Click here to switch to the map view.

The map label for this gene is uvrC

Identifier: 73541931

GI number: 73541931

Start: 2476430

End: 2478421

Strand: Reverse

Name: uvrC

Synonym: Reut_A2244

Alternate gene names: 73541931

Gene position: 2478421-2476430 (Counterclockwise)

Preceding gene: 73541934

Following gene: 73541930

Centisome position: 65.11

GC content: 66.21

Gene sequence:

>1992_bases
ATGTCCGACCAGCTTCCAGACGCTTCGGCTCAACCGCCTGATCCTGCCCAGGCAGAGCCCTTCGACCCCAAGCCGGTCAT
CGCCCGCCTGCCGGGCTTGCCTGGTGTGTACCGCTACATCGACAGTGCCGGCAACGTGCTGTATGTCGGTAAGGCGCGCA
ACCTCAAGAAGCGCGTATCGAGCTATTTCAACAAGACGCAGTTGTCGCCGCGCATCGCGATGATGGTGGCCAAGATCGCG
CGCATCGACACCACCGTCGTGCGCACCGAGGCCGAGGCGCTGCTGCTCGAGAACAACCTGATCAAGGCCCTGGCGCCGCG
GTACAACATCCTGTTCCGCGACGACAAGTCGTATCCGTTCCTCAAGCTCACGGGCCATCGCTTTCCGCGCATGGCCTACT
ACCGTGGCGCCACGGATCGCAAGCACCAGTACTTCGGCCCGTTCCCGAGCGCCTATGCGGTGCGCGAGAGCATGCAGATC
CTGCAGAAGGTGTTCCAGCTGCGCACCTGCGAAGACACCGTCTTCAACAACCGCACGCGGCCCTGCCTGCTGCATCAGAT
CCATCGCTGCACCGGGCCCTGCGTGGGTGCGATCAGCGAGGCTGACTATGCACGCGACGTCGGCAACGCGGCGAGTTTCC
TGCAAGGACGCGAGACGGAGGTTCTCGAAGGCTTGCAGTCGAAGATGGAAGAGCACGCCATGCAGTTGGAGTTCGAGCAG
GCCGCCGCGGTGCGCGACCAGATCGCAGCGCTGTCGACGGTGCTCAAGCGCCAGGCGGTGGAGGAAGTCGGCCAGGCACG
CGATATCGACGTGCTGGCGGTGGCCGTGGAAGGTGGCCGCGCGTGCGTCAACCTGGCCATGGTGCGTGGCGGCCGCCATC
TTGGCGACAAAGCGTATTTCCCCGCGCATGCCGACGAAGCGGCGATGATCGTCGAGGACGGTGACGAAGGCGCTGAAGGC
GGGGAAACCGAGCCGGCGCCGGCAGTGCCGCTTGGCGTGGAGCGCATTGCCGCACGCGTGCTGTCGGCATTCATGGTGCA
GCATTACCTCGACCAGGCGCCGCCGCCGATCATTGTCGTCAGCCATGTTCCGGACGATGCGGCGTTGCTGGAGGCGCTGG
CGCTTCACGCCGGTCGCAAGATCGCGCTGGTGCGGCAGCCGCAGGGCCAGCGCAAGGCCTGGCTGGAAATGGCGCAGCAG
GGCGCCGCGCTGGCGCTCGCGCGGCGGCTTTCGGAGCAGGGCAGCCAGGAGGCCCGTACACGCGCACTCGCGGAGACCAT
CGGCATCGACCTGGAAGATCTTGCACTGCTGCGCGTGGAGTGCTTCGACATCAGCCATACCGCGGGCGAAGCGACGCAGG
CGTCGTGCGTCGTGTTCCATCACCACGATATGCAGAATGGCGAGTACCGGCGCTACAACATCCAGGACATCACGCCGGGC
GACGACTACGCGGCCATGCGGCAGGTACTGACGCGCCGTTATCAGAAGCTCGTCGAGCTGATGCAGGAACAGGGCGGTCT
CGATCCGGCTGGCGAGGCTTCGTCGCCGATGCCGCATGTGGTGCTGATCGACGGGGGCAAGGGGCAGGTCGAGGTGGCGC
GGCAGGTGTTCGAGGAACTCGGTCTCGATATCGGGCTGCTGGTCGGCGTGGCCAAGGGGGAGGGCCGAAAGGTGGGCCTG
GAAACCCTGGTGTTCGCCGATGGCCGTCCATCGCTGGAACTGGGGCAGGGCAGTGCGGCGTTGATGCTGGTGGCGCAGAT
CCGCGATGAGGCACACCGCTTCGCCATCACCGGCATGCGCGCGCGCAGGGCCAAGGCGCGTACCACGTCGCGGCTAGAAG
AGATCGAGGGCGTGGGGGCGCGCCGGCGGCAGAAGCTGCTGACGCGGTTTGGCGGCCTGCGCGGCGTCATGGCGGCCAGT
ATCGACGAGCTCGCCAGCGTCGACGGCATCTCCCGTGGTCTGGCCGAAGAGATCTATCGCCAGCTACATTGA

Upstream 100 bases:

>100_bases
GGGGGCGGTGAATTGCACTAAACTTCGGCTCTAAACTCCGGATTTTAGAGCCGTTGCCGCGAATCGCGAGCCGGCCGCAT
CGATTTGGTCATCGTCCCTC

Downstream 100 bases:

>100_bases
TGTGCCCGTGCCCGGCGAATTGTCCCGTCGGGCGCGCATTGGTACGGAAATCGGCGACAATCGCGGAATTCGTCACTGCA
CTGTCGGTTTCCCAGCCCCA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 663; Mature: 662

Protein sequence:

>663_residues
MSDQLPDASAQPPDPAQAEPFDPKPVIARLPGLPGVYRYIDSAGNVLYVGKARNLKKRVSSYFNKTQLSPRIAMMVAKIA
RIDTTVVRTEAEALLLENNLIKALAPRYNILFRDDKSYPFLKLTGHRFPRMAYYRGATDRKHQYFGPFPSAYAVRESMQI
LQKVFQLRTCEDTVFNNRTRPCLLHQIHRCTGPCVGAISEADYARDVGNAASFLQGRETEVLEGLQSKMEEHAMQLEFEQ
AAAVRDQIAALSTVLKRQAVEEVGQARDIDVLAVAVEGGRACVNLAMVRGGRHLGDKAYFPAHADEAAMIVEDGDEGAEG
GETEPAPAVPLGVERIAARVLSAFMVQHYLDQAPPPIIVVSHVPDDAALLEALALHAGRKIALVRQPQGQRKAWLEMAQQ
GAALALARRLSEQGSQEARTRALAETIGIDLEDLALLRVECFDISHTAGEATQASCVVFHHHDMQNGEYRRYNIQDITPG
DDYAAMRQVLTRRYQKLVELMQEQGGLDPAGEASSPMPHVVLIDGGKGQVEVARQVFEELGLDIGLLVGVAKGEGRKVGL
ETLVFADGRPSLELGQGSAALMLVAQIRDEAHRFAITGMRARRAKARTTSRLEEIEGVGARRRQKLLTRFGGLRGVMAAS
IDELASVDGISRGLAEEIYRQLH

Sequences:

>Translated_663_residues
MSDQLPDASAQPPDPAQAEPFDPKPVIARLPGLPGVYRYIDSAGNVLYVGKARNLKKRVSSYFNKTQLSPRIAMMVAKIA
RIDTTVVRTEAEALLLENNLIKALAPRYNILFRDDKSYPFLKLTGHRFPRMAYYRGATDRKHQYFGPFPSAYAVRESMQI
LQKVFQLRTCEDTVFNNRTRPCLLHQIHRCTGPCVGAISEADYARDVGNAASFLQGRETEVLEGLQSKMEEHAMQLEFEQ
AAAVRDQIAALSTVLKRQAVEEVGQARDIDVLAVAVEGGRACVNLAMVRGGRHLGDKAYFPAHADEAAMIVEDGDEGAEG
GETEPAPAVPLGVERIAARVLSAFMVQHYLDQAPPPIIVVSHVPDDAALLEALALHAGRKIALVRQPQGQRKAWLEMAQQ
GAALALARRLSEQGSQEARTRALAETIGIDLEDLALLRVECFDISHTAGEATQASCVVFHHHDMQNGEYRRYNIQDITPG
DDYAAMRQVLTRRYQKLVELMQEQGGLDPAGEASSPMPHVVLIDGGKGQVEVARQVFEELGLDIGLLVGVAKGEGRKVGL
ETLVFADGRPSLELGQGSAALMLVAQIRDEAHRFAITGMRARRAKARTTSRLEEIEGVGARRRQKLLTRFGGLRGVMAAS
IDELASVDGISRGLAEEIYRQLH
>Mature_662_residues
SDQLPDASAQPPDPAQAEPFDPKPVIARLPGLPGVYRYIDSAGNVLYVGKARNLKKRVSSYFNKTQLSPRIAMMVAKIAR
IDTTVVRTEAEALLLENNLIKALAPRYNILFRDDKSYPFLKLTGHRFPRMAYYRGATDRKHQYFGPFPSAYAVRESMQIL
QKVFQLRTCEDTVFNNRTRPCLLHQIHRCTGPCVGAISEADYARDVGNAASFLQGRETEVLEGLQSKMEEHAMQLEFEQA
AAVRDQIAALSTVLKRQAVEEVGQARDIDVLAVAVEGGRACVNLAMVRGGRHLGDKAYFPAHADEAAMIVEDGDEGAEGG
ETEPAPAVPLGVERIAARVLSAFMVQHYLDQAPPPIIVVSHVPDDAALLEALALHAGRKIALVRQPQGQRKAWLEMAQQG
AALALARRLSEQGSQEARTRALAETIGIDLEDLALLRVECFDISHTAGEATQASCVVFHHHDMQNGEYRRYNIQDITPGD
DYAAMRQVLTRRYQKLVELMQEQGGLDPAGEASSPMPHVVLIDGGKGQVEVARQVFEELGLDIGLLVGVAKGEGRKVGLE
TLVFADGRPSLELGQGSAALMLVAQIRDEAHRFAITGMRARRAKARTTSRLEEIEGVGARRRQKLLTRFGGLRGVMAASI
DELASVDGISRGLAEEIYRQLH

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=655, Percent_Identity=45.8015267175573, Blast_Score=541, Evalue=1e-155,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_CUPPJ (Q46Z26)

Other databases:

- EMBL:   CP000090
- RefSeq:   YP_296451.1
- ProteinModelPortal:   Q46Z26
- GeneID:   3610296
- GenomeReviews:   CP000090_GR
- KEGG:   reu:Reut_A2244
- NMPDR:   fig|264198.3.peg.2847
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- BioCyc:   REUT264198:REUT_A2244-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 72742; Mature: 72611

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQLPDASAQPPDPAQAEPFDPKPVIARLPGLPGVYRYIDSAGNVLYVGKARNLKKRVS
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHCCCCEEEECCCHHHHHHHH
SYFNKTQLSPRIAMMVAKIARIDTTVVRTEAEALLLENNLIKALAPRYNILFRDDKSYPF
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCE
LKLTGHRFPRMAYYRGATDRKHQYFGPFPSAYAVRESMQILQKVFQLRTCEDTVFNNRTR
EEECCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PCLLHQIHRCTGPCVGAISEADYARDVGNAASFLQGRETEVLEGLQSKMEEHAMQLEFEQ
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
AAAVRDQIAALSTVLKRQAVEEVGQARDIDVLAVAVEGGRACVNLAMVRGGRHLGDKAYF
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCC
PAHADEAAMIVEDGDEGAEGGETEPAPAVPLGVERIAARVLSAFMVQHYLDQAPPPIIVV
CCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEE
SHVPDDAALLEALALHAGRKIALVRQPQGQRKAWLEMAQQGAALALARRLSEQGSQEART
ECCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHH
RALAETIGIDLEDLALLRVECFDISHTAGEATQASCVVFHHHDMQNGEYRRYNIQDITPG
HHHHHHHCCCHHHHHHHHHHEEECCCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCC
DDYAAMRQVLTRRYQKLVELMQEQGGLDPAGEASSPMPHVVLIDGGKGQVEVARQVFEEL
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHH
GLDIGLLVGVAKGEGRKVGLETLVFADGRPSLELGQGSAALMLVAQIRDEAHRFAITGMR
CCCEEEEEEEECCCCCEECCEEEEEECCCCCCEECCCCHHHHHHHHHHHHHHHHHHHCHH
ARRAKARTTSRLEEIEGVGARRRQKLLTRFGGLRGVMAASIDELASVDGISRGLAEEIYR
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLH
HCC
>Mature Secondary Structure 
SDQLPDASAQPPDPAQAEPFDPKPVIARLPGLPGVYRYIDSAGNVLYVGKARNLKKRVS
CCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHCCCCEEEECCCHHHHHHHH
SYFNKTQLSPRIAMMVAKIARIDTTVVRTEAEALLLENNLIKALAPRYNILFRDDKSYPF
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCE
LKLTGHRFPRMAYYRGATDRKHQYFGPFPSAYAVRESMQILQKVFQLRTCEDTVFNNRTR
EEECCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PCLLHQIHRCTGPCVGAISEADYARDVGNAASFLQGRETEVLEGLQSKMEEHAMQLEFEQ
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
AAAVRDQIAALSTVLKRQAVEEVGQARDIDVLAVAVEGGRACVNLAMVRGGRHLGDKAYF
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCC
PAHADEAAMIVEDGDEGAEGGETEPAPAVPLGVERIAARVLSAFMVQHYLDQAPPPIIVV
CCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEE
SHVPDDAALLEALALHAGRKIALVRQPQGQRKAWLEMAQQGAALALARRLSEQGSQEART
ECCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHH
RALAETIGIDLEDLALLRVECFDISHTAGEATQASCVVFHHHDMQNGEYRRYNIQDITPG
HHHHHHHCCCHHHHHHHHHHEEECCCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCC
DDYAAMRQVLTRRYQKLVELMQEQGGLDPAGEASSPMPHVVLIDGGKGQVEVARQVFEEL
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHH
GLDIGLLVGVAKGEGRKVGLETLVFADGRPSLELGQGSAALMLVAQIRDEAHRFAITGMR
CCCEEEEEEEECCCCCEECCEEEEEECCCCCCEECCCCHHHHHHHHHHHHHHHHHHHCHH
ARRAKARTTSRLEEIEGVGARRRQKLLTRFGGLRGVMAASIDELASVDGISRGLAEEIYR
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLH
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA