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The map label for this gene is xsc [H]

Identifier: 73537608

GI number: 73537608

Start: 373891

End: 375741

Strand: Reverse

Name: xsc [H]

Synonym: Reut_B3773

Alternate gene names: 73537608

Gene position: 375741-373891 (Counterclockwise)

Preceding gene: 73537610

Following gene: 73537607

Centisome position: 13.78

GC content: 65.26

Gene sequence:

>1851_bases
ATGCGCGACCTCGACACGACTACGCAGCCCGCCGTTTCCGGTGGCTCGGCCACCGAGACCCAGGTGCCAGCCGGCCCCCA
GACCATGACGCCGTCCGAAGCGTTCGTGGAGACCATGGTCGCCAATGGCGTGACCGAGATGTTCGGCATCATGGGCTCCG
CGTTCATGGACGCCATGGACATCTTCGCCCCGGCCGGCATTCGTCTTATCCCGGTCGTGCATGAACAGGGTGCTGGCCAT
ATGGCTGACGGCTATGCTCGCGTGTCGGGCCGCCATGGCGTGGTGATCGGCCAGAACGGTCCCGGCATCTCGAACTGCGT
GACGTCCATCGCTGCCGCGTACTGGGCGCATAGCCCGGTCGTGATCGTCACGCCCGAAGCCGGCACCACCGGCATCGGCC
TGGGCGGCTTCCAGGAAGCCAAGCAACTGCCGATGTTCCAGGAGTTCACCAAGTACCAGGGCCACGTCACGCATCCGCAG
CGCATGGCCGAGTTCACCGGCCGCTGCTTCGACCGCGCGCTGGCCGAAATGGGCCCGACCCAGCTCAACATCCCGCGTGA
CTACTTCTACGGCAAGGTCAATGTCGAGATTCCGAAGCCGCAGCGCCTGGACCGCGGCCCCGGCGGCGAACAGAGCCTGA
ACGAAGCGGCCGAGCTGCTGGCACAGGCCAAGTTCCCCGTGATCATCTCGGGCGGCGGCGTGGTGATGGCCGATGCCATC
GAGGAATGCAAGGCACTGGCCGAGCGTCTGGGCGCGCCGGTGGTCAACAGCTACCTGCACAACGACTCGTTCCCCGCCAG
CCACCCGCTGTGGTGCGGTCCGCTGGGCTACCAGGGTTCGAAGGCTGCAATGAAGCTGATCTCGCGCGCCGACGTGGTGA
TCGCACTGGGCTCGCGCCTCGGGCCGTTCGGCACGCTGCCGCAGCACGGCATGGACTACTGGCCGAAGAACGCGAAGATC
ATCCAGATCGACGCCGATCACAAGATGCTGGGCCTGGTGAAGAAGATCTCGGTGGGCATCTGCGGCGACGCCAAGGCTGC
CGCCATTGCGCTCACGCAGCGCCTGGCCAACCGCACGCTTGCCTGCGACAGCAGCCGCGACGGCCGCGCCACGGAAATCG
CCAACGAAAAGGCCGCATGGGAAAAGGAACTGGACGGTTGGACGCACGAGCGCGATCCGTACAGCCTGGACATGATCGAG
GAGCAGAAGAACGAGCGCACCTTCAACGGCGGCACGTACCTGCACCCGCGCCAGGTGCTGCGTGAACTCGAAAAGGCCAT
GCCAGCCGACGTGATGGTGTCGACCGACATCGGCAACATCAACTCAGTCGCCAACAGCTACCTGCGCTTCGAAAAGCCGC
GCAGCTTCTTCGCGGCGATGAGCTGGGGCAATTGCGGTTATGCGTTCCCGACCATCATCGGCGCCAAAGTAGCGGCACCG
CACCGTCCGGCCGTCTCGTACGCCGGTGACGGCGCCTGGGGCATGAGCCTGATGGAAACCATGACCTGCGTGCGCCACAA
CATCCCGGTGACGGCTGTGGTCTTCCACAACCGCCAGTGGGGCGCGGAGAAGAAGAACCAGGTGGACTTCTACAACCGCC
GCTTCGTCGCCGGCGAGCTCGACAACCAGAGCTTCGCCGCCATCGCCAAGGCCATGGGCGCGGAAGGCATCGTGGTGGAT
CGCCTGGAAGACGTGGGCCCGGCACTGAAGCGCGCCATCGACCTGCAGATGAACCACGGCAAGACCACGATCATCGAAGT
GCTGTGCACGCGTGAACTCGGCGACCCGTTCCGCCGCGACGCGCTGTCCAAGCCGGTGCGCTACCTGGACAAGTACAAGG
ACTACGTCTGA

Upstream 100 bases:

>100_bases
ACTTCCTATTGACCACGGGCTGTTCTCCGCCTACATTTCCCTCACCAAACAGTTTCTGGAACGAATCGTTCCACTTATTA
CGTCACACAGGAGACACCCC

Downstream 100 bases:

>100_bases
TCGAGTCTGATCGAAGCTGCGCCCTATCGTTCGCGATCGGGTGCGCCCTCTCCCGCTTGCGGGAGAGGGCGATAACACCA
AGGGCATAGCGCTGATCGCT

Product: sulfoacetaldehyde acetyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 616; Mature: 616

Protein sequence:

>616_residues
MRDLDTTTQPAVSGGSATETQVPAGPQTMTPSEAFVETMVANGVTEMFGIMGSAFMDAMDIFAPAGIRLIPVVHEQGAGH
MADGYARVSGRHGVVIGQNGPGISNCVTSIAAAYWAHSPVVIVTPEAGTTGIGLGGFQEAKQLPMFQEFTKYQGHVTHPQ
RMAEFTGRCFDRALAEMGPTQLNIPRDYFYGKVNVEIPKPQRLDRGPGGEQSLNEAAELLAQAKFPVIISGGGVVMADAI
EECKALAERLGAPVVNSYLHNDSFPASHPLWCGPLGYQGSKAAMKLISRADVVIALGSRLGPFGTLPQHGMDYWPKNAKI
IQIDADHKMLGLVKKISVGICGDAKAAAIALTQRLANRTLACDSSRDGRATEIANEKAAWEKELDGWTHERDPYSLDMIE
EQKNERTFNGGTYLHPRQVLRELEKAMPADVMVSTDIGNINSVANSYLRFEKPRSFFAAMSWGNCGYAFPTIIGAKVAAP
HRPAVSYAGDGAWGMSLMETMTCVRHNIPVTAVVFHNRQWGAEKKNQVDFYNRRFVAGELDNQSFAAIAKAMGAEGIVVD
RLEDVGPALKRAIDLQMNHGKTTIIEVLCTRELGDPFRRDALSKPVRYLDKYKDYV

Sequences:

>Translated_616_residues
MRDLDTTTQPAVSGGSATETQVPAGPQTMTPSEAFVETMVANGVTEMFGIMGSAFMDAMDIFAPAGIRLIPVVHEQGAGH
MADGYARVSGRHGVVIGQNGPGISNCVTSIAAAYWAHSPVVIVTPEAGTTGIGLGGFQEAKQLPMFQEFTKYQGHVTHPQ
RMAEFTGRCFDRALAEMGPTQLNIPRDYFYGKVNVEIPKPQRLDRGPGGEQSLNEAAELLAQAKFPVIISGGGVVMADAI
EECKALAERLGAPVVNSYLHNDSFPASHPLWCGPLGYQGSKAAMKLISRADVVIALGSRLGPFGTLPQHGMDYWPKNAKI
IQIDADHKMLGLVKKISVGICGDAKAAAIALTQRLANRTLACDSSRDGRATEIANEKAAWEKELDGWTHERDPYSLDMIE
EQKNERTFNGGTYLHPRQVLRELEKAMPADVMVSTDIGNINSVANSYLRFEKPRSFFAAMSWGNCGYAFPTIIGAKVAAP
HRPAVSYAGDGAWGMSLMETMTCVRHNIPVTAVVFHNRQWGAEKKNQVDFYNRRFVAGELDNQSFAAIAKAMGAEGIVVD
RLEDVGPALKRAIDLQMNHGKTTIIEVLCTRELGDPFRRDALSKPVRYLDKYKDYV
>Mature_616_residues
MRDLDTTTQPAVSGGSATETQVPAGPQTMTPSEAFVETMVANGVTEMFGIMGSAFMDAMDIFAPAGIRLIPVVHEQGAGH
MADGYARVSGRHGVVIGQNGPGISNCVTSIAAAYWAHSPVVIVTPEAGTTGIGLGGFQEAKQLPMFQEFTKYQGHVTHPQ
RMAEFTGRCFDRALAEMGPTQLNIPRDYFYGKVNVEIPKPQRLDRGPGGEQSLNEAAELLAQAKFPVIISGGGVVMADAI
EECKALAERLGAPVVNSYLHNDSFPASHPLWCGPLGYQGSKAAMKLISRADVVIALGSRLGPFGTLPQHGMDYWPKNAKI
IQIDADHKMLGLVKKISVGICGDAKAAAIALTQRLANRTLACDSSRDGRATEIANEKAAWEKELDGWTHERDPYSLDMIE
EQKNERTFNGGTYLHPRQVLRELEKAMPADVMVSTDIGNINSVANSYLRFEKPRSFFAAMSWGNCGYAFPTIIGAKVAAP
HRPAVSYAGDGAWGMSLMETMTCVRHNIPVTAVVFHNRQWGAEKKNQVDFYNRRFVAGELDNQSFAAIAKAMGAEGIVVD
RLEDVGPALKRAIDLQMNHGKTTIIEVLCTRELGDPFRRDALSKPVRYLDKYKDYV

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21361361, Length=613, Percent_Identity=24.1435562805873, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI93004078, Length=591, Percent_Identity=22.3350253807107, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI87081685, Length=570, Percent_Identity=26.6666666666667, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI1790104, Length=554, Percent_Identity=25.2707581227437, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1786717, Length=590, Percent_Identity=25.4237288135593, Blast_Score=155, Evalue=8e-39,
Organism=Escherichia coli, GI1787096, Length=594, Percent_Identity=23.9057239057239, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1788716, Length=497, Percent_Identity=24.9496981891348, Blast_Score=117, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17542570, Length=579, Percent_Identity=24.006908462867, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17531301, Length=588, Percent_Identity=23.2993197278912, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17531299, Length=588, Percent_Identity=23.2993197278912, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323755, Length=568, Percent_Identity=27.112676056338, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6320816, Length=592, Percent_Identity=22.4662162162162, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI19922626, Length=509, Percent_Identity=24.75442043222, Blast_Score=120, Evalue=3e-27,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017820
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.3.3.15 [H]

Molecular weight: Translated: 66934; Mature: 66934

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDLDTTTQPAVSGGSATETQVPAGPQTMTPSEAFVETMVANGVTEMFGIMGSAFMDAMD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFAPAGIRLIPVVHEQGAGHMADGYARVSGRHGVVIGQNGPGISNCVTSIAAAYWAHSPV
HHCCCCCEEEEEEECCCCCCCCCCHHEECCCCCEEECCCCCCHHHHHHHHHHHHHCCCCE
VIVTPEAGTTGIGLGGFQEAKQLPMFQEFTKYQGHVTHPQRMAEFTGRCFDRALAEMGPT
EEEECCCCCCCCCCCCHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCC
QLNIPRDYFYGKVNVEIPKPQRLDRGPGGEQSLNEAAELLAQAKFPVIISGGGVVMADAI
EECCCHHHEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCEEEHHHH
EECKALAERLGAPVVNSYLHNDSFPASHPLWCGPLGYQGSKAAMKLISRADVVIALGSRL
HHHHHHHHHHCCHHHHHHHCCCCCCCCCCCEECCCCCCCHHHHHHHHHHCCEEEEECCCC
GPFGTLPQHGMDYWPKNAKIIQIDADHKMLGLVKKISVGICGDAKAAAIALTQRLANRTL
CCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHCEECCCCHHHHHHHHHHHHCCCE
ACDSSRDGRATEIANEKAAWEKELDGWTHERDPYSLDMIEEQKNERTFNGGTYLHPRQVL
ECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCEECCCCEECHHHHH
RELEKAMPADVMVSTDIGNINSVANSYLRFEKPRSFFAAMSWGNCGYAFPTIIGAKVAAP
HHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHCCCC
HRPAVSYAGDGAWGMSLMETMTCVRHNIPVTAVVFHNRQWGAEKKNQVDFYNRRFVAGEL
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHCEEEEECC
DNQSFAAIAKAMGAEGIVVDRLEDVGPALKRAIDLQMNHGKTTIIEVLCTRELGDPFRRD
CCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHCCHHHHH
ALSKPVRYLDKYKDYV
HHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRDLDTTTQPAVSGGSATETQVPAGPQTMTPSEAFVETMVANGVTEMFGIMGSAFMDAMD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFAPAGIRLIPVVHEQGAGHMADGYARVSGRHGVVIGQNGPGISNCVTSIAAAYWAHSPV
HHCCCCCEEEEEEECCCCCCCCCCHHEECCCCCEEECCCCCCHHHHHHHHHHHHHCCCCE
VIVTPEAGTTGIGLGGFQEAKQLPMFQEFTKYQGHVTHPQRMAEFTGRCFDRALAEMGPT
EEEECCCCCCCCCCCCHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCC
QLNIPRDYFYGKVNVEIPKPQRLDRGPGGEQSLNEAAELLAQAKFPVIISGGGVVMADAI
EECCCHHHEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCEEEHHHH
EECKALAERLGAPVVNSYLHNDSFPASHPLWCGPLGYQGSKAAMKLISRADVVIALGSRL
HHHHHHHHHHCCHHHHHHHCCCCCCCCCCCEECCCCCCCHHHHHHHHHHCCEEEEECCCC
GPFGTLPQHGMDYWPKNAKIIQIDADHKMLGLVKKISVGICGDAKAAAIALTQRLANRTL
CCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHCEECCCCHHHHHHHHHHHHCCCE
ACDSSRDGRATEIANEKAAWEKELDGWTHERDPYSLDMIEEQKNERTFNGGTYLHPRQVL
ECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCEECCCCEECHHHHH
RELEKAMPADVMVSTDIGNINSVANSYLRFEKPRSFFAAMSWGNCGYAFPTIIGAKVAAP
HHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHCCCC
HRPAVSYAGDGAWGMSLMETMTCVRHNIPVTAVVFHNRQWGAEKKNQVDFYNRRFVAGEL
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHCEEEEECC
DNQSFAAIAKAMGAEGIVVDRLEDVGPALKRAIDLQMNHGKTTIIEVLCTRELGDPFRRD
CCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHCCHHHHH
ALSKPVRYLDKYKDYV
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12358600 [H]