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The map label for this gene is adhA [H]

Identifier: 73537512

GI number: 73537512

Start: 257884

End: 258912

Strand: Reverse

Name: adhA [H]

Synonym: Reut_B3677

Alternate gene names: 73537512

Gene position: 258912-257884 (Counterclockwise)

Preceding gene: 73537513

Following gene: 73537511

Centisome position: 9.5

GC content: 65.89

Gene sequence:

>1029_bases
ATGCCAGCGATGATGAAAGCTGCGGTGGTGCGTGCATTCGGCGCGCCGCTCACGATCGATGAAGTGCCCGTGCCGCAACC
CGGGCCCGGCCAGGTCCAGGTGAAGATTGAAGCCTCCGGTGTCTGCCATACCGACCTGCACGCCGCCGACGGCGACTGGC
CGGTCAAACCCACGCTGCCGTTTATCCCCGGCCATGAAGGCGTCGGCTATGTATCGGCCGTCGGCAGCGGCGTCAGCCGC
GTGAAGGAAGGTGACCGCGTCGGCGTTCCGTGGCTGTACAGCGCCTGTGGCTATTGCGAGCACTGCCTGCAAGGCTGGGA
AACGCTGTGCGAAAAGCAGCAGAACACCGGCTATTCGGTCAACGGCGGCTACGGCGAGTATGTGGTGGCCGACCCGAACT
ACGTTGGCCTGCTGCCCGACAAGGTGGGCTTCGTCGAAATCGCGCCGATCCTGTGCGCGGGCGTCACGGTGTACAAGGGC
CTGAAGGTCACGGATACGCGCCCCGGCCAGTGGGTGGTGATCTCCGGCATCGGCGGCCTGGGCCATGTGGCCGTGCAGTA
CGCCAGGGCGATGGGCCTGCGCGTGGCGGCTGTCGACATCGACGATGCCAAGCTCAACCTCGCCAGACGGCTCGGCGCGG
AAGTGGCCGTCAACGCGCGCGATACGGATCCGGCCGCATGGCTGCAGAAGGAAATCGGCGGCGCGCATGGCGTGCTGGTC
ACCGCCGTGTCGCCCAAGGCCTTTTCGCAGGCGATCGGCATGGTGCGGCGTGGTGGAACCATTGCCCTGAACGGTCTCCC
GCCGGGCGATTTCGGCACGCCGATCTTCGACGTGGTGCTCAAGGGCATCACCATCCGAGGCTCGATCGTCGGCACGCGCA
GCGACTTGCAAGAGTCGCTTGATTTTGCCGCGCATGGCGACGTGAAAGCCACGGTCTCGACAGCGAAGCTGGACGACGTC
AACGATGTGTTCGGACGGCTGCGCGAAGGCAAGGTGGAAGGCCGCGTGGTGCTGGACTTCTCGCGGTGA

Upstream 100 bases:

>100_bases
GCGTTTTACTGGTGAATCCGTAGTCCCGAGCCGCGAAGCGCGTGCTACTATCGTAACGGTGCCCTCCTCCCCGGGGCACC
GCTTCCAACAAGGAGTCGAT

Downstream 100 bases:

>100_bases
GACCAGTCATGCCCCGCGTCAGCGCCGATTCTGCAGGTGCAACTCCCGTGACCGTGACCCGCGTGGTCGCCACGCCGGCG
GCGCTCGCGCTGATCGGCGA

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MPAMMKAAVVRAFGAPLTIDEVPVPQPGPGQVQVKIEASGVCHTDLHAADGDWPVKPTLPFIPGHEGVGYVSAVGSGVSR
VKEGDRVGVPWLYSACGYCEHCLQGWETLCEKQQNTGYSVNGGYGEYVVADPNYVGLLPDKVGFVEIAPILCAGVTVYKG
LKVTDTRPGQWVVISGIGGLGHVAVQYARAMGLRVAAVDIDDAKLNLARRLGAEVAVNARDTDPAAWLQKEIGGAHGVLV
TAVSPKAFSQAIGMVRRGGTIALNGLPPGDFGTPIFDVVLKGITIRGSIVGTRSDLQESLDFAAHGDVKATVSTAKLDDV
NDVFGRLREGKVEGRVVLDFSR

Sequences:

>Translated_342_residues
MPAMMKAAVVRAFGAPLTIDEVPVPQPGPGQVQVKIEASGVCHTDLHAADGDWPVKPTLPFIPGHEGVGYVSAVGSGVSR
VKEGDRVGVPWLYSACGYCEHCLQGWETLCEKQQNTGYSVNGGYGEYVVADPNYVGLLPDKVGFVEIAPILCAGVTVYKG
LKVTDTRPGQWVVISGIGGLGHVAVQYARAMGLRVAAVDIDDAKLNLARRLGAEVAVNARDTDPAAWLQKEIGGAHGVLV
TAVSPKAFSQAIGMVRRGGTIALNGLPPGDFGTPIFDVVLKGITIRGSIVGTRSDLQESLDFAAHGDVKATVSTAKLDDV
NDVFGRLREGKVEGRVVLDFSR
>Mature_341_residues
PAMMKAAVVRAFGAPLTIDEVPVPQPGPGQVQVKIEASGVCHTDLHAADGDWPVKPTLPFIPGHEGVGYVSAVGSGVSRV
KEGDRVGVPWLYSACGYCEHCLQGWETLCEKQQNTGYSVNGGYGEYVVADPNYVGLLPDKVGFVEIAPILCAGVTVYKGL
KVTDTRPGQWVVISGIGGLGHVAVQYARAMGLRVAAVDIDDAKLNLARRLGAEVAVNARDTDPAAWLQKEIGGAHGVLVT
AVSPKAFSQAIGMVRRGGTIALNGLPPGDFGTPIFDVVLKGITIRGSIVGTRSDLQESLDFAAHGDVKATVSTAKLDDVN
DVFGRLREGKVEGRVVLDFSR

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=370, Percent_Identity=29.7297297297297, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI34577061, Length=369, Percent_Identity=29.2682926829268, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI4501929, Length=369, Percent_Identity=29.2682926829268, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI71565154, Length=241, Percent_Identity=31.9502074688797, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI71565152, Length=374, Percent_Identity=27.2727272727273, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI71743840, Length=254, Percent_Identity=29.1338582677165, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI262073058, Length=254, Percent_Identity=29.1338582677165, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI156523966, Length=239, Percent_Identity=30.5439330543933, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI4501939, Length=239, Percent_Identity=30.5439330543933, Blast_Score=95, Evalue=9e-20,
Organism=Escherichia coli, GI87081918, Length=312, Percent_Identity=45.5128205128205, Blast_Score=251, Evalue=4e-68,
Organism=Escherichia coli, GI1786518, Length=347, Percent_Identity=34.5821325648415, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI87082401, Length=343, Percent_Identity=30.9037900874636, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1788073, Length=269, Percent_Identity=33.457249070632, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1790045, Length=336, Percent_Identity=28.8690476190476, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87082125, Length=220, Percent_Identity=34.5454545454545, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1786552, Length=363, Percent_Identity=33.0578512396694, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI1788075, Length=318, Percent_Identity=30.188679245283, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788407, Length=277, Percent_Identity=31.0469314079422, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1787863, Length=341, Percent_Identity=27.8592375366569, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI226510992, Length=296, Percent_Identity=29.3918918918919, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790718, Length=283, Percent_Identity=24.7349823321555, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786825, Length=357, Percent_Identity=27.4509803921569, Blast_Score=75, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17562584, Length=346, Percent_Identity=42.1965317919075, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17562582, Length=347, Percent_Identity=40.6340057636888, Blast_Score=227, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI71988145, Length=343, Percent_Identity=37.3177842565598, Blast_Score=224, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI17562876, Length=333, Percent_Identity=30.9309309309309, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17562878, Length=209, Percent_Identity=35.4066985645933, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI25146526, Length=379, Percent_Identity=27.4406332453826, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71997431, Length=381, Percent_Identity=27.0341207349081, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17565904, Length=238, Percent_Identity=26.890756302521, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17507255, Length=265, Percent_Identity=26.0377358490566, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319621, Length=346, Percent_Identity=41.0404624277457, Blast_Score=265, Evalue=7e-72,
Organism=Saccharomyces cerevisiae, GI6323961, Length=346, Percent_Identity=40.1734104046243, Blast_Score=259, Evalue=6e-70,
Organism=Saccharomyces cerevisiae, GI6323729, Length=346, Percent_Identity=40.1734104046243, Blast_Score=256, Evalue=3e-69,
Organism=Saccharomyces cerevisiae, GI6324486, Length=346, Percent_Identity=39.5953757225434, Blast_Score=252, Evalue=5e-68,
Organism=Saccharomyces cerevisiae, GI6319949, Length=329, Percent_Identity=30.3951367781155, Blast_Score=112, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6323980, Length=319, Percent_Identity=29.7805642633229, Blast_Score=106, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6320033, Length=247, Percent_Identity=32.3886639676113, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322619, Length=312, Percent_Identity=29.1666666666667, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319955, Length=312, Percent_Identity=29.1666666666667, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=329, Percent_Identity=23.7082066869301, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17737895, Length=250, Percent_Identity=27.6, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17137530, Length=309, Percent_Identity=28.4789644012945, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17737897, Length=207, Percent_Identity=30.9178743961353, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35953; Mature: 35821

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAMMKAAVVRAFGAPLTIDEVPVPQPGPGQVQVKIEASGVCHTDLHAADGDWPVKPTLP
CCHHHHHHHHHHCCCCCEECCCCCCCCCCCEEEEEEEECCCEECCCCCCCCCCCCCCCCC
FIPGHEGVGYVSAVGSGVSRVKEGDRVGVPWLYSACGYCEHCLQGWETLCEKQQNTGYSV
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
NGGYGEYVVADPNYVGLLPDKVGFVEIAPILCAGVTVYKGLKVTDTRPGQWVVISGIGGL
CCCCCCEEEECCCEEEECCCCCCCEEHHHHHHHHHHHHCCEEEECCCCCCEEEEECCCCH
GHVAVQYARAMGLRVAAVDIDDAKLNLARRLGAEVAVNARDTDPAAWLQKEIGGAHGVLV
HHHHHHHHHHHCCEEEEEECCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCEEE
TAVSPKAFSQAIGMVRRGGTIALNGLPPGDFGTPIFDVVLKGITIRGSIVGTRSDLQESL
EEECHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHCCEEEEEEEEECHHHHHHHH
DFAAHGDVKATVSTAKLDDVNDVFGRLREGKVEGRVVLDFSR
CHHCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure 
PAMMKAAVVRAFGAPLTIDEVPVPQPGPGQVQVKIEASGVCHTDLHAADGDWPVKPTLP
CHHHHHHHHHHCCCCCEECCCCCCCCCCCEEEEEEEECCCEECCCCCCCCCCCCCCCCC
FIPGHEGVGYVSAVGSGVSRVKEGDRVGVPWLYSACGYCEHCLQGWETLCEKQQNTGYSV
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
NGGYGEYVVADPNYVGLLPDKVGFVEIAPILCAGVTVYKGLKVTDTRPGQWVVISGIGGL
CCCCCCEEEECCCEEEECCCCCCCEEHHHHHHHHHHHHCCEEEECCCCCCEEEEECCCCH
GHVAVQYARAMGLRVAAVDIDDAKLNLARRLGAEVAVNARDTDPAAWLQKEIGGAHGVLV
HHHHHHHHHHHCCEEEEEECCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCEEE
TAVSPKAFSQAIGMVRRGGTIALNGLPPGDFGTPIFDVVLKGITIRGSIVGTRSDLQESL
EEECHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHCCEEEEEEEEECHHHHHHHH
DFAAHGDVKATVSTAKLDDVNDVFGRLREGKVEGRVVLDFSR
CHHCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9659380; 11481432 [H]