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The map label for this gene is lysA [H]

Identifier: 73542823

GI number: 73542823

Start: 3449670

End: 3450929

Strand: Direct

Name: lysA [H]

Synonym: Reut_A3139

Alternate gene names: 73542823

Gene position: 3449670-3450929 (Clockwise)

Preceding gene: 73542822

Following gene: 73542832

Centisome position: 90.62

GC content: 65.4

Gene sequence:

>1260_bases
ATGACCGCATTTTTCCATCGCCAGGACGGCGCCCTGATGGCCGAACAGGTGCCGCTGGCGCAGATCGCCGCCGAATTCGG
CACGCCGGCCTATGTGTACTCGCGCGCCGCGCTGACCGCCGCGTACCAGGGCTACGCTGCCGCCTGCAAAGGCCGCAAGG
CGCAGGTGCAGTACGCCATGAAGGCCAACTCGAACCTGGCGGTACTGCAGGTCTTCGCAAAACTTGGCGCGGGCTTCGAC
ATCGTCTCCGGTGGCGAACTCAAGCGCGTGCTGGCCGCCGGTGGTGATCCGCGCAAGGTGGTGTTTTCCGGCGTCGGCAA
GAACGCGGCGGAGATGGAACTCGCGCTCGCCCATGACGTGCGCTGCTTCAACGTCGAATCGATTCCCGAACTGGACCGCC
TCAATGCCGTGGCCGGCCAGATCGGCAAGCGCGCGCGCGTGTCGCTGCGCATCAACCCGGACGTCGATGCCAAGACCCAC
CCATACATCTCGACGGGCCTGAAAGGCAACAAATTCGGCATCGCGTTCGAGGACGTGCTGCCCACGTACCGTGCTGCCGC
TGCGCTGCCGAATATCGAAGTCACCGGCATCGACTGCCACATCGGTTCGCAGATCACCGAAGTGGCACCGTATCTGGAAG
CGCTCGACAAGGTGCTCGACGTGGTCGAAGCGCTGGAGCGCGAAGGCATCGTACTCGAGCACATCGATGTCGGCGGCGGC
CTGGGTATCACCTACACCGACGAGACGCCGCCCGACATCACGGGCTTTGCCACCACGCTGCTTGACCGTGTGGCCGCACG
TGGCCATGCGCATCGCGAAGTGCTGTTCGAACCGGGTCGCTCGCTGGTCGGCAATGCCGGCGTGCTGCTGACGCAGGTGG
AATTCCTCAAGCCCGGCGCGGCCAAAAACTTCTGCATCGTCGATGCCGCCATGAACGACCTCGCGCGCCCGGCCATGTAC
GAGGCCTATCACCGTATCGAGCCGGTCAAGGCGAACGGCGGATCGCAGGTCGTCTACGACATCGTCGGTCCGGTGTGCGA
ATCGGGCGACTGGCTTGGCCGCGACCGCGCGCTGGCCGTGCAGCCGGGCGACCTGCTGGCAGTGATGTCGGCCGGTGCCT
ACGGCTTCGTGATGAGCTCCAACTACAACACCCGCCCCCGCGCCGCCGAAGTCATGGTCGACGGCGGCAAGGTCCACCTC
GTACGCGAACGCGAACTGGTCGAAGACCTGTTCCGCGACGAACGCCTGCTGCAGGACTGA

Upstream 100 bases:

>100_bases
TGCCCGATCCGGGCCTGGGCCATCCTGACGCCAAGCTGCCCGCGTCGGCAGCACCCACCACGCCTCCGGCCTCTTCCGAC
GCCCCCACCAGCCGATAACC

Downstream 100 bases:

>100_bases
TCCACCCGCCAGTCTCCCGGCCTGCCTGCCTCAGCGGGCGGCCGGACGCCAGCGCCACCACAGGCGCAGCCCCAGCAGCA
CGAACACCACTGCAGCGTAG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MTAFFHRQDGALMAEQVPLAQIAAEFGTPAYVYSRAALTAAYQGYAAACKGRKAQVQYAMKANSNLAVLQVFAKLGAGFD
IVSGGELKRVLAAGGDPRKVVFSGVGKNAAEMELALAHDVRCFNVESIPELDRLNAVAGQIGKRARVSLRINPDVDAKTH
PYISTGLKGNKFGIAFEDVLPTYRAAAALPNIEVTGIDCHIGSQITEVAPYLEALDKVLDVVEALEREGIVLEHIDVGGG
LGITYTDETPPDITGFATTLLDRVAARGHAHREVLFEPGRSLVGNAGVLLTQVEFLKPGAAKNFCIVDAAMNDLARPAMY
EAYHRIEPVKANGGSQVVYDIVGPVCESGDWLGRDRALAVQPGDLLAVMSAGAYGFVMSSNYNTRPRAAEVMVDGGKVHL
VRERELVEDLFRDERLLQD

Sequences:

>Translated_419_residues
MTAFFHRQDGALMAEQVPLAQIAAEFGTPAYVYSRAALTAAYQGYAAACKGRKAQVQYAMKANSNLAVLQVFAKLGAGFD
IVSGGELKRVLAAGGDPRKVVFSGVGKNAAEMELALAHDVRCFNVESIPELDRLNAVAGQIGKRARVSLRINPDVDAKTH
PYISTGLKGNKFGIAFEDVLPTYRAAAALPNIEVTGIDCHIGSQITEVAPYLEALDKVLDVVEALEREGIVLEHIDVGGG
LGITYTDETPPDITGFATTLLDRVAARGHAHREVLFEPGRSLVGNAGVLLTQVEFLKPGAAKNFCIVDAAMNDLARPAMY
EAYHRIEPVKANGGSQVVYDIVGPVCESGDWLGRDRALAVQPGDLLAVMSAGAYGFVMSSNYNTRPRAAEVMVDGGKVHL
VRERELVEDLFRDERLLQD
>Mature_418_residues
TAFFHRQDGALMAEQVPLAQIAAEFGTPAYVYSRAALTAAYQGYAAACKGRKAQVQYAMKANSNLAVLQVFAKLGAGFDI
VSGGELKRVLAAGGDPRKVVFSGVGKNAAEMELALAHDVRCFNVESIPELDRLNAVAGQIGKRARVSLRINPDVDAKTHP
YISTGLKGNKFGIAFEDVLPTYRAAAALPNIEVTGIDCHIGSQITEVAPYLEALDKVLDVVEALEREGIVLEHIDVGGGL
GITYTDETPPDITGFATTLLDRVAARGHAHREVLFEPGRSLVGNAGVLLTQVEFLKPGAAKNFCIVDAAMNDLARPAMYE
AYHRIEPVKANGGSQVVYDIVGPVCESGDWLGRDRALAVQPGDLLAVMSAGAYGFVMSSNYNTRPRAAEVMVDGGKVHLV
RERELVEDLFRDERLLQD

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=237, Percent_Identity=26.5822784810127, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1789203, Length=421, Percent_Identity=34.916864608076, Blast_Score=181, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI17562780, Length=358, Percent_Identity=24.8603351955307, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322664, Length=364, Percent_Identity=23.6263736263736, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24586474, Length=343, Percent_Identity=27.1137026239067, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24586472, Length=345, Percent_Identity=24.6376811594203, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 44969; Mature: 44838

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAFFHRQDGALMAEQVPLAQIAAEFGTPAYVYSRAALTAAYQGYAAACKGRKAQVQYAM
CCCEEECCCCCCHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHCCCCCEEEEEE
KANSNLAVLQVFAKLGAGFDIVSGGELKRVLAAGGDPRKVVFSGVGKNAAEMELALAHDV
CCCCCHHHHHHHHHHCCCCEEECCCHHHHHHHCCCCCCEEEEECCCCCHHHEEEEHHHCE
RCFNVESIPELDRLNAVAGQIGKRARVSLRINPDVDAKTHPYISTGLKGNKFGIAFEDVL
EEECCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCEECCCCCCCCCEEHHHHH
PTYRAAAALPNIEVTGIDCHIGSQITEVAPYLEALDKVLDVVEALEREGIVLEHIDVGGG
HHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCC
LGITYTDETPPDITGFATTLLDRVAARGHAHREVLFEPGRSLVGNAGVLLTQVEFLKPGA
EEEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHCCCCEEEEEHHHHCCCC
AKNFCIVDAAMNDLARPAMYEAYHRIEPVKANGGSQVVYDIVGPVCESGDWLGRDRALAV
CCCEEEEEHHHHHHCCHHHHHHHHHCCCEECCCCCEEEHHHHHHHHCCCCCCCCCCEEEE
QPGDLLAVMSAGAYGFVMSSNYNTRPRAAEVMVDGGKVHLVRERELVEDLFRDERLLQD
CCCCEEEEECCCCEEEEEECCCCCCCCEEEEEECCCEEEEEEHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TAFFHRQDGALMAEQVPLAQIAAEFGTPAYVYSRAALTAAYQGYAAACKGRKAQVQYAM
CCEEECCCCCCHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHCCCCCEEEEEE
KANSNLAVLQVFAKLGAGFDIVSGGELKRVLAAGGDPRKVVFSGVGKNAAEMELALAHDV
CCCCCHHHHHHHHHHCCCCEEECCCHHHHHHHCCCCCCEEEEECCCCCHHHEEEEHHHCE
RCFNVESIPELDRLNAVAGQIGKRARVSLRINPDVDAKTHPYISTGLKGNKFGIAFEDVL
EEECCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCEECCCCCCCCCEEHHHHH
PTYRAAAALPNIEVTGIDCHIGSQITEVAPYLEALDKVLDVVEALEREGIVLEHIDVGGG
HHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCC
LGITYTDETPPDITGFATTLLDRVAARGHAHREVLFEPGRSLVGNAGVLLTQVEFLKPGA
EEEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHCCCCEEEEEHHHHCCCC
AKNFCIVDAAMNDLARPAMYEAYHRIEPVKANGGSQVVYDIVGPVCESGDWLGRDRALAV
CCCEEEEEHHHHHHCCHHHHHHHHHCCCEECCCCCEEEHHHHHHHHCCCCCCCCCCEEEE
QPGDLLAVMSAGAYGFVMSSNYNTRPRAAEVMVDGGKVHLVRERELVEDLFRDERLLQD
CCCCEEEEECCCCEEEEEECCCCCCCCEEEEEECCCEEEEEEHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]