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The map label for this gene is lexA

Identifier: 73541696

GI number: 73541696

Start: 2197237

End: 2197893

Strand: Direct

Name: lexA

Synonym: Reut_A2008

Alternate gene names: 73541696

Gene position: 2197237-2197893 (Clockwise)

Preceding gene: 73541687

Following gene: 73541697

Centisome position: 57.72

GC content: 66.51

Gene sequence:

>657_bases
ATGGCGACCCTGACACCCCGGCAGCAGCAGATTTTCGATCTGATCCGCAACACGATCCGCAATACGGGCTTTCCGCCCAC
GCGCGCCGAGATTGCTGCCGAGTTCGGCTTCTCATCACCCAATGCCGCGGAAGAGCATCTGCGGGCGCTGGCACGCAAGG
GCGTGATCGAACTGACGCCGGGCGCCTCGCGCGGCATCCGCCTCAAGGTGGCGCGCAGCGATTCCGAGATGCCCGACCAG
TTCTCGCTGCCCGTGTCCGGCATCATGCAGCTCACGTTGCCGCTGGTGGGCCGCGTGGCCGCCGGCAGCCCGATCCTCGC
CGCCGAACATATCGACCGCCAGTATCAGGTAGACGCCTCGGTCTTCGACGAACGCCCCGACTACCTGCTGCGCGTGCGCG
GCCTGAGCATGCGCGACGCCGGCATCCTCGACGGCGACCTGCTCGCCGTGCGCAAGGCCAGCGAAGCGCCCAACGGCAAG
ATCGTCGTGGCCCGGCTCGGCGATGACGTGACCGTCAAGCGCTTGCAGCGCCGTGACGGCGCGATCGAACTGATCGCGGA
AAACCCGGACTTTCCGAACATCATGGTCACGCCCGGGCGAGAAGAATTCTCACTGGAAGGTATCGCCGTCGGGCTGATCC
GCTCCTCGGGCTTCTGA

Upstream 100 bases:

>100_bases
GCCGATACTGTATAAAATCACAGGCATACTGTTTAAACATACAGTGCCCGCCTGGCTGGCAGCCGTATTGCACCGGGGCA
CTCATCAAGGAAGCGTTTCC

Downstream 100 bases:

>100_bases
CCGACGCGGCCAGCCGCGCGCTGGTCGCCGCCCTCCCCTTTTGCTGTACCGATGCCGCCCGCCAGACGGGTGTTGACCCC
GCTTTTGCCGCTTTTTGCTG

Product: LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MATLTPRQQQIFDLIRNTIRNTGFPPTRAEIAAEFGFSSPNAAEEHLRALARKGVIELTPGASRGIRLKVARSDSEMPDQ
FSLPVSGIMQLTLPLVGRVAAGSPILAAEHIDRQYQVDASVFDERPDYLLRVRGLSMRDAGILDGDLLAVRKASEAPNGK
IVVARLGDDVTVKRLQRRDGAIELIAENPDFPNIMVTPGREEFSLEGIAVGLIRSSGF

Sequences:

>Translated_218_residues
MATLTPRQQQIFDLIRNTIRNTGFPPTRAEIAAEFGFSSPNAAEEHLRALARKGVIELTPGASRGIRLKVARSDSEMPDQ
FSLPVSGIMQLTLPLVGRVAAGSPILAAEHIDRQYQVDASVFDERPDYLLRVRGLSMRDAGILDGDLLAVRKASEAPNGK
IVVARLGDDVTVKRLQRRDGAIELIAENPDFPNIMVTPGREEFSLEGIAVGLIRSSGF
>Mature_217_residues
ATLTPRQQQIFDLIRNTIRNTGFPPTRAEIAAEFGFSSPNAAEEHLRALARKGVIELTPGASRGIRLKVARSDSEMPDQF
SLPVSGIMQLTLPLVGRVAAGSPILAAEHIDRQYQVDASVFDERPDYLLRVRGLSMRDAGILDGDLLAVRKASEAPNGKI
VVARLGDDVTVKRLQRRDGAIELIAENPDFPNIMVTPGREEFSLEGIAVGLIRSSGF

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family

Homologues:

Organism=Escherichia coli, GI1790476, Length=218, Percent_Identity=54.1284403669725, Blast_Score=232, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LEXA_CUPPJ (Q46ZR1)

Other databases:

- EMBL:   CP000090
- RefSeq:   YP_296216.1
- ProteinModelPortal:   Q46ZR1
- MEROPS:   S24.001
- GeneID:   3611654
- GenomeReviews:   CP000090_GR
- KEGG:   reu:Reut_A2008
- NMPDR:   fig|264198.3.peg.2663
- HOGENOM:   HBG679610
- OMA:   IAENPDF
- ProtClustDB:   PRK00215
- BioCyc:   REUT264198:REUT_A2008-MONOMER
- GO:   GO:0006508
- GO:   GO:0006350
- HAMAP:   MF_00015
- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991
- Gene3D:   G3DSA:2.10.109.10
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00726
- TIGRFAMs:   TIGR00498

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24; SSF51306 Pept_S24_S26_C

EC number: =3.4.21.88

Molecular weight: Translated: 23743; Mature: 23611

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: ACT_SITE 136-136 ACT_SITE 173-173

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATLTPRQQQIFDLIRNTIRNTGFPPTRAEIAAEFGFSSPNAAEEHLRALARKGVIELTP
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEECC
GASRGIRLKVARSDSEMPDQFSLPVSGIMQLTLPLVGRVAAGSPILAAEHIDRQYQVDAS
CCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEHHHCCCCEEECHH
VFDERPDYLLRVRGLSMRDAGILDGDLLAVRKASEAPNGKIVVARLGDDVTVKRLQRRDG
HHCCCCCEEEEECCCCCCCCCCCCCCHHEEECCCCCCCCCEEEEECCCCHHHHHHHHCCC
AIELIAENPDFPNIMVTPGREEFSLEGIAVGLIRSSGF
CEEEEECCCCCCEEEECCCCCCEEECCEEEEEEECCCC
>Mature Secondary Structure 
ATLTPRQQQIFDLIRNTIRNTGFPPTRAEIAAEFGFSSPNAAEEHLRALARKGVIELTP
CCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEECC
GASRGIRLKVARSDSEMPDQFSLPVSGIMQLTLPLVGRVAAGSPILAAEHIDRQYQVDAS
CCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEHHHCCCCEEECHH
VFDERPDYLLRVRGLSMRDAGILDGDLLAVRKASEAPNGKIVVARLGDDVTVKRLQRRDG
HHCCCCCEEEEECCCCCCCCCCCCCCHHEEECCCCCCCCCEEEEECCCCHHHHHHHHCCC
AIELIAENPDFPNIMVTPGREEFSLEGIAVGLIRSSGF
CEEEEECCCCCCEEEECCCCCCEEECCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA