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The map label for this gene is ywrD [H]

Identifier: 73537798

GI number: 73537798

Start: 598507

End: 600336

Strand: Direct

Name: ywrD [H]

Synonym: Reut_B3965

Alternate gene names: 73537798

Gene position: 598507-600336 (Clockwise)

Preceding gene: 73537796

Following gene: 73537799

Centisome position: 21.95

GC content: 69.89

Gene sequence:

>1830_bases
ATGTTCACTACCCGCCCGGAAATCGTCGGCACTTTTGGCGTGGCGGCCTCGACCCACTGGCTGGCCACGCAGACAGCGAT
GGGCGTGCTGGAGCGGGGCGGCAATGCCTTCGACGCCGCTGCCGCGGCTGGCTTTGTGCTGCAAGTGGTGGAGCCGCACC
TGAACGGTCCCGGTGGCGAAGTGCCGATCCTGTACTGGAGCGAACGCGAGCGCCGCGTACGCTCGGTCTGCGGGCAGGGC
GCCGCGCCGGCGCTGGCGGATCCGGCGCAGTTGCGCGCCATGGGGCTTGAGATGATGCCCGGCATCGGCCTGATGCCGGC
CACGGTGCCGGGCGCCTTTGGGGCCTGGCTGACCATGCTGCGCGAGCACGGCACGTGGTCGCTCGCTGACGTGCTGGCGC
CGGCCATCGGGTATGCGCGTGACGGATTTCCGCTGGTGCCCCGCATCTCTCGCGCGATTCTGGCCGTGCAGGCGCTGTTC
CGCGATGAATGGCATAGCTCTGCAGAGACCTGGCTGCCGGGCGGCAAGGTGCCGCGCCCGGGCAGCCTGCACACGCTGCC
GGTGCTGGCGGCCACCTACACGCGCATCGTCGAGGAAGCGCAACAGCGCAGCCAGACGCGCGAAGGACAGATCGACGCTG
CCATGGACTGCTGGTACCGAGGCTTCGTGGCCCGCGAGATCGACAACTATTGCCGCAACACGCCAGTGCGGGACACCACC
GGCGACAAGCATGCGGGCCTGCTTCGCTACGAGGACATGGCCGCATGGCAGCCCGACGTGGAAGCGCCCGTGACGCTTGA
CTTCGGCCGCTACACCGTTGCCAAGTGCGATATCTGGAGCCAGGGCCCGGTGTTCCTGCAGCAGCTCGGCATGCTGCGGC
AAGCGCAACTCGAACAGCACGCGCCGGACTCGGCGGAATTCGTGCACCGCATTGCCGAGGCTTGCAAGCTGGCCATGGCG
GACCGGCTCGCGTGGTACGGCGACCCCCGCTTCGGCGCCAGCCCGCTTGCCGCGCTGCTCGATGGCGATTATCTGGCCGG
CCGTGCGCAGCGCATCGGCGAACGCGCCTCGCGCGCGATCGACGCCGGCATGCCGGGCGGCGCGACGCCGCGGCTGCCCG
ACCTGGAAGCGGCGGTGCGCACGCTGCAGCGCGCCGATGTGCGCTTCGGCGTCGGCGAGCCGACGTTTGCCGAACTGCCG
CCGGTGTCCGAATGGGCGGAGCGCGAACTGTTCGTCGGCGATACCTGCCATGTGGACGTGATCGACCGGCACGGCAATAT
GGTGGCCGCCACGCCGTCCGGCGGCTGGCTGTCGTCGAGCCCGACCATCCCGGCGCTGGGCTTCGCGCTCAACACGCGCC
TGCAGATGACGTGGCTCGAGCCGGGCCTGCCGAATTCGCTCGAACCGGGCAAGCGCCCGTGCACGACGCTGTCGCCGTCG
CTCGCGCTGCGCGATGGCGAACCGTACATGGTGTTCGGCACGCCCGGCGGCGACCAGCAGGACCAGTGGTCGCTCGCGTT
TTTCCTGCGCCATGCGGTGCATGGCATGAACCTGCAGGAGGCCATCGATGCGCCCGCCTGGCATATCGACCATTTCCCGG
GCTCGTTCTGGCCGCGCCAGACCGTGCTCAACCGGATCACGATGGAATCCCGCTTCCCCGAGGCCACCCTTGCCGCATTG
CGCGATCGCGGCCATGACGTCCGCGTGGGCGATCCATGGTCCGAAGGGCGCATGTCTGCGTGCACGCGCGAGCGCGACGC
GCACGGGCGGCTGGTGCTGCGGGCCGGTGCCAATGCACGCGGCATGCAGGGCTATGCCGTCGGGCGCTGA

Upstream 100 bases:

>100_bases
AGCGAAGTCGTATAACCAATCGGTAATGCAATGATAACCAAAGACATCATTGCGGTTATTTCATGCTCCTATACTGGCTT
GAACCTTTGGAGCCCTATTC

Downstream 100 bases:

>100_bases
ATCCGGTCATTCATCAACAGAAAAGGGCGCGGGCAGCTGCACGTTGGCTCGCGCGCGATTGAGGATTGAGGAGAGCAAGA
CCATGAAATCCATTGTGAAA

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 609; Mature: 609

Protein sequence:

>609_residues
MFTTRPEIVGTFGVAASTHWLATQTAMGVLERGGNAFDAAAAAGFVLQVVEPHLNGPGGEVPILYWSERERRVRSVCGQG
AAPALADPAQLRAMGLEMMPGIGLMPATVPGAFGAWLTMLREHGTWSLADVLAPAIGYARDGFPLVPRISRAILAVQALF
RDEWHSSAETWLPGGKVPRPGSLHTLPVLAATYTRIVEEAQQRSQTREGQIDAAMDCWYRGFVAREIDNYCRNTPVRDTT
GDKHAGLLRYEDMAAWQPDVEAPVTLDFGRYTVAKCDIWSQGPVFLQQLGMLRQAQLEQHAPDSAEFVHRIAEACKLAMA
DRLAWYGDPRFGASPLAALLDGDYLAGRAQRIGERASRAIDAGMPGGATPRLPDLEAAVRTLQRADVRFGVGEPTFAELP
PVSEWAERELFVGDTCHVDVIDRHGNMVAATPSGGWLSSSPTIPALGFALNTRLQMTWLEPGLPNSLEPGKRPCTTLSPS
LALRDGEPYMVFGTPGGDQQDQWSLAFFLRHAVHGMNLQEAIDAPAWHIDHFPGSFWPRQTVLNRITMESRFPEATLAAL
RDRGHDVRVGDPWSEGRMSACTRERDAHGRLVLRAGANARGMQGYAVGR

Sequences:

>Translated_609_residues
MFTTRPEIVGTFGVAASTHWLATQTAMGVLERGGNAFDAAAAAGFVLQVVEPHLNGPGGEVPILYWSERERRVRSVCGQG
AAPALADPAQLRAMGLEMMPGIGLMPATVPGAFGAWLTMLREHGTWSLADVLAPAIGYARDGFPLVPRISRAILAVQALF
RDEWHSSAETWLPGGKVPRPGSLHTLPVLAATYTRIVEEAQQRSQTREGQIDAAMDCWYRGFVAREIDNYCRNTPVRDTT
GDKHAGLLRYEDMAAWQPDVEAPVTLDFGRYTVAKCDIWSQGPVFLQQLGMLRQAQLEQHAPDSAEFVHRIAEACKLAMA
DRLAWYGDPRFGASPLAALLDGDYLAGRAQRIGERASRAIDAGMPGGATPRLPDLEAAVRTLQRADVRFGVGEPTFAELP
PVSEWAERELFVGDTCHVDVIDRHGNMVAATPSGGWLSSSPTIPALGFALNTRLQMTWLEPGLPNSLEPGKRPCTTLSPS
LALRDGEPYMVFGTPGGDQQDQWSLAFFLRHAVHGMNLQEAIDAPAWHIDHFPGSFWPRQTVLNRITMESRFPEATLAAL
RDRGHDVRVGDPWSEGRMSACTRERDAHGRLVLRAGANARGMQGYAVGR
>Mature_609_residues
MFTTRPEIVGTFGVAASTHWLATQTAMGVLERGGNAFDAAAAAGFVLQVVEPHLNGPGGEVPILYWSERERRVRSVCGQG
AAPALADPAQLRAMGLEMMPGIGLMPATVPGAFGAWLTMLREHGTWSLADVLAPAIGYARDGFPLVPRISRAILAVQALF
RDEWHSSAETWLPGGKVPRPGSLHTLPVLAATYTRIVEEAQQRSQTREGQIDAAMDCWYRGFVAREIDNYCRNTPVRDTT
GDKHAGLLRYEDMAAWQPDVEAPVTLDFGRYTVAKCDIWSQGPVFLQQLGMLRQAQLEQHAPDSAEFVHRIAEACKLAMA
DRLAWYGDPRFGASPLAALLDGDYLAGRAQRIGERASRAIDAGMPGGATPRLPDLEAAVRTLQRADVRFGVGEPTFAELP
PVSEWAERELFVGDTCHVDVIDRHGNMVAATPSGGWLSSSPTIPALGFALNTRLQMTWLEPGLPNSLEPGKRPCTTLSPS
LALRDGEPYMVFGTPGGDQQDQWSLAFFLRHAVHGMNLQEAIDAPAWHIDHFPGSFWPRQTVLNRITMESRFPEATLAAL
RDRGHDVRVGDPWSEGRMSACTRERDAHGRLVLRAGANARGMQGYAVGR

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=563, Percent_Identity=22.9129662522202, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI73915090, Length=563, Percent_Identity=22.9129662522202, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI73915096, Length=563, Percent_Identity=22.9129662522202, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI73915094, Length=563, Percent_Identity=22.9129662522202, Blast_Score=107, Evalue=3e-23,
Organism=Escherichia coli, GI1789856, Length=577, Percent_Identity=24.0901213171577, Blast_Score=145, Evalue=6e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 66449; Mature: 66449

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTTRPEIVGTFGVAASTHWLATQTAMGVLERGGNAFDAAAAAGFVLQVVEPHLNGPGGE
CCCCCCCHHEECCCHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
VPILYWSERERRVRSVCGQGAAPALADPAQLRAMGLEMMPGIGLMPATVPGAFGAWLTML
EEEEEECCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
REHGTWSLADVLAPAIGYARDGFPLVPRISRAILAVQALFRDEWHSSAETWLPGGKVPRP
HHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GSLHTLPVLAATYTRIVEEAQQRSQTREGQIDAAMDCWYRGFVAREIDNYCRNTPVRDTT
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GDKHAGLLRYEDMAAWQPDVEAPVTLDFGRYTVAKCDIWSQGPVFLQQLGMLRQAQLEQH
CCCCCCEEEEHHHHCCCCCCCCCEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHC
APDSAEFVHRIAEACKLAMADRLAWYGDPRFGASPLAALLDGDYLAGRAQRIGERASRAI
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHH
DAGMPGGATPRLPDLEAAVRTLQRADVRFGVGEPTFAELPPVSEWAERELFVGDTCHVDV
HCCCCCCCCCCCCCHHHHHHHHHHHHCEECCCCCCCCCCCCHHHHHCCCEEECCCEEEEE
IDRHGNMVAATPSGGWLSSSPTIPALGFALNTRLQMTWLEPGLPNSLEPGKRPCTTLSPS
EECCCCEEEECCCCCCCCCCCCCCHHHHEECCEEEEEEECCCCCCCCCCCCCCCCCCCCC
LALRDGEPYMVFGTPGGDQQDQWSLAFFLRHAVHGMNLQEAIDAPAWHIDHFPGSFWPRQ
EEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCEEECCCCCCCCHHH
TVLNRITMESRFPEATLAALRDRGHDVRVGDPWSEGRMSACTRERDAHGRLVLRAGANAR
HHHHHHHHHHCCCHHHHHHHHHCCCEEECCCCCCCCHHHHHHHCCCCCCCEEEEECCCCC
GMQGYAVGR
CCCCCCCCC
>Mature Secondary Structure
MFTTRPEIVGTFGVAASTHWLATQTAMGVLERGGNAFDAAAAAGFVLQVVEPHLNGPGGE
CCCCCCCHHEECCCHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
VPILYWSERERRVRSVCGQGAAPALADPAQLRAMGLEMMPGIGLMPATVPGAFGAWLTML
EEEEEECCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
REHGTWSLADVLAPAIGYARDGFPLVPRISRAILAVQALFRDEWHSSAETWLPGGKVPRP
HHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GSLHTLPVLAATYTRIVEEAQQRSQTREGQIDAAMDCWYRGFVAREIDNYCRNTPVRDTT
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GDKHAGLLRYEDMAAWQPDVEAPVTLDFGRYTVAKCDIWSQGPVFLQQLGMLRQAQLEQH
CCCCCCEEEEHHHHCCCCCCCCCEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHC
APDSAEFVHRIAEACKLAMADRLAWYGDPRFGASPLAALLDGDYLAGRAQRIGERASRAI
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHH
DAGMPGGATPRLPDLEAAVRTLQRADVRFGVGEPTFAELPPVSEWAERELFVGDTCHVDV
HCCCCCCCCCCCCCHHHHHHHHHHHHCEECCCCCCCCCCCCHHHHHCCCEEECCCEEEEE
IDRHGNMVAATPSGGWLSSSPTIPALGFALNTRLQMTWLEPGLPNSLEPGKRPCTTLSPS
EECCCCEEEECCCCCCCCCCCCCCHHHHEECCEEEEEEECCCCCCCCCCCCCCCCCCCCC
LALRDGEPYMVFGTPGGDQQDQWSLAFFLRHAVHGMNLQEAIDAPAWHIDHFPGSFWPRQ
EEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCEEECCCCCCCCHHH
TVLNRITMESRFPEATLAALRDRGHDVRVGDPWSEGRMSACTRERDAHGRLVLRAGANAR
HHHHHHHHHHCCCHHHHHHHHHCCCEEECCCCCCCCHHHHHHHCCCCCCCEEEEECCCCC
GMQGYAVGR
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]