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The map label for this gene is cysM [C]

Identifier: 73542023

GI number: 73542023

Start: 2578166

End: 2579308

Strand: Reverse

Name: cysM [C]

Synonym: Reut_A2337

Alternate gene names: 73542023

Gene position: 2579308-2578166 (Counterclockwise)

Preceding gene: 73542024

Following gene: 73542022

Centisome position: 67.76

GC content: 65.79

Gene sequence:

>1143_bases
ATGCCGCATTCGGACTGGACCCACGAAGCGATCCACAGGATCGAGGCCGATTTCAACCGGTCTTCCGATACCCACCTGAT
TCCGCTGGACCTGCCGGGCTATCCGGATATCCGTTTCTACTTCAAGGACGAATCGAGCCACCCGACCGGCAGCCTCAAGC
ACCGGCTGGCGCGTTCGCTGTTCCTTTACGCGTTGTGCAACGGATGGCTGCACGCAGGCAGCACAGTGGTGGAGGCTTCC
AGCGGCTCGACCGCGATTTCGGAAGCGTATTTCGCGCGCCTGCTCGGACTGCCATTCGTGGCGGTGATCCCTGCCGGCAC
CTCGCGCGCGAAGGTGGAGGCGATCGAGTTCTACGGCGGGCGCTGCCACTTCGTCGCCAATCCGTCGGAGATCTACACCG
AGTCACACCGCATCGCGCGCGAATCGGGCGGGCACTTCATGGACCAGTTCACTTACGCCGAACGCGCGACGGACTGGCGG
GCCAACAACAATATTGCCGAGTCCATCTTCAAGCAGATGGCACAGGAGGCGCACCCCGTGCCCGCATGGATCGTGGCCAG
CGGGGGCACGGGCGGCACGGTAGCGACGCTCGGCCGCTACGTGGCGTACCGGCGGCATCAGACGCGCATCCTGTGCGCCG
ATCCGGAGAACTCGGTGTTCTTCGACCATTTCCAGGGTTGCCTGGAAGGCCAGCCGGACCTGGCGCTGACGCTTGATACG
GGCTCTCGCATCGAAGGCATTGGCCGCCCGCGCGTGGAGCGCTCCTTTATCCCGACGTGCGTCGACGCGATGCTCAAGGT
GCCCGACGCGCTCTCGTTTGCGGCCATGCGCTATCTGGCGCAACGCTTCGGGCGGCGCGTAGGCGGATCGACCGGTACCA
ACTTTGTCGGCGTGCTGTACCTCGCGCAACGCATGCGCGCGGCGGGGCAGGCCGGCGCGATCGTCACGCTGCTTTGCGAC
AGCGGCGAGCGGTACGCGACGACGTATTACGACGATGACTGGTACCAGGAGCAGCGCATTGCCGTGGATGTCGCGGATGC
GCTGATCGGGCGTGCGGTCAAGGGCGAGCCGGTGCTGACTCCGCACGCGGTGGCCGGGCTGGCAGAGGCCGGTTCCGGCA
TTCCCGGCAGCGCGGGACAATGA

Upstream 100 bases:

>100_bases
TGGAACGCCACGGCACTTCCTGTACGATGACGGCTCGCCCCACAGTTCCGGGCCGCCTGCCGCCCGGCCCGCCATCTGCA
GTTTTACCGGGGGAAGTGCC

Downstream 100 bases:

>100_bases
TCGCGCGCGTTTCTGTCACAATCGCGGCTTTCCTGCGCTGGCTGCGTCCAGCCCGCCCGAACAAGCAAGACATGACCCTA
CTGAAACGCAAATCGATCGA

Product: pyridoxal-5'-phosphate-dependent enzyme, beta subunit

Products: NA

Alternate protein names: O-acetylserine (Thiol)-lyase; O-acetylserine sulfhydrylase; CSase [H]

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MPHSDWTHEAIHRIEADFNRSSDTHLIPLDLPGYPDIRFYFKDESSHPTGSLKHRLARSLFLYALCNGWLHAGSTVVEAS
SGSTAISEAYFARLLGLPFVAVIPAGTSRAKVEAIEFYGGRCHFVANPSEIYTESHRIARESGGHFMDQFTYAERATDWR
ANNNIAESIFKQMAQEAHPVPAWIVASGGTGGTVATLGRYVAYRRHQTRILCADPENSVFFDHFQGCLEGQPDLALTLDT
GSRIEGIGRPRVERSFIPTCVDAMLKVPDALSFAAMRYLAQRFGRRVGGSTGTNFVGVLYLAQRMRAAGQAGAIVTLLCD
SGERYATTYYDDDWYQEQRIAVDVADALIGRAVKGEPVLTPHAVAGLAEAGSGIPGSAGQ

Sequences:

>Translated_380_residues
MPHSDWTHEAIHRIEADFNRSSDTHLIPLDLPGYPDIRFYFKDESSHPTGSLKHRLARSLFLYALCNGWLHAGSTVVEAS
SGSTAISEAYFARLLGLPFVAVIPAGTSRAKVEAIEFYGGRCHFVANPSEIYTESHRIARESGGHFMDQFTYAERATDWR
ANNNIAESIFKQMAQEAHPVPAWIVASGGTGGTVATLGRYVAYRRHQTRILCADPENSVFFDHFQGCLEGQPDLALTLDT
GSRIEGIGRPRVERSFIPTCVDAMLKVPDALSFAAMRYLAQRFGRRVGGSTGTNFVGVLYLAQRMRAAGQAGAIVTLLCD
SGERYATTYYDDDWYQEQRIAVDVADALIGRAVKGEPVLTPHAVAGLAEAGSGIPGSAGQ
>Mature_379_residues
PHSDWTHEAIHRIEADFNRSSDTHLIPLDLPGYPDIRFYFKDESSHPTGSLKHRLARSLFLYALCNGWLHAGSTVVEASS
GSTAISEAYFARLLGLPFVAVIPAGTSRAKVEAIEFYGGRCHFVANPSEIYTESHRIARESGGHFMDQFTYAERATDWRA
NNNIAESIFKQMAQEAHPVPAWIVASGGTGGTVATLGRYVAYRRHQTRILCADPENSVFFDHFQGCLEGQPDLALTLDTG
SRIEGIGRPRVERSFIPTCVDAMLKVPDALSFAAMRYLAQRFGRRVGGSTGTNFVGVLYLAQRMRAAGQAGAIVTLLCDS
GERYATTYYDDDWYQEQRIAVDVADALIGRAVKGEPVLTPHAVAGLAEAGSGIPGSAGQ

Specific function: As it is highly similar to bacterial and plant cysteine synthases, it is possible that it catalyzes a related reaction [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=300, Percent_Identity=27.3333333333333, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI295821200, Length=300, Percent_Identity=27.3333333333333, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI4557415, Length=300, Percent_Identity=27.3333333333333, Blast_Score=92, Evalue=7e-19,
Organism=Escherichia coli, GI2367138, Length=318, Percent_Identity=26.7295597484277, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71996324, Length=361, Percent_Identity=34.3490304709141, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17539640, Length=363, Percent_Identity=30.0275482093664, Blast_Score=157, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI17539800, Length=360, Percent_Identity=30, Blast_Score=157, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI17562970, Length=336, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI32566674, Length=306, Percent_Identity=28.1045751633987, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321594, Length=325, Percent_Identity=25.8461538461538, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6321449, Length=330, Percent_Identity=26.0606060606061, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24643623, Length=311, Percent_Identity=26.3665594855305, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI20129101, Length=311, Percent_Identity=26.3665594855305, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 41477; Mature: 41346

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHSDWTHEAIHRIEADFNRSSDTHLIPLDLPGYPDIRFYFKDESSHPTGSLKHRLARSL
CCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHH
FLYALCNGWLHAGSTVVEASSGSTAISEAYFARLLGLPFVAVIPAGTSRAKVEAIEFYGG
HHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEECCC
RCHFVANPSEIYTESHRIARESGGHFMDQFTYAERATDWRANNNIAESIFKQMAQEAHPV
EEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCC
PAWIVASGGTGGTVATLGRYVAYRRHQTRILCADPENSVFFDHFQGCLEGQPDLALTLDT
CEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCEEHHHHHHHHCCCCCEEEEECC
GSRIEGIGRPRVERSFIPTCVDAMLKVPDALSFAAMRYLAQRFGRRVGGSTGTNFVGVLY
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LAQRMRAAGQAGAIVTLLCDSGERYATTYYDDDWYQEQRIAVDVADALIGRAVKGEPVLT
HHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
PHAVAGLAEAGSGIPGSAGQ
HHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
PHSDWTHEAIHRIEADFNRSSDTHLIPLDLPGYPDIRFYFKDESSHPTGSLKHRLARSL
CCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHH
FLYALCNGWLHAGSTVVEASSGSTAISEAYFARLLGLPFVAVIPAGTSRAKVEAIEFYGG
HHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEECCC
RCHFVANPSEIYTESHRIARESGGHFMDQFTYAERATDWRANNNIAESIFKQMAQEAHPV
EEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCC
PAWIVASGGTGGTVATLGRYVAYRRHQTRILCADPENSVFFDHFQGCLEGQPDLALTLDT
CEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCEEHHHHHHHHCCCCCEEEEECC
GSRIEGIGRPRVERSFIPTCVDAMLKVPDALSFAAMRYLAQRFGRRVGGSTGTNFVGVLY
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LAQRMRAAGQAGAIVTLLCDSGERYATTYYDDDWYQEQRIAVDVADALIGRAVKGEPVLT
HHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
PHAVAGLAEAGSGIPGSAGQ
HHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]