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The map label for this gene is argF

Identifier: 73542448

GI number: 73542448

Start: 3031289

End: 3032212

Strand: Reverse

Name: argF

Synonym: Reut_A2763

Alternate gene names: 73542448

Gene position: 3032212-3031289 (Counterclockwise)

Preceding gene: 73542450

Following gene: 73542447

Centisome position: 79.66

GC content: 62.99

Gene sequence:

>924_bases
ATGAGCTCAACCCCGATCAAGCATTACCTCCAGTTCAGCGACTTGACTCCCGACGAGTACGAGTACCTGCTGGACCGCGC
ACGGATCCTCAAGGCCAAGTTCAAGAACTACGAGACATGGCATCCGCTGCACGACCGCACGCTGGCCATGATCTTCGAGA
AGAACTCGACGCGTACGCGCCTGTCGTTCGAAGCCGGCATCCACCAGCTCGGCGGCCATGCGGTGTTCCTCAACACGCGC
GACTCGCAGCTTGGCCGTGGCGAACCGATCGAAGATGCGGCGCAGGTGATTTCGCGCATGGTCGATATCATCATGATCCG
CACGTTCGGGCAGGACATCATCGAACGCTTCGCCGCGCATTCGCGCGTGCCGGTGATCAACGGCCTGACCAACGAATATC
ACCCGTGCCAGGTGCTGGCCGACGTGTTCACCTATATCGAGCAGCGCGGCAGCATCCGCGGCAAAACGGTGGCGTGGATC
GGCGATGCCAACAACATGGCCTATACCTGGATTCAGGCAGCCGAACGGCTGGGCTTCACGTTCCATTTCTCGGCGCCGCC
GGGGTACCAGCTCGATCCGGCCCTGGTGCCGGCATCGGCGGCAGGCCAGCTGAAGGTGTTTGAAGATCCGCTCGCTGCTT
GCAAGGGCGCGAGCCTGGTGACCACCGATGTGTGGACCAGCATGGGCTTCGAAGCCGAGAACGAGGCGCGCAAGCGCGCG
TTCCAGAACTGGATGGTGACCACGGCGATGATGGACCGTGCCGAGCCGGACGCTCTGTTCATGCACTGCCTGCCCGCCCA
CCGCGGCGAGGAAGTCGAGGCCGCCGTGATCGACGGCCCCAAGAGCGTGGTCTGGGACGAGGCGGAAAACCGCCTGCACG
TGCAGAAGGCGCTGATGGAATATCTGCTCTGCGGCCGCTACTGA

Upstream 100 bases:

>100_bases
CCAAGTAAATTGCGTATGCGACGCGAAAGGCGGCTCCGCGACGCGCTTCTGTCATGCACTTGATGACGGCGTGTCCCCTC
CGGGCCGCCTTCTTTGTTTT

Downstream 100 bases:

>100_bases
CACTGAGGCGCGCGCCGGCAGGCACAACGGGAGGGGCCGCCATGGCCCCTCTTTTTACGTGACCGCATCCACAAAACTGC
AATCAAGGAGATGGAAGTGA

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MSSTPIKHYLQFSDLTPDEYEYLLDRARILKAKFKNYETWHPLHDRTLAMIFEKNSTRTRLSFEAGIHQLGGHAVFLNTR
DSQLGRGEPIEDAAQVISRMVDIIMIRTFGQDIIERFAAHSRVPVINGLTNEYHPCQVLADVFTYIEQRGSIRGKTVAWI
GDANNMAYTWIQAAERLGFTFHFSAPPGYQLDPALVPASAAGQLKVFEDPLAACKGASLVTTDVWTSMGFEAENEARKRA
FQNWMVTTAMMDRAEPDALFMHCLPAHRGEEVEAAVIDGPKSVVWDEAENRLHVQKALMEYLLCGRY

Sequences:

>Translated_307_residues
MSSTPIKHYLQFSDLTPDEYEYLLDRARILKAKFKNYETWHPLHDRTLAMIFEKNSTRTRLSFEAGIHQLGGHAVFLNTR
DSQLGRGEPIEDAAQVISRMVDIIMIRTFGQDIIERFAAHSRVPVINGLTNEYHPCQVLADVFTYIEQRGSIRGKTVAWI
GDANNMAYTWIQAAERLGFTFHFSAPPGYQLDPALVPASAAGQLKVFEDPLAACKGASLVTTDVWTSMGFEAENEARKRA
FQNWMVTTAMMDRAEPDALFMHCLPAHRGEEVEAAVIDGPKSVVWDEAENRLHVQKALMEYLLCGRY
>Mature_306_residues
SSTPIKHYLQFSDLTPDEYEYLLDRARILKAKFKNYETWHPLHDRTLAMIFEKNSTRTRLSFEAGIHQLGGHAVFLNTRD
SQLGRGEPIEDAAQVISRMVDIIMIRTFGQDIIERFAAHSRVPVINGLTNEYHPCQVLADVFTYIEQRGSIRGKTVAWIG
DANNMAYTWIQAAERLGFTFHFSAPPGYQLDPALVPASAAGQLKVFEDPLAACKGASLVTTDVWTSMGFEAENEARKRAF
QNWMVTTAMMDRAEPDALFMHCLPAHRGEEVEAAVIDGPKSVVWDEAENRLHVQKALMEYLLCGRY

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family

Homologues:

Organism=Homo sapiens, GI38788445, Length=302, Percent_Identity=38.7417218543046, Blast_Score=217, Evalue=9e-57,
Organism=Homo sapiens, GI18105007, Length=310, Percent_Identity=27.0967741935484, Blast_Score=115, Evalue=7e-26,
Organism=Escherichia coli, GI1786469, Length=331, Percent_Identity=38.0664652567976, Blast_Score=200, Evalue=9e-53,
Organism=Escherichia coli, GI1790703, Length=331, Percent_Identity=38.0664652567976, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI2367364, Length=199, Percent_Identity=35.678391959799, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI48994908, Length=314, Percent_Identity=26.4331210191083, Blast_Score=74, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI193204318, Length=294, Percent_Identity=27.5510204081633, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322373, Length=328, Percent_Identity=33.2317073170732, Blast_Score=189, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6322331, Length=304, Percent_Identity=24.3421052631579, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24642586, Length=309, Percent_Identity=26.2135922330097, Blast_Score=104, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OTC_CUPPJ (Q46XK9)

Other databases:

- EMBL:   CP000090
- RefSeq:   YP_296968.1
- HSSP:   P96108
- ProteinModelPortal:   Q46XK9
- SMR:   Q46XK9
- GeneID:   3612333
- GenomeReviews:   CP000090_GR
- KEGG:   reu:Reut_A2763
- NMPDR:   fig|264198.3.peg.2195
- HOGENOM:   HBG579429
- OMA:   CVVTDTW
- ProtClustDB:   PRK00779
- BioCyc:   REUT264198:REUT_A2763-MONOMER
- HAMAP:   MF_01109
- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292
- PRINTS:   PR00100
- PRINTS:   PR00102
- TIGRFAMs:   TIGR00658

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N; SSF53671 Asp/Orn_carbamoyltranf

EC number: =2.1.3.3

Molecular weight: Translated: 34728; Mature: 34597

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: BINDING 107-107 BINDING 134-134

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTPIKHYLQFSDLTPDEYEYLLDRARILKAKFKNYETWHPLHDRTLAMIFEKNSTRTR
CCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCEE
LSFEAGIHQLGGHAVFLNTRDSQLGRGEPIEDAAQVISRMVDIIMIRTFGQDIIERFAAH
EEHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SRVPVINGLTNEYHPCQVLADVFTYIEQRGSIRGKTVAWIGDANNMAYTWIQAAERLGFT
CCCCEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHCCEE
FHFSAPPGYQLDPALVPASAAGQLKVFEDPLAACKGASLVTTDVWTSMGFEAENEARKRA
EEECCCCCCCCCCCCCCCCCCCCEEEHHCHHHHHCCCCEEEHHHHHHCCCCCHHHHHHHH
FQNWMVTTAMMDRAEPDALFMHCLPAHRGEEVEAAVIDGPKSVVWDEAENRLHVQKALME
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEEECCCCHHCCCCHHHHHHHHHHHHH
YLLCGRY
HHHHCCC
>Mature Secondary Structure 
SSTPIKHYLQFSDLTPDEYEYLLDRARILKAKFKNYETWHPLHDRTLAMIFEKNSTRTR
CCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCEE
LSFEAGIHQLGGHAVFLNTRDSQLGRGEPIEDAAQVISRMVDIIMIRTFGQDIIERFAAH
EEHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SRVPVINGLTNEYHPCQVLADVFTYIEQRGSIRGKTVAWIGDANNMAYTWIQAAERLGFT
CCCCEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHCCEE
FHFSAPPGYQLDPALVPASAAGQLKVFEDPLAACKGASLVTTDVWTSMGFEAENEARKRA
EEECCCCCCCCCCCCCCCCCCCCEEEHHCHHHHHCCCCEEEHHHHHHCCCCCHHHHHHHH
FQNWMVTTAMMDRAEPDALFMHCLPAHRGEEVEAAVIDGPKSVVWDEAENRLHVQKALME
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEEECCCCHHCCCCHHHHHHHHHHHHH
YLLCGRY
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA