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The map label for this gene is norM [H]

Identifier: 73541810

GI number: 73541810

Start: 2337930

End: 2339282

Strand: Direct

Name: norM [H]

Synonym: Reut_A2122

Alternate gene names: 73541810

Gene position: 2337930-2339282 (Clockwise)

Preceding gene: 73541809

Following gene: 73541812

Centisome position: 61.42

GC content: 63.49

Gene sequence:

>1353_bases
ATGAACCTGCTCCACGATCTGCGGCGCATCGCCCATCTTGCCGCACCAGTTTTGGTTGGCCAGCTAGCCGTTATAGCGTT
CGGCGTCATGGACACGGTCATGGCCGGTCGCGCGTCGGCCAGCGACCTCGCAGCGGTCGGCCTCGGCGGCTCGATCTATA
TCACCGTCTACATCAGCCTGATGGGCGTCCTGCAGGCGCTAGCGCCGATTGCCGGCCAGCTATATGGCGCGGGACGCAGC
GACGAGATCGGCAGCGAAGTCCGGCAAGCAGCGTGGCTCGGGTTGGCGCTATCCGTCCCTGGCGTACTGCTGCTCGCCTT
CCCGGAACCGCTGCTTGCCTTCGCCAAGGCGCCACCGGAATTGGTCGGCAAGGCGAGCCAGTATCTGCATATCGGCGCGT
TCGGCCTGCCCGCCGCGCTGGGCTTTCGCATCTATTCGGCGCTCAACAATGCGCTGTCGCGCCCGGTCATGGTGACAATG
CTGCAGATCGTCGGCCTGGCCCTGAAGGTGCCGCTCAATGCGTGGTTTATCAACGGTGGCTTCGGCGTGCCGGCCATGGG
CGGCCCCGGCTGCGCGCTCGCTTCGACACTGATCAGCTGGACCTGGTGCATCGCGGGGCTACTGATCCTGCGCTACAGCG
CGGTCTATCGGTCCCTGAAGATTTTCTCGGCCTGGAGCTGGCCCGTGGCCACACAGTTGCGGGCACTGTTGCGGCTGGGC
GTGCCGATGGGGCTGACTTACCTGATCGAGATCACATCGTTCACGCTGATGTCCATTTTCATCACGCGCATGGGCACCGT
CATGCTTGCCGGACACCAGATCATCGCCAACCTGGGTGCCGTGGCCTACATGCTGCCACTTTCGCTGGCCATCGCCACCT
CGACGCTGGTTGCCCAGTCGATTGGCGCGCGCGACATGGCTGGCGCCAGCCGCCTCGCGTGGCGCGGCATCTGCCTGGCA
GCAGCCTTGGCCATGTTGACCGGCTGCCTGCTATGGCTGCTGAGGGAGACTGTGCTGCACGCTTATACGAAGGATGGTGC
TGTCGTGGCCGCGGCACTGCCACTGGTGCTGTTTATCGCCTTCTATCAGGCTTTTGATGCCGTCCAGGTCATGACAGCCT
TTATCCTGCGCGCCTACAAAATTGCGCTGATTCCGACGCTGATTTACGCCGGTTCGTTGTGGGGCATCGGAATTGGTGGG
GGGTATGTGCTGGGATTCGGGCTGATCGATACCCTGCCCCCGTTCACGCGCGGCGCCTCCGGCTTCTGGATCGCCAACAG
CGCGAGCCTGGCAGTGGCCGGCTTTTTCCTGGTTCGGTATTTCATGCGTATCAGTGCAGCGGAACGGCACTGA

Upstream 100 bases:

>100_bases
GCCCCAGTAACCCTGAACCCTCCTGCCGGCGGCATGGCTGGCGGCCGCGCCGCCGCTGCCGGCTGACTTATGCGCTCTCT
CGCGCTCGTATGAATCCGGC

Downstream 100 bases:

>100_bases
GCATTATTGGGCGGGTATTGGCTCTCTGCCCGGATGGAGAGTGAATGGCCCGCGCTACTGGCACTGATCCGGTATTTGAT
ATTGAGCCAAGTACAAAAGA

Product: multi anti extrusion protein MatE

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MNLLHDLRRIAHLAAPVLVGQLAVIAFGVMDTVMAGRASASDLAAVGLGGSIYITVYISLMGVLQALAPIAGQLYGAGRS
DEIGSEVRQAAWLGLALSVPGVLLLAFPEPLLAFAKAPPELVGKASQYLHIGAFGLPAALGFRIYSALNNALSRPVMVTM
LQIVGLALKVPLNAWFINGGFGVPAMGGPGCALASTLISWTWCIAGLLILRYSAVYRSLKIFSAWSWPVATQLRALLRLG
VPMGLTYLIEITSFTLMSIFITRMGTVMLAGHQIIANLGAVAYMLPLSLAIATSTLVAQSIGARDMAGASRLAWRGICLA
AALAMLTGCLLWLLRETVLHAYTKDGAVVAAALPLVLFIAFYQAFDAVQVMTAFILRAYKIALIPTLIYAGSLWGIGIGG
GYVLGFGLIDTLPPFTRGASGFWIANSASLAVAGFFLVRYFMRISAAERH

Sequences:

>Translated_450_residues
MNLLHDLRRIAHLAAPVLVGQLAVIAFGVMDTVMAGRASASDLAAVGLGGSIYITVYISLMGVLQALAPIAGQLYGAGRS
DEIGSEVRQAAWLGLALSVPGVLLLAFPEPLLAFAKAPPELVGKASQYLHIGAFGLPAALGFRIYSALNNALSRPVMVTM
LQIVGLALKVPLNAWFINGGFGVPAMGGPGCALASTLISWTWCIAGLLILRYSAVYRSLKIFSAWSWPVATQLRALLRLG
VPMGLTYLIEITSFTLMSIFITRMGTVMLAGHQIIANLGAVAYMLPLSLAIATSTLVAQSIGARDMAGASRLAWRGICLA
AALAMLTGCLLWLLRETVLHAYTKDGAVVAAALPLVLFIAFYQAFDAVQVMTAFILRAYKIALIPTLIYAGSLWGIGIGG
GYVLGFGLIDTLPPFTRGASGFWIANSASLAVAGFFLVRYFMRISAAERH
>Mature_450_residues
MNLLHDLRRIAHLAAPVLVGQLAVIAFGVMDTVMAGRASASDLAAVGLGGSIYITVYISLMGVLQALAPIAGQLYGAGRS
DEIGSEVRQAAWLGLALSVPGVLLLAFPEPLLAFAKAPPELVGKASQYLHIGAFGLPAALGFRIYSALNNALSRPVMVTM
LQIVGLALKVPLNAWFINGGFGVPAMGGPGCALASTLISWTWCIAGLLILRYSAVYRSLKIFSAWSWPVATQLRALLRLG
VPMGLTYLIEITSFTLMSIFITRMGTVMLAGHQIIANLGAVAYMLPLSLAIATSTLVAQSIGARDMAGASRLAWRGICLA
AALAMLTGCLLWLLRETVLHAYTKDGAVVAAALPLVLFIAFYQAFDAVQVMTAFILRAYKIALIPTLIYAGSLWGIGIGG
GYVLGFGLIDTLPPFTRGASGFWIANSASLAVAGFFLVRYFMRISAAERH

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI153792564, Length=368, Percent_Identity=21.195652173913, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI22907060, Length=376, Percent_Identity=22.6063829787234, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI48994890, Length=448, Percent_Identity=31.4732142857143, Blast_Score=196, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6321821, Length=358, Percent_Identity=25.4189944134078, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320545, Length=384, Percent_Identity=25.5208333333333, Blast_Score=77, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 47518; Mature: 47518

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLHDLRRIAHLAAPVLVGQLAVIAFGVMDTVMAGRASASDLAAVGLGGSIYITVYISL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHH
MGVLQALAPIAGQLYGAGRSDEIGSEVRQAAWLGLALSVPGVLLLAFPEPLLAFAKAPPE
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHCCCHH
LVGKASQYLHIGAFGLPAALGFRIYSALNNALSRPVMVTMLQIVGLALKVPLNAWFINGG
HHCCHHHEEEECCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEECC
FGVPAMGGPGCALASTLISWTWCIAGLLILRYSAVYRSLKIFSAWSWPVATQLRALLRLG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
VPMGLTYLIEITSFTLMSIFITRMGTVMLAGHQIIANLGAVAYMLPLSLAIATSTLVAQS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGARDMAGASRLAWRGICLAAALAMLTGCLLWLLRETVLHAYTKDGAVVAAALPLVLFIA
CCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
FYQAFDAVQVMTAFILRAYKIALIPTLIYAGSLWGIGIGGGYVLGFGLIDTLPPFTRGAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHCCCCCCCCCC
GFWIANSASLAVAGFFLVRYFMRISAAERH
CEEEECCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNLLHDLRRIAHLAAPVLVGQLAVIAFGVMDTVMAGRASASDLAAVGLGGSIYITVYISL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHH
MGVLQALAPIAGQLYGAGRSDEIGSEVRQAAWLGLALSVPGVLLLAFPEPLLAFAKAPPE
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHCCCHH
LVGKASQYLHIGAFGLPAALGFRIYSALNNALSRPVMVTMLQIVGLALKVPLNAWFINGG
HHCCHHHEEEECCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEECC
FGVPAMGGPGCALASTLISWTWCIAGLLILRYSAVYRSLKIFSAWSWPVATQLRALLRLG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
VPMGLTYLIEITSFTLMSIFITRMGTVMLAGHQIIANLGAVAYMLPLSLAIATSTLVAQS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGARDMAGASRLAWRGICLAAALAMLTGCLLWLLRETVLHAYTKDGAVVAAALPLVLFIA
CCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
FYQAFDAVQVMTAFILRAYKIALIPTLIYAGSLWGIGIGGGYVLGFGLIDTLPPFTRGAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHCCCCCCCCCC
GFWIANSASLAVAGFFLVRYFMRISAAERH
CEEEECCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA