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The map label for this gene is nhaA [H]

Identifier: 73541958

GI number: 73541958

Start: 2502041

End: 2503225

Strand: Reverse

Name: nhaA [H]

Synonym: Reut_A2271

Alternate gene names: 73541958

Gene position: 2503225-2502041 (Counterclockwise)

Preceding gene: 73541959

Following gene: 73541955

Centisome position: 65.76

GC content: 64.3

Gene sequence:

>1185_bases
ATGACAGAACAGCAGAAACCGCCGCTTGGCGAATCGGGTCAGCCGGATGAACACGGGGTGGCCAGCCCGGCGGCAGCGCC
GGAAGGCACGGGCAGCAACGGCGAATCGGAACGTCTGGAGACGGCTCACAAGGCCGACTATCCGCTCGAACGCGAACTGA
GAGCCGCCGACGATGCCGCGCGCCGCGAGGCGGGCGAGCGCAAGGCGCGCTTGGAGGGCAGCAAGGCCAGCACGCCGGTG
GGCGGCGGTGCGGGCTGGGAGCGCGATGTGCTTGAGAAGGTGCTGATGGCGACGCTGCGCGAACAGCGCGCCGCGCGGCG
CTGGCGCATTTTCTTCCGCTTTGCCGTGCTGGGCATCCTTTTGGTGGTCTTCTTCGCGGTGTTCGATTTCAAGGGCGACA
GCGGGATCGGATCTGGCCGCCATACCGCCATGGTTTCGCTGGACGGCGAAATCGCTGCCGGGACACCGGCCAGCGCGGAA
TCGATCAACGCATCGCTGCAGGCTGCGTTTGCCGACAGCAATGCGGCCGGCGTGATTCTCAAGATCAACTCGCCGGGCGG
CTCGCCTGTGCAGGCCGGCATCATCAACGATGAGATCCATCGGCTGCGTACGCTGTATCCGTCCAAGCCGTTCTACGTGG
TTGTGGAAGAAATCTGCGCGTCGGGCGGCTACTACGTGGCGGCGGCGGCTGACAAGATCTACGTCGACAAGGCCAGCATC
GTCGGCTCGATCGGTGTGCTGATGGATGGCTTCGGCTTTACGGGTCTGATGGACAAGCTCGGCGTCGAGCGCCGTCTGTA
TACGTCGGGTGCCAACAAGGGCATGCTCGATCCGTTCTCTCCGCAGGTGCCGCGGCAGAAGGCCTATGCCGAGACGATGC
TCAAGGAAATCCATCAGCAGTTCATCGATGTGGTGAAGGAAGGGCGGGGCGATCGCCTCAAGAGCGATCCTGAGTTGTTC
TCGGGGCTGTTCTGGTCGGGCGAGCGCAGTGTCGAACTGGGGTTGGCGGACGGGCTGGGCAGTGCTGACTACGTCGCACG
CGACCTGTTCAAGGCCGAGGACATCGTCGACTACACCGTCAAGGAGAACATCGCCGAACGCGTGGCCAAGCGTTTTGGCG
CGGCCGTGGGCACGGCGGCGATGAAAACGATGCTCTGGAGCACCGGGATGCAGGGCATGCGGTAA

Upstream 100 bases:

>100_bases
CGAAGCGCCATATCATCCGGCCGACACGGCGGATAACGCGTAACTTGGCCAGGGTGCTGTCGCACCAGCCATTCCAAGAG
CCTTTCCACGAGCCACTTGC

Downstream 100 bases:

>100_bases
CAGGCAATACAGCGGGGCTCCCCGATGTTTTCGGGAGCCTTCCTCTTTTCTGTTTGCCTTGTATTTCAGCCCGCAAGCAG
CGAAAAGATGGCGGGGCGCT

Product: peptidase S49

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MTEQQKPPLGESGQPDEHGVASPAAAPEGTGSNGESERLETAHKADYPLERELRAADDAARREAGERKARLEGSKASTPV
GGGAGWERDVLEKVLMATLREQRAARRWRIFFRFAVLGILLVVFFAVFDFKGDSGIGSGRHTAMVSLDGEIAAGTPASAE
SINASLQAAFADSNAAGVILKINSPGGSPVQAGIINDEIHRLRTLYPSKPFYVVVEEICASGGYYVAAAADKIYVDKASI
VGSIGVLMDGFGFTGLMDKLGVERRLYTSGANKGMLDPFSPQVPRQKAYAETMLKEIHQQFIDVVKEGRGDRLKSDPELF
SGLFWSGERSVELGLADGLGSADYVARDLFKAEDIVDYTVKENIAERVAKRFGAAVGTAAMKTMLWSTGMQGMR

Sequences:

>Translated_394_residues
MTEQQKPPLGESGQPDEHGVASPAAAPEGTGSNGESERLETAHKADYPLERELRAADDAARREAGERKARLEGSKASTPV
GGGAGWERDVLEKVLMATLREQRAARRWRIFFRFAVLGILLVVFFAVFDFKGDSGIGSGRHTAMVSLDGEIAAGTPASAE
SINASLQAAFADSNAAGVILKINSPGGSPVQAGIINDEIHRLRTLYPSKPFYVVVEEICASGGYYVAAAADKIYVDKASI
VGSIGVLMDGFGFTGLMDKLGVERRLYTSGANKGMLDPFSPQVPRQKAYAETMLKEIHQQFIDVVKEGRGDRLKSDPELF
SGLFWSGERSVELGLADGLGSADYVARDLFKAEDIVDYTVKENIAERVAKRFGAAVGTAAMKTMLWSTGMQGMR
>Mature_393_residues
TEQQKPPLGESGQPDEHGVASPAAAPEGTGSNGESERLETAHKADYPLERELRAADDAARREAGERKARLEGSKASTPVG
GGAGWERDVLEKVLMATLREQRAARRWRIFFRFAVLGILLVVFFAVFDFKGDSGIGSGRHTAMVSLDGEIAAGTPASAES
INASLQAAFADSNAAGVILKINSPGGSPVQAGIINDEIHRLRTLYPSKPFYVVVEEICASGGYYVAAAADKIYVDKASIV
GSIGVLMDGFGFTGLMDKLGVERRLYTSGANKGMLDPFSPQVPRQKAYAETMLKEIHQQFIDVVKEGRGDRLKSDPELFS
GLFWSGERSVELGLADGLGSADYVARDLFKAEDIVDYTVKENIAERVAKRFGAAVGTAAMKTMLWSTGMQGMR

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1787527, Length=267, Percent_Identity=29.9625468164794, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1788064, Length=200, Percent_Identity=26, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 42331; Mature: 42200

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQQKPPLGESGQPDEHGVASPAAAPEGTGSNGESERLETAHKADYPLERELRAADDAA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
RREAGERKARLEGSKASTPVGGGAGWERDVLEKVLMATLREQRAARRWRIFFRFAVLGIL
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVVFFAVFDFKGDSGIGSGRHTAMVSLDGEIAAGTPASAESINASLQAAFADSNAAGVIL
HHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHCHHHHEEECCCCCCEEEE
KINSPGGSPVQAGIINDEIHRLRTLYPSKPFYVVVEEICASGGYYVAAAADKIYVDKASI
EEECCCCCCEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEECCEEEEEHHHH
VGSIGVLMDGFGFTGLMDKLGVERRLYTSGANKGMLDPFSPQVPRQKAYAETMLKEIHQQ
HHHHHHHHCCCCHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
FIDVVKEGRGDRLKSDPELFSGLFWSGERSVELGLADGLGSADYVARDLFKAEDIVDYTV
HHHHHHCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
KENIAERVAKRFGAAVGTAAMKTMLWSTGMQGMR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TEQQKPPLGESGQPDEHGVASPAAAPEGTGSNGESERLETAHKADYPLERELRAADDAA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
RREAGERKARLEGSKASTPVGGGAGWERDVLEKVLMATLREQRAARRWRIFFRFAVLGIL
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVVFFAVFDFKGDSGIGSGRHTAMVSLDGEIAAGTPASAESINASLQAAFADSNAAGVIL
HHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHCHHHHEEECCCCCCEEEE
KINSPGGSPVQAGIINDEIHRLRTLYPSKPFYVVVEEICASGGYYVAAAADKIYVDKASI
EEECCCCCCEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEECCEEEEEHHHH
VGSIGVLMDGFGFTGLMDKLGVERRLYTSGANKGMLDPFSPQVPRQKAYAETMLKEIHQQ
HHHHHHHHCCCCHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
FIDVVKEGRGDRLKSDPELFSGLFWSGERSVELGLADGLGSADYVARDLFKAEDIVDYTV
HHHHHHCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
KENIAERVAKRFGAAVGTAAMKTMLWSTGMQGMR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA