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The map label for this gene is fadA [C]

Identifier: 73538582

GI number: 73538582

Start: 1456008

End: 1457195

Strand: Reverse

Name: fadA [C]

Synonym: Reut_B4757

Alternate gene names: 73538582

Gene position: 1457195-1456008 (Counterclockwise)

Preceding gene: 73538583

Following gene: 73538581

Centisome position: 53.45

GC content: 66.41

Gene sequence:

>1188_bases
ATGAGCAACAAAGTGGTAGTGGCCGGCGTCGGCATGATCCCGTTCACCAAGCCTGGCGCCAGCGATGACTATGGCGTGAT
GGGCGCCAATGCGGCCAAGGCCGCGCTGGCAGATGCTGGCATCGACTACGCGCTGGTAGAGCAGGCCTACGTTGGCTATG
TGTTCGGCGATTCGACGTCGGGCCAGGCCGCCATCTACGGCGTCGGGCTGACCGGCATTCCGGTCATCAACGTCAACAAC
AACTGCGCCACCGGCTCGACCGCGCTGTTCCTGGCGCGCCAGGCCGTGGAAAGCGGCGCGATTGAATGCGCCATCGCGGT
CGGCTTCGAGCAGATGGTGCCGGGCGCGCTCAAGGGCGCCTATACCGACCGTCCTGGCCCGATGGAGCGCTTTGCGAAGA
CCATGGCGCAGGTCCAGGGCTTCGACGAGCAGGCGCCGCGCGCGGCGCAGTTCTTCGGCGGCGCGGGCCGTGCGTACATG
AAGGAATACGGCATCCGCCCGGACACCTTCGCGCGCATCTCGGTCAAGGCGCGCCAGCATGCCGCGCGCAACCCGTTTGC
AGTGTTCCGCAATACCGTTACGCTGGAAGAGGTCATGGCGGCGCCGACCGTGTTCGACCCGCTCACACGCCTGCAGTGCT
GCCCGCCGACCTGCGGCGCTGCCGCCGCGATCCTGTGCACGGAAGCGTTCGCGCGCAAGCATGGCCTCGACACGCGCGTG
AACATCGCCGCGCAAGCCATGACCACGGACCGCAACAGCACCTTCGACGAAGGCGACATGCGCAAGGTGGTGGGCTACGA
CATGACCGCTGCCGCAGCGAAAGCCGTCTACGAGAAGGCCGGTGTTGCGCCGACCGATATCGACGTGGTGGAACTGCACG
ACTGCTTCACCGCCAACGAGCTGATTACCTACGAAGGCCTGGGTCTGACTCCGGTCGGTACTGCCGAGAAATTCATCGTC
GATGGCGACAACACCTACGGCGGCCGCGTGGTTACCAATCCGTCGGGCGGCCTGCTGTCCAAGGGTCACCCGCTGGGTGC
CACCGGCCTCGCGCAATGCGCCGAACTGGTCTGGCAACTGCGCGGCAAGGCCGGTGACCGCCAGGTCGAAGGCGCGCGCC
TGGCGCTGCAGCACAACCTCGGCCTCGGTGGCGCCTGCGTGGTGACGCTGTACGAACGCCAGCAATAA

Upstream 100 bases:

>100_bases
CAAGATCCTCAAGCGCGATCTGCGCTCGCCGTACTGGAAAGACAGCACCCGGCAGGTCAACTGAGGCGGCCGCCTTCTTT
AATTCTCAGAGGAAATCGAC

Downstream 100 bases:

>100_bases
GCGGTAAAGGAAGCACAGAGATGATCGACAAGATCCATATCGGCGCGCTGATCTCGCGCCATTCCGTTGACGTGGAGGCC
GGACGCCTGCGCTTCTTCGC

Product: lipid-transfer protein

Products: CoA; oxoacyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MSNKVVVAGVGMIPFTKPGASDDYGVMGANAAKAALADAGIDYALVEQAYVGYVFGDSTSGQAAIYGVGLTGIPVINVNN
NCATGSTALFLARQAVESGAIECAIAVGFEQMVPGALKGAYTDRPGPMERFAKTMAQVQGFDEQAPRAAQFFGGAGRAYM
KEYGIRPDTFARISVKARQHAARNPFAVFRNTVTLEEVMAAPTVFDPLTRLQCCPPTCGAAAAILCTEAFARKHGLDTRV
NIAAQAMTTDRNSTFDEGDMRKVVGYDMTAAAAKAVYEKAGVAPTDIDVVELHDCFTANELITYEGLGLTPVGTAEKFIV
DGDNTYGGRVVTNPSGGLLSKGHPLGATGLAQCAELVWQLRGKAGDRQVEGARLALQHNLGLGGACVVTLYERQQ

Sequences:

>Translated_395_residues
MSNKVVVAGVGMIPFTKPGASDDYGVMGANAAKAALADAGIDYALVEQAYVGYVFGDSTSGQAAIYGVGLTGIPVINVNN
NCATGSTALFLARQAVESGAIECAIAVGFEQMVPGALKGAYTDRPGPMERFAKTMAQVQGFDEQAPRAAQFFGGAGRAYM
KEYGIRPDTFARISVKARQHAARNPFAVFRNTVTLEEVMAAPTVFDPLTRLQCCPPTCGAAAAILCTEAFARKHGLDTRV
NIAAQAMTTDRNSTFDEGDMRKVVGYDMTAAAAKAVYEKAGVAPTDIDVVELHDCFTANELITYEGLGLTPVGTAEKFIV
DGDNTYGGRVVTNPSGGLLSKGHPLGATGLAQCAELVWQLRGKAGDRQVEGARLALQHNLGLGGACVVTLYERQQ
>Mature_394_residues
SNKVVVAGVGMIPFTKPGASDDYGVMGANAAKAALADAGIDYALVEQAYVGYVFGDSTSGQAAIYGVGLTGIPVINVNNN
CATGSTALFLARQAVESGAIECAIAVGFEQMVPGALKGAYTDRPGPMERFAKTMAQVQGFDEQAPRAAQFFGGAGRAYMK
EYGIRPDTFARISVKARQHAARNPFAVFRNTVTLEEVMAAPTVFDPLTRLQCCPPTCGAAAAILCTEAFARKHGLDTRVN
IAAQAMTTDRNSTFDEGDMRKVVGYDMTAAAAKAVYEKAGVAPTDIDVVELHDCFTANELITYEGLGLTPVGTAEKFIVD
GDNTYGGRVVTNPSGGLLSKGHPLGATGLAQCAELVWQLRGKAGDRQVEGARLALQHNLGLGGACVVTLYERQQ

Specific function: Subunit Of The Multifunctional Enzyme Complex Of The Fatty Acid Degradation Cycle. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=393, Percent_Identity=56.9974554707379, Blast_Score=436, Evalue=1e-122,
Organism=Homo sapiens, GI302344760, Length=392, Percent_Identity=53.3163265306122, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI302344767, Length=324, Percent_Identity=56.4814814814815, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI302344762, Length=392, Percent_Identity=48.9795918367347, Blast_Score=352, Evalue=4e-97,
Organism=Homo sapiens, GI55956775, Length=354, Percent_Identity=44.9152542372881, Blast_Score=281, Evalue=6e-76,
Organism=Caenorhabditis elegans, GI17537653, Length=395, Percent_Identity=45.0632911392405, Blast_Score=333, Evalue=1e-91,
Organism=Drosophila melanogaster, GI24585051, Length=392, Percent_Identity=55.8673469387755, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI19921506, Length=392, Percent_Identity=55.8673469387755, Blast_Score=435, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16 [C]

Molecular weight: Translated: 41439; Mature: 41307

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKVVVAGVGMIPFTKPGASDDYGVMGANAAKAALADAGIDYALVEQAYVGYVFGDSTS
CCCCEEEEEECCCCCCCCCCCCCCCEECCCHHHHHHHHCCCCHHHHHHHHEEEEECCCCC
GQAAIYGVGLTGIPVINVNNNCATGSTALFLARQAVESGAIECAIAVGFEQMVPGALKGA
CCEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEEECHHHHCCHHHCCC
YTDRPGPMERFAKTMAQVQGFDEQAPRAAQFFGGAGRAYMKEYGIRPDTFARISVKARQH
CCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCHHHHHHCCCCCCCEEEEEEHHHHH
AARNPFAVFRNTVTLEEVMAAPTVFDPLTRLQCCPPTCGAAAAILCTEAFARKHGLDTRV
CCCCCHHHHHCCCCHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCEE
NIAAQAMTTDRNSTFDEGDMRKVVGYDMTAAAAKAVYEKAGVAPTDIDVVELHDCFTANE
EEEEEEEECCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCC
LITYEGLGLTPVGTAEKFIVDGDNTYGGRVVTNPSGGLLSKGHPLGATGLAQCAELVWQL
EEEECCCCCCCCCCCCEEEEECCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHH
RGKAGDRQVEGARLALQHNLGLGGACVVTLYERQQ
HCCCCCCCCCCEEEEEEECCCCCCEEEEEEEECCC
>Mature Secondary Structure 
SNKVVVAGVGMIPFTKPGASDDYGVMGANAAKAALADAGIDYALVEQAYVGYVFGDSTS
CCCEEEEEECCCCCCCCCCCCCCCEECCCHHHHHHHHCCCCHHHHHHHHEEEEECCCCC
GQAAIYGVGLTGIPVINVNNNCATGSTALFLARQAVESGAIECAIAVGFEQMVPGALKGA
CCEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEEECHHHHCCHHHCCC
YTDRPGPMERFAKTMAQVQGFDEQAPRAAQFFGGAGRAYMKEYGIRPDTFARISVKARQH
CCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCHHHHHHCCCCCCCEEEEEEHHHHH
AARNPFAVFRNTVTLEEVMAAPTVFDPLTRLQCCPPTCGAAAAILCTEAFARKHGLDTRV
CCCCCHHHHHCCCCHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCEE
NIAAQAMTTDRNSTFDEGDMRKVVGYDMTAAAAKAVYEKAGVAPTDIDVVELHDCFTANE
EEEEEEEECCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCC
LITYEGLGLTPVGTAEKFIVDGDNTYGGRVVTNPSGGLLSKGHPLGATGLAQCAELVWQL
EEEECCCCCCCCCCCCEEEEECCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHH
RGKAGDRQVEGARLALQHNLGLGGACVVTLYERQQ
HCCCCCCCCCCEEEEEEECCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acyl-CoA; acetyl-CoA [C]

Specific reaction: Acyl-CoA + acetyl-CoA = CoA + oxoacyl-CoA [C]

General reaction: Acyl group transfer; Claisen condensation [C]

Inhibitor: Tris (hydroxy methyl) aminomethane [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]