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The map label for this gene is gcvT [H]

Identifier: 73543011

GI number: 73543011

Start: 3638781

End: 3639908

Strand: Direct

Name: gcvT [H]

Synonym: Reut_A3329

Alternate gene names: 73543011

Gene position: 3638781-3639908 (Clockwise)

Preceding gene: 73543010

Following gene: 73543012

Centisome position: 95.59

GC content: 67.02

Gene sequence:

>1128_bases
ATGACGCTCCAGGCCACGCCCCTCAATGCCATCCACCGCGCCCTCGGCGCCCGCATGGTCGACTTCGGCGGCTGGGACAT
GCCGGTCAACTACGGCTCCCAGATCGAGGAACACAACGCGGTGCGCAGCGACGCCGGCATGTTCGATGTGTCGCATATGT
GCGTGGTCGACCTGAACGGCGCCAATACGCGTGCGTTCCTGCGCGGCCTGCTGGCCAACAACGTCGATAAGCTGCAGACG
CCGGGCAAGGCTTTGTATTCCTGCATGCTCGACGAAAAAGGCGGCGTGATCGACGACCTGATCGTCTACTTCTTCGCCGA
GGATCGCTTCCGCCTGGTGGTCAATGCCAGCACCGCGCTTGGCGATATCGAGTGGATCCGCGCACGCAATGACGCGACCG
GCAGCGGCGTGACCATCACCCCGCGCCGTGGCGATGTGGCACCGGCGGGCGCGCTGCCGCTGGCGATTGTCGCCGTGCAG
GGCCCGAACGCGCGCACCAAGGTGTGGAACACCTTCCCGTCCACCCAGCCTTCCGACGCTCTCAAGCCATTCAACGCCGT
CGTGGTCCACGACCCGGCCATCGGCGAGATCATGGTCGCGCGCACCGGCTACACCGGCGAAGACGGCTTTGAACTCGTGG
TGCCTGCCGAGAACGTCGCTGCCGTGTGGGAAAAGCTCGATGCCGCCGGCGTGCGCCCGGCCGGCCTCGGCGCGCGCGAC
ACGCTGCGCCTGGAAGCCGGCATGAACCTGTACGGCCAGGACATGGATATCAACACCTCGCCGCTCGACGCCGGCCTGGC
CTGGACCGTCGACCTGCAGAGCGAGCGCGATTTCACCGGCAAGGCGGCGCTTGCCGCCGCCGGCCAGCGCCAGCAGTTCC
TGGGCCTGATCCTGCGTGACAAGGGCGGCGTGCTGCGCGCGCACCAGAAGGTCGTCACCGCGGCCGGTGATGGCGAAATC
ACGAGCGGCACCTTCAGCCCGTCGCTGTCGCAATCGATCGCTTTCGCGCGCCTGCCGATGGGCGTGGCGGTCGGCGACAC
GGTGCAGGTGGAGATCCGCGACCGCAAACTCGCGGCGACTGTGGTTAAACTGCCGTTTGTGCGTAATGGCAAGGCACTCG
TGAGCTGA

Upstream 100 bases:

>100_bases
TCATCCGCCGCAGCGGATTGCGAAGCCATTTGGGCGAAGCAAGCGCTGCGGCGGATGACCTTTTTTCGTTTTCGCAACCG
AGATTGCCCCGAGGATTCCC

Downstream 100 bases:

>100_bases
GGCGGCAACGCCCCCGCTCACCACAACGGTCGCCCGTCGCGCCTGCCCCCTCGACCGATGGCAGGCGCCCGAACCAAGAA
CAAATCTGAATCCCGGAGAA

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MTLQATPLNAIHRALGARMVDFGGWDMPVNYGSQIEEHNAVRSDAGMFDVSHMCVVDLNGANTRAFLRGLLANNVDKLQT
PGKALYSCMLDEKGGVIDDLIVYFFAEDRFRLVVNASTALGDIEWIRARNDATGSGVTITPRRGDVAPAGALPLAIVAVQ
GPNARTKVWNTFPSTQPSDALKPFNAVVVHDPAIGEIMVARTGYTGEDGFELVVPAENVAAVWEKLDAAGVRPAGLGARD
TLRLEAGMNLYGQDMDINTSPLDAGLAWTVDLQSERDFTGKAALAAAGQRQQFLGLILRDKGGVLRAHQKVVTAAGDGEI
TSGTFSPSLSQSIAFARLPMGVAVGDTVQVEIRDRKLAATVVKLPFVRNGKALVS

Sequences:

>Translated_375_residues
MTLQATPLNAIHRALGARMVDFGGWDMPVNYGSQIEEHNAVRSDAGMFDVSHMCVVDLNGANTRAFLRGLLANNVDKLQT
PGKALYSCMLDEKGGVIDDLIVYFFAEDRFRLVVNASTALGDIEWIRARNDATGSGVTITPRRGDVAPAGALPLAIVAVQ
GPNARTKVWNTFPSTQPSDALKPFNAVVVHDPAIGEIMVARTGYTGEDGFELVVPAENVAAVWEKLDAAGVRPAGLGARD
TLRLEAGMNLYGQDMDINTSPLDAGLAWTVDLQSERDFTGKAALAAAGQRQQFLGLILRDKGGVLRAHQKVVTAAGDGEI
TSGTFSPSLSQSIAFARLPMGVAVGDTVQVEIRDRKLAATVVKLPFVRNGKALVS
>Mature_374_residues
TLQATPLNAIHRALGARMVDFGGWDMPVNYGSQIEEHNAVRSDAGMFDVSHMCVVDLNGANTRAFLRGLLANNVDKLQTP
GKALYSCMLDEKGGVIDDLIVYFFAEDRFRLVVNASTALGDIEWIRARNDATGSGVTITPRRGDVAPAGALPLAIVAVQG
PNARTKVWNTFPSTQPSDALKPFNAVVVHDPAIGEIMVARTGYTGEDGFELVVPAENVAAVWEKLDAAGVRPAGLGARDT
LRLEAGMNLYGQDMDINTSPLDAGLAWTVDLQSERDFTGKAALAAAGQRQQFLGLILRDKGGVLRAHQKVVTAAGDGEIT
SGTFSPSLSQSIAFARLPMGVAVGDTVQVEIRDRKLAATVVKLPFVRNGKALVS

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=376, Percent_Identity=33.5106382978723, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI257796258, Length=347, Percent_Identity=33.4293948126801, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI257796254, Length=376, Percent_Identity=31.9148936170213, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI257796256, Length=318, Percent_Identity=32.0754716981132, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI24797151, Length=359, Percent_Identity=29.2479108635098, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI197927446, Length=295, Percent_Identity=26.7796610169492, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI21361378, Length=295, Percent_Identity=26.7796610169492, Blast_Score=92, Evalue=8e-19,
Organism=Escherichia coli, GI1789272, Length=380, Percent_Identity=51.5789473684211, Blast_Score=349, Evalue=1e-97,
Organism=Caenorhabditis elegans, GI17560118, Length=379, Percent_Identity=33.245382585752, Blast_Score=150, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI71994045, Length=385, Percent_Identity=23.8961038961039, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI71994052, Length=385, Percent_Identity=23.8961038961039, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI32563613, Length=269, Percent_Identity=24.907063197026, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320222, Length=389, Percent_Identity=32.9048843187661, Blast_Score=174, Evalue=3e-44,
Organism=Drosophila melanogaster, GI20129441, Length=386, Percent_Identity=33.160621761658, Blast_Score=168, Evalue=6e-42,
Organism=Drosophila melanogaster, GI20130091, Length=281, Percent_Identity=25.2669039145907, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28571104, Length=275, Percent_Identity=25.8181818181818, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 39911; Mature: 39780

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLQATPLNAIHRALGARMVDFGGWDMPVNYGSQIEEHNAVRSDAGMFDVSHMCVVDLNG
CCEECCCHHHHHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHCCCCCEEECEEEEEEECC
ANTRAFLRGLLANNVDKLQTPGKALYSCMLDEKGGVIDDLIVYFFAEDRFRLVVNASTAL
CCHHHHHHHHHHCCHHHHCCCHHHHHHHHHCCCCCHHHHHHEEEEECCEEEEEEECCCCC
GDIEWIRARNDATGSGVTITPRRGDVAPAGALPLAIVAVQGPNARTKVWNTFPSTQPSDA
CCEEEEEECCCCCCCCEEEECCCCCCCCCCCCEEEEEEEECCCCCCEEEECCCCCCCCHH
LKPFNAVVVHDPAIGEIMVARTGYTGEDGFELVVPAENVAAVWEKLDAAGVRPAGLGARD
CCCCCEEEEECCCCCEEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCC
TLRLEAGMNLYGQDMDINTSPLDAGLAWTVDLQSERDFTGKAALAAAGQRQQFLGLILRD
EEEEECCCCEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHCCCHHHEEEEEEEC
KGGVLRAHQKVVTAAGDGEITSGTFSPSLSQSIAFARLPMGVAVGDTVQVEIRDRKLAAT
CCCEEEECEEEEEECCCCCEECCCCCCCHHHHHHHHHCCCCEEECCEEEEEEECCEEEEE
VVKLPFVRNGKALVS
EEECCEEECCCCCCC
>Mature Secondary Structure 
TLQATPLNAIHRALGARMVDFGGWDMPVNYGSQIEEHNAVRSDAGMFDVSHMCVVDLNG
CEECCCHHHHHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHCCCCCEEECEEEEEEECC
ANTRAFLRGLLANNVDKLQTPGKALYSCMLDEKGGVIDDLIVYFFAEDRFRLVVNASTAL
CCHHHHHHHHHHCCHHHHCCCHHHHHHHHHCCCCCHHHHHHEEEEECCEEEEEEECCCCC
GDIEWIRARNDATGSGVTITPRRGDVAPAGALPLAIVAVQGPNARTKVWNTFPSTQPSDA
CCEEEEEECCCCCCCCEEEECCCCCCCCCCCCEEEEEEEECCCCCCEEEECCCCCCCCHH
LKPFNAVVVHDPAIGEIMVARTGYTGEDGFELVVPAENVAAVWEKLDAAGVRPAGLGARD
CCCCCEEEEECCCCCEEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCC
TLRLEAGMNLYGQDMDINTSPLDAGLAWTVDLQSERDFTGKAALAAAGQRQQFLGLILRD
EEEEECCCCEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHCCCHHHEEEEEEEC
KGGVLRAHQKVVTAAGDGEITSGTFSPSLSQSIAFARLPMGVAVGDTVQVEIRDRKLAAT
CCCEEEECEEEEEECCCCCEECCCCCCCHHHHHHHHHCCCCEEECCEEEEEEECCEEEEE
VVKLPFVRNGKALVS
EEECCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA