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The map label for this gene is pbpC [H]

Identifier: 73543065

GI number: 73543065

Start: 3704642

End: 3706882

Strand: Reverse

Name: pbpC [H]

Synonym: Reut_A3383

Alternate gene names: 73543065

Gene position: 3706882-3704642 (Counterclockwise)

Preceding gene: 73543066

Following gene: 73543064

Centisome position: 97.38

GC content: 66.98

Gene sequence:

>2241_bases
ATGAAAAGGCCGGCAGCACATCGTGCGGCAGTTGTCATGTTTGCGATTGCGCTGACATGCACAACACTCCCCGCCCATGC
ACTTCCAAGCTTCACCCAAGTCCGCGCAGACTGGCGAAGCTCCGACCTCGTCATCACCGATCGCAACGGCGAAACCGTGG
CGCGCATACGTGACGATTTCCGCGTGCGCCGCGGTGATTGGGTCACCCTGCAGGAAACCTCGCCGGCGTTGCGCACGGCC
ATCGTGCTGTCGGAGGACAAGCGCTTCTACGCACACAGCGGCGTCGACTGGCAAGGCGTGGCTGCAGCGGCCTGGGCCAA
TCTCTTTAACACGCGGACGCGCGGTGCTTCCACGCTGACGATGCAACTGGCAGGCCTGCTCGATGAGGACCTGCGCAGGC
CGGGCGCCGCGGGGCAGGGCCGCAGCGTCACGCAGAAGCTCGGACAGGCTGCCGGCGCCGCGTCGCTGGAACGAAGCTGG
AGCAAGGACCAGATCCTTGAAGCCTATCTGAACCTCGTGCCGTTCCGTGGCGAACTTGTCGGGCTGTCGGCGATGTCGCA
AGTGTTGTTCGGCAAGTTTCCGGAGGGACTGGACGCGCGTGAATCGGCGCTGGCCGTGGCGCTCGTGCGTGCGCCCAACG
CAAAGGCAGCGCAGGTGTCGCGCCGCGCATGCGGCATCCTGCGCGAGATGCGCTTGCCGCGCGAGTGCGAGGGGCTGGAA
GGCTTTGCACAACTGGCATTGCTGCGCTCAGGCACCGTCGCGCAGCGCGGCACGGCAGCGTCGCCGCAGCCGAGGCAACT
CGCACCGCATCTTGGTCGTATGCTGGCGAGTCAGGCGCGTGCGCAACCACGGACAGATCTGGCGCAGTCGTACCTTCGAT
CGACGCTTGACGCAGATCTCCAGCGCGTGGCCACGGCGAGCCTGCAGCGGCATCTGCGCGAACTGGCCGGACGCCATGTG
GAAGACGGCGCCGTGGTGGTGATCGACAACGCGAGCGGCGACGTGCTGGCCTACGTGGGCTCGTCCGGCGAGTTGTCCGG
TGCGTCGGAAGTCGATCATGCACAGGCGCTGCGGCAGGCGGGTTCAACGCTGAAACCATTCCTGTACGAGCAGGCGCTGG
AAGAACGGCGGCTGACGGCTGCTTCGCTGCTCGACGACCGGCCTGTCAACCTGCCGGTCGGCGGCGGGCTGTACGTGCCG
CAGAACTACGACCATCGCTACGCGGGCTGGGTCAGTACGCGCGCGGCGCTTGCTGCTTCGCTGAACGTGCCCGCGGTGCG
CACGCTCGTGATGGTGACACCGCACCGCTTTCACAAACGCTTGGTGTCGCTGGGACTGCCGTTGACAGAAGCCGGCGACT
ACTACGGATATAGCCTTGCGCTCGGCAGCGCCGATGTGTCGCTGCTGGCGCTGACCAACGCGTATCGCGCGCTTGCCAAC
AGCGGTCGCTATGCACCGGTGCGCATGCGTGCGGGCATGGCGGCAGTGCCGACTACGGCGGTGATGGCGCCAGCAGCGAG
CTACGTGATCGGCGACATCCTGTCCGACCGCCACGCACGGGCGCGCACGTTCGGGCTCGACAGTCCGCTGACCACGCGTT
TCTGGACTGCGGTGAAGACCGGTACGAGCAAGGACATGCGCGACAACTGGTGCATCGGCTGGTCACGGCGTTATACCGTT
GGCGTGTGGGTTGGCAATGCGAGCGGGGCCAGCATGCATGACGTATCGGGGGTATCCGGCGCGGCGCCGGTCTGGCATGA
CGTGATGGAGGCGCTGCACCGTTCGCAGCCGAGCATGGCGCCTGCGGCGCCGGCGGGCGTGGAGCGCGTCGCGCTGGCGT
TTGACGATGACCTCGAGCCAGCGCGTGAAGAAGTGTTTCTCGTTGGTACGGCCCAGACACGTGTCGGCGTGGGGATGTCG
TCAGCGCGATCTGGCGTGCCGGCCATTGCCAATCCGGCCAACGGCACGGTGTTTGCGCTGGACCCTGACATGCCGCCGTC
GGCGCAACGTGTGTGGTTCCACGCCGAAGGCGTAACGGGCCAGACCGCGCGTTCTGTGACGTGGCGCATGGATGGCAAGC
CGCTTGGGCGTGGCGGTGAAGTGGCGTGGCTGCCGTGGCCCGGCCGGCATCAGGTTGAGTTGCTCGACGCCGCGGGCAAG
GTGGTGGACCGTATCGGCATTGAAGTGCGCGGGGCAAGCGTGCGTGCTCCCGCCGCGCAAACGGGGCGCGGCGCTCGCTG
A

Upstream 100 bases:

>100_bases
TGCCGTTCGACAGTTTCCAGCTCGGTATCTGGTGGACGTATTGGGCGGCACAGGTGCTGATCGTCGCGGGCATTGTGGCG
AATCGTGGAGAGCGGGGGGG

Downstream 100 bases:

>100_bases
TCCTGCGCGTGGTACCTTGAACCAGTCGCACGCCTCGCAGCGCTTCAAGCTGGCGTGCATTCGTCGCCGCGCGCGACGCC
AACCGACAGGAGCAAGCATG

Product: penicillin-binding protein 1C

Products: NA

Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]

Number of amino acids: Translated: 746; Mature: 746

Protein sequence:

>746_residues
MKRPAAHRAAVVMFAIALTCTTLPAHALPSFTQVRADWRSSDLVITDRNGETVARIRDDFRVRRGDWVTLQETSPALRTA
IVLSEDKRFYAHSGVDWQGVAAAAWANLFNTRTRGASTLTMQLAGLLDEDLRRPGAAGQGRSVTQKLGQAAGAASLERSW
SKDQILEAYLNLVPFRGELVGLSAMSQVLFGKFPEGLDARESALAVALVRAPNAKAAQVSRRACGILREMRLPRECEGLE
GFAQLALLRSGTVAQRGTAASPQPRQLAPHLGRMLASQARAQPRTDLAQSYLRSTLDADLQRVATASLQRHLRELAGRHV
EDGAVVVIDNASGDVLAYVGSSGELSGASEVDHAQALRQAGSTLKPFLYEQALEERRLTAASLLDDRPVNLPVGGGLYVP
QNYDHRYAGWVSTRAALAASLNVPAVRTLVMVTPHRFHKRLVSLGLPLTEAGDYYGYSLALGSADVSLLALTNAYRALAN
SGRYAPVRMRAGMAAVPTTAVMAPAASYVIGDILSDRHARARTFGLDSPLTTRFWTAVKTGTSKDMRDNWCIGWSRRYTV
GVWVGNASGASMHDVSGVSGAAPVWHDVMEALHRSQPSMAPAAPAGVERVALAFDDDLEPAREEVFLVGTAQTRVGVGMS
SARSGVPAIANPANGTVFALDPDMPPSAQRVWFHAEGVTGQTARSVTWRMDGKPLGRGGEVAWLPWPGRHQVELLDAAGK
VVDRIGIEVRGASVRAPAAQTGRGAR

Sequences:

>Translated_746_residues
MKRPAAHRAAVVMFAIALTCTTLPAHALPSFTQVRADWRSSDLVITDRNGETVARIRDDFRVRRGDWVTLQETSPALRTA
IVLSEDKRFYAHSGVDWQGVAAAAWANLFNTRTRGASTLTMQLAGLLDEDLRRPGAAGQGRSVTQKLGQAAGAASLERSW
SKDQILEAYLNLVPFRGELVGLSAMSQVLFGKFPEGLDARESALAVALVRAPNAKAAQVSRRACGILREMRLPRECEGLE
GFAQLALLRSGTVAQRGTAASPQPRQLAPHLGRMLASQARAQPRTDLAQSYLRSTLDADLQRVATASLQRHLRELAGRHV
EDGAVVVIDNASGDVLAYVGSSGELSGASEVDHAQALRQAGSTLKPFLYEQALEERRLTAASLLDDRPVNLPVGGGLYVP
QNYDHRYAGWVSTRAALAASLNVPAVRTLVMVTPHRFHKRLVSLGLPLTEAGDYYGYSLALGSADVSLLALTNAYRALAN
SGRYAPVRMRAGMAAVPTTAVMAPAASYVIGDILSDRHARARTFGLDSPLTTRFWTAVKTGTSKDMRDNWCIGWSRRYTV
GVWVGNASGASMHDVSGVSGAAPVWHDVMEALHRSQPSMAPAAPAGVERVALAFDDDLEPAREEVFLVGTAQTRVGVGMS
SARSGVPAIANPANGTVFALDPDMPPSAQRVWFHAEGVTGQTARSVTWRMDGKPLGRGGEVAWLPWPGRHQVELLDAAGK
VVDRIGIEVRGASVRAPAAQTGRGAR
>Mature_746_residues
MKRPAAHRAAVVMFAIALTCTTLPAHALPSFTQVRADWRSSDLVITDRNGETVARIRDDFRVRRGDWVTLQETSPALRTA
IVLSEDKRFYAHSGVDWQGVAAAAWANLFNTRTRGASTLTMQLAGLLDEDLRRPGAAGQGRSVTQKLGQAAGAASLERSW
SKDQILEAYLNLVPFRGELVGLSAMSQVLFGKFPEGLDARESALAVALVRAPNAKAAQVSRRACGILREMRLPRECEGLE
GFAQLALLRSGTVAQRGTAASPQPRQLAPHLGRMLASQARAQPRTDLAQSYLRSTLDADLQRVATASLQRHLRELAGRHV
EDGAVVVIDNASGDVLAYVGSSGELSGASEVDHAQALRQAGSTLKPFLYEQALEERRLTAASLLDDRPVNLPVGGGLYVP
QNYDHRYAGWVSTRAALAASLNVPAVRTLVMVTPHRFHKRLVSLGLPLTEAGDYYGYSLALGSADVSLLALTNAYRALAN
SGRYAPVRMRAGMAAVPTTAVMAPAASYVIGDILSDRHARARTFGLDSPLTTRFWTAVKTGTSKDMRDNWCIGWSRRYTV
GVWVGNASGASMHDVSGVSGAAPVWHDVMEALHRSQPSMAPAAPAGVERVALAFDDDLEPAREEVFLVGTAQTRVGVGMS
SARSGVPAIANPANGTVFALDPDMPPSAQRVWFHAEGVTGQTARSVTWRMDGKPLGRGGEVAWLPWPGRHQVELLDAAGK
VVDRIGIEVRGASVRAPAAQTGRGAR

Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]

COG id: COG4953

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1788867, Length=562, Percent_Identity=33.0960854092527, Blast_Score=202, Evalue=5e-53,
Organism=Escherichia coli, GI1786343, Length=579, Percent_Identity=26.2521588946459, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI87082258, Length=281, Percent_Identity=27.7580071174377, Blast_Score=86, Evalue=9e-18,
Organism=Escherichia coli, GI1789601, Length=194, Percent_Identity=31.9587628865979, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011815
- InterPro:   IPR009647
- InterPro:   IPR001460 [H]

Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 79963; Mature: 79963

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRPAAHRAAVVMFAIALTCTTLPAHALPSFTQVRADWRSSDLVITDRNGETVARIRDDF
CCCCHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHCCCCCCEEEECCCCCCHHHHHHHH
RVRRGDWVTLQETSPALRTAIVLSEDKRFYAHSGVDWQGVAAAAWANLFNTRTRGASTLT
EEECCCEEEEECCCCCCEEEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHH
MQLAGLLDEDLRRPGAAGQGRSVTQKLGQAAGAASLERSWSKDQILEAYLNLVPFRGELV
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHCCCCCCEE
GLSAMSQVLFGKFPEGLDARESALAVALVRAPNAKAAQVSRRACGILREMRLPRECEGLE
CHHHHHHHHHCCCCCCCCCHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHCCHH
GFAQLALLRSGTVAQRGTAASPQPRQLAPHLGRMLASQARAQPRTDLAQSYLRSTLDADL
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
QRVATASLQRHLRELAGRHVEDGAVVVIDNASGDVLAYVGSSGELSGASEVDHAQALRQA
HHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHC
GSTLKPFLYEQALEERRLTAASLLDDRPVNLPVGGGLYVPQNYDHRYAGWVSTRAALAAS
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHC
LNVPAVRTLVMVTPHRFHKRLVSLGLPLTEAGDYYGYSLALGSADVSLLALTNAYRALAN
CCCCHHEEEEEECCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEHHHHHHHHHHHC
SGRYAPVRMRAGMAAVPTTAVMAPAASYVIGDILSDRHARARTFGLDSPLTTRFWTAVKT
CCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHC
GTSKDMRDNWCIGWSRRYTVGVWVGNASGASMHDVSGVSGAAPVWHDVMEALHRSQPSMA
CCCCCCCCCCEECCCCEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
PAAPAGVERVALAFDDDLEPAREEVFLVGTAQTRVGVGMSSARSGVPAIANPANGTVFAL
CCCCCCCCEEEEEECCCCCCCCCCEEEEEECCHHHCCCHHHHCCCCCCCCCCCCCEEEEE
DPDMPPSAQRVWFHAEGVTGQTARSVTWRMDGKPLGRGGEVAWLPWPGRHQVELLDAAGK
CCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCHHHHHHHH
VVDRIGIEVRGASVRAPAAQTGRGAR
HHHHHCCEEECCCEECCCCCCCCCCC
>Mature Secondary Structure
MKRPAAHRAAVVMFAIALTCTTLPAHALPSFTQVRADWRSSDLVITDRNGETVARIRDDF
CCCCHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHCCCCCCEEEECCCCCCHHHHHHHH
RVRRGDWVTLQETSPALRTAIVLSEDKRFYAHSGVDWQGVAAAAWANLFNTRTRGASTLT
EEECCCEEEEECCCCCCEEEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHH
MQLAGLLDEDLRRPGAAGQGRSVTQKLGQAAGAASLERSWSKDQILEAYLNLVPFRGELV
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHCCCCCCEE
GLSAMSQVLFGKFPEGLDARESALAVALVRAPNAKAAQVSRRACGILREMRLPRECEGLE
CHHHHHHHHHCCCCCCCCCHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHCCHH
GFAQLALLRSGTVAQRGTAASPQPRQLAPHLGRMLASQARAQPRTDLAQSYLRSTLDADL
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
QRVATASLQRHLRELAGRHVEDGAVVVIDNASGDVLAYVGSSGELSGASEVDHAQALRQA
HHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHC
GSTLKPFLYEQALEERRLTAASLLDDRPVNLPVGGGLYVPQNYDHRYAGWVSTRAALAAS
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHC
LNVPAVRTLVMVTPHRFHKRLVSLGLPLTEAGDYYGYSLALGSADVSLLALTNAYRALAN
CCCCHHEEEEEECCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEHHHHHHHHHHHC
SGRYAPVRMRAGMAAVPTTAVMAPAASYVIGDILSDRHARARTFGLDSPLTTRFWTAVKT
CCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHC
GTSKDMRDNWCIGWSRRYTVGVWVGNASGASMHDVSGVSGAAPVWHDVMEALHRSQPSMA
CCCCCCCCCCEECCCCEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
PAAPAGVERVALAFDDDLEPAREEVFLVGTAQTRVGVGMSSARSGVPAIANPANGTVFAL
CCCCCCCCEEEEEECCCCCCCCCCEEEEEECCHHHCCCHHHHCCCCCCCCCCCCCEEEEE
DPDMPPSAQRVWFHAEGVTGQTARSVTWRMDGKPLGRGGEVAWLPWPGRHQVELLDAAGK
CCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCHHHHHHHH
VVDRIGIEVRGASVRAPAAQTGRGAR
HHHHHCCEEECCCEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10542235; 9205837; 9278503; 9841666 [H]