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The map label for this gene is paaH [H]

Identifier: 73537789

GI number: 73537789

Start: 591365

End: 592333

Strand: Direct

Name: paaH [H]

Synonym: Reut_B3956

Alternate gene names: 73537789

Gene position: 591365-592333 (Clockwise)

Preceding gene: 73537786

Following gene: 73537790

Centisome position: 21.69

GC content: 67.39

Gene sequence:

>969_bases
ATGCAGAATTCCGCTACGCCTGTGCCCCTCGACCGTCCCGGCAGCGCCCATGCCGTCGTGGTCGGCGGCGGCACCATGGG
CGCCGATGTCGCTGTGGTCCTGACGCGGGCACTGTGCCGCACCACCGTGATCGAACCTGATGCCGGGCGGGCCGCCGCGA
TGCCGGGACGCGTGGCCGCGAATCTGGAGGCTATCGGTCGCTCTGAAGGCGCCGACCGGCTGGCCGTGGTGCCGGATCTT
GATGCTCTCGACTGGTCGACGGTGGATCTCGTGATCGAATGCATTCCCGAGCGCCTGGATCTGAAGCAGGCGCTGTTCGC
GGATCTGGCTGCGCGCGCCCGGCCCGATGCCGTGCTCGCCAGCAATAGTTCCAGCTTTCCGATCAGCGCCATCGACGATG
GCCTGTCGGGGCACGGCCGCATGCTAGGCCTGCACTTCTTCATGCCGGCGCATCTGGTGCCGCTGGTGGAGGTGGTCATG
GGCATCGGCAGCGATGAAGCGTGTGCCGACGCGCTGATCGCGTTTATGCGCCGCTGCGGCATGGTCCCGGTCAAGGTAAA
GCAGGACCTGCCCGGTTTCCTGGCCAACCGCCTGCAGCACGCACTGTCGCGCGAGGCATTCAGCCTGATCGACCGCGGCA
TTGCTTCTGCTGAAGACGTGGATGCCGCCGTGCGCTTCGGTTTTGGCTTCCGCTTTCTGGCTGCGGGCCCTGTGCTGCAG
CGCGACCATGCCGGCATCGACGTGCATGCGGCCGCCGGCGCTACCATGTACCCGACGTTCTGCAATGACGACCATCCCGC
GCGCTGCCTCGCGGAGCGCGCCGCAGATGGCCGACACGGCATGAAGCGCGGCGAGGGCTTCTACGCGTGGACGCCCGAAA
CCATTGCCGCCGAACGCGCGCGTTACGACAGGCTGCTACGCGCCGGCCTTGACCTGATTGCCCCCGAACTGCCCGAGATC
CAGCCATGA

Upstream 100 bases:

>100_bases
ATCAATCAAAGCGCCTTCTCTACACTGCTGCCATTCCCGATTCACCCATTCGGGCGGGGGCCAAAGCGTGCCGGCCGCCT
TAGCCATCTGAAGAGACGCC

Downstream 100 bases:

>100_bases
CGCAAGCGACCCAAATTCCCAGCCAGCAACCGCTGGCCAGTTCACCGCTGATCATCACGGTGGCGCCTAACGGCGCCTAC
AAGCGCGCGAGCGACCACGC

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MQNSATPVPLDRPGSAHAVVVGGGTMGADVAVVLTRALCRTTVIEPDAGRAAAMPGRVAANLEAIGRSEGADRLAVVPDL
DALDWSTVDLVIECIPERLDLKQALFADLAARARPDAVLASNSSSFPISAIDDGLSGHGRMLGLHFFMPAHLVPLVEVVM
GIGSDEACADALIAFMRRCGMVPVKVKQDLPGFLANRLQHALSREAFSLIDRGIASAEDVDAAVRFGFGFRFLAAGPVLQ
RDHAGIDVHAAAGATMYPTFCNDDHPARCLAERAADGRHGMKRGEGFYAWTPETIAAERARYDRLLRAGLDLIAPELPEI
QP

Sequences:

>Translated_322_residues
MQNSATPVPLDRPGSAHAVVVGGGTMGADVAVVLTRALCRTTVIEPDAGRAAAMPGRVAANLEAIGRSEGADRLAVVPDL
DALDWSTVDLVIECIPERLDLKQALFADLAARARPDAVLASNSSSFPISAIDDGLSGHGRMLGLHFFMPAHLVPLVEVVM
GIGSDEACADALIAFMRRCGMVPVKVKQDLPGFLANRLQHALSREAFSLIDRGIASAEDVDAAVRFGFGFRFLAAGPVLQ
RDHAGIDVHAAAGATMYPTFCNDDHPARCLAERAADGRHGMKRGEGFYAWTPETIAAERARYDRLLRAGLDLIAPELPEI
QP
>Mature_322_residues
MQNSATPVPLDRPGSAHAVVVGGGTMGADVAVVLTRALCRTTVIEPDAGRAAAMPGRVAANLEAIGRSEGADRLAVVPDL
DALDWSTVDLVIECIPERLDLKQALFADLAARARPDAVLASNSSSFPISAIDDGLSGHGRMLGLHFFMPAHLVPLVEVVM
GIGSDEACADALIAFMRRCGMVPVKVKQDLPGFLANRLQHALSREAFSLIDRGIASAEDVDAAVRFGFGFRFLAAGPVLQ
RDHAGIDVHAAAGATMYPTFCNDDHPARCLAERAADGRHGMKRGEGFYAWTPETIAAERARYDRLLRAGLDLIAPELPEI
QP

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=290, Percent_Identity=30.3448275862069, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI296179427, Length=307, Percent_Identity=28.6644951140065, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI68989263, Length=292, Percent_Identity=28.0821917808219, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI261878539, Length=292, Percent_Identity=28.0821917808219, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI115430219, Length=148, Percent_Identity=33.1081081081081, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI20127408, Length=286, Percent_Identity=25.5244755244755, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1787661, Length=285, Percent_Identity=34.3859649122807, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1790281, Length=229, Percent_Identity=31.4410480349345, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1788682, Length=226, Percent_Identity=30.5309734513274, Blast_Score=100, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17549919, Length=298, Percent_Identity=31.5436241610738, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17553560, Length=294, Percent_Identity=29.9319727891156, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17563036, Length=203, Percent_Identity=30.5418719211823, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71985923, Length=304, Percent_Identity=27.3026315789474, Blast_Score=94, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17508953, Length=282, Percent_Identity=26.5957446808511, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI25144276, Length=282, Percent_Identity=26.5957446808511, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17508951, Length=282, Percent_Identity=26.5957446808511, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71985930, Length=287, Percent_Identity=26.4808362369338, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17558304, Length=284, Percent_Identity=27.4647887323944, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI115533614, Length=140, Percent_Identity=33.5714285714286, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI193203623, Length=140, Percent_Identity=33.5714285714286, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI45549573, Length=176, Percent_Identity=32.9545454545455, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI20129993, Length=171, Percent_Identity=32.1637426900585, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI19921000, Length=280, Percent_Identity=26.4285714285714, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24583077, Length=280, Percent_Identity=26.4285714285714, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24583079, Length=280, Percent_Identity=26.4285714285714, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR011967
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 34178; Mature: 34178

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNSATPVPLDRPGSAHAVVVGGGTMGADVAVVLTRALCRTTVIEPDAGRAAAMPGRVAA
CCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
NLEAIGRSEGADRLAVVPDLDALDWSTVDLVIECIPERLDLKQALFADLAARARPDAVLA
HHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
SNSSSFPISAIDDGLSGHGRMLGLHFFMPAHLVPLVEVVMGIGSDEACADALIAFMRRCG
CCCCCCCCHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
MVPVKVKQDLPGFLANRLQHALSREAFSLIDRGIASAEDVDAAVRFGFGFRFLAAGPVLQ
CCEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHCCCCCC
RDHAGIDVHAAAGATMYPTFCNDDHPARCLAERAADGRHGMKRGEGFYAWTPETIAAERA
CCCCCEEEEECCCCEECCCCCCCCCHHHHHHHHHCCCCCCHHCCCCEEEECCHHHHHHHH
RYDRLLRAGLDLIAPELPEIQP
HHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQNSATPVPLDRPGSAHAVVVGGGTMGADVAVVLTRALCRTTVIEPDAGRAAAMPGRVAA
CCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
NLEAIGRSEGADRLAVVPDLDALDWSTVDLVIECIPERLDLKQALFADLAARARPDAVLA
HHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
SNSSSFPISAIDDGLSGHGRMLGLHFFMPAHLVPLVEVVMGIGSDEACADALIAFMRRCG
CCCCCCCCHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
MVPVKVKQDLPGFLANRLQHALSREAFSLIDRGIASAEDVDAAVRFGFGFRFLAAGPVLQ
CCEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHCCCCCC
RDHAGIDVHAAAGATMYPTFCNDDHPARCLAERAADGRHGMKRGEGFYAWTPETIAAERA
CCCCCEEEEECCCCEECCCCCCCCCHHHHHHHHHCCCCCCHHCCCCEEEECCHHHHHHHH
RYDRLLRAGLDLIAPELPEIQP
HHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]