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The map label for this gene is hldD

Identifier: 73542248

GI number: 73542248

Start: 2808054

End: 2809049

Strand: Reverse

Name: hldD

Synonym: Reut_A2563

Alternate gene names: 73542248

Gene position: 2809049-2808054 (Counterclockwise)

Preceding gene: 73542249

Following gene: 73542247

Centisome position: 73.8

GC content: 61.85

Gene sequence:

>996_bases
ATGACCATCATCGTCACCGGCGCTGCAGGATTCATCGGCAGCAACCTCGTCAAGGGATTGAACGCGCGCGGCGAGAACCA
CATCGTCGCGGTCGACAATCTGCACCGCGCGGACAAGTTCCACAATCTGGTGGACTGTGAAATCCGCGACTACCTCGATA
AGGACGATTTCCTGTCCCGGTTCGAGCGGGGCGAGTTCGGCCGGGTACGCGCTGTTTTCCATCTTGGGGCCTGCACCGAC
ACGATGGAGCAGGACGGGCGCTACCTGATGGAGAACAACTATCGCTACAGCAAGACGCTGATGGAGCTCTGCCTTGCGCA
GGACACCCAGTTCATCTATGCCTCGTCTGCGGCGGTCTACGGCGAGTCGCACTCGTTTCGCGAAGCGCGCGAGTACGAGC
GGCCGCTGAGCGTCTACGGCTACTCCAAGTTCCTGTTCGACCAGGCCGTGCGCAACAGGCTCGATGGCGCGCTGTCTCAA
GTGGTCGGGCTGCGCTATTTCAACGTGTATGGCCCGGGTGAGGCGCACAAGGCCCGCATGGCCTCGATCGTGTGCCAGCA
GTTCGAGCAATTCCGTGCCGAAGGCACCGTCAAGCTGTTCGGCGAGCACGGCGGCCATGGGCCGGGCTGCCAGAGCCACG
ATTTCGTTTCCATCGACGATGTGGTCAAGGTGAACCTGTTCTTTCTCGATCATCCGCGCCGATCGGGCATCTTCAACGTC
GGTTCCGGCCATGCGCGCTCATTCAACGATGTCGCCTGTGTTGTCGTCAACACCCTGCGCGCGGCGGAGGACAAGCCGCC
GTTGGCCCTTGAGGAGCTCGTGCAGGAAGGGCTGCTGGAATACTTGCGATTCCCCGATGCACTGCGCGGGCGCTACCAGA
GCTTCACCCAATCGGACAGTTCGCGCCTTCGCGAAGCTGGCTACACCGCTCCTTTCGTTGCGATGGAGGAAGGCGTGGCA
CGCTATTGCCAGTGGCTGCTCGAACGCGGCCAGTGA

Upstream 100 bases:

>100_bases
CTGGGTACTGCCGTCGTCAGCTACCCGGAACTGTTCGGCGCTGCCGGCTGATCGCCTGTGTCTTCCGGCGCGCCCTGTTG
AACTCTCTGTCGGACCGATC

Downstream 100 bases:

>100_bases
GCGCGCCCGGCGGCGCTTCGATGCTCGGAAACATCTCCGTGCAATCCACGTGAACGTTTGTTGCCGCATGCGCTGGCGCA
TGCGGCGGGTCCTATCCTGA

Product: ADP-glyceromanno-heptose 6-epimerase precursor

Products: NA

Alternate protein names: ADP-L-glycero-beta-D-manno-heptose-6-epimerase; ADP-glyceromanno-heptose 6-epimerase; ADP-hep 6-epimerase; AGME

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MTIIVTGAAGFIGSNLVKGLNARGENHIVAVDNLHRADKFHNLVDCEIRDYLDKDDFLSRFERGEFGRVRAVFHLGACTD
TMEQDGRYLMENNYRYSKTLMELCLAQDTQFIYASSAAVYGESHSFREAREYERPLSVYGYSKFLFDQAVRNRLDGALSQ
VVGLRYFNVYGPGEAHKARMASIVCQQFEQFRAEGTVKLFGEHGGHGPGCQSHDFVSIDDVVKVNLFFLDHPRRSGIFNV
GSGHARSFNDVACVVVNTLRAAEDKPPLALEELVQEGLLEYLRFPDALRGRYQSFTQSDSSRLREAGYTAPFVAMEEGVA
RYCQWLLERGQ

Sequences:

>Translated_331_residues
MTIIVTGAAGFIGSNLVKGLNARGENHIVAVDNLHRADKFHNLVDCEIRDYLDKDDFLSRFERGEFGRVRAVFHLGACTD
TMEQDGRYLMENNYRYSKTLMELCLAQDTQFIYASSAAVYGESHSFREAREYERPLSVYGYSKFLFDQAVRNRLDGALSQ
VVGLRYFNVYGPGEAHKARMASIVCQQFEQFRAEGTVKLFGEHGGHGPGCQSHDFVSIDDVVKVNLFFLDHPRRSGIFNV
GSGHARSFNDVACVVVNTLRAAEDKPPLALEELVQEGLLEYLRFPDALRGRYQSFTQSDSSRLREAGYTAPFVAMEEGVA
RYCQWLLERGQ
>Mature_330_residues
TIIVTGAAGFIGSNLVKGLNARGENHIVAVDNLHRADKFHNLVDCEIRDYLDKDDFLSRFERGEFGRVRAVFHLGACTDT
MEQDGRYLMENNYRYSKTLMELCLAQDTQFIYASSAAVYGESHSFREAREYERPLSVYGYSKFLFDQAVRNRLDGALSQV
VGLRYFNVYGPGEAHKARMASIVCQQFEQFRAEGTVKLFGEHGGHGPGCQSHDFVSIDDVVKVNLFFLDHPRRSGIFNVG
SGHARSFNDVACVVVNTLRAAEDKPPLALEELVQEGLLEYLRFPDALRGRYQSFTQSDSSRLREAGYTAPFVAMEEGVAR
YCQWLLERGQ

Specific function: Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. HldD subfamily

Homologues:

Organism=Escherichia coli, GI1790049, Length=326, Percent_Identity=51.5337423312883, Blast_Score=308, Evalue=3e-85,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): HLDD_CUPPJ (Q46Y59)

Other databases:

- EMBL:   CP000090
- RefSeq:   YP_296768.1
- ProteinModelPortal:   Q46Y59
- SMR:   Q46Y59
- GeneID:   3609045
- GenomeReviews:   CP000090_GR
- KEGG:   reu:Reut_A2563
- NMPDR:   fig|264198.3.peg.3307
- HOGENOM:   HBG755066
- OMA:   GFIGSAM
- BioCyc:   REUT264198:REUT_A2563-MONOMER
- HAMAP:   MF_01601
- InterPro:   IPR001509
- InterPro:   IPR011912
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR10366:SF29
- TIGRFAMs:   TIGR02197

Pfam domain/function: PF01370 Epimerase

EC number: =5.1.3.20

Molecular weight: Translated: 37376; Mature: 37245

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: ACT_SITE 139-139 ACT_SITE 177-177 BINDING 39-39 BINDING 54-54 BINDING 92-92 BINDING 143-143 BINDING 168-168 BINDING 169-169 BINDING 177-177 BINDING 179-179 BINDING 186-186 BINDING 213-213 BINDING 292-292

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIIVTGAAGFIGSNLVKGLNARGENHIVAVDNLHRADKFHNLVDCEIRDYLDKDDFLSR
CEEEEECCHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHCCHHCCHHHHHCCHHHHHHH
FERGEFGRVRAVFHLGACTDTMEQDGRYLMENNYRYSKTLMELCLAQDTQFIYASSAAVY
HHCCCCCCEEEEEEECCHHHHHHHCCCEEHHCCCHHHHHHHHHHHHCCCCEEEECCEEEE
GESHSFREAREYERPLSVYGYSKFLFDQAVRNRLDGALSQVVGLRYFNVYGPGEAHKARM
CCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHH
ASIVCQQFEQFRAEGTVKLFGEHGGHGPGCQSHDFVSIDDVVKVNLFFLDHPRRSGIFNV
HHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCEEC
GSGHARSFNDVACVVVNTLRAAEDKPPLALEELVQEGLLEYLRFPDALRGRYQSFTQSDS
CCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
SRLREAGYTAPFVAMEEGVARYCQWLLERGQ
HHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TIIVTGAAGFIGSNLVKGLNARGENHIVAVDNLHRADKFHNLVDCEIRDYLDKDDFLSR
EEEEECCHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHCCHHCCHHHHHCCHHHHHHH
FERGEFGRVRAVFHLGACTDTMEQDGRYLMENNYRYSKTLMELCLAQDTQFIYASSAAVY
HHCCCCCCEEEEEEECCHHHHHHHCCCEEHHCCCHHHHHHHHHHHHCCCCEEEECCEEEE
GESHSFREAREYERPLSVYGYSKFLFDQAVRNRLDGALSQVVGLRYFNVYGPGEAHKARM
CCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHH
ASIVCQQFEQFRAEGTVKLFGEHGGHGPGCQSHDFVSIDDVVKVNLFFLDHPRRSGIFNV
HHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCEEC
GSGHARSFNDVACVVVNTLRAAEDKPPLALEELVQEGLLEYLRFPDALRGRYQSFTQSDS
CCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
SRLREAGYTAPFVAMEEGVARYCQWLLERGQ
HHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA