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The map label for this gene is ilvD [H]

Identifier: 73537783

GI number: 73537783

Start: 582950

End: 584713

Strand: Direct

Name: ilvD [H]

Synonym: Reut_B3950

Alternate gene names: 73537783

Gene position: 582950-584713 (Clockwise)

Preceding gene: 73537781

Following gene: 73537784

Centisome position: 21.38

GC content: 68.59

Gene sequence:

>1764_bases
ATGCCTTACGCCGACGACCCCAAGCTGCCCCAGGACGGCGCCGCCCCCACCGAAGGACTTGCCAAGGGCCTCACGAACTA
TGGCGACACAGGCTTCTCGCTGTTCCTGCGCAAGGCCTTCATCAAAGGGGCGGGCTTTACTGACGACGCGCTGTCGCGTC
CGGTGATCGGCATCGTCAACACGGGCAGCAGCTACAACCCCTGCCACGGCAATGCGCCGCAGCTCGTAGAGGCGGTCAAG
CGCGGCGTGATGCTCGCGGGCGGTCTGCCGGTGGATTTCCCGACGATCTCGGTGCACGAGAGCTTCTCCGCGCCGACCAG
CATGTACCTGCGCAACCTGATGTCGATGGACACCGAAGAGATGATCCGCGCGCAGCCCATGGACGCCGTGGTGCTGATCG
GCGGCTGCGACAAGACGGTGCCGGCGCAGCTGATGGGGGCGGCGTCGGCCGGCGTGCCCGCGATCCAGCTTGTGACCGGA
TCGATGCTGACCGGGTCGCATCGCAGCGAACGGGTTGGGGCGTGCACGGACTGCCGCCGCTACTGGGGCCGCTACCGCGC
CGAGGAGATTGACAGCGCGGAGATTGCCGACGTCAACAACCAGCTCGTGGCAAGCGTGGGCACGTGTTCGGTAATGGGCA
CGGCCAGCACCATGGCGTGTGTTGCCGAAGCGCTGGGCATGATGGTGAGCGGCGGCGCGTCAGCACCCGCGGTGACCGCC
GACCGCGTGCGTGTGGCGGAGCGCACCGGTACCACGGCGGTCGGCATGGCCGCCGCCCGGCTGACGCCCGACCGCATCCT
GACCGGCAAGGCCTTCGAGAACGCGCTGCGCGTGCTGCTGGCCATCGGCGGATCGACCAACGGCATCGTCCACCTGACGG
CGATCGCCGGGCGCCTGGGCATCGACATCGACCTGGCAGGGCTCGATCGCATGAGCCGGGAAACGCCGGTGCTGGTCGAC
CTGAAGCCTTCGGGCCAGCACTACATGGAAGACTTCCACAAGGCAGGCGGCATGCTGACACTGCTGCGCGAACTGCGTCC
GCTGCTGCATCTCGACACGCTGACCGTGTCAGGCCGCACGCTCGGCGAGGAGCTCGACGCTGCGCCGCCGCTGTTCCCGC
AGGACGTGATTCGCAGTGCCGGCAACCCGATCTACCCGGCCGGCGGCCTGGCGGTACTGCGCGGCAACCTGGCACCGGGC
GGCGCCATCATCAAGCAGTCGGCCGCCAACCCCGCGCTGATGGAGCACGAAGGGCGTGCGGTGGTGTTCGAGAATGCCGA
GGACATGGCACAGCGCATTGACGACGAGTCGCTCGACGTCAAGGCCGACGACATCCTCGTGCTCAAGCGCATCGGGCCGA
CCGGCGCGCCGGGCATGCCCGAAGCCGGCTATATGCCGATCCCCAAGAAGCTCGCACGCGCAGGCGTGAAGGACATGGTG
CGTGTGTCGGACGGGCGCATGAGCGGTACCGCGGCCGGCACCATCGTGCTGCATGTGACGCCCGAAGCGGCCATCGGCGG
GCCGCTGGCGCTTGTGCAGAGCGGCGACCGCATCCGGCTGTCGGTCGCGAACCGTGAGATCGCGCTGCTCGTCGACGACG
CCGAGCTGGCCCGCCGCGCTGCCGCGCAGCCAGTCGAACGCCCGCGCGCGGAACGTGGTTATCGCAAGCTGTTCCTCGAG
ACCGTGACGCAGGCTGACCAGGGCGTCGATTTCGACTTCTTGCGCGCCGCGCAGACGGTCGATACCGTGCCGAAGCAGGG
CTGA

Upstream 100 bases:

>100_bases
GCAGATTAATTTGCCGCAAGCACCGCAGCCCTTGCGGCCTGTGGGCAAGCCCCGCTAAGCTTCGCGTCTCGATTATCAAT
AATCTTATCGGAGACGCAGA

Downstream 100 bases:

>100_bases
GCCATGACTGCGACCACGGCAACGGTCACCGCCATCGACGGCGGCGACGCGATGGAGCAGGCGCTCGACACGCTCGAAGA
AGACATCGTCTTCGGCCGCC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 587; Mature: 586

Protein sequence:

>587_residues
MPYADDPKLPQDGAAPTEGLAKGLTNYGDTGFSLFLRKAFIKGAGFTDDALSRPVIGIVNTGSSYNPCHGNAPQLVEAVK
RGVMLAGGLPVDFPTISVHESFSAPTSMYLRNLMSMDTEEMIRAQPMDAVVLIGGCDKTVPAQLMGAASAGVPAIQLVTG
SMLTGSHRSERVGACTDCRRYWGRYRAEEIDSAEIADVNNQLVASVGTCSVMGTASTMACVAEALGMMVSGGASAPAVTA
DRVRVAERTGTTAVGMAAARLTPDRILTGKAFENALRVLLAIGGSTNGIVHLTAIAGRLGIDIDLAGLDRMSRETPVLVD
LKPSGQHYMEDFHKAGGMLTLLRELRPLLHLDTLTVSGRTLGEELDAAPPLFPQDVIRSAGNPIYPAGGLAVLRGNLAPG
GAIIKQSAANPALMEHEGRAVVFENAEDMAQRIDDESLDVKADDILVLKRIGPTGAPGMPEAGYMPIPKKLARAGVKDMV
RVSDGRMSGTAAGTIVLHVTPEAAIGGPLALVQSGDRIRLSVANREIALLVDDAELARRAAAQPVERPRAERGYRKLFLE
TVTQADQGVDFDFLRAAQTVDTVPKQG

Sequences:

>Translated_587_residues
MPYADDPKLPQDGAAPTEGLAKGLTNYGDTGFSLFLRKAFIKGAGFTDDALSRPVIGIVNTGSSYNPCHGNAPQLVEAVK
RGVMLAGGLPVDFPTISVHESFSAPTSMYLRNLMSMDTEEMIRAQPMDAVVLIGGCDKTVPAQLMGAASAGVPAIQLVTG
SMLTGSHRSERVGACTDCRRYWGRYRAEEIDSAEIADVNNQLVASVGTCSVMGTASTMACVAEALGMMVSGGASAPAVTA
DRVRVAERTGTTAVGMAAARLTPDRILTGKAFENALRVLLAIGGSTNGIVHLTAIAGRLGIDIDLAGLDRMSRETPVLVD
LKPSGQHYMEDFHKAGGMLTLLRELRPLLHLDTLTVSGRTLGEELDAAPPLFPQDVIRSAGNPIYPAGGLAVLRGNLAPG
GAIIKQSAANPALMEHEGRAVVFENAEDMAQRIDDESLDVKADDILVLKRIGPTGAPGMPEAGYMPIPKKLARAGVKDMV
RVSDGRMSGTAAGTIVLHVTPEAAIGGPLALVQSGDRIRLSVANREIALLVDDAELARRAAAQPVERPRAERGYRKLFLE
TVTQADQGVDFDFLRAAQTVDTVPKQG
>Mature_586_residues
PYADDPKLPQDGAAPTEGLAKGLTNYGDTGFSLFLRKAFIKGAGFTDDALSRPVIGIVNTGSSYNPCHGNAPQLVEAVKR
GVMLAGGLPVDFPTISVHESFSAPTSMYLRNLMSMDTEEMIRAQPMDAVVLIGGCDKTVPAQLMGAASAGVPAIQLVTGS
MLTGSHRSERVGACTDCRRYWGRYRAEEIDSAEIADVNNQLVASVGTCSVMGTASTMACVAEALGMMVSGGASAPAVTAD
RVRVAERTGTTAVGMAAARLTPDRILTGKAFENALRVLLAIGGSTNGIVHLTAIAGRLGIDIDLAGLDRMSRETPVLVDL
KPSGQHYMEDFHKAGGMLTLLRELRPLLHLDTLTVSGRTLGEELDAAPPLFPQDVIRSAGNPIYPAGGLAVLRGNLAPGG
AIIKQSAANPALMEHEGRAVVFENAEDMAQRIDDESLDVKADDILVLKRIGPTGAPGMPEAGYMPIPKKLARAGVKDMVR
VSDGRMSGTAAGTIVLHVTPEAAIGGPLALVQSGDRIRLSVANREIALLVDDAELARRAAAQPVERPRAERGYRKLFLET
VTQADQGVDFDFLRAAQTVDTVPKQG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=597, Percent_Identity=30.9882747068677, Blast_Score=241, Evalue=8e-65,
Organism=Escherichia coli, GI1788157, Length=492, Percent_Identity=33.3333333333333, Blast_Score=168, Evalue=9e-43,
Organism=Escherichia coli, GI2367371, Length=452, Percent_Identity=31.6371681415929, Blast_Score=158, Evalue=7e-40,
Organism=Escherichia coli, GI1786464, Length=503, Percent_Identity=29.8210735586481, Blast_Score=152, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6322476, Length=549, Percent_Identity=32.2404371584699, Blast_Score=273, Evalue=5e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 61738; Mature: 61606

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYADDPKLPQDGAAPTEGLAKGLTNYGDTGFSLFLRKAFIKGAGFTDDALSRPVIGIVN
CCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHCCCEEEEEE
TGSSYNPCHGNAPQLVEAVKRGVMLAGGLPVDFPTISVHESFSAPTSMYLRNLMSMDTEE
CCCCCCCCCCCHHHHHHHHHCCEEEECCCCCCCCEEEECCCCCCCHHHHHHHHHCCCHHH
MIRAQPMDAVVLIGGCDKTVPAQLMGAASAGVPAIQLVTGSMLTGSHRSERVGACTDCRR
HHHCCCCCEEEEEECCCCCCHHHHHHHHCCCCCEEEEEECCHHCCCCCCCCCCCHHHHHH
YWGRYRAEEIDSAEIADVNNQLVASVGTCSVMGTASTMACVAEALGMMVSGGASAPAVTA
HHHHHHHHHCCCCHHHCCCCHHHHHCCCEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCH
DRVRVAERTGTTAVGMAAARLTPDRILTGKAFENALRVLLAIGGSTNGIVHLTAIAGRLG
HHHHHHHHCCCHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCC
IDIDLAGLDRMSRETPVLVDLKPSGQHYMEDFHKAGGMLTLLRELRPLLHLDTLTVSGRT
CEEEECCCHHCCCCCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEECCCH
LGEELDAAPPLFPQDVIRSAGNPIYPAGGLAVLRGNLAPGGAIIKQSAANPALMEHEGRA
HHHHHCCCCCCCHHHHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHCCCCCCCEECCCCE
VVFENAEDMAQRIDDESLDVKADDILVLKRIGPTGAPGMPEAGYMPIPKKLARAGVKDMV
EEECCHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHCCHHHHH
RVSDGRMSGTAAGTIVLHVTPEAAIGGPLALVQSGDRIRLSVANREIALLVDDAELARRA
HHCCCCCCCCEEEEEEEEECCCCCCCCCEEEEECCCEEEEEECCCEEEEEECCHHHHHHH
AAQPVERPRAERGYRKLFLETVTQADQGVDFDFLRAAQTVDTVPKQG
HCCCHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PYADDPKLPQDGAAPTEGLAKGLTNYGDTGFSLFLRKAFIKGAGFTDDALSRPVIGIVN
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHCCCEEEEEE
TGSSYNPCHGNAPQLVEAVKRGVMLAGGLPVDFPTISVHESFSAPTSMYLRNLMSMDTEE
CCCCCCCCCCCHHHHHHHHHCCEEEECCCCCCCCEEEECCCCCCCHHHHHHHHHCCCHHH
MIRAQPMDAVVLIGGCDKTVPAQLMGAASAGVPAIQLVTGSMLTGSHRSERVGACTDCRR
HHHCCCCCEEEEEECCCCCCHHHHHHHHCCCCCEEEEEECCHHCCCCCCCCCCCHHHHHH
YWGRYRAEEIDSAEIADVNNQLVASVGTCSVMGTASTMACVAEALGMMVSGGASAPAVTA
HHHHHHHHHCCCCHHHCCCCHHHHHCCCEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCH
DRVRVAERTGTTAVGMAAARLTPDRILTGKAFENALRVLLAIGGSTNGIVHLTAIAGRLG
HHHHHHHHCCCHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCC
IDIDLAGLDRMSRETPVLVDLKPSGQHYMEDFHKAGGMLTLLRELRPLLHLDTLTVSGRT
CEEEECCCHHCCCCCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEECCCH
LGEELDAAPPLFPQDVIRSAGNPIYPAGGLAVLRGNLAPGGAIIKQSAANPALMEHEGRA
HHHHHCCCCCCCHHHHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHCCCCCCCEECCCCE
VVFENAEDMAQRIDDESLDVKADDILVLKRIGPTGAPGMPEAGYMPIPKKLARAGVKDMV
EEECCHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHCCHHHHH
RVSDGRMSGTAAGTIVLHVTPEAAIGGPLALVQSGDRIRLSVANREIALLVDDAELARRA
HHCCCCCCCCEEEEEEEEECCCCCCCCCEEEEECCCEEEEEECCCEEEEEECCHHHHHHH
AAQPVERPRAERGYRKLFLETVTQADQGVDFDFLRAAQTVDTVPKQG
HCCCHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA