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The map label for this gene is exuT [H]

Identifier: 73538855

GI number: 73538855

Start: 1763402

End: 1764727

Strand: Direct

Name: exuT [H]

Synonym: Reut_B5030

Alternate gene names: 73538855

Gene position: 1763402-1764727 (Clockwise)

Preceding gene: 73538854

Following gene: 73538856

Centisome position: 64.68

GC content: 65.91

Gene sequence:

>1326_bases
ATGACCACGATTCACAAGGAGATCCCGGCCACCGCCGTGCCCGGCCACTCCCTGGCTGACAAGATCCGCGCCGGGTTCGC
GCTCGGCAAGGTGCGCTGGGGCATGCTCGCGCTGGTGTTCTTTGCCACCACGCTCAACTACGTCGACCGCGCCGCGCTCG
GCGTGCTGCAGCCGGTGCTGGCCAAGGCCATGGCCTGGACCGCCCAGGACTACGCCAACATCAACTTCTGGTTCCAGGTC
GGCTACGCCATCGGCTTTGCACTGCAGGGCCGCTTCATCGACATGGTCGGCGTCAAGCGCGCCTTTGCGCTGGCCGTGCT
GCTGTGGAGCATTGCCTGCGGCGCGCACGCGTTGGCGGCCTCCGCCGTCGGCTTCATGATCTGCCGCTTCTTCCTCGGCC
TGACTGAAGCCGCCAACTACCCGGCCTGCGTCAAGACCACGCGCACGTGGTTCCCGGCCAGCGAACGGGCCGTGGCGACC
GGCATCTTCAATGCCGGCACCAACGTCGGCGCCATGCTCACACCGATCATGCTGCCGCTGATCCTGCAGGCCTGGGGCTG
GCAGGCCGCGTTCCTGATCGTCGGTGCGATGGGCGCGCTCTGGCTCGTGTTCTGGATGATCAAGTACCACAACCCCGATG
AGCATCCCACGGTCACGCAAGCGGAACTCGCACACGTCAGCCGCGATGTCGAGCCCGCGCCGCAGCGCATCCCGTACTCG
AAGATCCTGCGCATGCGCGGCACCTGGGCCTTCGCCTTCGCCTATGCCATCACCGCGCCGGTGTTCTGGTTCTACCTGTA
CTGGCTGCCGCCGTTCCTGAACCAGCAGTACCAGCTCGGCATCAGCGTCACGCAGATGGGCATCCCGCTGATCGTCATCT
ACCTGTGTGCCGATATCGGCAGCGTGGGCGGCGGCGCCCTGTCGTCGTGGCTCATCAGCCACGGCATGGCGGCGGTCCGC
GCTCGGCTGCTCTCGATGCTGATCTTCGCGGTGTGCATCACGTCGATCGTGTTCGCCGCCGGCGCCAGCAGCCTGTGGAC
GGCCGTCGCCGCGATATCGGTCGCCATCGGTGCGCACCAGGCGTGGACTGCCAATATCTGGAGCATGGTGATGGACTACA
CGCCCAAGCATGTGGTCAGCTCGGTATTCGGCTTCGGCGGCATGATCGGCGCAGTCGGCGGCATGTTCATGACCCAGCTC
GTGGGCTATGTCCTGACGGCCACGCACAACAACTACGCCGTGCTCTTCACGATGATCCCCTGCGCGTACTTCATCGCGCT
GACCTGGATGTTCCTGACCGCGCCGCGCAAGGTGCCCGAGCACTGA

Upstream 100 bases:

>100_bases
GCCTGCGCACTCCCGCCACGAACAAGACCGGTTGCCAGCCTGTCCAGGCGCTACAGGGCATACCGGAAAGCACATTGCAT
CCAATGGTGGAGACAAACAA

Downstream 100 bases:

>100_bases
GCCACACGCCAGCCCCCAACACCTTGCAACACGCCTGACGACAAAAAGGCATTCGAGCCACACTACAGCGGGACATCCAA
CACACCATGAAGAAGCAACT

Product: major facilitator transporter

Products: galacturonate [Cytoplasm]; Proton [Cytoplasm]; glucuronate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MTTIHKEIPATAVPGHSLADKIRAGFALGKVRWGMLALVFFATTLNYVDRAALGVLQPVLAKAMAWTAQDYANINFWFQV
GYAIGFALQGRFIDMVGVKRAFALAVLLWSIACGAHALAASAVGFMICRFFLGLTEAANYPACVKTTRTWFPASERAVAT
GIFNAGTNVGAMLTPIMLPLILQAWGWQAAFLIVGAMGALWLVFWMIKYHNPDEHPTVTQAELAHVSRDVEPAPQRIPYS
KILRMRGTWAFAFAYAITAPVFWFYLYWLPPFLNQQYQLGISVTQMGIPLIVIYLCADIGSVGGGALSSWLISHGMAAVR
ARLLSMLIFAVCITSIVFAAGASSLWTAVAAISVAIGAHQAWTANIWSMVMDYTPKHVVSSVFGFGGMIGAVGGMFMTQL
VGYVLTATHNNYAVLFTMIPCAYFIALTWMFLTAPRKVPEH

Sequences:

>Translated_441_residues
MTTIHKEIPATAVPGHSLADKIRAGFALGKVRWGMLALVFFATTLNYVDRAALGVLQPVLAKAMAWTAQDYANINFWFQV
GYAIGFALQGRFIDMVGVKRAFALAVLLWSIACGAHALAASAVGFMICRFFLGLTEAANYPACVKTTRTWFPASERAVAT
GIFNAGTNVGAMLTPIMLPLILQAWGWQAAFLIVGAMGALWLVFWMIKYHNPDEHPTVTQAELAHVSRDVEPAPQRIPYS
KILRMRGTWAFAFAYAITAPVFWFYLYWLPPFLNQQYQLGISVTQMGIPLIVIYLCADIGSVGGGALSSWLISHGMAAVR
ARLLSMLIFAVCITSIVFAAGASSLWTAVAAISVAIGAHQAWTANIWSMVMDYTPKHVVSSVFGFGGMIGAVGGMFMTQL
VGYVLTATHNNYAVLFTMIPCAYFIALTWMFLTAPRKVPEH
>Mature_440_residues
TTIHKEIPATAVPGHSLADKIRAGFALGKVRWGMLALVFFATTLNYVDRAALGVLQPVLAKAMAWTAQDYANINFWFQVG
YAIGFALQGRFIDMVGVKRAFALAVLLWSIACGAHALAASAVGFMICRFFLGLTEAANYPACVKTTRTWFPASERAVATG
IFNAGTNVGAMLTPIMLPLILQAWGWQAAFLIVGAMGALWLVFWMIKYHNPDEHPTVTQAELAHVSRDVEPAPQRIPYSK
ILRMRGTWAFAFAYAITAPVFWFYLYWLPPFLNQQYQLGISVTQMGIPLIVIYLCADIGSVGGGALSSWLISHGMAAVRA
RLLSMLIFAVCITSIVFAAGASSLWTAVAAISVAIGAHQAWTANIWSMVMDYTPKHVVSSVFGFGGMIGAVGGMFMTQLV
GYVLTATHNNYAVLFTMIPCAYFIALTWMFLTAPRKVPEH

Specific function: Aldohexuronate transport system [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI154350196, Length=386, Percent_Identity=24.8704663212435, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI9966811, Length=355, Percent_Identity=22.5352112676056, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI21322234, Length=289, Percent_Identity=23.1833910034602, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI9945322, Length=286, Percent_Identity=21.6783216783217, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI2367193, Length=367, Percent_Identity=28.3378746594005, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1789515, Length=431, Percent_Identity=25.754060324826, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI2367379, Length=421, Percent_Identity=23.9904988123515, Blast_Score=134, Evalue=8e-33,
Organism=Escherichia coli, GI1789152, Length=430, Percent_Identity=24.4186046511628, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI87082320, Length=389, Percent_Identity=24.6786632390745, Blast_Score=117, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17535049, Length=410, Percent_Identity=23.6585365853659, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI115533554, Length=185, Percent_Identity=27.5675675675676, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI115533556, Length=185, Percent_Identity=27.5675675675676, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17552542, Length=283, Percent_Identity=27.5618374558304, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71997452, Length=274, Percent_Identity=25.1824817518248, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25145964, Length=198, Percent_Identity=29.2929292929293, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI19920686, Length=382, Percent_Identity=22.5130890052356, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24583789, Length=389, Percent_Identity=20.5655526992288, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24641682, Length=316, Percent_Identity=22.7848101265823, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI20129235, Length=339, Percent_Identity=24.7787610619469, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24580790, Length=299, Percent_Identity=21.4046822742475, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI62484226, Length=316, Percent_Identity=22.4683544303797, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24584153, Length=347, Percent_Identity=20.4610951008646, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48075; Mature: 47944

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTIHKEIPATAVPGHSLADKIRAGFALGKVRWGMLALVFFATTLNYVDRAALGVLQPVL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKAMAWTAQDYANINFWFQVGYAIGFALQGRFIDMVGVKRAFALAVLLWSIACGAHALAA
HHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAVGFMICRFFLGLTEAANYPACVKTTRTWFPASERAVATGIFNAGTNVGAMLTPIMLPL
HHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHH
ILQAWGWQAAFLIVGAMGALWLVFWMIKYHNPDEHPTVTQAELAHVSRDVEPAPQRIPYS
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHH
KILRMRGTWAFAFAYAITAPVFWFYLYWLPPFLNQQYQLGISVTQMGIPLIVIYLCADIG
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHCHHCCCCCEECCCHHHHHHHHHHHHHHHHHC
SVGGGALSSWLISHGMAAVRARLLSMLIFAVCITSIVFAAGASSLWTAVAAISVAIGAHQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCH
AWTANIWSMVMDYTPKHVVSSVFGFGGMIGAVGGMFMTQLVGYVLTATHNNYAVLFTMIP
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHH
CAYFIALTWMFLTAPRKVPEH
HHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TTIHKEIPATAVPGHSLADKIRAGFALGKVRWGMLALVFFATTLNYVDRAALGVLQPVL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH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HHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: galacturonate [Periplasm]; Proton [Periplasm]; glucuronate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + galacturonate [Periplasm] = galacturonate [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + glucuronate [Periplasm] = Proton [Cytoplasm] + glucuronate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]