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The map label for this gene is mhpF [C]

Identifier: 73539644

GI number: 73539644

Start: 2652501

End: 2653442

Strand: Reverse

Name: mhpF [C]

Synonym: Reut_B5824

Alternate gene names: 73539644

Gene position: 2653442-2652501 (Counterclockwise)

Preceding gene: 73539646

Following gene: 73539643

Centisome position: 97.33

GC content: 65.92

Gene sequence:

>942_bases
TTGGCGACAAGGAAACTCAAGGCCGCGATCATCGGATCCGGCAATATCGGCACGGACCTGATGATCAAGATCCTGCGCCA
TGGCAAGCACCTTGAGATGGGCGCCATGGTCGGCATCGATCCGGCATCGGATGGCCTGGCGCGTGCTGCCCGCATGGGTG
TGGCGACCACGCATGAAGGCGTGGAGGGGCTGATCAGCCTGCCGAATTTCGCCGACATCGACGTCGTCTTCGACGCCACC
AGCGCTGGCGCCCACGTCAAGAACGACGCGCGCCTGCGCGAAGTCAAGCCGGGCATCCGCATGATCGACCTCACCCCGGC
GGCCATCGGCCCCTACTGCGTGCCCGTGGTCAATCTGGACGACCGCCTCGACGCGCTGAACGTCAACATGGTCACCTGCG
GCGGCCAGGCAACCATCCCCATGGTCGCGGCCGTGTCACGCGTCGCAAAGGTCCACTACGCCGAAATCGTTGCATCGATC
TCCAGCAAGTCGGCCGGCCCGGGCACGCGCGCCAACATCGACGAGTTCACCGAGACCACGTCGAAGGCGATTGAAGTGAT
CGGAGGCGCCGCCAAGGGCAAGGCCATCATCGTGCTGAACCCGGCCGAGCCGCCGCTGATCATGCGCGACACGGTCTACG
TGCTGAGCGCCGCCGCCAACCGCGCGGAGGTGGAAGCCTCCATCGAGGAAATGGCCGCCGCCGTGCAGCAGTACGTGCCC
GGCTACCGCCTCAAGCAGAAAGTGCAGTTCGACGAGATTCCGGCCAGCGCTCCGCTCAATATCCCGGGCCTCGGCAAGTT
CAGCGGCCTGAAAACCTCGGTGTTCCTGGAGGTCGAGGGCGCCGCCCACTACCTGCCCGCCTACGCCGGCAATCTGGACA
TCATGACCTCCGCCGCGCTGGCCACCGCCGAGCGCATGGCGCAGGCCGCACTGACTGCTTGA

Upstream 100 bases:

>100_bases
CGTCCATGGGCGCGGCCACCGAATCCCGCAAGACCGCCCCTGCTGCCCATTCCCGACACAACAGAGGGCCGGCAGCAACG
CGCCACCCAAGGAGGCTCAA

Downstream 100 bases:

>100_bases
GGAGACACCCGCCATGCCTTTCAACCCCGGCAAGAAGCTCTACATTTCCGACGTGACGCTGCGTGACGGCAGCCACGCCA
TCCGCCACCAGTATTCGATT

Product: acetaldehyde dehydrogenase

Products: NA

Alternate protein names: Acetaldehyde dehydrogenase [acetylating]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MATRKLKAAIIGSGNIGTDLMIKILRHGKHLEMGAMVGIDPASDGLARAARMGVATTHEGVEGLISLPNFADIDVVFDAT
SAGAHVKNDARLREVKPGIRMIDLTPAAIGPYCVPVVNLDDRLDALNVNMVTCGGQATIPMVAAVSRVAKVHYAEIVASI
SSKSAGPGTRANIDEFTETTSKAIEVIGGAAKGKAIIVLNPAEPPLIMRDTVYVLSAAANRAEVEASIEEMAAAVQQYVP
GYRLKQKVQFDEIPASAPLNIPGLGKFSGLKTSVFLEVEGAAHYLPAYAGNLDIMTSAALATAERMAQAALTA

Sequences:

>Translated_313_residues
MATRKLKAAIIGSGNIGTDLMIKILRHGKHLEMGAMVGIDPASDGLARAARMGVATTHEGVEGLISLPNFADIDVVFDAT
SAGAHVKNDARLREVKPGIRMIDLTPAAIGPYCVPVVNLDDRLDALNVNMVTCGGQATIPMVAAVSRVAKVHYAEIVASI
SSKSAGPGTRANIDEFTETTSKAIEVIGGAAKGKAIIVLNPAEPPLIMRDTVYVLSAAANRAEVEASIEEMAAAVQQYVP
GYRLKQKVQFDEIPASAPLNIPGLGKFSGLKTSVFLEVEGAAHYLPAYAGNLDIMTSAALATAERMAQAALTA
>Mature_312_residues
ATRKLKAAIIGSGNIGTDLMIKILRHGKHLEMGAMVGIDPASDGLARAARMGVATTHEGVEGLISLPNFADIDVVFDATS
AGAHVKNDARLREVKPGIRMIDLTPAAIGPYCVPVVNLDDRLDALNVNMVTCGGQATIPMVAAVSRVAKVHYAEIVASIS
SKSAGPGTRANIDEFTETTSKAIEVIGGAAKGKAIIVLNPAEPPLIMRDTVYVLSAAANRAEVEASIEEMAAAVQQYVPG
YRLKQKVQFDEIPASAPLNIPGLGKFSGLKTSVFLEVEGAAHYLPAYAGNLDIMTSAALATAERMAQAALTA

Specific function: Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds

COG id: COG4569

COG function: function code Q; Acetaldehyde dehydrogenase (acetylating)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetaldehyde dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1786547, Length=305, Percent_Identity=82.6229508196721, Blast_Score=525, Evalue=1e-150,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACDH_CUPPJ (Q46NW7)

Other databases:

- EMBL:   CP000091
- RefSeq:   YP_300011.1
- ProteinModelPortal:   Q46NW7
- SMR:   Q46NW7
- GeneID:   3614066
- GenomeReviews:   CP000091_GR
- KEGG:   reu:Reut_B5824
- NMPDR:   fig|264198.3.peg.6472
- HOGENOM:   HBG300125
- OMA:   HVKNDAF
- ProtClustDB:   PRK08300
- BioCyc:   REUT264198:REUT_B5824-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01657
- InterPro:   IPR003361
- InterPro:   IPR015426
- InterPro:   IPR016040
- InterPro:   IPR000534
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR21123
- PIRSF:   PIRSF015689
- SMART:   SM00859
- TIGRFAMs:   TIGR03215

Pfam domain/function: PF09290 AcetDehyd-dimer; PF01118 Semialdhyde_dh

EC number: =1.2.1.10

Molecular weight: Translated: 32655; Mature: 32524

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: BINDING 291-291

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATRKLKAAIIGSGNIGTDLMIKILRHGKHLEMGAMVGIDPASDGLARAARMGVATTHEG
CCCCCEEEEEEECCCCCHHHHHHHHHCCCCEECCEEEECCCCCHHHHHHHHHCCCCCHHH
VEGLISLPNFADIDVVFDATSAGAHVKNDARLREVKPGIRMIDLTPAAIGPYCVPVVNLD
HHHHCCCCCCCCEEEEEECCCCCCCCCCCCHHHHCCCCCEEEEECCCCCCCEEEEEECCC
DRLDALNVNMVTCGGQATIPMVAAVSRVAKVHYAEIVASISSKSAGPGTRANIDEFTETT
CCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
SKAIEVIGGAAKGKAIIVLNPAEPPLIMRDTVYVLSAAANRAEVEASIEEMAAAVQQYVP
HHHHHHHCCCCCCCEEEEECCCCCCEEEHHHHEEHHHCCCHHHHHHHHHHHHHHHHHHCC
GYRLKQKVQFDEIPASAPLNIPGLGKFSGLKTSVFLEVEGAAHYLPAYAGNLDIMTSAAL
CHHHHHHCCHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHCCCCHHHHHHHH
ATAERMAQAALTA
HHHHHHHHHHHCC
>Mature Secondary Structure 
ATRKLKAAIIGSGNIGTDLMIKILRHGKHLEMGAMVGIDPASDGLARAARMGVATTHEG
CCCCEEEEEEECCCCCHHHHHHHHHCCCCEECCEEEECCCCCHHHHHHHHHCCCCCHHH
VEGLISLPNFADIDVVFDATSAGAHVKNDARLREVKPGIRMIDLTPAAIGPYCVPVVNLD
HHHHCCCCCCCCEEEEEECCCCCCCCCCCCHHHHCCCCCEEEEECCCCCCCEEEEEECCC
DRLDALNVNMVTCGGQATIPMVAAVSRVAKVHYAEIVASISSKSAGPGTRANIDEFTETT
CCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
SKAIEVIGGAAKGKAIIVLNPAEPPLIMRDTVYVLSAAANRAEVEASIEEMAAAVQQYVP
HHHHHHHCCCCCCCEEEEECCCCCCEEEHHHHEEHHHCCCHHHHHHHHHHHHHHHHHHCC
GYRLKQKVQFDEIPASAPLNIPGLGKFSGLKTSVFLEVEGAAHYLPAYAGNLDIMTSAAL
CHHHHHHCCHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHCCCCHHHHHHHH
ATAERMAQAALTA
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA