Click here to switch to the map view.

The map label for this gene is xdhA [H]

Identifier: 73542760

GI number: 73542760

Start: 3385679

End: 3387952

Strand: Direct

Name: xdhA [H]

Synonym: Reut_A3076

Alternate gene names: 73542760

Gene position: 3385679-3387952 (Clockwise)

Preceding gene: 73542759

Following gene: 73542761

Centisome position: 88.94

GC content: 64.25

Gene sequence:

>2274_bases
ATGACCCACGCCGTGATCGGACACAGCGTCAAGCGCACCGACCTGCTCGACAAGGTCACCGGCAATGCGAAGTACGTTGC
CGACATGCCGTTCGCCGGCCTGCTGTTCGGCAAGATCAAGCGCTGCGAAGTCGCGCACGCAAAGATCCGCCGCATCGACA
CATCGCGCGCGCTTGCGCTGCCCGGCGTCAAGGCCGTGCTCACCCACGAGAACGTGCCGCGCGTGTTGCATGCCGGATCG
CCGCATCCGCGCTCTGCGTCAGTGACGTGCGACCAGTACATCCTCGACGACAAGGTGCGCTACTGGGGCGAAGGCGTGGC
CGCCGTGGCCGCGACTAGCGAGGACATCGCGGCGCATGCGATCGAACTGATCGAAGTCGAATACGAGACGCTGCCCGCCG
TATTCACGACAGAAGATGCCGAACGTTCCGACGCGCCGCGCATCCACGACCGCGAACCCGGCGGCAACCTGGTGTTGCCG
CCTGTCATCGTCAAGCGCGGTGATGTCGAAGCCGGCTTTGCCGAAGCGGATTTCATCCTCGAAGGCATCTATGAAGGCGG
CCGCCCTACCCCGGCCTACATGGAACCGAACGTCTGCACCTGCAACTGGGACGGCAACGGCAATCTGACCGTGTGGATTT
CCACGCAGACCGCGTTCATGGTACGCGGCATCATGGCCGAAGTGCTGGGCCTGCCGCTGCACAAGGTACGCGTGCTGGTC
GACCATATGGGCGGCGGCTTTGGTGCGAAGCAAGACCTGTTTCAGCATGAGTTTCTGTGCGCATTGATGGCGCGCGAGAC
GCGCCGGCCGGTGCGCATGGAATACACGCGCGAGGAAACCTTCCTCGGCGGACGCACACGCCATCCGGCCAGGATCTGGC
TCAAGCAGGGCTTCCGCAACGACGGCACCATCACTGCGCGCCAGGCGAAGGTGGTGTTCAACTCGGGCGCGTATGGCTCG
CATGGTCCCGGCGTCACCAACGTCGGCACCGCAGCCATGGTCTCGCTGTACCGCTGCGACAACGTGCTGCTCGAAGGGCG
TTGCGTCTACACCAACAGCCCGATCGCGGGCGCGTTCCGTGGCTATGGCGTGGTGCAGACCTACTATGCGCTCGATGTCC
AGATGGACGAGGCGGCCGAACATCTCGGCATGGACCCCGCCGACCTAAAACTGAAGAACGCCGTGCGCGAAGGCGATATC
GCACCGTCCAATCACCCGCTCATCGGCCACGGGCTGGAAGCATGCATCAGCAAGGGCATGGAAGCCACCCGTTGGGCCGC
ACTGCGACAGCGCCCACGCGATACGGAAGGCCCGATCCGCACCGGCTGGGGCATCGGTTGCGAGATGCACGGCAGCAGCG
CCTATCCGGGCATCAAGGAGCAGGGCAACGCGATCATCAAGATGAACGAGGATGGCACCGTCGTGCTGCTGACGGGTGCT
GCAGGCCTTGGCACGGGAGCGCATACGGCGCTCGCGCAAATCGTGGCAGAGGAACTGACGCTGCCGTTCGAGTCGGTGTC
TGTGGTCCACGGCGATACCGATGTGGTGCCGTGGGACATCGGCGCCTTCGCGAGCCATACGACGTACATGGTCGGCAAGG
CTGCGCAGATGGCGGCGGGCGAGATCAAGCGGCAACTGTTCGATCGCGCGGCGAAGCTGCTCGAATGCACCCCTGATGCA
TTGATGCTCACGGCTGGCGTGATCGCGGTGCGCGACCGCGAAGGTCCAACGCTGACGGTGCGCGAAGCAGTCATGCCACG
CAAGGGTATTCCTGCCGCGCAACTGGTCGGCACCGCCACATACCACCCGACCAAGTCGTATTCGTTCGCCGCGCATTTCG
TGCAAGTCGAAGTCGACACGGAAACGGGCTTCATTACCGTGAAGCAGGTAGTGCCCGTGCATGACGTCGGCAAGGTGATC
CACCCCGTGGCGGCGGCCGGCCAGATCGAGGGTGGCATCCAGCAAGGCATCGGCCATACGCTGTACGAGGACTACCAGAT
CGACATGCGCACCGGCCGCTCGCTCAATGCCAACTTCGTCGACTACAAGATGCCGCTCGCGATGGACATGCCGGAGATTC
ACACCATCATCCTTGAAGCGGCCCCCGATCCTGGCGGACCGTTCGGCGCCAAGGGCGTAGGGGAGGATCCGATCGTCGCG
ATCGGACCGGCCATTTCCAACGCCGTGTTCGATGCGATCGGCGTGCGCTTCCGGCACTACCCGATCCGGCCGGAGCAGGT
GCTGCAGGCGCTTGCCAAAAAGGCGGCGGCATGA

Upstream 100 bases:

>100_bases
GCTTTGCGATTGCTGGCAACATCTGCCGCTGCACGGGGTACACCAAGATCATCGAGGCGATCGAAAAGACTGCCGCCGCG
ATGGCGAACCAGGAGGCATG

Downstream 100 bases:

>100_bases
CGAAGCGCCTTGTCGTCGCTATCACCGGTGCGAGTGGCGCGGTCTATGGCGTGCGCGTGTTGCAGGCGCTGTCACCGCTG
GCGGACTGGGAAACGCATCT

Product: xanthine dehydrogenase, molybdenum binding subunit apoprotein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 757; Mature: 756

Protein sequence:

>757_residues
MTHAVIGHSVKRTDLLDKVTGNAKYVADMPFAGLLFGKIKRCEVAHAKIRRIDTSRALALPGVKAVLTHENVPRVLHAGS
PHPRSASVTCDQYILDDKVRYWGEGVAAVAATSEDIAAHAIELIEVEYETLPAVFTTEDAERSDAPRIHDREPGGNLVLP
PVIVKRGDVEAGFAEADFILEGIYEGGRPTPAYMEPNVCTCNWDGNGNLTVWISTQTAFMVRGIMAEVLGLPLHKVRVLV
DHMGGGFGAKQDLFQHEFLCALMARETRRPVRMEYTREETFLGGRTRHPARIWLKQGFRNDGTITARQAKVVFNSGAYGS
HGPGVTNVGTAAMVSLYRCDNVLLEGRCVYTNSPIAGAFRGYGVVQTYYALDVQMDEAAEHLGMDPADLKLKNAVREGDI
APSNHPLIGHGLEACISKGMEATRWAALRQRPRDTEGPIRTGWGIGCEMHGSSAYPGIKEQGNAIIKMNEDGTVVLLTGA
AGLGTGAHTALAQIVAEELTLPFESVSVVHGDTDVVPWDIGAFASHTTYMVGKAAQMAAGEIKRQLFDRAAKLLECTPDA
LMLTAGVIAVRDREGPTLTVREAVMPRKGIPAAQLVGTATYHPTKSYSFAAHFVQVEVDTETGFITVKQVVPVHDVGKVI
HPVAAAGQIEGGIQQGIGHTLYEDYQIDMRTGRSLNANFVDYKMPLAMDMPEIHTIILEAAPDPGGPFGAKGVGEDPIVA
IGPAISNAVFDAIGVRFRHYPIRPEQVLQALAKKAAA

Sequences:

>Translated_757_residues
MTHAVIGHSVKRTDLLDKVTGNAKYVADMPFAGLLFGKIKRCEVAHAKIRRIDTSRALALPGVKAVLTHENVPRVLHAGS
PHPRSASVTCDQYILDDKVRYWGEGVAAVAATSEDIAAHAIELIEVEYETLPAVFTTEDAERSDAPRIHDREPGGNLVLP
PVIVKRGDVEAGFAEADFILEGIYEGGRPTPAYMEPNVCTCNWDGNGNLTVWISTQTAFMVRGIMAEVLGLPLHKVRVLV
DHMGGGFGAKQDLFQHEFLCALMARETRRPVRMEYTREETFLGGRTRHPARIWLKQGFRNDGTITARQAKVVFNSGAYGS
HGPGVTNVGTAAMVSLYRCDNVLLEGRCVYTNSPIAGAFRGYGVVQTYYALDVQMDEAAEHLGMDPADLKLKNAVREGDI
APSNHPLIGHGLEACISKGMEATRWAALRQRPRDTEGPIRTGWGIGCEMHGSSAYPGIKEQGNAIIKMNEDGTVVLLTGA
AGLGTGAHTALAQIVAEELTLPFESVSVVHGDTDVVPWDIGAFASHTTYMVGKAAQMAAGEIKRQLFDRAAKLLECTPDA
LMLTAGVIAVRDREGPTLTVREAVMPRKGIPAAQLVGTATYHPTKSYSFAAHFVQVEVDTETGFITVKQVVPVHDVGKVI
HPVAAAGQIEGGIQQGIGHTLYEDYQIDMRTGRSLNANFVDYKMPLAMDMPEIHTIILEAAPDPGGPFGAKGVGEDPIVA
IGPAISNAVFDAIGVRFRHYPIRPEQVLQALAKKAAA
>Mature_756_residues
THAVIGHSVKRTDLLDKVTGNAKYVADMPFAGLLFGKIKRCEVAHAKIRRIDTSRALALPGVKAVLTHENVPRVLHAGSP
HPRSASVTCDQYILDDKVRYWGEGVAAVAATSEDIAAHAIELIEVEYETLPAVFTTEDAERSDAPRIHDREPGGNLVLPP
VIVKRGDVEAGFAEADFILEGIYEGGRPTPAYMEPNVCTCNWDGNGNLTVWISTQTAFMVRGIMAEVLGLPLHKVRVLVD
HMGGGFGAKQDLFQHEFLCALMARETRRPVRMEYTREETFLGGRTRHPARIWLKQGFRNDGTITARQAKVVFNSGAYGSH
GPGVTNVGTAAMVSLYRCDNVLLEGRCVYTNSPIAGAFRGYGVVQTYYALDVQMDEAAEHLGMDPADLKLKNAVREGDIA
PSNHPLIGHGLEACISKGMEATRWAALRQRPRDTEGPIRTGWGIGCEMHGSSAYPGIKEQGNAIIKMNEDGTVVLLTGAA
GLGTGAHTALAQIVAEELTLPFESVSVVHGDTDVVPWDIGAFASHTTYMVGKAAQMAAGEIKRQLFDRAAKLLECTPDAL
MLTAGVIAVRDREGPTLTVREAVMPRKGIPAAQLVGTATYHPTKSYSFAAHFVQVEVDTETGFITVKQVVPVHDVGKVIH
PVAAAGQIEGGIQQGIGHTLYEDYQIDMRTGRSLNANFVDYKMPLAMDMPEIHTIILEAAPDPGGPFGAKGVGEDPIVAI
GPAISNAVFDAIGVRFRHYPIRPEQVLQALAKKAAA

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=764, Percent_Identity=26.9633507853403, Blast_Score=221, Evalue=3e-57,
Organism=Homo sapiens, GI71773480, Length=780, Percent_Identity=27.0512820512821, Blast_Score=204, Evalue=3e-52,
Organism=Escherichia coli, GI1789230, Length=754, Percent_Identity=34.8806366047745, Blast_Score=424, Evalue=1e-120,
Organism=Escherichia coli, GI1789246, Length=796, Percent_Identity=33.1658291457286, Blast_Score=380, Evalue=1e-106,
Organism=Escherichia coli, GI1786478, Length=759, Percent_Identity=28.1949934123847, Blast_Score=206, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17540638, Length=761, Percent_Identity=24.7043363994744, Blast_Score=177, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17539860, Length=734, Percent_Identity=25.7493188010899, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI32566215, Length=579, Percent_Identity=24.6977547495682, Blast_Score=135, Evalue=8e-32,
Organism=Drosophila melanogaster, GI17737937, Length=745, Percent_Identity=28.993288590604, Blast_Score=203, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24647193, Length=763, Percent_Identity=24.6395806028834, Blast_Score=142, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24647195, Length=744, Percent_Identity=23.3870967741935, Blast_Score=129, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24647197, Length=734, Percent_Identity=23.5694822888283, Blast_Score=126, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24647199, Length=758, Percent_Identity=22.6912928759894, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24647201, Length=755, Percent_Identity=24.1059602649007, Blast_Score=115, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 81645; Mature: 81514

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHAVIGHSVKRTDLLDKVTGNAKYVADMPFAGLLFGKIKRCEVAHAKIRRIDTSRALAL
CCCCCCCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEC
PGVKAVLTHENVPRVLHAGSPHPRSASVTCDQYILDDKVRYWGEGVAAVAATSEDIAAHA
CCCEEEEECCCCCHHEECCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHH
IELIEVEYETLPAVFTTEDAERSDAPRIHDREPGGNLVLPPVIVKRGDVEAGFAEADFIL
HHHEEEEHHHCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCEEECCCCCCCCHHHHHHH
EGIYEGGRPTPAYMEPNVCTCNWDGNGNLTVWISTQTAFMVRGIMAEVLGLPLHKVRVLV
HHHHCCCCCCCCEECCCEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHCCCHHHHHHHH
DHMGGGFGAKQDLFQHEFLCALMARETRRPVRMEYTREETFLGGRTRHPARIWLKQGFRN
HHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHCCCCCCCCCHHHHHHHCCCC
DGTITARQAKVVFNSGAYGSHGPGVTNVGTAAMVSLYRCDNVLLEGRCVYTNSPIAGAFR
CCEEEEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCEEECCEEEEECCCCCHHHH
GYGVVQTYYALDVQMDEAAEHLGMDPADLKLKNAVREGDIAPSNHPLIGHGLEACISKGM
CCCCEEEEEEEEEEHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCC
EATRWAALRQRPRDTEGPIRTGWGIGCEMHGSSAYPGIKEQGNAIIKMNEDGTVVLLTGA
HHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHCCCEEEEECCCCEEEEEECC
AGLGTGAHTALAQIVAEELTLPFESVSVVHGDTDVVPWDIGAFASHTTYMVGKAAQMAAG
CCCCCCHHHHHHHHHHHHHCCCHHHEEEEECCCCCCCCCCHHHHCCCEEECCCHHHHHHH
EIKRQLFDRAAKLLECTPDALMLTAGVIAVRDREGPTLTVREAVMPRKGIPAAQLVGTAT
HHHHHHHHHHHHHHHCCCCHHHHHCCEEEEECCCCCEEEEHHHHCCCCCCCHHHHHCCCC
YHPTKSYSFAAHFVQVEVDTETGFITVKQVVPVHDVGKVIHPVAAAGQIEGGIQQGIGHT
CCCCCCCEEEEEEEEEEEECCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCHHHHCCCCH
LYEDYQIDMRTGRSLNANFVDYKMPLAMDMPEIHTIILEAAPDPGGPFGAKGVGEDPIVA
HHCCEEEEECCCCCCCCCEEEEECCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEE
IGPAISNAVFDAIGVRFRHYPIRPEQVLQALAKKAAA
ECCHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
THAVIGHSVKRTDLLDKVTGNAKYVADMPFAGLLFGKIKRCEVAHAKIRRIDTSRALAL
CCCCCCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEC
PGVKAVLTHENVPRVLHAGSPHPRSASVTCDQYILDDKVRYWGEGVAAVAATSEDIAAHA
CCCEEEEECCCCCHHEECCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHH
IELIEVEYETLPAVFTTEDAERSDAPRIHDREPGGNLVLPPVIVKRGDVEAGFAEADFIL
HHHEEEEHHHCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCEEECCCCCCCCHHHHHHH
EGIYEGGRPTPAYMEPNVCTCNWDGNGNLTVWISTQTAFMVRGIMAEVLGLPLHKVRVLV
HHHHCCCCCCCCEECCCEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHCCCHHHHHHHH
DHMGGGFGAKQDLFQHEFLCALMARETRRPVRMEYTREETFLGGRTRHPARIWLKQGFRN
HHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHCCCCCCCCCHHHHHHHCCCC
DGTITARQAKVVFNSGAYGSHGPGVTNVGTAAMVSLYRCDNVLLEGRCVYTNSPIAGAFR
CCEEEEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCEEECCEEEEECCCCCHHHH
GYGVVQTYYALDVQMDEAAEHLGMDPADLKLKNAVREGDIAPSNHPLIGHGLEACISKGM
CCCCEEEEEEEEEEHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCC
EATRWAALRQRPRDTEGPIRTGWGIGCEMHGSSAYPGIKEQGNAIIKMNEDGTVVLLTGA
HHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHCCCEEEEECCCCEEEEEECC
AGLGTGAHTALAQIVAEELTLPFESVSVVHGDTDVVPWDIGAFASHTTYMVGKAAQMAAG
CCCCCCHHHHHHHHHHHHHCCCHHHEEEEECCCCCCCCCCHHHHCCCEEECCCHHHHHHH
EIKRQLFDRAAKLLECTPDALMLTAGVIAVRDREGPTLTVREAVMPRKGIPAAQLVGTAT
HHHHHHHHHHHHHHHCCCCHHHHHCCEEEEECCCCCEEEEHHHHCCCCCCCHHHHHCCCC
YHPTKSYSFAAHFVQVEVDTETGFITVKQVVPVHDVGKVIHPVAAAGQIEGGIQQGIGHT
CCCCCCCEEEEEEEEEEEECCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCHHHHCCCCH
LYEDYQIDMRTGRSLNANFVDYKMPLAMDMPEIHTIILEAAPDPGGPFGAKGVGEDPIVA
HHCCEEEEECCCCCCCCCEEEEECCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEE
IGPAISNAVFDAIGVRFRHYPIRPEQVLQALAKKAAA
ECCHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]