Click here to switch to the map view.

The map label for this gene is nhaK [H]

Identifier: 73542590

GI number: 73542590

Start: 3181524

End: 3182819

Strand: Direct

Name: nhaK [H]

Synonym: Reut_A2906

Alternate gene names: 73542590

Gene position: 3181524-3182819 (Clockwise)

Preceding gene: 73542589

Following gene: 73542597

Centisome position: 83.58

GC content: 67.9

Gene sequence:

>1296_bases
ATGGAACCCTCTGTCGAACTCACACTGCGCATCGGCTGTCTGCTGGCCGTGATCGCCGCCTGCAATGTTGCCGCAATCAA
GCTGCGGTTGCCCGATGCGCTCACGCTCACCGCTGCCGGTCTCGCGCTTGGCACGGGCTTGCTGATCACCAGCACCGTGG
CCCCGACATTTACTGCGCAGACCATCCAGCCCTTTCTGTCTCCGTCGCTGCGGCCCGAAGGCTATCTCTGGATCTTTCTG
CCTCCGATTCTCTTCCAGGCCGCGCTGGAGGCCGATGCCGGCGCGATGGCACGGGACCTGCTCCCCATCCTGGTTCTGGC
GATCGGCGCGGTGTTCGCTGCGACACTGCTGGTGGGCGTCACGGCGCATGCGATTTCCGGCGCGAACCTGGCGGTTTGCC
TGCTGGTCGGAGCCATTGTCAGCACCACGGATCCGTCGGCCGTGATCGACCTGTTCCGCAGTAGTGGCGTGCCTGCGCGC
ATGGTGCGGCTGGTGGAGGGCGAGAGCCTGCTGAATGATGCAGCGGCGATTACGCTCGCGTCGCACCTGATGGCGCGCAT
CGTTGGCCAGCCGGCGCACGCCATGACAGGCTCGGTCCTGGGCGACCTGTTTGGCTCGCTGTTTGCCGGCGGGCTACTCG
GCGCGCTCGCGGGTGCGTTGCTGGCGCGCGCGTGCCGGGCCATTCCCGCTGCGCCGCTGTCGCGCTTCACGCTATCTCTG
GCGCTGCCGAATCTGCTCTATCCGATTGCCGACCTGTGGCTGCATGTGTCGGGCGTGGTGACGGTGGTGTCGGCCGGGCT
GACCGCCGGCACGTTGTTGCGGCGCTCCAGCACACCCGAGGAACACGCGATATTCCGGCACTTGTGGCGCAGCATGGGGG
GCATGGCAGGCGGCATGGTCTTTCTGCTCGCGGCGATGCACGTGCCTGACTTGCTGCGCGGGCTGCGTGGATCCGACCTG
TGGCTGATCCTCGGTGTGCTGGTCGCGGCCCTGTTCAGCCGCTGGGCCGTGCTTGGCTCCAGCCTGCCGCTGCTGAGCCG
CCTCGGCATGTGCGCGCCGCTGCCGCGCGCGCACCGACTGGCCATCACGTGGGGCGGCGTGCGCGGCCCCGTGACACTCG
TCCTGGCCCTATGCGCCGCGCAGGCAACAAGTTTGCCGCCGGAGGCAAGGCATCTGGCCTCCGTGGTGGCCGTCGGCTTT
GTCCTGGTCAACCTGACGTGCAACGGGCTGACGCTGCGGCCGCTGGTGCGCCGGCTGGGAATTGGCGGCGACGTCAATGC
AGGGAATCATGCCTGA

Upstream 100 bases:

>100_bases
AAGCCCGCATTACGGAATAACCCATTTCCAGATTCGACAAGAACATAGCGGACAGGCCGCTTGTCAGACAGCGTACGCCA
CCTGACGCTTGCGTCCCCGC

Downstream 100 bases:

>100_bases
CGCCTGAGCGCGCACGACCGCCGTTCAGCGTCCCTGCCACTTCGGTGGCCGGCGATTCACGAACGCATCGACGCCCTCAT
GGAAGTCATTGCTGCCGTAG

Product: Sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MEPSVELTLRIGCLLAVIAACNVAAIKLRLPDALTLTAAGLALGTGLLITSTVAPTFTAQTIQPFLSPSLRPEGYLWIFL
PPILFQAALEADAGAMARDLLPILVLAIGAVFAATLLVGVTAHAISGANLAVCLLVGAIVSTTDPSAVIDLFRSSGVPAR
MVRLVEGESLLNDAAAITLASHLMARIVGQPAHAMTGSVLGDLFGSLFAGGLLGALAGALLARACRAIPAAPLSRFTLSL
ALPNLLYPIADLWLHVSGVVTVVSAGLTAGTLLRRSSTPEEHAIFRHLWRSMGGMAGGMVFLLAAMHVPDLLRGLRGSDL
WLILGVLVAALFSRWAVLGSSLPLLSRLGMCAPLPRAHRLAITWGGVRGPVTLVLALCAAQATSLPPEARHLASVVAVGF
VLVNLTCNGLTLRPLVRRLGIGGDVNAGNHA

Sequences:

>Translated_431_residues
MEPSVELTLRIGCLLAVIAACNVAAIKLRLPDALTLTAAGLALGTGLLITSTVAPTFTAQTIQPFLSPSLRPEGYLWIFL
PPILFQAALEADAGAMARDLLPILVLAIGAVFAATLLVGVTAHAISGANLAVCLLVGAIVSTTDPSAVIDLFRSSGVPAR
MVRLVEGESLLNDAAAITLASHLMARIVGQPAHAMTGSVLGDLFGSLFAGGLLGALAGALLARACRAIPAAPLSRFTLSL
ALPNLLYPIADLWLHVSGVVTVVSAGLTAGTLLRRSSTPEEHAIFRHLWRSMGGMAGGMVFLLAAMHVPDLLRGLRGSDL
WLILGVLVAALFSRWAVLGSSLPLLSRLGMCAPLPRAHRLAITWGGVRGPVTLVLALCAAQATSLPPEARHLASVVAVGF
VLVNLTCNGLTLRPLVRRLGIGGDVNAGNHA
>Mature_431_residues
MEPSVELTLRIGCLLAVIAACNVAAIKLRLPDALTLTAAGLALGTGLLITSTVAPTFTAQTIQPFLSPSLRPEGYLWIFL
PPILFQAALEADAGAMARDLLPILVLAIGAVFAATLLVGVTAHAISGANLAVCLLVGAIVSTTDPSAVIDLFRSSGVPAR
MVRLVEGESLLNDAAAITLASHLMARIVGQPAHAMTGSVLGDLFGSLFAGGLLGALAGALLARACRAIPAAPLSRFTLSL
ALPNLLYPIADLWLHVSGVVTVVSAGLTAGTLLRRSSTPEEHAIFRHLWRSMGGMAGGMVFLLAAMHVPDLLRGLRGSDL
WLILGVLVAALFSRWAVLGSSLPLLSRLGMCAPLPRAHRLAITWGGVRGPVTLVLALCAAQATSLPPEARHLASVVAVGF
VLVNLTCNGLTLRPLVRRLGIGGDVNAGNHA

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Homo sapiens, GI5454070, Length=367, Percent_Identity=27.2479564032698, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI294997330, Length=333, Percent_Identity=27.3273273273273, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI110227626, Length=333, Percent_Identity=27.3273273273273, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI27734935, Length=382, Percent_Identity=23.5602094240838, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI15529998, Length=420, Percent_Identity=22.3809523809524, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI41872703, Length=370, Percent_Identity=24.3243243243243, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI14211919, Length=334, Percent_Identity=24.5508982035928, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI27777632, Length=374, Percent_Identity=24.8663101604278, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71993582, Length=325, Percent_Identity=24.3076923076923, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71993590, Length=325, Percent_Identity=24.3076923076923, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71992107, Length=320, Percent_Identity=24.375, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71992101, Length=320, Percent_Identity=24.375, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71999819, Length=408, Percent_Identity=22.0588235294118, Blast_Score=65, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6320663, Length=331, Percent_Identity=21.7522658610272, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221510740, Length=376, Percent_Identity=24.468085106383, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI221510734, Length=375, Percent_Identity=24.2666666666667, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI221510738, Length=375, Percent_Identity=24.2666666666667, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221510732, Length=381, Percent_Identity=23.6220472440945, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221510736, Length=381, Percent_Identity=23.6220472440945, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24585580, Length=381, Percent_Identity=23.6220472440945, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24585578, Length=381, Percent_Identity=23.6220472440945, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 44457; Mature: 44457

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPSVELTLRIGCLLAVIAACNVAAIKLRLPDALTLTAAGLALGTGLLITSTVAPTFTAQ
CCCCHHHHHHHHHHHHHHHHCCHHEEEEECCCHHHHHHHHHHHHCCHHHHHHCCCCHHHH
TIQPFLSPSLRPEGYLWIFLPPILFQAALEADAGAMARDLLPILVLAIGAVFAATLLVGV
HHHHHHCCCCCCCCEEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAHAISGANLAVCLLVGAIVSTTDPSAVIDLFRSSGVPARMVRLVEGESLLNDAAAITLA
HHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHHHHHH
SHLMARIVGQPAHAMTGSVLGDLFGSLFAGGLLGALAGALLARACRAIPAAPLSRFTLSL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
ALPNLLYPIADLWLHVSGVVTVVSAGLTAGTLLRRSSTPEEHAIFRHLWRSMGGMAGGMV
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHH
FLLAAMHVPDLLRGLRGSDLWLILGVLVAALFSRWAVLGSSLPLLSRLGMCAPLPRAHRL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCEE
AITWGGVRGPVTLVLALCAAQATSLPPEARHLASVVAVGFVLVNLTCNGLTLRPLVRRLG
EEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHC
IGGDVNAGNHA
CCCCCCCCCCC
>Mature Secondary Structure
MEPSVELTLRIGCLLAVIAACNVAAIKLRLPDALTLTAAGLALGTGLLITSTVAPTFTAQ
CCCCHHHHHHHHHHHHHHHHCCHHEEEEECCCHHHHHHHHHHHHCCHHHHHHCCCCHHHH
TIQPFLSPSLRPEGYLWIFLPPILFQAALEADAGAMARDLLPILVLAIGAVFAATLLVGV
HHHHHHCCCCCCCCEEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAHAISGANLAVCLLVGAIVSTTDPSAVIDLFRSSGVPARMVRLVEGESLLNDAAAITLA
HHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHHHHHH
SHLMARIVGQPAHAMTGSVLGDLFGSLFAGGLLGALAGALLARACRAIPAAPLSRFTLSL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
ALPNLLYPIADLWLHVSGVVTVVSAGLTAGTLLRRSSTPEEHAIFRHLWRSMGGMAGGMV
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHH
FLLAAMHVPDLLRGLRGSDLWLILGVLVAALFSRWAVLGSSLPLLSRLGMCAPLPRAHRL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCEE
AITWGGVRGPVTLVLALCAAQATSLPPEARHLASVVAVGFVLVNLTCNGLTLRPLVRRLG
EEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHC
IGGDVNAGNHA
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA