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The map label for this gene is pgsA [H]

Identifier: 73541930

GI number: 73541930

Start: 2475731

End: 2476330

Strand: Reverse

Name: pgsA [H]

Synonym: Reut_A2243

Alternate gene names: 73541930

Gene position: 2476330-2475731 (Counterclockwise)

Preceding gene: 73541931

Following gene: 73541928

Centisome position: 65.05

GC content: 62.67

Gene sequence:

>600_bases
ATGCCCTTCAATATCCCGATCCTGCTGACCTGGTTGCGCGTTGCCATGATTCCCCTCGTGGTGGGCGTGTACTACCTGCC
GGAAGCATGGCTGCCGATGCACACGAAGAACATCACTGCGGCGTCGTTTTTCATCATCGCAGCGGTCACCGACTGGCTGG
ACGGATTCCTCGCGCGGCGCTGGAACCAGACCTCGGCGTTCGGTGCGTTCCTGGATCCGGTTGCGGACAAGCTGATGGTC
ACGGCTGCGCTGCTATCGCTGCTGGCCCTGGGCCGCGTGGCGGATCTGGTGGCGCTGGTCATCATTGGCCGCGAGATCAC
GATCTCGGCGTTGCGCGAGTGGATGGCGCAGATCGGCGCTTCCAAGAGCGTCGCGGTCAACTTCCTCGGCAAGCTGAAGA
CGACGGTGCAGATGATCGCGATCCCCTTGTTGCTCTACACGGACCGCCTGTTCGGCGTCGACGCGCAGGTGCTGGGTACG
TGGATGATCTACCTGGCGGCAGTGCTGACGCTGTGGTCGATGTTCTATTACATGAAGCTGGCGTGGCCGCAGATCCGCGA
GCGCAGCGGCGTGCTCAACGAAGCGCGCGCGCCAAAATGA

Upstream 100 bases:

>100_bases
ATGTGCCCGTGCCCGGCGAATTGTCCCGTCGGGCGCGCATTGGTACGGAAATCGGCGACAATCGCGGAATTCGTCACTGC
ACTGTCGGTTTCCCAGCCCC

Downstream 100 bases:

>100_bases
TGTCCCGCGCAAAAAAGTGTTGACGAACGGATTCATTCTTTGCAATAATCTCGTTCTCGCTGCTGACGACGCAAACGAAA
GCAGCAAGATAAGCCGGTTT

Product: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 199; Mature: 198

Protein sequence:

>199_residues
MPFNIPILLTWLRVAMIPLVVGVYYLPEAWLPMHTKNITAASFFIIAAVTDWLDGFLARRWNQTSAFGAFLDPVADKLMV
TAALLSLLALGRVADLVALVIIGREITISALREWMAQIGASKSVAVNFLGKLKTTVQMIAIPLLLYTDRLFGVDAQVLGT
WMIYLAAVLTLWSMFYYMKLAWPQIRERSGVLNEARAPK

Sequences:

>Translated_199_residues
MPFNIPILLTWLRVAMIPLVVGVYYLPEAWLPMHTKNITAASFFIIAAVTDWLDGFLARRWNQTSAFGAFLDPVADKLMV
TAALLSLLALGRVADLVALVIIGREITISALREWMAQIGASKSVAVNFLGKLKTTVQMIAIPLLLYTDRLFGVDAQVLGT
WMIYLAAVLTLWSMFYYMKLAWPQIRERSGVLNEARAPK
>Mature_198_residues
PFNIPILLTWLRVAMIPLVVGVYYLPEAWLPMHTKNITAASFFIIAAVTDWLDGFLARRWNQTSAFGAFLDPVADKLMVT
AALLSLLALGRVADLVALVIIGREITISALREWMAQIGASKSVAVNFLGKLKTTVQMIAIPLLLYTDRLFGVDAQVLGTW
MIYLAAVLTLWSMFYYMKLAWPQIRERSGVLNEARAPK

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids [H]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Homo sapiens, GI188536108, Length=172, Percent_Identity=30.2325581395349, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI10092647, Length=200, Percent_Identity=28.5, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1788220, Length=183, Percent_Identity=50.8196721311475, Blast_Score=162, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 22231; Mature: 22100

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFNIPILLTWLRVAMIPLVVGVYYLPEAWLPMHTKNITAASFFIIAAVTDWLDGFLARR
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
WNQTSAFGAFLDPVADKLMVTAALLSLLALGRVADLVALVIIGREITISALREWMAQIGA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
SKSVAVNFLGKLKTTVQMIAIPLLLYTDRLFGVDAQVLGTWMIYLAAVLTLWSMFYYMKL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AWPQIRERSGVLNEARAPK
HHHHHHHHCCCHHHCCCCC
>Mature Secondary Structure 
PFNIPILLTWLRVAMIPLVVGVYYLPEAWLPMHTKNITAASFFIIAAVTDWLDGFLARR
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
WNQTSAFGAFLDPVADKLMVTAALLSLLALGRVADLVALVIIGREITISALREWMAQIGA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
SKSVAVNFLGKLKTTVQMIAIPLLLYTDRLFGVDAQVLGTWMIYLAAVLTLWSMFYYMKL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AWPQIRERSGVLNEARAPK
HHHHHHHHCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]