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The map label for this gene is ffh [H]

Identifier: 73542631

GI number: 73542631

Start: 3232862

End: 3234250

Strand: Direct

Name: ffh [H]

Synonym: Reut_A2947

Alternate gene names: 73542631

Gene position: 3232862-3234250 (Clockwise)

Preceding gene: 73542622

Following gene: 73542632

Centisome position: 84.93

GC content: 65.73

Gene sequence:

>1389_bases
ATGCTGGACAATCTCACTCAACGCCTGGCGCGGGTCGTCAAGACCATGCGCGGCGAGGCCCGCCTGACCGAGGCCAATAC
CGCCGAAATGCTGCGCGAAGTGCGCCTGGCCATGCTCGAGGCCGACGTGGCGCTCCCAGTCGTCCGCGACTTCATTGCCC
GCGTCAAGGAAAAGGCGATGGGCGAGGACGTCGTCTCGAGCCTGACCCCGGGCCAGGCCCTGGTCGGCGTGGTGCAGCGC
GAGCTGACCACGGTGATCGGCGGCGAGGAAGCCATCTCCGGCAAGGGTGCGGAGCTGAACCTGGCCGTGCAGCCCCCCGC
CATCATCCTGATGGCAGGCCTGCAGGGCGCCGGCAAGACCACCACCGTCGGCAAGCTGGCCAAGTGGCTTAAAGAGAACA
AGAAGAAGAAAGTGCTGACGGTCTCGTGCGACGTGTACCGTCCGGCAGCTATCGCCCAGCTGAAGACGGTGTCCGAACAG
GTCGGCGCCGAATTCTTCCCGTCCCAGCCCGACCAGAAGCCGGTCGACATCGCCCGCGCGGCGGTGGACTGGGCGCGCAA
GCATTACCACGACGTGCTGATCGTCGATACGGCGGGCCGTCTCGGTATCGACGAGGCGATGATGCAGGAAATCGCCGCGC
TGCACGCCGAGCTGAAGCCGGCCGAAACGCTGTTCGTGGTCGACGCCATGCTCGGCCAGGACGCGGTCAACACGGCCAAG
GCCTTCAACGACACCCTGCCGCTGACGGGCGTGGTGCTGACCAAGCTGGACGGCGATGCGCGCGGCGGTGCCGCGCTGTC
GGTGCGCCATGTCACTGGCCGGCCGATCAAGTTCGTCGGCGTCGGCGAAAAGCTCGACGGCCTGGAGCCGTTCTACCCCG
ACCGCATGGCCCAGCGTATTCTGGGCATGGGCGACATCCTCGCACTGGTCGAGGAAGCCCAGCGCGGCGTGGACATGGAC
GCCGCCGAGAAGCTGGCCAAGAAGATCAAGAAGACTGGCGGCTTCGACCTGGAAGACTTCAAGGCCCAGATCGGCCAGAT
GAAGAAGATGGGCGGCCTCGGCAGCCTGGTCGACAAGCTGCCCGCGCAGTTCGCGCAGCAGGCCCAGGGCGCCAATATGG
ATCAGGCGGAAAAGCAGGTGCGCCGCATGGAAGGCATCATCAACAGCATGACTGCCGCCGAGCGCGCCAAGCCCGAGCTG
ATCAAGGCCAGCCGCAAGCGCCGCATTGCCGCGGGCGCGGGCGTGCCGGTGCAGGAAGTGAACCGCCTGCTGAACCAGTT
CGACCAGATGCAAGGCATGATGAAGAAGCTCAAGGGCGGCGGCATGATGAAGATGATGCGCCAGATGGGTGCAATGAAGG
GCGGCATGAAGGGCCTTTTCAACCGCTGA

Upstream 100 bases:

>100_bases
TGACCATTTGCGCAGTTTACCTTAGTGCCTCCTGCCAGTGGCGGGCGGCTAACGCGGTAACAAAGGCCGCAACACAGCCC
TTTCTTCCCCCATTCCTGCC

Downstream 100 bases:

>100_bases
TCGGCGCCGCGCTCCCTACCTGCCCTACCCCGCAAGAGACAAGAACAGGAAAGACATCATGATGACCGCTGAACAGGCCC
GCGAACTGTGGGCCAACTCC

Product: signal recognition particle subunit FFH/SRP54 (srp54)

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MLDNLTQRLARVVKTMRGEARLTEANTAEMLREVRLAMLEADVALPVVRDFIARVKEKAMGEDVVSSLTPGQALVGVVQR
ELTTVIGGEEAISGKGAELNLAVQPPAIILMAGLQGAGKTTTVGKLAKWLKENKKKKVLTVSCDVYRPAAIAQLKTVSEQ
VGAEFFPSQPDQKPVDIARAAVDWARKHYHDVLIVDTAGRLGIDEAMMQEIAALHAELKPAETLFVVDAMLGQDAVNTAK
AFNDTLPLTGVVLTKLDGDARGGAALSVRHVTGRPIKFVGVGEKLDGLEPFYPDRMAQRILGMGDILALVEEAQRGVDMD
AAEKLAKKIKKTGGFDLEDFKAQIGQMKKMGGLGSLVDKLPAQFAQQAQGANMDQAEKQVRRMEGIINSMTAAERAKPEL
IKASRKRRIAAGAGVPVQEVNRLLNQFDQMQGMMKKLKGGGMMKMMRQMGAMKGGMKGLFNR

Sequences:

>Translated_462_residues
MLDNLTQRLARVVKTMRGEARLTEANTAEMLREVRLAMLEADVALPVVRDFIARVKEKAMGEDVVSSLTPGQALVGVVQR
ELTTVIGGEEAISGKGAELNLAVQPPAIILMAGLQGAGKTTTVGKLAKWLKENKKKKVLTVSCDVYRPAAIAQLKTVSEQ
VGAEFFPSQPDQKPVDIARAAVDWARKHYHDVLIVDTAGRLGIDEAMMQEIAALHAELKPAETLFVVDAMLGQDAVNTAK
AFNDTLPLTGVVLTKLDGDARGGAALSVRHVTGRPIKFVGVGEKLDGLEPFYPDRMAQRILGMGDILALVEEAQRGVDMD
AAEKLAKKIKKTGGFDLEDFKAQIGQMKKMGGLGSLVDKLPAQFAQQAQGANMDQAEKQVRRMEGIINSMTAAERAKPEL
IKASRKRRIAAGAGVPVQEVNRLLNQFDQMQGMMKKLKGGGMMKMMRQMGAMKGGMKGLFNR
>Mature_462_residues
MLDNLTQRLARVVKTMRGEARLTEANTAEMLREVRLAMLEADVALPVVRDFIARVKEKAMGEDVVSSLTPGQALVGVVQR
ELTTVIGGEEAISGKGAELNLAVQPPAIILMAGLQGAGKTTTVGKLAKWLKENKKKKVLTVSCDVYRPAAIAQLKTVSEQ
VGAEFFPSQPDQKPVDIARAAVDWARKHYHDVLIVDTAGRLGIDEAMMQEIAALHAELKPAETLFVVDAMLGQDAVNTAK
AFNDTLPLTGVVLTKLDGDARGGAALSVRHVTGRPIKFVGVGEKLDGLEPFYPDRMAQRILGMGDILALVEEAQRGVDMD
AAEKLAKKIKKTGGFDLEDFKAQIGQMKKMGGLGSLVDKLPAQFAQQAQGANMDQAEKQVRRMEGIINSMTAAERAKPEL
IKASRKRRIAAGAGVPVQEVNRLLNQFDQMQGMMKKLKGGGMMKMMRQMGAMKGGMKGLFNR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=466, Percent_Identity=30.0429184549356, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI226371618, Length=358, Percent_Identity=32.122905027933, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI89061728, Length=163, Percent_Identity=36.1963190184049, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI23308697, Length=204, Percent_Identity=33.3333333333333, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI295424842, Length=204, Percent_Identity=33.3333333333333, Blast_Score=108, Evalue=1e-23,
Organism=Escherichia coli, GI1788963, Length=431, Percent_Identity=64.0371229698376, Blast_Score=547, Evalue=1e-157,
Organism=Escherichia coli, GI1789874, Length=271, Percent_Identity=33.5793357933579, Blast_Score=138, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17539958, Length=467, Percent_Identity=28.9079229122056, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI193206261, Length=201, Percent_Identity=35.8208955223881, Blast_Score=104, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6325345, Length=419, Percent_Identity=31.7422434367542, Blast_Score=193, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6320498, Length=316, Percent_Identity=25.9493670886076, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI17647949, Length=472, Percent_Identity=29.6610169491525, Blast_Score=195, Evalue=7e-50,
Organism=Drosophila melanogaster, GI24641198, Length=202, Percent_Identity=33.6633663366337, Blast_Score=110, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49981; Mature: 49981

Theoretical pI: Translated: 10.22; Mature: 10.22

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDNLTQRLARVVKTMRGEARLTEANTAEMLREVRLAMLEADVALPVVRDFIARVKEKAM
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEDVVSSLTPGQALVGVVQRELTTVIGGEEAISGKGAELNLAVQPPAIILMAGLQGAGKT
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHCCCCCCEEEEEECCCCEEEEECCCCCCCC
TTVGKLAKWLKENKKKKVLTVSCDVYRPAAIAQLKTVSEQVGAEFFPSQPDQKPVDIARA
HHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
AVDWARKHYHDVLIVDTAGRLGIDEAMMQEIAALHAELKPAETLFVVDAMLGQDAVNTAK
HHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHH
AFNDTLPLTGVVLTKLDGDARGGAALSVRHVTGRPIKFVGVGEKLDGLEPFYPDRMAQRI
HHCCCCCCHHEEEEECCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHH
LGMGDILALVEEAQRGVDMDAAEKLAKKIKKTGGFDLEDFKAQIGQMKKMGGLGSLVDKL
HCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHH
PAQFAQQAQGANMDQAEKQVRRMEGIINSMTAAERAKPELIKASRKRRIAAGAGVPVQEV
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHH
NRLLNQFDQMQGMMKKLKGGGMMKMMRQMGAMKGGMKGLFNR
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHCCC
>Mature Secondary Structure
MLDNLTQRLARVVKTMRGEARLTEANTAEMLREVRLAMLEADVALPVVRDFIARVKEKAM
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEDVVSSLTPGQALVGVVQRELTTVIGGEEAISGKGAELNLAVQPPAIILMAGLQGAGKT
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHCCCCCCEEEEEECCCCEEEEECCCCCCCC
TTVGKLAKWLKENKKKKVLTVSCDVYRPAAIAQLKTVSEQVGAEFFPSQPDQKPVDIARA
HHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
AVDWARKHYHDVLIVDTAGRLGIDEAMMQEIAALHAELKPAETLFVVDAMLGQDAVNTAK
HHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHH
AFNDTLPLTGVVLTKLDGDARGGAALSVRHVTGRPIKFVGVGEKLDGLEPFYPDRMAQRI
HHCCCCCCHHEEEEECCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHH
LGMGDILALVEEAQRGVDMDAAEKLAKKIKKTGGFDLEDFKAQIGQMKKMGGLGSLVDKL
HCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHH
PAQFAQQAQGANMDQAEKQVRRMEGIINSMTAAERAKPELIKASRKRRIAAGAGVPVQEV
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHH
NRLLNQFDQMQGMMKKLKGGGMMKMMRQMGAMKGGMKGLFNR
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]