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The map label for this gene is 73541483

Identifier: 73541483

GI number: 73541483

Start: 1958291

End: 1959601

Strand: Direct

Name: 73541483

Synonym: Reut_A1794

Alternate gene names: NA

Gene position: 1958291-1959601 (Clockwise)

Preceding gene: 73541482

Following gene: 73541484

Centisome position: 51.45

GC content: 65.06

Gene sequence:

>1311_bases
ATGGAACTGAACCACACGCATGATGCATCGCGCCGCAGCTGGCTGGATTCGGCCAATCTTGCAGGCACCGATTTCCCCCT
GCAAAACCTGCCGCTTGGTGTGTTCCGGCGCAAAGGGAGCGCTGAAACGTGGCGTGGCGGCGTAGCCATCGGTGACCAGA
TCGTCGACCTGGCCGCGCTCGAGTCGCTTCCCGGACTGCAGGACCGTGTCGCCAACGCCATGCGCGCTGCGGCAGTACCC
ACGCTCAATGGCCTGCTTGAGCAAGGGCCGGAAGCCTGGCAGGCCCTGCGCCATGGACTTTTTGCGCTGCTACAGGATGG
CAGCCTGCTGGAACGGCGGGTCCGTGAAGCGCTCGTGCCGCAGGCGGATGCCGAGCACGCAGTCCCCGTGGGTATTGGCG
ACTACACGGACTTCTACACCTCGCTGGACCACGCCGTGAATTGCTGCCGCCAGTTCGGCATCGAGGTCAATCCGAACTTC
GACTGGCTGCCCGTCGGCTACCACGGCCGCGTGTCTTCGATAGATGTCAGTGGTCAGCAGGTCTATCGGCCGATGGGCCA
GTACCGCATGGATCAAGACTCTGCGCCCGTGTATGGACCCTGCCAACGCCTTGACTACGAACTCGAAGTCGGCGCGGTGA
TCGGCATCGGGAACGCCCGTGGGACGCCAATTCCTTTGGCCACGGCGCAGCAGCACATCTTCGGCCTGTGCCTGCTCAAT
GACTGGTCCGCGCGCGACATCCAGACCTGGGAGATGCCACCGCTCGGGCCCTTTCTCGCCAAGAACTTCGCCACGACGTT
GTCGCCGTGGATCGTGACCCTGGAAGCGTTGCTGCCCTATCGCCAGGGTTGGATGCGTGCGCCCGATCGCCCGCAGCCGC
TCGACTACCTCCACGCCCCCGCCAACGCTGCGCATGGCGCGTTTGACATCCGGCTCGAAGCCGCGATCCTCAGCGCGCGC
CAACTGGCGCAGGGCCGCAAGCCGCGCACGTTGACGCACACCAGCTTTCGTCACCAGTACTGGACGCTGGGTCAGATGAT
TGCCCACCACACCGTGGGCGGCTGCAACCTGCAGCCCGGCGATCTCCTTGGCAGCGGCACCGTTTCAGGCCCCACCCCCG
GCGAGGCCGGAGCGCTGATCGAACTGACGGTATCCGGGACGCAACCCGTGGATATCGGCGACGGCGAGCAACGCGGATTT
CTTGAAGATGGCGATACGGTCGTGTTCCGTGGCGGGTGCGAGCGCGAGGGCTTTGCGCGCATCGGCTTCGGCCTCAACTA
CGCGACCGTAATGGCGGCCCCTGCCTTTTGA

Upstream 100 bases:

>100_bases
TACATCTCGTGTTTTCCTCACAAGATTCGCGGCGCCTCGGCGGGCTGGACCCGTGCCGTGGCCATCTTCGACGACGCCCT
CAACGCTGCGTGAAATCGCC

Downstream 100 bases:

>100_bases
CCAGACCGAAGCAACCACGACGGAGGAGATCGACTTGACCAAGGAACGACAGCCGGCTTGTGCCAGGCAAGGCACGGCTT
CCAGCCGGCGCAGGAATCCG

Product: fumarylacetoacetate hydrolase

Products: acetoacetate; fumarate

Alternate protein names: Fumarylacetoacetate Hydrolase; Hydroxylase; Fumarylacetoacetate Hydrolase Family Protein; Fumarylacetoacetase Hydrolase; LOW QUALITY PROTEIN Fumarylacetoacetase

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MELNHTHDASRRSWLDSANLAGTDFPLQNLPLGVFRRKGSAETWRGGVAIGDQIVDLAALESLPGLQDRVANAMRAAAVP
TLNGLLEQGPEAWQALRHGLFALLQDGSLLERRVREALVPQADAEHAVPVGIGDYTDFYTSLDHAVNCCRQFGIEVNPNF
DWLPVGYHGRVSSIDVSGQQVYRPMGQYRMDQDSAPVYGPCQRLDYELEVGAVIGIGNARGTPIPLATAQQHIFGLCLLN
DWSARDIQTWEMPPLGPFLAKNFATTLSPWIVTLEALLPYRQGWMRAPDRPQPLDYLHAPANAAHGAFDIRLEAAILSAR
QLAQGRKPRTLTHTSFRHQYWTLGQMIAHHTVGGCNLQPGDLLGSGTVSGPTPGEAGALIELTVSGTQPVDIGDGEQRGF
LEDGDTVVFRGGCEREGFARIGFGLNYATVMAAPAF

Sequences:

>Translated_436_residues
MELNHTHDASRRSWLDSANLAGTDFPLQNLPLGVFRRKGSAETWRGGVAIGDQIVDLAALESLPGLQDRVANAMRAAAVP
TLNGLLEQGPEAWQALRHGLFALLQDGSLLERRVREALVPQADAEHAVPVGIGDYTDFYTSLDHAVNCCRQFGIEVNPNF
DWLPVGYHGRVSSIDVSGQQVYRPMGQYRMDQDSAPVYGPCQRLDYELEVGAVIGIGNARGTPIPLATAQQHIFGLCLLN
DWSARDIQTWEMPPLGPFLAKNFATTLSPWIVTLEALLPYRQGWMRAPDRPQPLDYLHAPANAAHGAFDIRLEAAILSAR
QLAQGRKPRTLTHTSFRHQYWTLGQMIAHHTVGGCNLQPGDLLGSGTVSGPTPGEAGALIELTVSGTQPVDIGDGEQRGF
LEDGDTVVFRGGCEREGFARIGFGLNYATVMAAPAF
>Mature_436_residues
MELNHTHDASRRSWLDSANLAGTDFPLQNLPLGVFRRKGSAETWRGGVAIGDQIVDLAALESLPGLQDRVANAMRAAAVP
TLNGLLEQGPEAWQALRHGLFALLQDGSLLERRVREALVPQADAEHAVPVGIGDYTDFYTSLDHAVNCCRQFGIEVNPNF
DWLPVGYHGRVSSIDVSGQQVYRPMGQYRMDQDSAPVYGPCQRLDYELEVGAVIGIGNARGTPIPLATAQQHIFGLCLLN
DWSARDIQTWEMPPLGPFLAKNFATTLSPWIVTLEALLPYRQGWMRAPDRPQPLDYLHAPANAAHGAFDIRLEAAILSAR
QLAQGRKPRTLTHTSFRHQYWTLGQMIAHHTVGGCNLQPGDLLGSGTVSGPTPGEAGALIELTVSGTQPVDIGDGEQRGF
LEDGDTVVFRGGCEREGFARIGFGLNYATVMAAPAF

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557587, Length=421, Percent_Identity=44.8931116389549, Blast_Score=339, Evalue=2e-93,
Organism=Caenorhabditis elegans, GI17568863, Length=425, Percent_Identity=45.1764705882353, Blast_Score=315, Evalue=4e-86,
Organism=Drosophila melanogaster, GI24657182, Length=421, Percent_Identity=44.4180522565321, Blast_Score=316, Evalue=2e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.2

Molecular weight: Translated: 47405; Mature: 47405

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELNHTHDASRRSWLDSANLAGTDFPLQNLPLGVFRRKGSAETWRGGVAIGDQIVDLAAL
CCCCCCCCHHHHHHHCCCCCCCCCCCHHHCCHHHHCCCCCCCCCCCCEEECHHHHHHHHH
ESLPGLQDRVANAMRAAAVPTLNGLLEQGPEAWQALRHGLFALLQDGSLLERRVREALVP
HHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
QADAEHAVPVGIGDYTDFYTSLDHAVNCCRQFGIEVNPNFDWLPVGYHGRVSSIDVSGQQ
CCCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCCEECCCCCEEECCCCCCEEEEECCHHH
VYRPMGQYRMDQDSAPVYGPCQRLDYELEVGAVIGIGNARGTPIPLATAQQHIFGLCLLN
HHHHHHHHCCCCCCCCCCCCHHHCCCEEEEEEEEECCCCCCCCCCHHHHHHHHEEEEEEC
DWSARDIQTWEMPPLGPFLAKNFATTLSPWIVTLEALLPYRQGWMRAPDRPQPLDYLHAP
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCC
ANAAHGAFDIRLEAAILSARQLAQGRKPRTLTHTSFRHQYWTLGQMIAHHTVGGCNLQPG
CCCCCCEEEEEEHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCC
DLLGSGTVSGPTPGEAGALIELTVSGTQPVDIGDGEQRGFLEDGDTVVFRGGCEREGFAR
CCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEE
IGFGLNYATVMAAPAF
ECCCCCCHHHEECCCC
>Mature Secondary Structure
MELNHTHDASRRSWLDSANLAGTDFPLQNLPLGVFRRKGSAETWRGGVAIGDQIVDLAAL
CCCCCCCCHHHHHHHCCCCCCCCCCCHHHCCHHHHCCCCCCCCCCCCEEECHHHHHHHHH
ESLPGLQDRVANAMRAAAVPTLNGLLEQGPEAWQALRHGLFALLQDGSLLERRVREALVP
HHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
QADAEHAVPVGIGDYTDFYTSLDHAVNCCRQFGIEVNPNFDWLPVGYHGRVSSIDVSGQQ
CCCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCCEECCCCCEEECCCCCCEEEEECCHHH
VYRPMGQYRMDQDSAPVYGPCQRLDYELEVGAVIGIGNARGTPIPLATAQQHIFGLCLLN
HHHHHHHHCCCCCCCCCCCCHHHCCCEEEEEEEEECCCCCCCCCCHHHHHHHHEEEEEEC
DWSARDIQTWEMPPLGPFLAKNFATTLSPWIVTLEALLPYRQGWMRAPDRPQPLDYLHAP
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCC
ANAAHGAFDIRLEAAILSARQLAQGRKPRTLTHTSFRHQYWTLGQMIAHHTVGGCNLQPG
CCCCCCEEEEEEHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCC
DLLGSGTVSGPTPGEAGALIELTVSGTQPVDIGDGEQRGFLEDGDTVVFRGGCEREGFAR
CCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEE
IGFGLNYATVMAAPAF
ECCCCCCHHHEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA