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The map label for this gene is folP [H]

Identifier: 73541857

GI number: 73541857

Start: 2392433

End: 2393383

Strand: Reverse

Name: folP [H]

Synonym: Reut_A2169

Alternate gene names: 73541857

Gene position: 2393383-2392433 (Counterclockwise)

Preceding gene: 73541858

Following gene: 73541856

Centisome position: 62.88

GC content: 63.41

Gene sequence:

>951_bases
GTGCCCTTGGCACCGGCTTTTTCGTTTCTGCGCGGAGCGTGCGCAGATCTTCTATTTTTGTTTCCGGCTTCTACCTTGCA
GCAGACTTCGCCATCCACGTATTTCCAGTGCGGCCGCTTTCGCTTTGCGCTGGACCGCCGCCCGCTTGTCATGGGCATTC
TCAACGTAACGCCTGATTCATTCTCCGATGGCGGCATGCATGCCACCCGGGACGCTGCCCTGCGGCACGCCGAGCAGCTC
ATCGCAGAAGGTGTGGACATCATCGATATCGGTGGCGAGTCGAGCCGTCCGGGTTCCGACGCATTGCCGCTGGATGAAGA
GTTGGCCCGCGTGATTCCCATCGTCGAGGCGCTGCGCGATTGCGGCAAGCCGCTATCGATCGATACCTACAAGCCGGAGG
TCATGCGCGCATCGCTCGCGGCCGGTGCAGATCTCATCAACGATATCTGGGGCTTCCGCATGCCCGGCGCCGTCGAGGCG
GTGGCGCAGGGGCAGGCCGGTCTGTGTGTGATGCACATGCAGCGGGACCCGCAGACAATGCAGGAGGACCCGCAGTACAC
CGATGTGGTGGCCGAGGTCGCTGCTTTCCTCGATGAACGCGTGGCCGTGCTGCGCCAGGCTGGCGTCGACACGGCCCGCA
TCACGCTCGACCCGGGATTTGGCTTCGGCAAGACTCCGGATCATAATTTGCGCCTGCTTGGGCAATTGCCAGCCCTTGCG
AAAGCCAGGCTGCCTTTGCTGGTGGGCCTGTCCCGCAAGTCAACGCTTGGCGCGATCCTGGGTGGCCGGCCGCCGCTGCA
GCGTGTGGCGGCCAGCATTGCCGCAGCGGTATGTGCGGCAGAGCGCGGAGCGTATATCGTGCGCGTGCATGATGTGCAGG
ATACGGTGGATGCCCTCAAGACCTGGTGGGCAGTCCGGAATGAAGCCGTGACAGGAGTGGAACGGCAGTAG

Upstream 100 bases:

>100_bases
GTGGTTCGCCGGTGGCGCCGACCAACGCGCCTGCCACGGCCTGATGGCACGGATCGCACTGTCAGCGAGACGGTGACGAC
CTAGCTGTTCCGACAAGCCG

Downstream 100 bases:

>100_bases
TCACATTCATAGTTGCCAGACAGAGCAAGCAAGAAAGGATTTAAGGGAATGACGCGCAAGTATTTCGGGACTGATGGCGT
ACGCGGCAAAGTCGGCGAAT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MPLAPAFSFLRGACADLLFLFPASTLQQTSPSTYFQCGRFRFALDRRPLVMGILNVTPDSFSDGGMHATRDAALRHAEQL
IAEGVDIIDIGGESSRPGSDALPLDEELARVIPIVEALRDCGKPLSIDTYKPEVMRASLAAGADLINDIWGFRMPGAVEA
VAQGQAGLCVMHMQRDPQTMQEDPQYTDVVAEVAAFLDERVAVLRQAGVDTARITLDPGFGFGKTPDHNLRLLGQLPALA
KARLPLLVGLSRKSTLGAILGGRPPLQRVAASIAAAVCAAERGAYIVRVHDVQDTVDALKTWWAVRNEAVTGVERQ

Sequences:

>Translated_316_residues
MPLAPAFSFLRGACADLLFLFPASTLQQTSPSTYFQCGRFRFALDRRPLVMGILNVTPDSFSDGGMHATRDAALRHAEQL
IAEGVDIIDIGGESSRPGSDALPLDEELARVIPIVEALRDCGKPLSIDTYKPEVMRASLAAGADLINDIWGFRMPGAVEA
VAQGQAGLCVMHMQRDPQTMQEDPQYTDVVAEVAAFLDERVAVLRQAGVDTARITLDPGFGFGKTPDHNLRLLGQLPALA
KARLPLLVGLSRKSTLGAILGGRPPLQRVAASIAAAVCAAERGAYIVRVHDVQDTVDALKTWWAVRNEAVTGVERQ
>Mature_315_residues
PLAPAFSFLRGACADLLFLFPASTLQQTSPSTYFQCGRFRFALDRRPLVMGILNVTPDSFSDGGMHATRDAALRHAEQLI
AEGVDIIDIGGESSRPGSDALPLDEELARVIPIVEALRDCGKPLSIDTYKPEVMRASLAAGADLINDIWGFRMPGAVEAV
AQGQAGLCVMHMQRDPQTMQEDPQYTDVVAEVAAFLDERVAVLRQAGVDTARITLDPGFGFGKTPDHNLRLLGQLPALAK
ARLPLLVGLSRKSTLGAILGGRPPLQRVAASIAAAVCAAERGAYIVRVHDVQDTVDALKTWWAVRNEAVTGVERQ

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=259, Percent_Identity=50.965250965251, Blast_Score=259, Evalue=1e-70,
Organism=Saccharomyces cerevisiae, GI6324073, Length=350, Percent_Identity=29.4285714285714, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 33994; Mature: 33863

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLAPAFSFLRGACADLLFLFPASTLQQTSPSTYFQCGRFRFALDRRPLVMGILNVTPDS
CCCCHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHCCEEEEECCCCCEEEEEECCCCC
FSDGGMHATRDAALRHAEQLIAEGVDIIDIGGESSRPGSDALPLDEELARVIPIVEALRD
CCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
CGKPLSIDTYKPEVMRASLAAGADLINDIWGFRMPGAVEAVAQGQAGLCVMHMQRDPQTM
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEEECCCCHHH
QEDPQYTDVVAEVAAFLDERVAVLRQAGVDTARITLDPGFGFGKTPDHNLRLLGQLPALA
HCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHCCHHH
KARLPLLVGLSRKSTLGAILGGRPPLQRVAASIAAAVCAAERGAYIVRVHDVQDTVDALK
HHCCCCEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEEEEEECHHHHHHHHH
TWWAVRNEAVTGVERQ
HHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PLAPAFSFLRGACADLLFLFPASTLQQTSPSTYFQCGRFRFALDRRPLVMGILNVTPDS
CCCHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHCCEEEEECCCCCEEEEEECCCCC
FSDGGMHATRDAALRHAEQLIAEGVDIIDIGGESSRPGSDALPLDEELARVIPIVEALRD
CCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
CGKPLSIDTYKPEVMRASLAAGADLINDIWGFRMPGAVEAVAQGQAGLCVMHMQRDPQTM
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEEECCCCHHH
QEDPQYTDVVAEVAAFLDERVAVLRQAGVDTARITLDPGFGFGKTPDHNLRLLGQLPALA
HCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHCCHHH
KARLPLLVGLSRKSTLGAILGGRPPLQRVAASIAAAVCAAERGAYIVRVHDVQDTVDALK
HHCCCCEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEEEEEECHHHHHHHHH
TWWAVRNEAVTGVERQ
HHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]