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The map label for this gene is pntB [H]

Identifier: 73539543

GI number: 73539543

Start: 2551121

End: 2552590

Strand: Direct

Name: pntB [H]

Synonym: Reut_B5722

Alternate gene names: 73539543

Gene position: 2551121-2552590 (Clockwise)

Preceding gene: 73539542

Following gene: 73539546

Centisome position: 93.58

GC content: 63.13

Gene sequence:

>1470_bases
ATGAACGGACTGTCCATGAATACCGTGACGCTGTTCTACCTGGGCGCGTCGGTCTGCTTTATCCAGGCCCTCAAAGGGCT
TTCGCACCCGGCTTCGGCCCGCAAGGGCAATGCCTTCGGCATGATCGGCATGGCGGTGGCGGCACTCACCACGGTGGCGC
TGATCCTCAAGCTCAAGAACGAGTTCCTCGCTGCCGGTAACGGCACGACAGCCGGGTCTGGCCTTGCGCTGATCCTGGCT
GGCCTGGTCGTCGGCGGCGGCATCGGCGCCTACGTGGCAAAGAAGGTCGAGATGACCAAGATGCCAGAACTGGTCGCGGC
GATGCACTCGCTGATCGGTCTCGCGGCGGTGTGCATTGCGGTGGCCGCGGTGGCGGAACCTTCCGCCTTTGGTATTGCGC
CGGCGGGTTCGCATGAGATTCCGATGGGCAACCGCATCGAACTGTTCATCGGCTGCTTCGTCGGCGCCATCACGTTCTCC
GGTTCCGTGATCGCCTTCGGCAAGCTGGCAGGTCGCTACAAGTTCCGCCTGTTCCAGGGTGCCCCCGTTGTGTTCGCGGG
CCAGCACATGCTGAACCTGGCGCTGGCCGTCGCCATGGTCGGCTTCGGCATTGCGTTCTTCATGACGCAGGAGTGGACGC
CGTTCCTCGTCATGCTGGCCATCGCCTTCGTGCTCGGCGTGCTGATCATCATCCCGATCGGCGGCGCCGACATGCCGGTG
GTGGTGTCGATGCTGAACTCGTACTCGGGCTGGGCGGCCGCCGGTATCGGCTTCTCGCTGAACAACCCGATGCTGATCAT
TGCCGGTTCGCTGGTGGGTTCGTCCGGTGCCATCCTCTCGTACATCATGTGCAAGGCGATGAACCGTTCGTTCTTCAACG
TGATCCTCGGCGGCTTCGGCAGCGATGCGGGAGCGAGCGCAGCAGGTGGTTCGCAAGTGCAGCGCAACGTAAAGTCGGGC
TCCGCCGATGACGCCTCGTTCCTGATGGGCAATGCCGAGACCGTGATCATCGTGCCGGGTTACGGCCTGGCAGTGGCGCG
CGCCCAGCACGCACTCAAGGAACTGACCGAAAAGCTGACCGAGAAGGGCGTGACCGTGAAATACGCGATCCACCCCGTCG
CAGGCCGCATGCCGGGCCACATGAACGTGCTGCTGGCCGAGGCCGAGGTGCCGTACGACCAGGTCTTCGAGATGGAAGAC
ATCAACAGCGAGTTCGGCCAGGCCGACGTGGTGCTGGTGCTCGGCGCGAACGACGTGGTGAACCCGTCGGCCAAGACCGA
TCCGAAGTCGCCGATCGCGGGCATGCCGATCCTGGAGGCGTACAAGGCCAAGACCATCATCGTGAACAAGCGGTCGATGG
CCGCCGGCTACGCCGGGCTGGACAACGAACTGTTCTATATGGACAAGACCATGATGGTGTTCGGCGACGCCAAGAAGGTG
GTCGAGGACATGGTCAAGGCTGTTGAATGA

Upstream 100 bases:

>100_bases
TGCTAGAGATGTTCCGCAAGAAGGCGCCGAAGGTGAAGGCCGAGGCGCAGCCCGCAAAGACGCCCGCGCACGCCGGCGGA
GAACTGGTGGAGATGCCGCG

Downstream 100 bases:

>100_bases
ATAGCTGGGGATTCCCGCGGTCGATGTGATCAGAGTTGAAGGAAGCAGTAGTGCTGGCTGCCAGGCAACCAGGGCACCTC
AGAAGATCAACAAAAATGCA

Product: NAD(P) transhydrogenase subunit beta

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit beta; Proton-translocating transhydrogenase NADP(H)-binding component; Pyridine nucleotide transhydrogenase subunit beta; dIII [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MNGLSMNTVTLFYLGASVCFIQALKGLSHPASARKGNAFGMIGMAVAALTTVALILKLKNEFLAAGNGTTAGSGLALILA
GLVVGGGIGAYVAKKVEMTKMPELVAAMHSLIGLAAVCIAVAAVAEPSAFGIAPAGSHEIPMGNRIELFIGCFVGAITFS
GSVIAFGKLAGRYKFRLFQGAPVVFAGQHMLNLALAVAMVGFGIAFFMTQEWTPFLVMLAIAFVLGVLIIIPIGGADMPV
VVSMLNSYSGWAAAGIGFSLNNPMLIIAGSLVGSSGAILSYIMCKAMNRSFFNVILGGFGSDAGASAAGGSQVQRNVKSG
SADDASFLMGNAETVIIVPGYGLAVARAQHALKELTEKLTEKGVTVKYAIHPVAGRMPGHMNVLLAEAEVPYDQVFEMED
INSEFGQADVVLVLGANDVVNPSAKTDPKSPIAGMPILEAYKAKTIIVNKRSMAAGYAGLDNELFYMDKTMMVFGDAKKV
VEDMVKAVE

Sequences:

>Translated_489_residues
MNGLSMNTVTLFYLGASVCFIQALKGLSHPASARKGNAFGMIGMAVAALTTVALILKLKNEFLAAGNGTTAGSGLALILA
GLVVGGGIGAYVAKKVEMTKMPELVAAMHSLIGLAAVCIAVAAVAEPSAFGIAPAGSHEIPMGNRIELFIGCFVGAITFS
GSVIAFGKLAGRYKFRLFQGAPVVFAGQHMLNLALAVAMVGFGIAFFMTQEWTPFLVMLAIAFVLGVLIIIPIGGADMPV
VVSMLNSYSGWAAAGIGFSLNNPMLIIAGSLVGSSGAILSYIMCKAMNRSFFNVILGGFGSDAGASAAGGSQVQRNVKSG
SADDASFLMGNAETVIIVPGYGLAVARAQHALKELTEKLTEKGVTVKYAIHPVAGRMPGHMNVLLAEAEVPYDQVFEMED
INSEFGQADVVLVLGANDVVNPSAKTDPKSPIAGMPILEAYKAKTIIVNKRSMAAGYAGLDNELFYMDKTMMVFGDAKKV
VEDMVKAVE
>Mature_489_residues
MNGLSMNTVTLFYLGASVCFIQALKGLSHPASARKGNAFGMIGMAVAALTTVALILKLKNEFLAAGNGTTAGSGLALILA
GLVVGGGIGAYVAKKVEMTKMPELVAAMHSLIGLAAVCIAVAAVAEPSAFGIAPAGSHEIPMGNRIELFIGCFVGAITFS
GSVIAFGKLAGRYKFRLFQGAPVVFAGQHMLNLALAVAMVGFGIAFFMTQEWTPFLVMLAIAFVLGVLIIIPIGGADMPV
VVSMLNSYSGWAAAGIGFSLNNPMLIIAGSLVGSSGAILSYIMCKAMNRSFFNVILGGFGSDAGASAAGGSQVQRNVKSG
SADDASFLMGNAETVIIVPGYGLAVARAQHALKELTEKLTEKGVTVKYAIHPVAGRMPGHMNVLLAEAEVPYDQVFEMED
INSEFGQADVVLVLGANDVVNPSAKTDPKSPIAGMPILEAYKAKTIIVNKRSMAAGYAGLDNELFYMDKTMMVFGDAKKV
VEDMVKAVE

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG1282

COG function: function code C; NAD/NADP transhydrogenase beta subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNT beta subunit family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=491, Percent_Identity=46.6395112016293, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI122939153, Length=491, Percent_Identity=46.6395112016293, Blast_Score=402, Evalue=1e-112,
Organism=Escherichia coli, GI1787886, Length=484, Percent_Identity=50.6198347107438, Blast_Score=452, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI17550456, Length=482, Percent_Identity=41.9087136929461, Blast_Score=361, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012136
- InterPro:   IPR004003 [H]

Pfam domain/function: PF02233 PNTB [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 50741; Mature: 50741

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGLSMNTVTLFYLGASVCFIQALKGLSHPASARKGNAFGMIGMAVAALTTVALILKLKN
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
EFLAAGNGTTAGSGLALILAGLVVGGGIGAYVAKKVEMTKMPELVAAMHSLIGLAAVCIA
HHEECCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAAVAEPSAFGIAPAGSHEIPMGNRIELFIGCFVGAITFSGSVIAFGKLAGRYKFRLFQG
HHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHHCCEEEEEEECC
APVVFAGQHMLNLALAVAMVGFGIAFFMTQEWTPFLVMLAIAFVLGVLIIIPIGGADMPV
CCEEEECHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECCCCCHHH
VVSMLNSYSGWAAAGIGFSLNNPMLIIAGSLVGSSGAILSYIMCKAMNRSFFNVILGGFG
HHHHHHCCCCCEEECCCEECCCCEEEEEECCCCCCCHHHHHHHHHHHCHHHHHHHHHCCC
SDAGASAAGGSQVQRNVKSGSADDASFLMGNAETVIIVPGYGLAVARAQHALKELTEKLT
CCCCCCCCCCHHHHHHHHCCCCCCCHHEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
EKGVTVKYAIHPVAGRMPGHMNVLLAEAEVPYDQVFEMEDINSEFGQADVVLVLGANDVV
HCCCEEEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCC
NPSAKTDPKSPIAGMPILEAYKAKTIIVNKRSMAAGYAGLDNELFYMDKTMMVFGDAKKV
CCCCCCCCCCCCCCCCHHHHHCCEEEEEECCHHHCCCCCCCCCEEEECCEEEEECCHHHH
VEDMVKAVE
HHHHHHHCC
>Mature Secondary Structure
MNGLSMNTVTLFYLGASVCFIQALKGLSHPASARKGNAFGMIGMAVAALTTVALILKLKN
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
EFLAAGNGTTAGSGLALILAGLVVGGGIGAYVAKKVEMTKMPELVAAMHSLIGLAAVCIA
HHEECCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAAVAEPSAFGIAPAGSHEIPMGNRIELFIGCFVGAITFSGSVIAFGKLAGRYKFRLFQG
HHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHHCCEEEEEEECC
APVVFAGQHMLNLALAVAMVGFGIAFFMTQEWTPFLVMLAIAFVLGVLIIIPIGGADMPV
CCEEEECHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECCCCCHHH
VVSMLNSYSGWAAAGIGFSLNNPMLIIAGSLVGSSGAILSYIMCKAMNRSFFNVILGGFG
HHHHHHCCCCCEEECCCEECCCCEEEEEECCCCCCCHHHHHHHHHHHCHHHHHHHHHCCC
SDAGASAAGGSQVQRNVKSGSADDASFLMGNAETVIIVPGYGLAVARAQHALKELTEKLT
CCCCCCCCCCHHHHHHHHCCCCCCCHHEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
EKGVTVKYAIHPVAGRMPGHMNVLLAEAEVPYDQVFEMEDINSEFGQADVVLVLGANDVV
HCCCEEEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCC
NPSAKTDPKSPIAGMPILEAYKAKTIIVNKRSMAAGYAGLDNELFYMDKTMMVFGDAKKV
CCCCCCCCCCCCCCCCHHHHHCCEEEEEECCHHHCCCCCCCCCEEEECCEEEEECCHHHH
VEDMVKAVE
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]