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The map label for this gene is glxR [H]

Identifier: 73542976

GI number: 73542976

Start: 3601964

End: 3602884

Strand: Direct

Name: glxR [H]

Synonym: Reut_A3293

Alternate gene names: 73542976

Gene position: 3601964-3602884 (Clockwise)

Preceding gene: 73542975

Following gene: 73542977

Centisome position: 94.63

GC content: 65.58

Gene sequence:

>921_bases
ATGGCAAACCAACGCAACGTCGGCTTCATCGGTCTGGGCATCATGGGCGCACCCATGGCGGGCCACCTGCGCGCCGCCGG
CCACACGCTGTTCGTGCATGACGTCAACCCGGCCCCGCAAGCGCTGGTCGATGCAGGCGTGACCGTCTGCACCAGCGCGG
AGGAAGTCGCCAAGCGCGCCGACATCATCGTCATCATGGTGCCGGACACGCCGCACGTCGAAGCCGTGCTGTTTGCCGAC
AAAGGCGTTGCCGCCGCGCTGAAGGCCGCGGGCAAGGAAGCCAGCTACAGCAAGATCGTCGTCGACATGAGCTCGATCTC
GCCGATCGCGACCAAGGACTTCGCTGCGCGCATCAACAAGCTGGGCGCTTCGTACCTGGACGCGCCGGTGTCGGGCGGTG
AAGTCGGCGCCAAGGCTGCATCGCTGACGATCATGGTTGGTGGTCCGGAAGAAGCGTTCGACCAGGTCAAGCCGCTGTTC
GAGCTGATGGGCAAGAACATCACGCTGGTCGGCGGCAACGGCGACGGCCAGACCACCAAGGTGGCCAACCAGATCATCGT
CGCGCTGAACATCCAGGCTGTGTCCGAAGCGCTGCTGTTCGCCTCGAAGGCGGGTGCCGATCCGGCACGCGTGCGCCAGG
CGCTGATGGGCGGCTTCGCCGCATCGCGCATCCTGGAAGTGCATGGCGAGCGCATGGTCAAGCGCACCTTCGACCCGGGC
TTCCGCATCGAACTGCACCAGAAGGACCTGAACCTGGCCCTGCAAGGCGCCAAGGCGCTGGGCGTAGCGCTGCCGAATAC
CGCGACCGCGCAGGAACTGTTCAACACCTGCGCTGCCAACGGCTTCGGCAAGGCCGACCACTCGGCCCTGTGCCGCGCGA
TCGAGATCATGTCGAACCACGACATCGCCAGCGCCAAGTAA

Upstream 100 bases:

>100_bases
GGGCTGGCGCGCCGCCCACGGCGTGCAGTAACAGCGTGCAGTAACGGGTTACCGCACACGCAATCCATCACAGACTTAAC
ATCCAATCGGAGACATCAAC

Downstream 100 bases:

>100_bases
GCACATCGCTGCACACGCAAGATCTGCAGTACCTGTAGTTGCAGCAAACGCCGTCCCCTTCGCGGGGACGGCCTCAGTTT
CAGTTCCCAGGATTCCCCAT

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MANQRNVGFIGLGIMGAPMAGHLRAAGHTLFVHDVNPAPQALVDAGVTVCTSAEEVAKRADIIVIMVPDTPHVEAVLFAD
KGVAAALKAAGKEASYSKIVVDMSSISPIATKDFAARINKLGASYLDAPVSGGEVGAKAASLTIMVGGPEEAFDQVKPLF
ELMGKNITLVGGNGDGQTTKVANQIIVALNIQAVSEALLFASKAGADPARVRQALMGGFAASRILEVHGERMVKRTFDPG
FRIELHQKDLNLALQGAKALGVALPNTATAQELFNTCAANGFGKADHSALCRAIEIMSNHDIASAK

Sequences:

>Translated_306_residues
MANQRNVGFIGLGIMGAPMAGHLRAAGHTLFVHDVNPAPQALVDAGVTVCTSAEEVAKRADIIVIMVPDTPHVEAVLFAD
KGVAAALKAAGKEASYSKIVVDMSSISPIATKDFAARINKLGASYLDAPVSGGEVGAKAASLTIMVGGPEEAFDQVKPLF
ELMGKNITLVGGNGDGQTTKVANQIIVALNIQAVSEALLFASKAGADPARVRQALMGGFAASRILEVHGERMVKRTFDPG
FRIELHQKDLNLALQGAKALGVALPNTATAQELFNTCAANGFGKADHSALCRAIEIMSNHDIASAK
>Mature_305_residues
ANQRNVGFIGLGIMGAPMAGHLRAAGHTLFVHDVNPAPQALVDAGVTVCTSAEEVAKRADIIVIMVPDTPHVEAVLFADK
GVAAALKAAGKEASYSKIVVDMSSISPIATKDFAARINKLGASYLDAPVSGGEVGAKAASLTIMVGGPEEAFDQVKPLFE
LMGKNITLVGGNGDGQTTKVANQIIVALNIQAVSEALLFASKAGADPARVRQALMGGFAASRILEVHGERMVKRTFDPGF
RIELHQKDLNLALQGAKALGVALPNTATAQELFNTCAANGFGKADHSALCRAIEIMSNHDIASAK

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=309, Percent_Identity=32.0388349514563, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI40556376, Length=290, Percent_Identity=25.5172413793103, Blast_Score=93, Evalue=4e-19,
Organism=Escherichia coli, GI1786719, Length=298, Percent_Identity=67.7852348993289, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI145693186, Length=298, Percent_Identity=41.6107382550336, Blast_Score=227, Evalue=6e-61,
Organism=Escherichia coli, GI1790315, Length=294, Percent_Identity=33.3333333333333, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI1789092, Length=307, Percent_Identity=29.9674267100977, Blast_Score=102, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17557316, Length=289, Percent_Identity=30.4498269896194, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24655230, Length=294, Percent_Identity=36.0544217687075, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI19922568, Length=294, Percent_Identity=36.0544217687075, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI28574115, Length=289, Percent_Identity=26.643598615917, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 31718; Mature: 31587

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANQRNVGFIGLGIMGAPMAGHLRAAGHTLFVHDVNPAPQALVDAGVTVCTSAEEVAKRA
CCCCCCCCEEEECCCCCCCCCCHHHCCCEEEEEECCCCHHHHHHCCCCEECCHHHHHHHC
DIIVIMVPDTPHVEAVLFADKGVAAALKAAGKEASYSKIVVDMSSISPIATKDFAARINK
CEEEEEECCCCCEEEEEEECCCHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHH
LGASYLDAPVSGGEVGAKAASLTIMVGGPEEAFDQVKPLFELMGKNITLVGGNGDGQTTK
HCHHHHCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCCHHH
VANQIIVALNIQAVSEALLFASKAGADPARVRQALMGGFAASRILEVHGERMVKRTFDPG
HHCEEEEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FRIELHQKDLNLALQGAKALGVALPNTATAQELFNTCAANGFGKADHSALCRAIEIMSNH
CEEEEECCCCCEEEECCCEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
DIASAK
CCCCCC
>Mature Secondary Structure 
ANQRNVGFIGLGIMGAPMAGHLRAAGHTLFVHDVNPAPQALVDAGVTVCTSAEEVAKRA
CCCCCCCEEEECCCCCCCCCCHHHCCCEEEEEECCCCHHHHHHCCCCEECCHHHHHHHC
DIIVIMVPDTPHVEAVLFADKGVAAALKAAGKEASYSKIVVDMSSISPIATKDFAARINK
CEEEEEECCCCCEEEEEEECCCHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHH
LGASYLDAPVSGGEVGAKAASLTIMVGGPEEAFDQVKPLFELMGKNITLVGGNGDGQTTK
HCHHHHCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCCHHH
VANQIIVALNIQAVSEALLFASKAGADPARVRQALMGGFAASRILEVHGERMVKRTFDPG
HHCEEEEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FRIELHQKDLNLALQGAKALGVALPNTATAQELFNTCAANGFGKADHSALCRAIEIMSNH
CEEEEECCCCCEEEECCCEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
DIASAK
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]