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The map label for this gene is hipA [H]

Identifier: 73537781

GI number: 73537781

Start: 579861

End: 581201

Strand: Direct

Name: hipA [H]

Synonym: Reut_B3947

Alternate gene names: 73537781

Gene position: 579861-581201 (Clockwise)

Preceding gene: 73537780

Following gene: 73537783

Centisome position: 21.27

GC content: 64.8

Gene sequence:

>1341_bases
ATGGCCATACGCAAGACGCGGACACCAGCGCTGTCGGTCTGGGCCAATGGCCAGCGCGTGGGAACATGGCGCAATCCGGG
AAGTGCCGCGACAGAGTTCGAGTACGACACGGCGTGGATGCACTCGGACACGGGCCGGCCGCTGTCGCTGTCGCTCGACT
ATGCATTGGGTACCCGCAAGGTCATCCGTGGCGAACCGGTGCATCACTATTTCGATAACCTGTTGCCCGACAGCGAACCG
ATCCGGCGCCGGCTGGCTATGCGATTCGGGACCGGCTCGACCGATGCCTTCGCGCTGCTGTCGGCGATCGGCCGCGATTG
CGTCGGCGCGGTGCAGCTGCTCGGTGAAGACGAGATCCCCGCAGGCCATGACCGCATCGAGGGAGAGCCGCTGTCCGACC
AGCAGATCGAGCAATGGCTGCGCGACACCGTGTCGACGCCGGCACCAGGACATGACCAGGACGACGACTTCCGCATCTCG
ATTGCCGGCGCGCAGGAAAAGACGGCGTTGCTGCGGCATGCGGGGCAGTGGCTGCGCCCGCACGGTGCCACGCCGACCAC
GCATATCCTGAAGCTGCCCCTGGGGCTGGTCGGCAACCGGCGCGCCGACCTGAGCGCATCGGTCGAGAACGAATGGCTAT
GCCTGAATATCCTTGGCGCCTACGGGCTGCCGGTCGCGCATAGCGAAATGCTGACGTTCGGCGAGCAGAAGGTGCTGAGC
GTGAGCCGCTTCGACCGCCAGATGCATGCTTCGGGAAACTGGTTGCTGCGCCTCCCGCAGGAGGATTTCTGCCAGGTTTT
CGGGCTCAGTTCGCTGCAGAAGTACGAAGCCGATGGCGGTCCGGGCATGGAGCGGATCGCGACGGTGCTGCGCAATTCCG
AAACCCCCACGCAGGACCTGGAAACGCTGTTCAGTGCCCAACTGCTGTTCTGGCTGCTTGCCGCGCCCGACGGACATGCG
AAGAACTTCAGCATCCGCCTGCTGGCCGGCGGGCGCTACCGGATGACGCCGCTCTATGACGTCATGTCGGTCTGGCCGGT
CATTGGAGACGGTCCGAACCAGTTTTCGTGGCATCGCACCAAGCTGGCCATGGCCGTCGCGGGCAAGAGCCGGCACTATG
CGCTGCGCGACATCCAGCGCCGGCACTTCAACGCCATGGCGTCGCAATGTTTCCTGGGCACCAATGCTGAGCCGGTGATC
GAGCGGTTGATTGCCCGCACGCCTGCGGTGATCGATACCGTGGGAGCGATGCTTCCACCAGGATTCCCGCAGCGCGTGGC
AGACACGATCCTGAACGGCTTGCGCACGTCGGTCGAAAGGCTGGCCAGCATGCAGCCATAG

Upstream 100 bases:

>100_bases
TCAGCGTAGACCAGTTGCTGGCCTTGATCGGGGTGCTCGGACTCGAACTGGTGGTGCAGGAAAAGCGTGGCGGCGTGGAT
GCCGAGGCGGGGTGGTGACC

Downstream 100 bases:

>100_bases
TTTCGCTGCCCGACGGCGGGGTGCTCGTATCGAACGCCGCATGAAGGATAATCACGTTGACGAGAGTCTGCGGATACTCG
GCAGCCTCGTCGCGCTGGGC

Product: HipA-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MAIRKTRTPALSVWANGQRVGTWRNPGSAATEFEYDTAWMHSDTGRPLSLSLDYALGTRKVIRGEPVHHYFDNLLPDSEP
IRRRLAMRFGTGSTDAFALLSAIGRDCVGAVQLLGEDEIPAGHDRIEGEPLSDQQIEQWLRDTVSTPAPGHDQDDDFRIS
IAGAQEKTALLRHAGQWLRPHGATPTTHILKLPLGLVGNRRADLSASVENEWLCLNILGAYGLPVAHSEMLTFGEQKVLS
VSRFDRQMHASGNWLLRLPQEDFCQVFGLSSLQKYEADGGPGMERIATVLRNSETPTQDLETLFSAQLLFWLLAAPDGHA
KNFSIRLLAGGRYRMTPLYDVMSVWPVIGDGPNQFSWHRTKLAMAVAGKSRHYALRDIQRRHFNAMASQCFLGTNAEPVI
ERLIARTPAVIDTVGAMLPPGFPQRVADTILNGLRTSVERLASMQP

Sequences:

>Translated_446_residues
MAIRKTRTPALSVWANGQRVGTWRNPGSAATEFEYDTAWMHSDTGRPLSLSLDYALGTRKVIRGEPVHHYFDNLLPDSEP
IRRRLAMRFGTGSTDAFALLSAIGRDCVGAVQLLGEDEIPAGHDRIEGEPLSDQQIEQWLRDTVSTPAPGHDQDDDFRIS
IAGAQEKTALLRHAGQWLRPHGATPTTHILKLPLGLVGNRRADLSASVENEWLCLNILGAYGLPVAHSEMLTFGEQKVLS
VSRFDRQMHASGNWLLRLPQEDFCQVFGLSSLQKYEADGGPGMERIATVLRNSETPTQDLETLFSAQLLFWLLAAPDGHA
KNFSIRLLAGGRYRMTPLYDVMSVWPVIGDGPNQFSWHRTKLAMAVAGKSRHYALRDIQRRHFNAMASQCFLGTNAEPVI
ERLIARTPAVIDTVGAMLPPGFPQRVADTILNGLRTSVERLASMQP
>Mature_445_residues
AIRKTRTPALSVWANGQRVGTWRNPGSAATEFEYDTAWMHSDTGRPLSLSLDYALGTRKVIRGEPVHHYFDNLLPDSEPI
RRRLAMRFGTGSTDAFALLSAIGRDCVGAVQLLGEDEIPAGHDRIEGEPLSDQQIEQWLRDTVSTPAPGHDQDDDFRISI
AGAQEKTALLRHAGQWLRPHGATPTTHILKLPLGLVGNRRADLSASVENEWLCLNILGAYGLPVAHSEMLTFGEQKVLSV
SRFDRQMHASGNWLLRLPQEDFCQVFGLSSLQKYEADGGPGMERIATVLRNSETPTQDLETLFSAQLLFWLLAAPDGHAK
NFSIRLLAGGRYRMTPLYDVMSVWPVIGDGPNQFSWHRTKLAMAVAGKSRHYALRDIQRRHFNAMASQCFLGTNAEPVIE
RLIARTPAVIDTVGAMLPPGFPQRVADTILNGLRTSVERLASMQP

Specific function: Unbalanced or excessive expression of hipA is toxic to the cell [H]

COG id: COG3550

COG function: function code R; Uncharacterized protein related to capsule biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae HI_0665 [H]

Homologues:

Organism=Escherichia coli, GI1787785, Length=427, Percent_Identity=43.0913348946136, Blast_Score=314, Evalue=6e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012893
- InterPro:   IPR012894
- InterPro:   IPR017508 [H]

Pfam domain/function: PF07804 HipA_C; PF07805 HipA_N [H]

EC number: NA

Molecular weight: Translated: 49418; Mature: 49287

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIRKTRTPALSVWANGQRVGTWRNPGSAATEFEYDTAWMHSDTGRPLSLSLDYALGTRK
CCCCCCCCCEEEEEECCEEEECCCCCCCCCCCCCCCHHEEECCCCCEEEEEEEHHHCCHH
VIRGEPVHHYFDNLLPDSEPIRRRLAMRFGTGSTDAFALLSAIGRDCVGAVQLLGEDEIP
HHCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
AGHDRIEGEPLSDQQIEQWLRDTVSTPAPGHDQDDDFRISIAGAQEKTALLRHAGQWLRP
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCC
HGATPTTHILKLPLGLVGNRRADLSASVENEWLCLNILGAYGLPVAHSEMLTFGEQKVLS
CCCCCCHHHHHCCHHHCCCCCCCCCCCCCCCEEEEEEHHHCCCCCCHHHHHHHCHHHHHH
VSRFDRQMHASGNWLLRLPQEDFCQVFGLSSLQKYEADGGPGMERIATVLRNSETPTQDL
HHHHHHHHHCCCCEEEECCHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHH
ETLFSAQLLFWLLAAPDGHAKNFSIRLLAGGRYRMTPLYDVMSVWPVIGDGPNQFSWHRT
HHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCEECCHHHHHHHHHCCCCCCCCCCCHHHH
KLAMAVAGKSRHYALRDIQRRHFNAMASQCFLGTNAEPVIERLIARTPAVIDTVGAMLPP
HEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHCCC
GFPQRVADTILNGLRTSVERLASMQP
CCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AIRKTRTPALSVWANGQRVGTWRNPGSAATEFEYDTAWMHSDTGRPLSLSLDYALGTRK
CCCCCCCCEEEEEECCEEEECCCCCCCCCCCCCCCHHEEECCCCCEEEEEEEHHHCCHH
VIRGEPVHHYFDNLLPDSEPIRRRLAMRFGTGSTDAFALLSAIGRDCVGAVQLLGEDEIP
HHCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
AGHDRIEGEPLSDQQIEQWLRDTVSTPAPGHDQDDDFRISIAGAQEKTALLRHAGQWLRP
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCC
HGATPTTHILKLPLGLVGNRRADLSASVENEWLCLNILGAYGLPVAHSEMLTFGEQKVLS
CCCCCCHHHHHCCHHHCCCCCCCCCCCCCCCEEEEEEHHHCCCCCCHHHHHHHCHHHHHH
VSRFDRQMHASGNWLLRLPQEDFCQVFGLSSLQKYEADGGPGMERIATVLRNSETPTQDL
HHHHHHHHHCCCCEEEECCHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHH
ETLFSAQLLFWLLAAPDGHAKNFSIRLLAGGRYRMTPLYDVMSVWPVIGDGPNQFSWHRT
HHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCEECCHHHHHHHHHCCCCCCCCCCCHHHH
KLAMAVAGKSRHYALRDIQRRHFNAMASQCFLGTNAEPVIERLIARTPAVIDTVGAMLPP
HEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHCCC
GFPQRVADTILNGLRTSVERLASMQP
CCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1715862; 9278503; 8021189 [H]