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The map label for this gene is lrhA [H]

Identifier: 73538133

GI number: 73538133

Start: 962834

End: 963715

Strand: Direct

Name: lrhA [H]

Synonym: Reut_B4303

Alternate gene names: 73538133

Gene position: 962834-963715 (Clockwise)

Preceding gene: 73538131

Following gene: 73538135

Centisome position: 35.32

GC content: 67.12

Gene sequence:

>882_bases
ATGACAATCACGGCCATGCTAAACCCGGTCTGGATCCAAACCTTCGCCACCGTGGCCGCCGCACGCAGCTTCACCGAAGC
GGGGCGGCAGCTTGGTTTGTCCCAATCGAGCGTCAGCGACCATATCCGTCGCCTGGAGCAAAGCGTGGGTCGCCGCCTGT
TCGTGCGCGATACGCATTCGCTGTCGATGACGCCCGACGGCGAAGCACTGCTCGTGCATGCACGGCTCATCCTGGAGGCG
CTGGCGCGTGCGGAATCGCAGTTCACCGCGCCGCGGCTGCGAGGCCGCGTGCGGCTCGGCACCTCCGAAGACCTGGCGCA
GGGGCCGCTGTCAGGGGTGTTGTCCGCGTTCCGCAATACACACCCTGACGTGGAGATGGAAATCACCATCGCCATGACCA
GCAAGCTGTACGAACTGATGGATGCGGGCTCGCTCGACCTGATGCTTGGCAAGCGCCGCCAGGGGGATCGCCGTGGCGTA
CCGCTGTTTCGCGGCTCGCTGGAGTGGCTGGCGCGTCCCGGGACGGTGGTGGACCTGTCGCAACCGCTGCCGCTGATCCT
GGTGCACGAGCCCAGCGTGACGCGGTCGGTCGTACTCGATACGCTGGCCAAGGCCGGCTGCCAGTGGCAAGTCGTCTGCA
GCAGCAGTAGCCATTCCGGCTGCCTTGCCGCCGCGCGCGGCGGGCTCGGACTGACGGTGCGCTCGCGCTACCTGTATGGC
GAAGGCGTCGCCCCTCCGCTCAACTGGGAAAAGCTGCCGGCGCTGCCCGAGGTGGAATTCATTTCCTTGTCCGCGCGCCG
GCTGAGCCAGCCGGCCGAGACACTGCTGCGGCTGCTGCAGAAGAGCGATCTGCGCGCCGCCAGCAGCTGGACAAGCGCCT
AG

Upstream 100 bases:

>100_bases
GTCGGCAAAGCCCTGGCAGCCAGGCCATGGAACCGATCATAGTCACCACCCACCCGATCGGGAACCCCACTGGAGATGTT
GACTGCGATCGGATTTGCCG

Downstream 100 bases:

>100_bases
CTCTCGAGGTCCGGCAGCTCGGCGTAGGCTGTGGCGAGATGGTATGGCGACGTCGATGGCATTTCGGCGCGCACCACCTC
GCCCGAGGGAGCCAGGCATT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MTITAMLNPVWIQTFATVAAARSFTEAGRQLGLSQSSVSDHIRRLEQSVGRRLFVRDTHSLSMTPDGEALLVHARLILEA
LARAESQFTAPRLRGRVRLGTSEDLAQGPLSGVLSAFRNTHPDVEMEITIAMTSKLYELMDAGSLDLMLGKRRQGDRRGV
PLFRGSLEWLARPGTVVDLSQPLPLILVHEPSVTRSVVLDTLAKAGCQWQVVCSSSSHSGCLAAARGGLGLTVRSRYLYG
EGVAPPLNWEKLPALPEVEFISLSARRLSQPAETLLRLLQKSDLRAASSWTSA

Sequences:

>Translated_293_residues
MTITAMLNPVWIQTFATVAAARSFTEAGRQLGLSQSSVSDHIRRLEQSVGRRLFVRDTHSLSMTPDGEALLVHARLILEA
LARAESQFTAPRLRGRVRLGTSEDLAQGPLSGVLSAFRNTHPDVEMEITIAMTSKLYELMDAGSLDLMLGKRRQGDRRGV
PLFRGSLEWLARPGTVVDLSQPLPLILVHEPSVTRSVVLDTLAKAGCQWQVVCSSSSHSGCLAAARGGLGLTVRSRYLYG
EGVAPPLNWEKLPALPEVEFISLSARRLSQPAETLLRLLQKSDLRAASSWTSA
>Mature_292_residues
TITAMLNPVWIQTFATVAAARSFTEAGRQLGLSQSSVSDHIRRLEQSVGRRLFVRDTHSLSMTPDGEALLVHARLILEAL
ARAESQFTAPRLRGRVRLGTSEDLAQGPLSGVLSAFRNTHPDVEMEITIAMTSKLYELMDAGSLDLMLGKRRQGDRRGVP
LFRGSLEWLARPGTVVDLSQPLPLILVHEPSVTRSVVLDTLAKAGCQWQVVCSSSSHSGCLAAARGGLGLTVRSRYLYGE
GVAPPLNWEKLPALPEVEFISLSARRLSQPAETLLRLLQKSDLRAASSWTSA

Specific function: Not known, does not seem to act on the proton translocating NADH dehydrogenase genes (nuoA-N) which are part of the lrhA operon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788626, Length=250, Percent_Identity=28.4, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1787601, Length=169, Percent_Identity=28.9940828402367, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1790208, Length=143, Percent_Identity=31.4685314685315, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787589, Length=136, Percent_Identity=33.0882352941176, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788887, Length=220, Percent_Identity=30, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1786401, Length=252, Percent_Identity=27.7777777777778, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788296, Length=224, Percent_Identity=29.0178571428571, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 31947; Mature: 31816

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITAMLNPVWIQTFATVAAARSFTEAGRQLGLSQSSVSDHIRRLEQSVGRRLFVRDTHS
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEEEEECCC
LSMTPDGEALLVHARLILEALARAESQFTAPRLRGRVRLGTSEDLAQGPLSGVLSAFRNT
EEECCCCCEEHHHHHHHHHHHHHHHHHCCCHHHCCEEEECCCHHHHHCHHHHHHHHHHCC
HPDVEMEITIAMTSKLYELMDAGSLDLMLGKRRQGDRRGVPLFRGSLEWLARPGTVVDLS
CCCCEEEEEEEHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCHHHHCCCCCEEECC
QPLPLILVHEPSVTRSVVLDTLAKAGCQWQVVCSSSSHSGCLAAARGGLGLTVRSRYLYG
CCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHCCCCEEEEEEEEEEC
EGVAPPLNWEKLPALPEVEFISLSARRLSQPAETLLRLLQKSDLRAASSWTSA
CCCCCCCCCCCCCCCCCCHHEEHHHHHCCCHHHHHHHHHHHHCCHHHHCCCCC
>Mature Secondary Structure 
TITAMLNPVWIQTFATVAAARSFTEAGRQLGLSQSSVSDHIRRLEQSVGRRLFVRDTHS
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEEEEECCC
LSMTPDGEALLVHARLILEALARAESQFTAPRLRGRVRLGTSEDLAQGPLSGVLSAFRNT
EEECCCCCEEHHHHHHHHHHHHHHHHHCCCHHHCCEEEECCCHHHHHCHHHHHHHHHHCC
HPDVEMEITIAMTSKLYELMDAGSLDLMLGKRRQGDRRGVPLFRGSLEWLARPGTVVDLS
CCCCEEEEEEEHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCHHHHCCCCCEEECC
QPLPLILVHEPSVTRSVVLDTLAKAGCQWQVVCSSSSHSGCLAAARGGLGLTVRSRYLYG
CCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHCCCCEEEEEEEEEEC
EGVAPPLNWEKLPALPEVEFISLSARRLSQPAETLLRLLQKSDLRAASSWTSA
CCCCCCCCCCCCCCCCCCHHEEHHHHHCCCHHHHHHHHHHHHCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]