAQMYGNAPVAWDDGLEGVERLRVIVNAFTR
CCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
LRYCSAAGEMEFHHKGAPGTQPSGWLPWFDVPARKSADLAVVFGHWSTLGLVNRDDLIAL
HHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCEECCCCCCCEEEE
DTGCLWGGALSAVRLEDRQVFAVKCRQARSPTG
ECCCCCCCHHHEEEECCCEEEEEEHHHCCCCCC
>Mature Secondary Structure 
PTYAIGDIQGCHEPLLRLLDVVRFDAASDRLWFVGDLVNRGPDSLETLRFIRGLGDAAV
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHCCCCHHHHHHHHHCCCCEEE
CVLGNHDLHLIALAAGHGRAHKGDTLDAVLAAPDRDELLGWLRRQKLAWREGDWLMVHAG
EEECCCCEEEEEEEECCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHCEECCCEEEEECC
VLPGWTADEVMRHAAEAEAVLAGAHYRDFLAQMYGNAPVAWDDGLEGVERLRVIVNAFTR
CCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
LRYCSAAGEMEFHHKGAPGTQPSGWLPWFDVPARKSADLAVVFGHWSTLGLVNRDDLIAL
HHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCEECCCCCCCEEEE
DTGCLWGGALSAVRLEDRQVFAVKCRQARSPTG
ECCCCCCCHHHEEEECCCEEEEEEHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA