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The map label for this gene is hisN [H]

Identifier: 73541458

GI number: 73541458

Start: 1925403

End: 1926194

Strand: Direct

Name: hisN [H]

Synonym: Reut_A1769

Alternate gene names: 73541458

Gene position: 1925403-1926194 (Clockwise)

Preceding gene: 73541457

Following gene: 73541461

Centisome position: 50.58

GC content: 64.39

Gene sequence:

>792_bases
ATGTCAATGCACGCCGACCAGCAGTCCGAATATCTCGCCTTCGCCGGTCGCCTGGCCGATGCGGCAAGTGCCGTGACGCT
TCCTTATTTTCGCGCCCCGATTAGCGTGGTCGACAAAGGTACCGCGCGCTTCGACCCCGTCACGGTGGCCGATCGGGAGG
CGGAACTGGCAATGCGCGCACTGATTCGAAGCACGTATCCCGCCCACGGCATCCTTGGCGAAGAAGAGCAAAGGATTACC
GGTACTGACCCGCACCATTGGGTACTCGATCCGATCGACGGCACGCGCGCCTTCATTACCGGGCTGCCGCTCTGGGGCAC
CCTGATTGCACTCAATGATGGCCAGCGTCCCGTGCTCGGCGTGATGGACCAGCCCTTCACACGCGAGCGTTTTTCCGGTG
ACCGCGAGCGAGCCTGGCTCAATGGCAATCCGCTGCAGGTGCGCCCCTGCGCGGCGTTGTCGGAAGCCACGCTGCTCTGC
ACCACGCCGGACATGTTTGAATCCGGCGAACAATGGGATGCGTTCCAGCGCGTGGCACGCGCTGCGCGCATGCAGCGCTA
TGGCGGCGATTGCTACGGCTATTGCATGGTCGCCGCAGGCCAGGTCGACGCCGTGGTGGAAGCAGGCTTGCAGCCGTATG
ACGTGCAGGCCCTGATCCCCATCGTCGAGGGTGCCGGCGGCATCATGACAAGCTGGACCGGCGGCGATCCTCAGCATGGC
GGGGCAGTCGTCGCTTGCGGCGATGCCCGTGTCCATGCAGAGATCCTCCGGCTACTGAATTCGCCGGGCTGA

Upstream 100 bases:

>100_bases
GCAGGAATAGACATGCCCGGACCGGAGCGCGTGCAAGCGGGCGGCATGCTGCCCGCTACAATGGACGCCCTTCCATTCTC
GCCACAGCAGGCACACCGCA

Downstream 100 bases:

>100_bases
TCGGACTACTCCTCCACATAGCCCTTGCGCAGTTTCTCAGCGACCAGCTTGTCCATTTCACGGCGGGCCCGACCGGGCTC
GTCGAAGACCTTGACGCTCG

Product: histidinol-phosphate phosphatase, putative, inositol monophosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MSMHADQQSEYLAFAGRLADAASAVTLPYFRAPISVVDKGTARFDPVTVADREAELAMRALIRSTYPAHGILGEEEQRIT
GTDPHHWVLDPIDGTRAFITGLPLWGTLIALNDGQRPVLGVMDQPFTRERFSGDRERAWLNGNPLQVRPCAALSEATLLC
TTPDMFESGEQWDAFQRVARAARMQRYGGDCYGYCMVAAGQVDAVVEAGLQPYDVQALIPIVEGAGGIMTSWTGGDPQHG
GAVVACGDARVHAEILRLLNSPG

Sequences:

>Translated_263_residues
MSMHADQQSEYLAFAGRLADAASAVTLPYFRAPISVVDKGTARFDPVTVADREAELAMRALIRSTYPAHGILGEEEQRIT
GTDPHHWVLDPIDGTRAFITGLPLWGTLIALNDGQRPVLGVMDQPFTRERFSGDRERAWLNGNPLQVRPCAALSEATLLC
TTPDMFESGEQWDAFQRVARAARMQRYGGDCYGYCMVAAGQVDAVVEAGLQPYDVQALIPIVEGAGGIMTSWTGGDPQHG
GAVVACGDARVHAEILRLLNSPG
>Mature_262_residues
SMHADQQSEYLAFAGRLADAASAVTLPYFRAPISVVDKGTARFDPVTVADREAELAMRALIRSTYPAHGILGEEEQRITG
TDPHHWVLDPIDGTRAFITGLPLWGTLIALNDGQRPVLGVMDQPFTRERFSGDRERAWLNGNPLQVRPCAALSEATLLCT
TPDMFESGEQWDAFQRVARAARMQRYGGDCYGYCMVAAGQVDAVVEAGLQPYDVQALIPIVEGAGGIMTSWTGGDPQHGG
AVVACGDARVHAEILRLLNSPG

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI5031789, Length=260, Percent_Identity=26.1538461538462, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI221625487, Length=260, Percent_Identity=26.1538461538462, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI7657236, Length=214, Percent_Identity=28.5046728971963, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1788882, Length=252, Percent_Identity=31.3492063492063, Blast_Score=101, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI193202570, Length=247, Percent_Identity=28.3400809716599, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI193202572, Length=245, Percent_Identity=27.3469387755102, Blast_Score=88, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6320493, Length=213, Percent_Identity=28.169014084507, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24664918, Length=247, Percent_Identity=29.1497975708502, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21357957, Length=238, Percent_Identity=29.8319327731092, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24664922, Length=203, Percent_Identity=29.064039408867, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24664926, Length=216, Percent_Identity=26.8518518518519, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21357329, Length=203, Percent_Identity=30.0492610837438, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21357303, Length=205, Percent_Identity=28.2926829268293, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 28426; Mature: 28295

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00629 IMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMHADQQSEYLAFAGRLADAASAVTLPYFRAPISVVDKGTARFDPVTVADREAELAMRA
CCCCCCCHHHHHHHHHHHHHHHHHEECHHHHCCHHHHCCCCCCCCCEEECCCHHHHHHHH
LIRSTYPAHGILGEEEQRITGTDPHHWVLDPIDGTRAFITGLPLWGTLIALNDGQRPVLG
HHHHCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCHHHCCCCCHHEEEEECCCCCCEEE
VMDQPFTRERFSGDRERAWLNGNPLQVRPCAALSEATLLCTTPDMFESGEQWDAFQRVAR
CCCCCCCHHHHCCCCCEEEECCCCEEEECCCCCCCCEEEEECCHHHHCCCHHHHHHHHHH
AARMQRYGGDCYGYCMVAAGQVDAVVEAGLQPYDVQALIPIVEGAGGIMTSWTGGDPQHG
HHHHHHHCCCEEEEEEEECCCHHHHHHCCCCCCCCEEEEEECCCCCCEEEECCCCCCCCC
GAVVACGDARVHAEILRLLNSPG
CEEEEECCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SMHADQQSEYLAFAGRLADAASAVTLPYFRAPISVVDKGTARFDPVTVADREAELAMRA
CCCCCCHHHHHHHHHHHHHHHHHEECHHHHCCHHHHCCCCCCCCCEEECCCHHHHHHHH
LIRSTYPAHGILGEEEQRITGTDPHHWVLDPIDGTRAFITGLPLWGTLIALNDGQRPVLG
HHHHCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCHHHCCCCCHHEEEEECCCCCCEEE
VMDQPFTRERFSGDRERAWLNGNPLQVRPCAALSEATLLCTTPDMFESGEQWDAFQRVAR
CCCCCCCHHHHCCCCCEEEECCCCEEEECCCCCCCCEEEEECCHHHHCCCHHHHHHHHHH
AARMQRYGGDCYGYCMVAAGQVDAVVEAGLQPYDVQALIPIVEGAGGIMTSWTGGDPQHG
HHHHHHHCCCEEEEEEEECCCHHHHHHCCCCCCCCEEEEEECCCCCCEEEECCCCCCCCC
GAVVACGDARVHAEILRLLNSPG
CEEEEECCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]