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The map label for this gene is moaA [H]

Identifier: 73541963

GI number: 73541963

Start: 2509381

End: 2510571

Strand: Direct

Name: moaA [H]

Synonym: Reut_A2276

Alternate gene names: 73541963

Gene position: 2509381-2510571 (Clockwise)

Preceding gene: 73541962

Following gene: 73541964

Centisome position: 65.92

GC content: 64.23

Gene sequence:

>1191_bases
ATGGCACCAGAATGCATCCGGTTCCCCCGAGCCTTGCTCGCCGGAGGCATCGCCCACCCACAGGCCATGACCGACACCGT
CATTCCGATCTTCGACCTGCGCGATCATCGCTACCGCTCGATGACGCCCAGCATCCCCGAAACGCTGGTCGAGCCTTCCG
GGCTGGTCGCCGATACCCGTGCGCGGCCGCTGCACGACCTGCGCATCTCGGTGACGGACCGCTGCAATTTCCGCTGTGTG
TATTGCATGCCGAAGGAAGTCTTCGACAAGGACTACACCTTCCTGCCGCATTCGGAGTTGCTGAGCTTCGAGGAAATCGA
ACGCACCGCGCGCCTGTTCGTGAGCCTTGGCGTCGAGAAGATCCGTCTGACCGGCGGCGAACCACTGTTGCGCAAGAACA
TTGAGAAGCTCGTCGAAATGCTCGCGCGCATCGACACCGTCTCGGGCAAGCCGCTGGACCTGACGCTGACGACCAACGCG
TCACTGCTCGCGCGCAAGGCGCAGTCGCTGCGCGATGCCGGCCTGCGCCGCGTGAGCGTGAGCCTCGACGCCATCGATGA
CGTCACCTTCCGCCGCATGAACGATGTGGACTTTGCCGTGGCCGATGTGCTGCACGGCATCGAGACCGCTCAGGCCGTTG
GGCTGGCGCCGATCAAGGTCAATATGGTGGTCAAACGCGGCACCAACGATGCCGAGATCGTGCCGATGGCGCGCCACTTC
CGCGGCAGCGGCATCATCGTGCGCTATATCGAGTTTATGGATGTCGGCGCCAGCAACCACTGGCAGATGGATGAAGTGCT
GCCGTCCGCCGAGGTGGTTCGCCGCATCGACGAAGTTTTTCCGCTGGAGGCCGTTCAGGCGAACTACGCCGGAGAAACCG
CCGAGCGCTGGCGCTACCGCGATGGCGGCGGGGAGATCGGCGTGATCTCCAGCGTGACGCACGCGTTCTGCGGCGACTGC
AGCCGCATCCGGCTGTCCACCGAAGGCCGCCTCTACCTGTGCCTGTTCGCGACCGAAGGCTATGACTTGCGCGCACTGCT
GCGCGGCGACTACAGCGACCTGCAGGTTGCGAATGCGATCGCGCAGGTCTGGCAGGGCCGCACCGACAATTACTCGGAGC
AGCGCAGCAACCCGGCGGTACGGCAGGCGCGCGCCGAGCGCAAGATCGAAATGTCATACATCGGTGGATGA

Upstream 100 bases:

>100_bases
CACCACATCCGCGTCAGTGGAGAATAAAAGGGGACGGCCGAGGCCGTCCCCTTTTTTCGTGCATGGGCAATCCCGATGCC
GGTGGCCCGCCTCGGCTAGA

Downstream 100 bases:

>100_bases
CCCGCCGACCTCCCTTCCTCCGATGATTGCACGCGACGACATTACCGGCCTGATCCTCGCAGGCGGCAGGGGCAGCCGCA
TGGGCGGCACGGACAAAGGC

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MAPECIRFPRALLAGGIAHPQAMTDTVIPIFDLRDHRYRSMTPSIPETLVEPSGLVADTRARPLHDLRISVTDRCNFRCV
YCMPKEVFDKDYTFLPHSELLSFEEIERTARLFVSLGVEKIRLTGGEPLLRKNIEKLVEMLARIDTVSGKPLDLTLTTNA
SLLARKAQSLRDAGLRRVSVSLDAIDDVTFRRMNDVDFAVADVLHGIETAQAVGLAPIKVNMVVKRGTNDAEIVPMARHF
RGSGIIVRYIEFMDVGASNHWQMDEVLPSAEVVRRIDEVFPLEAVQANYAGETAERWRYRDGGGEIGVISSVTHAFCGDC
SRIRLSTEGRLYLCLFATEGYDLRALLRGDYSDLQVANAIAQVWQGRTDNYSEQRSNPAVRQARAERKIEMSYIGG

Sequences:

>Translated_396_residues
MAPECIRFPRALLAGGIAHPQAMTDTVIPIFDLRDHRYRSMTPSIPETLVEPSGLVADTRARPLHDLRISVTDRCNFRCV
YCMPKEVFDKDYTFLPHSELLSFEEIERTARLFVSLGVEKIRLTGGEPLLRKNIEKLVEMLARIDTVSGKPLDLTLTTNA
SLLARKAQSLRDAGLRRVSVSLDAIDDVTFRRMNDVDFAVADVLHGIETAQAVGLAPIKVNMVVKRGTNDAEIVPMARHF
RGSGIIVRYIEFMDVGASNHWQMDEVLPSAEVVRRIDEVFPLEAVQANYAGETAERWRYRDGGGEIGVISSVTHAFCGDC
SRIRLSTEGRLYLCLFATEGYDLRALLRGDYSDLQVANAIAQVWQGRTDNYSEQRSNPAVRQARAERKIEMSYIGG
>Mature_395_residues
APECIRFPRALLAGGIAHPQAMTDTVIPIFDLRDHRYRSMTPSIPETLVEPSGLVADTRARPLHDLRISVTDRCNFRCVY
CMPKEVFDKDYTFLPHSELLSFEEIERTARLFVSLGVEKIRLTGGEPLLRKNIEKLVEMLARIDTVSGKPLDLTLTTNAS
LLARKAQSLRDAGLRRVSVSLDAIDDVTFRRMNDVDFAVADVLHGIETAQAVGLAPIKVNMVVKRGTNDAEIVPMARHFR
GSGIIVRYIEFMDVGASNHWQMDEVLPSAEVVRRIDEVFPLEAVQANYAGETAERWRYRDGGGEIGVISSVTHAFCGDCS
RIRLSTEGRLYLCLFATEGYDLRALLRGDYSDLQVANAIAQVWQGRTDNYSEQRSNPAVRQARAERKIEMSYIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=315, Percent_Identity=35.2380952380952, Blast_Score=178, Evalue=8e-45,
Organism=Homo sapiens, GI22027536, Length=315, Percent_Identity=35.2380952380952, Blast_Score=178, Evalue=8e-45,
Organism=Escherichia coli, GI1786999, Length=343, Percent_Identity=31.7784256559767, Blast_Score=165, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17561210, Length=305, Percent_Identity=31.8032786885246, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI32566329, Length=303, Percent_Identity=32.6732673267327, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI32566331, Length=303, Percent_Identity=32.6732673267327, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI28574488, Length=335, Percent_Identity=32.5373134328358, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI28574490, Length=336, Percent_Identity=32.4404761904762, Blast_Score=164, Evalue=7e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 44347; Mature: 44216

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPECIRFPRALLAGGIAHPQAMTDTVIPIFDLRDHRYRSMTPSIPETLVEPSGLVADTR
CCCHHHHHHHHHHHCCCCCCCHHHCCCEEEEECCCCHHCCCCCCCHHHHCCCCCCEECCC
ARPLHDLRISVTDRCNFRCVYCMPKEVFDKDYTFLPHSELLSFEEIERTARLFVSLGVEK
CCCCEEEEEEEECCCCEEEEEECCHHHCCCCCCCCCHHHHCCHHHHHHHHHHHHHHCCEE
IRLTGGEPLLRKNIEKLVEMLARIDTVSGKPLDLTLTTNASLLARKAQSLRDAGLRRVSV
EEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEE
SLDAIDDVTFRRMNDVDFAVADVLHGIETAQAVGLAPIKVNMVVKRGTNDAEIVPMARHF
EHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCEEEEHHHHC
RGSGIIVRYIEFMDVGASNHWQMDEVLPSAEVVRRIDEVFPLEAVQANYAGETAERWRYR
CCCCEEEEEEEHHCCCCCCCCCHHHHCCHHHHHHHHHHHCCHHHHHHCCCCCHHHHCEEE
DGGGEIGVISSVTHAFCGDCSRIRLSTEGRLYLCLFATEGYDLRALLRGDYSDLQVANAI
CCCCCEEHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHH
AQVWQGRTDNYSEQRSNPAVRQARAERKIEMSYIGG
HHHHCCCCCCCHHHCCCHHHHHHHHHCCEEEEECCC
>Mature Secondary Structure 
APECIRFPRALLAGGIAHPQAMTDTVIPIFDLRDHRYRSMTPSIPETLVEPSGLVADTR
CCHHHHHHHHHHHCCCCCCCHHHCCCEEEEECCCCHHCCCCCCCHHHHCCCCCCEECCC
ARPLHDLRISVTDRCNFRCVYCMPKEVFDKDYTFLPHSELLSFEEIERTARLFVSLGVEK
CCCCEEEEEEEECCCCEEEEEECCHHHCCCCCCCCCHHHHCCHHHHHHHHHHHHHHCCEE
IRLTGGEPLLRKNIEKLVEMLARIDTVSGKPLDLTLTTNASLLARKAQSLRDAGLRRVSV
EEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEE
SLDAIDDVTFRRMNDVDFAVADVLHGIETAQAVGLAPIKVNMVVKRGTNDAEIVPMARHF
EHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCEEEEHHHHC
RGSGIIVRYIEFMDVGASNHWQMDEVLPSAEVVRRIDEVFPLEAVQANYAGETAERWRYR
CCCCEEEEEEEHHCCCCCCCCCHHHHCCHHHHHHHHHHHCCHHHHHHCCCCCHHHHCEEE
DGGGEIGVISSVTHAFCGDCSRIRLSTEGRLYLCLFATEGYDLRALLRGDYSDLQVANAI
CCCCCEEHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHH
AQVWQGRTDNYSEQRSNPAVRQARAERKIEMSYIGG
HHHHCCCCCCCHHHCCCHHHHHHHHHCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]