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The map label for this gene is betA [H]

Identifier: 73539654

GI number: 73539654

Start: 2665101

End: 2666834

Strand: Reverse

Name: betA [H]

Synonym: Reut_B5834

Alternate gene names: 73539654

Gene position: 2666834-2665101 (Counterclockwise)

Preceding gene: 73539655

Following gene: 73539653

Centisome position: 97.82

GC content: 65.51

Gene sequence:

>1734_bases
ATGAGTGCAATCCACGAATACGACTACATCATCGTCGGCGCCGGGTCGGCAGGCTGCGTGCTGGCCGCGCGGCTGACCGA
AGACGCCGATGTGACGGTGCTGCTGCTCGAAGCCGGCGGACCGGACTGGCGGCTCGACTGGCGTACGCAGATGCCGGCAG
CGCTGGCCTATCCGCTCCAGGGCACCACCTACAACTGGGCTTACGTCACCGAGCCGGAGCCGCATATGAACGGCCGCCGC
ATGACGCAGGGCCGTGGCAAGGGCCTCGGCGGCTCGTCTCTGATCAACGGCATGGTCTACATCCGCGGCAATGCGATGGA
CTATGAGGATTGGTCGCAGAACAGGTCGCTGGAAAACTGGAGCTACGCAGACTGCCTGCCCTACTTCCGCAAGGCCGAAA
CCTATGACAAGGGCACGAACGACTATCACGGCGGCAATGGCCCGCTGCATGTCACCACGCCCAAGGCCGGCATCAGCCCG
CTGTTCGATGCGTTCATCGCCGCCGGCGAGCAGGCCGGCTACGCACGCACCGAAGACCTGAACGGCTACCGCCAGGAAGG
CTTCGGCCCGATGGACCGCACCACCACTGCGAAGGGCCGCCGCTGCAGCACGTCGCTCGCCTATCTCGACCAGGCGAAAG
AGCGCCCGAACCTCACGGTGCACACGCGCGCACTGGCCGACCGCGTACTGTTCGACGGCGCCCGCGCCACCGGCGTTTCC
TACCTTCAGGGAGACTACGTGCGCGAAGCCCGGGCGCGCCGCGAGGTGATCGTCAGCAACGGTGCCATCGCCTCGCCGCA
ATTGCTGCTGCGCTCGGGCGTGGGCAATGCCGACGAACTTCGCGTGCTAGGCATCGACCCCGTCATCGACCTGAAGGGCG
TGGGCGAAAACCTGCAAGATCACCTGGAGATGTACCTGCAGTACGAATGCACAAAGCCTGTATCGCTGTACCCCGCGCTC
AAGTGGTGGAACAAGCCAGGCATCGGCATGGAGTGGTATCTGCGCGGCACGGGCATCGCGGCGTCGAACCACTTCGAGGC
GGGCGGTTTCATCCGCAGCAGCGAAGAGTTCGACTTCCCGAACCTGCAGTACCACTTCATCCCGCTGGCGATGAACTACG
ACGGCAGCAACCCGGTCCAGTCGCACGGCTTCCAGTGCCACGTAGGCTCGATGCGGTCGCCCAGCACAGGCTTCGTCAAG
CTGGCCAGCCGCGACCCGCGCGTCAAGCCGCGCCTGCTGTTCAACTACATGGCGCACGACGTGGACTGGCGCGAGTTCCG
CGCCGCGGTCCGCCTGACGCGAGAGATCATCGGCCAGCAGGCCATGGACCAGTTCCGCGGCCGCGAGATCAAGCCCGGCT
TGATGATCCAGTCCGATGCCGAGATCGACACCTTCGTGCGCGAGCACGCGGAGACCGCACTGCATCCGTCCTGCACCTGC
AAGATGGGCAACGCCTCCGACCCGATGGCCGTGGTCGACAACCAGGGCCGTGTGCATGGGCTGTCCGGGCTGCGCGTGGT
CGACGCGTCGATCATGCCGAAGATCGTGACCGGAAACCTGAATGCGCCGACGATCATGATGGCAGAGAAGCTCGCCGACG
TGATTCGCGGACGCGCACCGTTGCAGCGGTCAAACGCACCTTACTACAAGGCGACGCCGATGCGCGGGCACGCGGCAAAC
CCGCAGGACGCGCGAATGCGGACAACGGCGACACCGATGTTCGCGCCTGCCTGA

Upstream 100 bases:

>100_bases
CTGAAGCACAGCTACATCAACCTCGCGCCGAAGGCGATGGGGTGGTTCGGCGCCTGAGCGCCGGCGTCGCCCACATCACC
CATCAGGAGGAGACAGCTCG

Downstream 100 bases:

>100_bases
CGACGGCGCGACGCTCGCGGGTGTAACCCGCGCCCCCTCCGACGAACGATGACACCGGGACTGCCAGTCCCGAAGGACAC
CGCACGCCCGGAGGCTGCGT

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 577; Mature: 576

Protein sequence:

>577_residues
MSAIHEYDYIIVGAGSAGCVLAARLTEDADVTVLLLEAGGPDWRLDWRTQMPAALAYPLQGTTYNWAYVTEPEPHMNGRR
MTQGRGKGLGGSSLINGMVYIRGNAMDYEDWSQNRSLENWSYADCLPYFRKAETYDKGTNDYHGGNGPLHVTTPKAGISP
LFDAFIAAGEQAGYARTEDLNGYRQEGFGPMDRTTTAKGRRCSTSLAYLDQAKERPNLTVHTRALADRVLFDGARATGVS
YLQGDYVREARARREVIVSNGAIASPQLLLRSGVGNADELRVLGIDPVIDLKGVGENLQDHLEMYLQYECTKPVSLYPAL
KWWNKPGIGMEWYLRGTGIAASNHFEAGGFIRSSEEFDFPNLQYHFIPLAMNYDGSNPVQSHGFQCHVGSMRSPSTGFVK
LASRDPRVKPRLLFNYMAHDVDWREFRAAVRLTREIIGQQAMDQFRGREIKPGLMIQSDAEIDTFVREHAETALHPSCTC
KMGNASDPMAVVDNQGRVHGLSGLRVVDASIMPKIVTGNLNAPTIMMAEKLADVIRGRAPLQRSNAPYYKATPMRGHAAN
PQDARMRTTATPMFAPA

Sequences:

>Translated_577_residues
MSAIHEYDYIIVGAGSAGCVLAARLTEDADVTVLLLEAGGPDWRLDWRTQMPAALAYPLQGTTYNWAYVTEPEPHMNGRR
MTQGRGKGLGGSSLINGMVYIRGNAMDYEDWSQNRSLENWSYADCLPYFRKAETYDKGTNDYHGGNGPLHVTTPKAGISP
LFDAFIAAGEQAGYARTEDLNGYRQEGFGPMDRTTTAKGRRCSTSLAYLDQAKERPNLTVHTRALADRVLFDGARATGVS
YLQGDYVREARARREVIVSNGAIASPQLLLRSGVGNADELRVLGIDPVIDLKGVGENLQDHLEMYLQYECTKPVSLYPAL
KWWNKPGIGMEWYLRGTGIAASNHFEAGGFIRSSEEFDFPNLQYHFIPLAMNYDGSNPVQSHGFQCHVGSMRSPSTGFVK
LASRDPRVKPRLLFNYMAHDVDWREFRAAVRLTREIIGQQAMDQFRGREIKPGLMIQSDAEIDTFVREHAETALHPSCTC
KMGNASDPMAVVDNQGRVHGLSGLRVVDASIMPKIVTGNLNAPTIMMAEKLADVIRGRAPLQRSNAPYYKATPMRGHAAN
PQDARMRTTATPMFAPA
>Mature_576_residues
SAIHEYDYIIVGAGSAGCVLAARLTEDADVTVLLLEAGGPDWRLDWRTQMPAALAYPLQGTTYNWAYVTEPEPHMNGRRM
TQGRGKGLGGSSLINGMVYIRGNAMDYEDWSQNRSLENWSYADCLPYFRKAETYDKGTNDYHGGNGPLHVTTPKAGISPL
FDAFIAAGEQAGYARTEDLNGYRQEGFGPMDRTTTAKGRRCSTSLAYLDQAKERPNLTVHTRALADRVLFDGARATGVSY
LQGDYVREARARREVIVSNGAIASPQLLLRSGVGNADELRVLGIDPVIDLKGVGENLQDHLEMYLQYECTKPVSLYPALK
WWNKPGIGMEWYLRGTGIAASNHFEAGGFIRSSEEFDFPNLQYHFIPLAMNYDGSNPVQSHGFQCHVGSMRSPSTGFVKL
ASRDPRVKPRLLFNYMAHDVDWREFRAAVRLTREIIGQQAMDQFRGREIKPGLMIQSDAEIDTFVREHAETALHPSCTCK
MGNASDPMAVVDNQGRVHGLSGLRVVDASIMPKIVTGNLNAPTIMMAEKLADVIRGRAPLQRSNAPYYKATPMRGHAANP
QDARMRTTATPMFAPA

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=550, Percent_Identity=52.1818181818182, Blast_Score=554, Evalue=1e-158,
Organism=Escherichia coli, GI1786503, Length=551, Percent_Identity=67.8765880217786, Blast_Score=789, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17532301, Length=551, Percent_Identity=48.2758620689655, Blast_Score=501, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24642048, Length=599, Percent_Identity=36.3939899833055, Blast_Score=309, Evalue=3e-84,
Organism=Drosophila melanogaster, GI45549471, Length=572, Percent_Identity=37.4125874125874, Blast_Score=307, Evalue=1e-83,
Organism=Drosophila melanogaster, GI45551458, Length=572, Percent_Identity=37.4125874125874, Blast_Score=306, Evalue=2e-83,
Organism=Drosophila melanogaster, GI24642059, Length=575, Percent_Identity=36.5217391304348, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI24642042, Length=572, Percent_Identity=37.0629370629371, Blast_Score=293, Evalue=3e-79,
Organism=Drosophila melanogaster, GI24642055, Length=578, Percent_Identity=37.5432525951557, Blast_Score=289, Evalue=5e-78,
Organism=Drosophila melanogaster, GI24650267, Length=570, Percent_Identity=35.9649122807018, Blast_Score=273, Evalue=3e-73,
Organism=Drosophila melanogaster, GI24642039, Length=578, Percent_Identity=37.0242214532872, Blast_Score=268, Evalue=7e-72,
Organism=Drosophila melanogaster, GI17137792, Length=558, Percent_Identity=33.8709677419355, Blast_Score=267, Evalue=1e-71,
Organism=Drosophila melanogaster, GI18859995, Length=579, Percent_Identity=35.5785837651123, Blast_Score=257, Evalue=2e-68,
Organism=Drosophila melanogaster, GI24642035, Length=576, Percent_Identity=32.4652777777778, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI18859993, Length=576, Percent_Identity=33.3333333333333, Blast_Score=231, Evalue=8e-61,
Organism=Drosophila melanogaster, GI24642051, Length=568, Percent_Identity=31.5140845070423, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24642037, Length=306, Percent_Identity=41.1764705882353, Blast_Score=182, Evalue=7e-46,
Organism=Drosophila melanogaster, GI24645930, Length=583, Percent_Identity=26.7581475128645, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24642057, Length=592, Percent_Identity=29.0540540540541, Blast_Score=129, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 63841; Mature: 63710

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIHEYDYIIVGAGSAGCVLAARLTEDADVTVLLLEAGGPDWRLDWRTQMPAALAYPLQ
CCCCCCCCEEEEECCCCCEEEEEEECCCCCEEEEEEECCCCCEEEECCCCCCCEEECCCC
GTTYNWAYVTEPEPHMNGRRMTQGRGKGLGGSSLINGMVYIRGNAMDYEDWSQNRSLENW
CCEEEEEEEECCCCCCCCCEECCCCCCCCCHHHHHCCEEEEECCCCCCHHHHCCCCCCCC
SYADCLPYFRKAETYDKGTNDYHGGNGPLHVTTPKAGISPLFDAFIAAGEQAGYARTEDL
CHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCC
NGYRQEGFGPMDRTTTAKGRRCSTSLAYLDQAKERPNLTVHTRALADRVLFDGARATGVS
CCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHCCCCCCCCH
YLQGDYVREARARREVIVSNGAIASPQLLLRSGVGNADELRVLGIDPVIDLKGVGENLQD
HHHHHHHHHHHHHHEEEEECCCCCCHHHHHHCCCCCCCCEEEEECCCEEECCCCCCCHHH
HLEMYLQYECTKPVSLYPALKWWNKPGIGMEWYLRGTGIAASNHFEAGGFIRSSEEFDFP
HHHHHEEEECCCCCEECHHHHHCCCCCCCEEEEEEECCEEECCCCCCCCEEECCCCCCCC
NLQYHFIPLAMNYDGSNPVQSHGFQCHVGSMRSPSTGFVKLASRDPRVKPRLLFNYMAHD
CCEEEEEEEEEECCCCCCHHHCCEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHCC
VDWREFRAAVRLTREIIGQQAMDQFRGREIKPGLMIQSDAEIDTFVREHAETALHPSCTC
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCEEE
KMGNASDPMAVVDNQGRVHGLSGLRVVDASIMPKIVTGNLNAPTIMMAEKLADVIRGRAP
ECCCCCCCEEEECCCCCEECCCCCEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCC
LQRSNAPYYKATPMRGHAANPQDARMRTTATPMFAPA
CCCCCCCCEEECCCCCCCCCCCCCCEEECCCCCCCCC
>Mature Secondary Structure 
SAIHEYDYIIVGAGSAGCVLAARLTEDADVTVLLLEAGGPDWRLDWRTQMPAALAYPLQ
CCCCCCCEEEEECCCCCEEEEEEECCCCCEEEEEEECCCCCEEEECCCCCCCEEECCCC
GTTYNWAYVTEPEPHMNGRRMTQGRGKGLGGSSLINGMVYIRGNAMDYEDWSQNRSLENW
CCEEEEEEEECCCCCCCCCEECCCCCCCCCHHHHHCCEEEEECCCCCCHHHHCCCCCCCC
SYADCLPYFRKAETYDKGTNDYHGGNGPLHVTTPKAGISPLFDAFIAAGEQAGYARTEDL
CHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCC
NGYRQEGFGPMDRTTTAKGRRCSTSLAYLDQAKERPNLTVHTRALADRVLFDGARATGVS
CCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHCCCCCCCCH
YLQGDYVREARARREVIVSNGAIASPQLLLRSGVGNADELRVLGIDPVIDLKGVGENLQD
HHHHHHHHHHHHHHEEEEECCCCCCHHHHHHCCCCCCCCEEEEECCCEEECCCCCCCHHH
HLEMYLQYECTKPVSLYPALKWWNKPGIGMEWYLRGTGIAASNHFEAGGFIRSSEEFDFP
HHHHHEEEECCCCCEECHHHHHCCCCCCCEEEEEEECCEEECCCCCCCCEEECCCCCCCC
NLQYHFIPLAMNYDGSNPVQSHGFQCHVGSMRSPSTGFVKLASRDPRVKPRLLFNYMAHD
CCEEEEEEEEEECCCCCCHHHCCEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHCC
VDWREFRAAVRLTREIIGQQAMDQFRGREIKPGLMIQSDAEIDTFVREHAETALHPSCTC
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCEEE
KMGNASDPMAVVDNQGRVHGLSGLRVVDASIMPKIVTGNLNAPTIMMAEKLADVIRGRAP
ECCCCCCCEEEECCCCCEECCCCCEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCC
LQRSNAPYYKATPMRGHAANPQDARMRTTATPMFAPA
CCCCCCCCEEECCCCCCCCCCCCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA