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The map label for this gene is kbl [C]

Identifier: 73538628

GI number: 73538628

Start: 1503052

End: 1504254

Strand: Reverse

Name: kbl [C]

Synonym: Reut_B4803

Alternate gene names: 73538628

Gene position: 1504254-1503052 (Counterclockwise)

Preceding gene: 73538631

Following gene: 73538627

Centisome position: 55.18

GC content: 63.67

Gene sequence:

>1203_bases
ATGTCGAGTGCCGAGGCCTTCTACGCGTCCGTGCGTGCAGAGCTTGACGCCATCCGGGAAGCGGGGCTGTACAAGGAAGA
GCGCGTCATCGCGACGCCGCAGGGTGCGCGCGTGCGGACCGCCGATGGCCGGGAGGTCATCAACCTGTGTGCCAACAATT
ACCTTGGCCTGTCTTCGCATCCCGGCGTCATCGAAGCCGCGCACGAAGCGCTGCGTACGCATGGCTTCGGGCTGAGTTCG
GTGCGCTTTATCTGCGGTACGCAGGATTTGCACAAGACCTTGGAGGCCAGGTTGTCCAGTTTCCTTGGCACCGAGGACAC
CATCCTCTACGGCTCAGCATTCGACGCCAACGGCGGCCTGTTCGAGACGCTGCTGGGTGCCGAAGATGCCATCATCAGCG
ACGAGTTGAATCACGCATCGATCATCGACGGCATCCGCCTGAGCAAGGCGCGCCGCTACCGCTACAAGCACAACGACATG
GACGACCTGCGCGCACAACTGGCGCAGGCCGATGCCGATGGTGCGCGCTACAAGCTAGTGTTCACCGATGGTGTGTTTTC
CATGGACGGTACCATCGCGCGCCTGGATGAAATGCGCACGATCTGCGACGCGCATGGCGCGCTGCTTGGTATCGACGAAT
GCCATGCCACGGGTTTCCTCGGCTCGCGCGGCCGGGGCACGCACGAGTTTCGCGGGCTGTTCGGCAAGATCGACATCATT
ACCGGCACGCTTGGCAAGGCGCTCGGCGGAGCGTCGGGCGGCTTCACCAGTGCGCGCAAGGAAGTGGTCGCGCTGCTGCG
CCAGCGTTCGCGGCCGTACCTGTTTTCGAACACGGTGGCGCCGGCCATCGTCGGCGCATCGATTGCCGTGCTAGATATCC
TCGAAGGCAGCACGGAACTGCGCGACCGGCTCGAGCGCAACACGGTGTTCTTCCGCAAGGGCCTGACGGCGCTTGGTTTC
GATGTGAAGCCGGGCGAGCACCCGATTATCCCGATCATGGTCTACGATGCGGAGAAAGCCCAGCAACTTGCGCAGCGGCT
ATTAGAGCTCGGCGTGTACGTGGTCGGCTTCTTCTATCCCGTGGTGCCGAAGGGCCAGGCGCGCATCCGCGTGCAGATGA
GCGCGCTGCACGATGAAGCGGCACTGAAGGCGGCGCTCGAGGCCTTCGGCCAGGCCGGGAAAGAACTGGGGCTGACCCGA
TGA

Upstream 100 bases:

>100_bases
GGGTTGCGTCATGCAGTGTGGTTCGTTATATTGCACAAAACGTTCGGTATAACGGACGTGTTCAATTTATCGATCAGATC
CTAGCATCGGGAGTCAAACC

Downstream 100 bases:

>100_bases
GCGACGCGGCACCAAAAATCCTGATCGTCGGCGCGAACGGCCAGATCGGCTCCGAACTGGCGCTGGCCCTGGCCGAGCGC
TATGGCCGAACCAATGTCAT

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MSSAEAFYASVRAELDAIREAGLYKEERVIATPQGARVRTADGREVINLCANNYLGLSSHPGVIEAAHEALRTHGFGLSS
VRFICGTQDLHKTLEARLSSFLGTEDTILYGSAFDANGGLFETLLGAEDAIISDELNHASIIDGIRLSKARRYRYKHNDM
DDLRAQLAQADADGARYKLVFTDGVFSMDGTIARLDEMRTICDAHGALLGIDECHATGFLGSRGRGTHEFRGLFGKIDII
TGTLGKALGGASGGFTSARKEVVALLRQRSRPYLFSNTVAPAIVGASIAVLDILEGSTELRDRLERNTVFFRKGLTALGF
DVKPGEHPIIPIMVYDAEKAQQLAQRLLELGVYVVGFFYPVVPKGQARIRVQMSALHDEAALKAALEAFGQAGKELGLTR

Sequences:

>Translated_400_residues
MSSAEAFYASVRAELDAIREAGLYKEERVIATPQGARVRTADGREVINLCANNYLGLSSHPGVIEAAHEALRTHGFGLSS
VRFICGTQDLHKTLEARLSSFLGTEDTILYGSAFDANGGLFETLLGAEDAIISDELNHASIIDGIRLSKARRYRYKHNDM
DDLRAQLAQADADGARYKLVFTDGVFSMDGTIARLDEMRTICDAHGALLGIDECHATGFLGSRGRGTHEFRGLFGKIDII
TGTLGKALGGASGGFTSARKEVVALLRQRSRPYLFSNTVAPAIVGASIAVLDILEGSTELRDRLERNTVFFRKGLTALGF
DVKPGEHPIIPIMVYDAEKAQQLAQRLLELGVYVVGFFYPVVPKGQARIRVQMSALHDEAALKAALEAFGQAGKELGLTR
>Mature_399_residues
SSAEAFYASVRAELDAIREAGLYKEERVIATPQGARVRTADGREVINLCANNYLGLSSHPGVIEAAHEALRTHGFGLSSV
RFICGTQDLHKTLEARLSSFLGTEDTILYGSAFDANGGLFETLLGAEDAIISDELNHASIIDGIRLSKARRYRYKHNDMD
DLRAQLAQADADGARYKLVFTDGVFSMDGTIARLDEMRTICDAHGALLGIDECHATGFLGSRGRGTHEFRGLFGKIDIIT
GTLGKALGGASGGFTSARKEVVALLRQRSRPYLFSNTVAPAIVGASIAVLDILEGSTELRDRLERNTVFFRKGLTALGFD
VKPGEHPIIPIMVYDAEKAQQLAQRLLELGVYVVGFFYPVVPKGQARIRVQMSALHDEAALKAALEAFGQAGKELGLTR

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=386, Percent_Identity=54.6632124352332, Blast_Score=418, Evalue=1e-117,
Organism=Homo sapiens, GI284448556, Length=412, Percent_Identity=51.2135922330097, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI83977440, Length=362, Percent_Identity=35.9116022099448, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI83977442, Length=362, Percent_Identity=35.9116022099448, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI83977444, Length=362, Percent_Identity=35.9116022099448, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI4758668, Length=371, Percent_Identity=34.7708894878706, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI119220554, Length=373, Percent_Identity=34.3163538873995, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI4502025, Length=362, Percent_Identity=33.7016574585635, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI40316939, Length=362, Percent_Identity=33.7016574585635, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI5454084, Length=276, Percent_Identity=28.9855072463768, Blast_Score=112, Evalue=9e-25,
Organism=Escherichia coli, GI1790046, Length=392, Percent_Identity=60.4591836734694, Blast_Score=490, Evalue=1e-140,
Organism=Escherichia coli, GI1786993, Length=360, Percent_Identity=33.6111111111111, Blast_Score=182, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI71994529, Length=400, Percent_Identity=54.5, Blast_Score=438, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI32566772, Length=374, Percent_Identity=32.0855614973262, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17560912, Length=367, Percent_Identity=31.0626702997275, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17560914, Length=367, Percent_Identity=31.0626702997275, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71982617, Length=265, Percent_Identity=25.6603773584906, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71982625, Length=265, Percent_Identity=25.6603773584906, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320438, Length=394, Percent_Identity=29.9492385786802, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6320267, Length=369, Percent_Identity=31.1653116531165, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6323954, Length=272, Percent_Identity=29.7794117647059, Blast_Score=120, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24662918, Length=389, Percent_Identity=52.4421593830334, Blast_Score=428, Evalue=1e-120,
Organism=Drosophila melanogaster, GI17137420, Length=341, Percent_Identity=35.7771260997067, Blast_Score=202, Evalue=5e-52,
Organism=Drosophila melanogaster, GI17136286, Length=370, Percent_Identity=33.5135135135135, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24653280, Length=387, Percent_Identity=27.390180878553, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24653276, Length=387, Percent_Identity=27.390180878553, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24653278, Length=387, Percent_Identity=27.390180878553, Blast_Score=116, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011282
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 43333; Mature: 43202

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAEAFYASVRAELDAIREAGLYKEERVIATPQGARVRTADGREVINLCANNYLGLSSH
CCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEECCCHHHHHHHHCCCCCCCCC
PGVIEAAHEALRTHGFGLSSVRFICGTQDLHKTLEARLSSFLGTEDTILYGSAFDANGGL
CCHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCH
FETLLGAEDAIISDELNHASIIDGIRLSKARRYRYKHNDMDDLRAQLAQADADGARYKLV
HHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEE
FTDGVFSMDGTIARLDEMRTICDAHGALLGIDECHATGFLGSRGRGTHEFRGLFGKIDII
EECCEEECCCHHHHHHHHHHHHHHCCCEEECHHHHHCCCCCCCCCCCHHHHHHHHEEEEE
TGTLGKALGGASGGFTSARKEVVALLRQRSRPYLFSNTVAPAIVGASIAVLDILEGSTEL
ECHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHCCCHHH
RDRLERNTVFFRKGLTALGFDVKPGEHPIIPIMVYDAEKAQQLAQRLLELGVYVVGFFYP
HHHHHHHHHHHHCCCHHHCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
VVPKGQARIRVQMSALHDEAALKAALEAFGQAGKELGLTR
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SSAEAFYASVRAELDAIREAGLYKEERVIATPQGARVRTADGREVINLCANNYLGLSSH
CCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEECCCHHHHHHHHCCCCCCCCC
PGVIEAAHEALRTHGFGLSSVRFICGTQDLHKTLEARLSSFLGTEDTILYGSAFDANGGL
CCHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCH
FETLLGAEDAIISDELNHASIIDGIRLSKARRYRYKHNDMDDLRAQLAQADADGARYKLV
HHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEE
FTDGVFSMDGTIARLDEMRTICDAHGALLGIDECHATGFLGSRGRGTHEFRGLFGKIDII
EECCEEECCCHHHHHHHHHHHHHHCCCEEECHHHHHCCCCCCCCCCCHHHHHHHHEEEEE
TGTLGKALGGASGGFTSARKEVVALLRQRSRPYLFSNTVAPAIVGASIAVLDILEGSTEL
ECHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHCCCHHH
RDRLERNTVFFRKGLTALGFDVKPGEHPIIPIMVYDAEKAQQLAQRLLELGVYVVGFFYP
HHHHHHHHHHHHCCCHHHCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
VVPKGQARIRVQMSALHDEAALKAALEAFGQAGKELGLTR
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]