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The map label for this gene is fbp

Identifier: 73542130

GI number: 73542130

Start: 2682231

End: 2683250

Strand: Direct

Name: fbp

Synonym: Reut_A2444

Alternate gene names: 73542130

Gene position: 2682231-2683250 (Clockwise)

Preceding gene: 73542129

Following gene: 73542131

Centisome position: 70.46

GC content: 63.53

Gene sequence:

>1020_bases
ATGACTCGCATCAGCCTGACCCGCTATCTGGTCGAGGAGCAGCGCAAGCACAACACGATCCAGCCCGAACTGCGGCTGCT
GATCGAAGTGGTGGCGCGCGCCTGCAAGGCCATTTCCAACTCTGTCAACAAGGGCGCACTGGCCGGCGTGCTCGGCTCGG
CCGGCACCGGCAATGTGCAGGGCGAAACCCAGCAGAAGCTGGACGTGATCGCCAACGAAGTGCTGCTCGACGCCAACGAA
TGGGGCGGCCACCTCGCCGCCATGGCTTCGGAAGAAATGGAATCGTTCTACGAGATTCCCAACCGCTATCCGAAGGGCGA
ATACCTGCTGATGTTCGACCCGCTCGATGGTTCGTCCAACATCGACGTCAATGTCTCGATCGGCACGATCTTCTCCGTGC
TGCACATGCCCAAGCCCGGCCAGACCGTGACCGAGGCTGACTTCCTGCAGCCTGGCACGCACCAGGTCGCCGCCGGCTAC
GCCGTGTACGGCCCGCAGACCACGCTGGTACTGACCGTCGGCAACGGCGTGCACGTCTTCACGCTGGACCGCGAGGCGGG
CAGCTTCGTGCTGACCCAGTCCGATGTGCAGATTCCCGAAGACACCAAGGAATTCGCCATCAACATGTCCAACATGCGCC
ACTGGGCCCCCCCCGTGCGCAAGTACATCGACGAATGCCTGGCAGGCGACGAAGGCCCGCGCGGCAAGAACTTCAACATG
CGCTGGATCGCCTCGATGGTCGCCGACGTGCACCGCATCCTCACGCGCGGCGGCATCTTCATGTACCCGTGGGACAAGCG
CGAGCCAGAAAAGGCCGGCAAGCTGCGCCTGATGTATGAGGCCAACCCGATGGCGATGCTGATCGAACAGGCCGGCGGCG
CGGCCACCAACGGGCACATCCGCATTCTGGACGTGCAACCGGAAAAGCTGCACCAGCGCGTGTCGGTGATCCTGGGGTCG
AAGAATGAGGTGGAGCGGGTTACGCGCTATCACCATGAGGCGGCTGGCCAGCAGGGCTGA

Upstream 100 bases:

>100_bases
TCGGCAAGGCGCTGGCCGCCTGACGCCAGGGCAGCCGGCGCCCGCGCGGCGCCGGCCCTCGCGGCACATGTAGAATTGCG
GCCATCCAAGGAGAACCATC

Downstream 100 bases:

>100_bases
GGCCCACAGGCCGTTCCGGTCCGCAAGGACGATCGGCCTGGCAAAAAAATGATTGCAGCGCCGTAATAGCGCTGCTATGA
TTGCGGGCTGTTCCAGTTCA

Product: fructose-1,6-bisphosphatase

Products: NA

Alternate protein names: FBPase class 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MTRISLTRYLVEEQRKHNTIQPELRLLIEVVARACKAISNSVNKGALAGVLGSAGTGNVQGETQQKLDVIANEVLLDANE
WGGHLAAMASEEMESFYEIPNRYPKGEYLLMFDPLDGSSNIDVNVSIGTIFSVLHMPKPGQTVTEADFLQPGTHQVAAGY
AVYGPQTTLVLTVGNGVHVFTLDREAGSFVLTQSDVQIPEDTKEFAINMSNMRHWAPPVRKYIDECLAGDEGPRGKNFNM
RWIASMVADVHRILTRGGIFMYPWDKREPEKAGKLRLMYEANPMAMLIEQAGGAATNGHIRILDVQPEKLHQRVSVILGS
KNEVERVTRYHHEAAGQQG

Sequences:

>Translated_339_residues
MTRISLTRYLVEEQRKHNTIQPELRLLIEVVARACKAISNSVNKGALAGVLGSAGTGNVQGETQQKLDVIANEVLLDANE
WGGHLAAMASEEMESFYEIPNRYPKGEYLLMFDPLDGSSNIDVNVSIGTIFSVLHMPKPGQTVTEADFLQPGTHQVAAGY
AVYGPQTTLVLTVGNGVHVFTLDREAGSFVLTQSDVQIPEDTKEFAINMSNMRHWAPPVRKYIDECLAGDEGPRGKNFNM
RWIASMVADVHRILTRGGIFMYPWDKREPEKAGKLRLMYEANPMAMLIEQAGGAATNGHIRILDVQPEKLHQRVSVILGS
KNEVERVTRYHHEAAGQQG
>Mature_338_residues
TRISLTRYLVEEQRKHNTIQPELRLLIEVVARACKAISNSVNKGALAGVLGSAGTGNVQGETQQKLDVIANEVLLDANEW
GGHLAAMASEEMESFYEIPNRYPKGEYLLMFDPLDGSSNIDVNVSIGTIFSVLHMPKPGQTVTEADFLQPGTHQVAAGYA
VYGPQTTLVLTVGNGVHVFTLDREAGSFVLTQSDVQIPEDTKEFAINMSNMRHWAPPVRKYIDECLAGDEGPRGKNFNMR
WIASMVADVHRILTRGGIFMYPWDKREPEKAGKLRLMYEANPMAMLIEQAGGAATNGHIRILDVQPEKLHQRVSVILGSK
NEVERVTRYHHEAAGQQG

Specific function: INVOLVED IN SEVERAL METABOLIC PATHWAYS. IN E.COLI AND YEAST IT IS NECESSARY FOR GROWTH ON SUBSTANCES SUCH AS GLYCEROL, SUCCINATE AND ACETATE. [C]

COG id: COG0158

COG function: function code G; Fructose-1,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FBPase class 1 family

Homologues:

Organism=Homo sapiens, GI189083692, Length=335, Percent_Identity=42.089552238806, Blast_Score=238, Evalue=8e-63,
Organism=Homo sapiens, GI16579888, Length=335, Percent_Identity=42.089552238806, Blast_Score=238, Evalue=8e-63,
Organism=Homo sapiens, GI22907028, Length=334, Percent_Identity=41.3173652694611, Blast_Score=233, Evalue=2e-61,
Organism=Escherichia coli, GI1790679, Length=330, Percent_Identity=46.3636363636364, Blast_Score=280, Evalue=9e-77,
Organism=Caenorhabditis elegans, GI17508131, Length=327, Percent_Identity=44.0366972477064, Blast_Score=266, Evalue=2e-71,
Organism=Saccharomyces cerevisiae, GI6323409, Length=324, Percent_Identity=39.8148148148148, Blast_Score=248, Evalue=1e-66,
Organism=Drosophila melanogaster, GI45550998, Length=327, Percent_Identity=44.3425076452599, Blast_Score=259, Evalue=3e-69,
Organism=Drosophila melanogaster, GI19921562, Length=327, Percent_Identity=44.3425076452599, Blast_Score=258, Evalue=3e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): F16PA_CUPPJ (Q46YH7)

Other databases:

- EMBL:   CP000090
- RefSeq:   YP_296650.1
- HSSP:   P0A993
- ProteinModelPortal:   Q46YH7
- SMR:   Q46YH7
- GeneID:   3612274
- GenomeReviews:   CP000090_GR
- KEGG:   reu:Reut_A2444
- NMPDR:   fig|264198.3.peg.3167
- HOGENOM:   HBG731261
- OMA:   HWEAPVQ
- ProtClustDB:   PRK09293
- BioCyc:   REUT264198:REUT_A2444-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01855
- InterPro:   IPR000146
- PANTHER:   PTHR11556
- PRINTS:   PR00115

Pfam domain/function: PF00316 FBPase

EC number: =3.1.3.11

Molecular weight: Translated: 37494; Mature: 37363

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00124 FBPASE

Important sites: BINDING 208-208 BINDING 274-274

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRISLTRYLVEEQRKHNTIQPELRLLIEVVARACKAISNSVNKGALAGVLGSAGTGNVQ
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCC
GETQQKLDVIANEVLLDANEWGGHLAAMASEEMESFYEIPNRYPKGEYLLMFDPLDGSSN
CCHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCC
IDVNVSIGTIFSVLHMPKPGQTVTEADFLQPGTHQVAAGYAVYGPQTTLVLTVGNGVHVF
EEEEEEHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHCCEEEECCCEEEEEEECCCEEEE
TLDREAGSFVLTQSDVQIPEDTKEFAINMSNMRHWAPPVRKYIDECLAGDEGPRGKNFNM
EEECCCCCEEEEECCCCCCCCHHHHHEEHHHCHHCCCHHHHHHHHHHCCCCCCCCCCCCH
RWIASMVADVHRILTRGGIFMYPWDKREPEKAGKLRLMYEANPMAMLIEQAGGAATNGHI
HHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCE
RILDVQPEKLHQRVSVILGSKNEVERVTRYHHEAAGQQG
EEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TRISLTRYLVEEQRKHNTIQPELRLLIEVVARACKAISNSVNKGALAGVLGSAGTGNVQ
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCC
GETQQKLDVIANEVLLDANEWGGHLAAMASEEMESFYEIPNRYPKGEYLLMFDPLDGSSN
CCHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCC
IDVNVSIGTIFSVLHMPKPGQTVTEADFLQPGTHQVAAGYAVYGPQTTLVLTVGNGVHVF
EEEEEEHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHCCEEEECCCEEEEEEECCCEEEE
TLDREAGSFVLTQSDVQIPEDTKEFAINMSNMRHWAPPVRKYIDECLAGDEGPRGKNFNM
EEECCCCCEEEEECCCCCCCCHHHHHEEHHHCHHCCCHHHHHHHHHHCCCCCCCCCCCCH
RWIASMVADVHRILTRGGIFMYPWDKREPEKAGKLRLMYEANPMAMLIEQAGGAATNGHI
HHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCE
RILDVQPEKLHQRVSVILGSKNEVERVTRYHHEAAGQQG
EEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA