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The map label for this gene is lepB [H]

Identifier: 73541941

GI number: 73541941

Start: 2485926

End: 2486825

Strand: Reverse

Name: lepB [H]

Synonym: Reut_A2254

Alternate gene names: 73541941

Gene position: 2486825-2485926 (Counterclockwise)

Preceding gene: 73541942

Following gene: 73541940

Centisome position: 65.33

GC content: 58.0

Gene sequence:

>900_bases
ATGAATTTTGCACTGATCCTTTTTGTGCTGGTGGTGATTACAGGTATCGCGTGGGTCGCGGACAAGCTCGTGTTCGAGCG
GCAACGGCGCGCTTCAGCGCGGCTTGCGCTGGCCGAGTTCGATTCGCGCCAGTCGGACCTGCAGGGCCGCTTCGGTTCCG
GCGAGGTTGATTCGACGCGCAAGCGTCTGGCCGAAGAAAAGCTGCGCCAGCCGTGGTGGCTTGAGTATTCGGCGAGCTTC
TTCCCGGTCATCCTGGCCGTGTTCGTACTGCGCTCGTTCGTGGTCGAGCCGTTCAAGATTCCGTCCGGCTCGATGATTCC
CACGCTGCTGATCGGCGATTTCATCCTGGTCAACAAGTACGACTACGGGATTCGCCTGCCGGTGGTGAACAAGAAGATCG
TCGACGTCGGCGAGCCGCAGCGCGGCGACGTCATGGTGTTCCGCTACCCGAAAGACCCCTCGCTCGATTACATCAAGCGC
GTGATCGGCGTGCCTGGCGATGTGGTGCAGTATTCGAACAAGCATTTGACAATCAACGGCAAGCCCGCTGACTACACGCC
ACTGCCTGATTATCTGGATGAGGAACGCCTGGCCTATTCCAAGCATTTCCGGGAGAAACTGCCCGGCGGCGTGGAGCACG
GCATCCTTAATGATGTGGATCGACCGGCATTTGTCGCCGGTGCCGATCCGGATTTCCCGTTCCGGGAAAACTGCACTTAC
AATCAGCAGGGTGTGACCTGCAAGGTGCCTGCAGGTCACTATTTCGTGATGGGTGACAATCGCGACAACAGCCTGGATTC
CCGTTACTGGGGATTCGTGCCGGACGAGAATATCGTCGGCAAGGCGTTCGTGATCTGGATGAACCTCGGCAATTTTGGAC
GCGTCGGTTCATTCAAATAA

Upstream 100 bases:

>100_bases
ACAAGTAAGCGGTTTCGCGAACAGGAACGGGGCTGCCGCGTCTGAGGCGCGGCGGTAGTAGAAGAGGCTGTAGCAAGACA
TCCAAGAACCAGAAGCCGTC

Downstream 100 bases:

>100_bases
CACCTGCGCGGCGCAGAACACTCAACTAGAACGAGGGAAGCGCAAATGGGTCAGATGGGTCAATTGGGTTGGGTCGGGAA
AGATAGCCGGCGGCGGGCAA

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MNFALILFVLVVITGIAWVADKLVFERQRRASARLALAEFDSRQSDLQGRFGSGEVDSTRKRLAEEKLRQPWWLEYSASF
FPVILAVFVLRSFVVEPFKIPSGSMIPTLLIGDFILVNKYDYGIRLPVVNKKIVDVGEPQRGDVMVFRYPKDPSLDYIKR
VIGVPGDVVQYSNKHLTINGKPADYTPLPDYLDEERLAYSKHFREKLPGGVEHGILNDVDRPAFVAGADPDFPFRENCTY
NQQGVTCKVPAGHYFVMGDNRDNSLDSRYWGFVPDENIVGKAFVIWMNLGNFGRVGSFK

Sequences:

>Translated_299_residues
MNFALILFVLVVITGIAWVADKLVFERQRRASARLALAEFDSRQSDLQGRFGSGEVDSTRKRLAEEKLRQPWWLEYSASF
FPVILAVFVLRSFVVEPFKIPSGSMIPTLLIGDFILVNKYDYGIRLPVVNKKIVDVGEPQRGDVMVFRYPKDPSLDYIKR
VIGVPGDVVQYSNKHLTINGKPADYTPLPDYLDEERLAYSKHFREKLPGGVEHGILNDVDRPAFVAGADPDFPFRENCTY
NQQGVTCKVPAGHYFVMGDNRDNSLDSRYWGFVPDENIVGKAFVIWMNLGNFGRVGSFK
>Mature_299_residues
MNFALILFVLVVITGIAWVADKLVFERQRRASARLALAEFDSRQSDLQGRFGSGEVDSTRKRLAEEKLRQPWWLEYSASF
FPVILAVFVLRSFVVEPFKIPSGSMIPTLLIGDFILVNKYDYGIRLPVVNKKIVDVGEPQRGDVMVFRYPKDPSLDYIKR
VIGVPGDVVQYSNKHLTINGKPADYTPLPDYLDEERLAYSKHFREKLPGGVEHGILNDVDRPAFVAGADPDFPFRENCTY
NQQGVTCKVPAGHYFVMGDNRDNSLDSRYWGFVPDENIVGKAFVIWMNLGNFGRVGSFK

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=315, Percent_Identity=41.5873015873016, Blast_Score=215, Evalue=3e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 33923; Mature: 33923

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFALILFVLVVITGIAWVADKLVFERQRRASARLALAEFDSRQSDLQGRFGSGEVDSTR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCHHHH
KRLAEEKLRQPWWLEYSASFFPVILAVFVLRSFVVEPFKIPSGSMIPTLLIGDFILVNKY
HHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHCCEEEEEEC
DYGIRLPVVNKKIVDVGEPQRGDVMVFRYPKDPSLDYIKRVIGVPGDVVQYSNKHLTING
CCCEECCCCCCEEEECCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHEECCCEEEECC
KPADYTPLPDYLDEERLAYSKHFREKLPGGVEHGILNDVDRPAFVAGADPDFPFRENCTY
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHCHHCCCCCCEEEECCCCCCCCCCCCCC
NQQGVTCKVPAGHYFVMGDNRDNSLDSRYWGFVPDENIVGKAFVIWMNLGNFGRVGSFK
CCCCCEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MNFALILFVLVVITGIAWVADKLVFERQRRASARLALAEFDSRQSDLQGRFGSGEVDSTR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCHHHH
KRLAEEKLRQPWWLEYSASFFPVILAVFVLRSFVVEPFKIPSGSMIPTLLIGDFILVNKY
HHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHCCEEEEEEC
DYGIRLPVVNKKIVDVGEPQRGDVMVFRYPKDPSLDYIKRVIGVPGDVVQYSNKHLTING
CCCEECCCCCCEEEECCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHEECCCEEEECC
KPADYTPLPDYLDEERLAYSKHFREKLPGGVEHGILNDVDRPAFVAGADPDFPFRENCTY
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHCHHCCCCCCEEEECCCCCCCCCCCCCC
NQQGVTCKVPAGHYFVMGDNRDNSLDSRYWGFVPDENIVGKAFVIWMNLGNFGRVGSFK
CCCCCEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1546969 [H]