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The map label for this gene is alsR [H]

Identifier: 73539517

GI number: 73539517

Start: 2524621

End: 2525511

Strand: Reverse

Name: alsR [H]

Synonym: Reut_B5695

Alternate gene names: 73539517

Gene position: 2525511-2524621 (Counterclockwise)

Preceding gene: 73539520

Following gene: 73539516

Centisome position: 92.64

GC content: 61.84

Gene sequence:

>891_bases
ATGTCAGAACGCCTCGATTCCCGATCTCTTTCCCTGTTCCTTGCGGTTGCGGAGGCACTTAGCTTCCGCCAGGCAGCGGA
GCGGCTCCATCTTTCTCAGCCGCCGCTGAGTCGGGCGATTCGGGAACTCGAAGAGCGATTGGGGACGCGCCTGTTTGACA
GAAACACGAAGGGCGTCACACTTACCGCGGCGGGAGAGAAGCTCGTGCCTTACGCGCGCAAGGTTGCCAAAATACTTCGC
GAGGCCGAAATCGCGATCGCGGACGAAGGGGAGCCGGCCAACCTCAGGGTCGGCGTCACAAGCGCCGTGGAGCCGGCCTG
GTTTCTCGGTCTGGCTCAACGCGTGCAAGCCACTCACCCTGAAATGGTCGTTTCGATGTTCTCCGATACATCGCCACGAC
TCATACGTCAGCTTCGCGCGGGCAAACTGGACGCCGCCTTCATCGCGCTGCCGACGGAAGCGCAGGGGCTGGACGTCCAG
GAACTCGACCGACTGCCAATGATCGTCGCGATCCCTTCAACCCATCCTCTGGCGAAGCGCAGGATCGTTGGCCTCGCGGA
CCTGGAGCGTGAAAAGGTCTTCTGGTTCGAGCGCGCACGGCAGCCGGCTTTCTATGATCACTGCCAAGCGGTTTTTTCGC
GCCATGGGTTCACTCCGTCAAAACTGAGGGAGCCAGCCGACCACCACGTCCTGCTGGGCGAGGTCGCGAATGGGCGAGGT
ATCGCGCTGTTGCCAAAATCGTTCACCGCATTGAGGCGGGCAGGCGTCGTCTACAGGACGCTGGCCGAAGGCGAGCAACT
ATCGGTTGGCATCGGGCTCGCTTCGCACACGGACCGGCCAGGCGTGCGGGACATACTGGCAACAGCTGCTGAAGTGAACC
GAGATACCTGA

Upstream 100 bases:

>100_bases
ACGTTCGGCGCTCATAGTTTTTCTCCAGAAGTGTTGGTACGACGACTGTATGGCACGCTTCGAACGTGCGGAATGATCAA
TATCGTGATACCTTTTTGAT

Downstream 100 bases:

>100_bases
GATTCCGAACTTGGCGTGGATCACGACTGGCGAGTTTTGTAGAACGACGGTCTTCTGCAAGCAGATCTAATCGGACCCGT
GTTTCTCCAGTCCCTCCTGA

Product: regulatory protein LysR

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MSERLDSRSLSLFLAVAEALSFRQAAERLHLSQPPLSRAIRELEERLGTRLFDRNTKGVTLTAAGEKLVPYARKVAKILR
EAEIAIADEGEPANLRVGVTSAVEPAWFLGLAQRVQATHPEMVVSMFSDTSPRLIRQLRAGKLDAAFIALPTEAQGLDVQ
ELDRLPMIVAIPSTHPLAKRRIVGLADLEREKVFWFERARQPAFYDHCQAVFSRHGFTPSKLREPADHHVLLGEVANGRG
IALLPKSFTALRRAGVVYRTLAEGEQLSVGIGLASHTDRPGVRDILATAAEVNRDT

Sequences:

>Translated_296_residues
MSERLDSRSLSLFLAVAEALSFRQAAERLHLSQPPLSRAIRELEERLGTRLFDRNTKGVTLTAAGEKLVPYARKVAKILR
EAEIAIADEGEPANLRVGVTSAVEPAWFLGLAQRVQATHPEMVVSMFSDTSPRLIRQLRAGKLDAAFIALPTEAQGLDVQ
ELDRLPMIVAIPSTHPLAKRRIVGLADLEREKVFWFERARQPAFYDHCQAVFSRHGFTPSKLREPADHHVLLGEVANGRG
IALLPKSFTALRRAGVVYRTLAEGEQLSVGIGLASHTDRPGVRDILATAAEVNRDT
>Mature_295_residues
SERLDSRSLSLFLAVAEALSFRQAAERLHLSQPPLSRAIRELEERLGTRLFDRNTKGVTLTAAGEKLVPYARKVAKILRE
AEIAIADEGEPANLRVGVTSAVEPAWFLGLAQRVQATHPEMVVSMFSDTSPRLIRQLRAGKLDAAFIALPTEAQGLDVQE
LDRLPMIVAIPSTHPLAKRRIVGLADLEREKVFWFERARQPAFYDHCQAVFSRHGFTPSKLREPADHHVLLGEVANGRGI
ALLPKSFTALRRAGVVYRTLAEGEQLSVGIGLASHTDRPGVRDILATAAEVNRDT

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=272, Percent_Identity=30.5147058823529, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1790399, Length=258, Percent_Identity=31.7829457364341, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1788887, Length=295, Percent_Identity=28.135593220339, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI2367136, Length=293, Percent_Identity=31.740614334471, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI145693105, Length=184, Percent_Identity=32.0652173913043, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI157672245, Length=190, Percent_Identity=34.2105263157895, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787806, Length=249, Percent_Identity=28.5140562248996, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1788297, Length=246, Percent_Identity=26.4227642276423, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787601, Length=146, Percent_Identity=34.9315068493151, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI48994962, Length=157, Percent_Identity=31.2101910828025, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790208, Length=250, Percent_Identity=27.6, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI87081904, Length=186, Percent_Identity=26.8817204301075, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786401, Length=157, Percent_Identity=33.1210191082803, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789506, Length=247, Percent_Identity=23.0769230769231, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790262, Length=266, Percent_Identity=25.9398496240602, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788748, Length=245, Percent_Identity=24.4897959183673, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32646; Mature: 32515

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERLDSRSLSLFLAVAEALSFRQAAERLHLSQPPLSRAIRELEERLGTRLFDRNTKGVT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEE
LTAAGEKLVPYARKVAKILREAEIAIADEGEPANLRVGVTSAVEPAWFLGLAQRVQATHP
EEECCCHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEEECHHCCHHHHHHHHHHHHHCCH
EMVVSMFSDTSPRLIRQLRAGKLDAAFIALPTEAQGLDVQELDRLPMIVAIPSTHPLAKR
HHHHHHHCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHCCCEEEEECCCCCHHHH
RIVGLADLEREKVFWFERARQPAFYDHCQAVFSRHGFTPSKLREPADHHVLLGEVANGRG
HHHCHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHCCCCCCEEEEEEECCCCE
IALLPKSFTALRRAGVVYRTLAEGEQLSVGIGLASHTDRPGVRDILATAAEVNRDT
EEECCHHHHHHHHCCHHHHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SERLDSRSLSLFLAVAEALSFRQAAERLHLSQPPLSRAIRELEERLGTRLFDRNTKGVT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEE
LTAAGEKLVPYARKVAKILREAEIAIADEGEPANLRVGVTSAVEPAWFLGLAQRVQATHP
EEECCCHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEEECHHCCHHHHHHHHHHHHHCCH
EMVVSMFSDTSPRLIRQLRAGKLDAAFIALPTEAQGLDVQELDRLPMIVAIPSTHPLAKR
HHHHHHHCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHCCCEEEEECCCCCHHHH
RIVGLADLEREKVFWFERARQPAFYDHCQAVFSRHGFTPSKLREPADHHVLLGEVANGRG
HHHCHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHCCCCCCEEEEEEECCCCE
IALLPKSFTALRRAGVVYRTLAEGEQLSVGIGLASHTDRPGVRDILATAAEVNRDT
EEECCHHHHHHHHCCHHHHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]