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The map label for this gene is frlR [H]

Identifier: 73542012

GI number: 73542012

Start: 2564694

End: 2565557

Strand: Reverse

Name: frlR [H]

Synonym: Reut_A2326

Alternate gene names: 73542012

Gene position: 2565557-2564694 (Counterclockwise)

Preceding gene: 73542020

Following gene: 73542011

Centisome position: 67.4

GC content: 65.16

Gene sequence:

>864_bases
ATGTCCTCCCTGCCTACGTCCCTGACCGGCGCTGCCCTACCCGGAGCGCAGGATTCTGCCGCCGCCACCTCCGGCGCCGG
GGCGCAGCCGTCGTCTTCCTCATCGTCTTCCCAGCAGCCGCCTTCCACCGCTGTCCACGCCGTGCCGTCGCCGACTTTCA
GTCCGCTTTACCAGCAGATCAAGGCCCTGATCACGCGCAGCCTGCAATCGGGCGAGTGGAAACCGGGTGACATGATACCC
AGCGAAATGGAGCTGGCATCGCGCTACAAGGTCAGCCAGGGCACCGTGCGCAAGGCCATCGATGAACTGGCGGCCGAAAA
CCTGGTGGCGCGGCGGCAAGGCAAGGGTACCTTCGTCACCACCCACCACGAAGACGTGGTCAAGTTCCGCTTCCTGCGGC
TGGTGCCGGACGAAGGCGAACCGCATTATGGCGCCAGCCACGTGCTCGAATGCAAGCGGCTGCGCGCGCCCGCCGAGATC
GCTCGGCTGCTCGATATCCGCACCGGCGACAGCGTCGTGCAGATTCGCCGCGTGCTGACATTTTCGGGCGAGTCGACCGT
GCTGGACGAGATCTGGCTGCTCGGCGCCAACTTCAAGGGGCTCACGGCAGAGAAGCTGACTGAGTGGAAGGGCCCCATGT
ACGCATTGTTCGAGGCCGAATTCGGTACCCGCATGATTCGGGCCTCTGAGAAGATTCGCGCGGTGGCTGCCGACGAGACG
GCGGCCGCCCTGCTTTCCGTCCCGGTCGGGTCACCGCTGCTGTCAGTCGAGCGTGTGTCGTACACGTATGGCGACCGTCC
GGTCGAAGTGCGGCGCGGCCTGTATGTGACGACGCGCCACTATTACCAGAACGACCTGAGCTGA

Upstream 100 bases:

>100_bases
CCGGGGCTCCCCCTCATGTCAATTCATATGTCTTATATAAGACATAAGACGTTTAACGTCAGGCTGGACGGGCTTCGCCG
TTTTGTGGTGAAATCCGGCT

Downstream 100 bases:

>100_bases
ATGCCGCCGGGATTATTGCGGCAATTGTCATGATCGCGGTAGCTGTTGCGTGGCAGGGGTGGATTTGGCGCATCGCGACG
CGCCGTGTGCGATTGTCGCG

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MSSLPTSLTGAALPGAQDSAAATSGAGAQPSSSSSSSQQPPSTAVHAVPSPTFSPLYQQIKALITRSLQSGEWKPGDMIP
SEMELASRYKVSQGTVRKAIDELAAENLVARRQGKGTFVTTHHEDVVKFRFLRLVPDEGEPHYGASHVLECKRLRAPAEI
ARLLDIRTGDSVVQIRRVLTFSGESTVLDEIWLLGANFKGLTAEKLTEWKGPMYALFEAEFGTRMIRASEKIRAVAADET
AAALLSVPVGSPLLSVERVSYTYGDRPVEVRRGLYVTTRHYYQNDLS

Sequences:

>Translated_287_residues
MSSLPTSLTGAALPGAQDSAAATSGAGAQPSSSSSSSQQPPSTAVHAVPSPTFSPLYQQIKALITRSLQSGEWKPGDMIP
SEMELASRYKVSQGTVRKAIDELAAENLVARRQGKGTFVTTHHEDVVKFRFLRLVPDEGEPHYGASHVLECKRLRAPAEI
ARLLDIRTGDSVVQIRRVLTFSGESTVLDEIWLLGANFKGLTAEKLTEWKGPMYALFEAEFGTRMIRASEKIRAVAADET
AAALLSVPVGSPLLSVERVSYTYGDRPVEVRRGLYVTTRHYYQNDLS
>Mature_286_residues
SSLPTSLTGAALPGAQDSAAATSGAGAQPSSSSSSSQQPPSTAVHAVPSPTFSPLYQQIKALITRSLQSGEWKPGDMIPS
EMELASRYKVSQGTVRKAIDELAAENLVARRQGKGTFVTTHHEDVVKFRFLRLVPDEGEPHYGASHVLECKRLRAPAEIA
RLLDIRTGDSVVQIRRVLTFSGESTVLDEIWLLGANFKGLTAEKLTEWKGPMYALFEAEFGTRMIRASEKIRAVAADETA
AALLSVPVGSPLLSVERVSYTYGDRPVEVRRGLYVTTRHYYQNDLS

Specific function: May regulate the transcription of the frlABCD operon [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082252, Length=222, Percent_Identity=27.9279279279279, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790540, Length=232, Percent_Identity=27.5862068965517, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1790118, Length=210, Percent_Identity=28.0952380952381, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1786950, Length=232, Percent_Identity=27.5862068965517, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 31206; Mature: 31074

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLPTSLTGAALPGAQDSAAATSGAGAQPSSSSSSSQQPPSTAVHAVPSPTFSPLYQQI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHH
KALITRSLQSGEWKPGDMIPSEMELASRYKVSQGTVRKAIDELAAENLVARRQGKGTFVT
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEE
THHEDVVKFRFLRLVPDEGEPHYGASHVLECKRLRAPAEIARLLDIRTGDSVVQIRRVLT
ECHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHH
FSGESTVLDEIWLLGANFKGLTAEKLTEWKGPMYALFEAEFGTRMIRASEKIRAVAADET
CCCCCHHHHHHHHCCCCCCCCCHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHCCHH
AAALLSVPVGSPLLSVERVSYTYGDRPVEVRRGLYVTTRHYYQNDLS
HHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHCCEEEEEHHHHHCCCC
>Mature Secondary Structure 
SSLPTSLTGAALPGAQDSAAATSGAGAQPSSSSSSSQQPPSTAVHAVPSPTFSPLYQQI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHH
KALITRSLQSGEWKPGDMIPSEMELASRYKVSQGTVRKAIDELAAENLVARRQGKGTFVT
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEE
THHEDVVKFRFLRLVPDEGEPHYGASHVLECKRLRAPAEIARLLDIRTGDSVVQIRRVLT
ECHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHH
FSGESTVLDEIWLLGANFKGLTAEKLTEWKGPMYALFEAEFGTRMIRASEKIRAVAADET
CCCCCHHHHHHHHCCCCCCCCCHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHCCHH
AAALLSVPVGSPLLSVERVSYTYGDRPVEVRRGLYVTTRHYYQNDLS
HHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHCCEEEEEHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]