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The map label for this gene is kefC [H]

Identifier: 73541397

GI number: 73541397

Start: 1843323

End: 1844483

Strand: Direct

Name: kefC [H]

Synonym: Reut_A1708

Alternate gene names: 73541397

Gene position: 1843323-1844483 (Clockwise)

Preceding gene: 73541395

Following gene: 73541400

Centisome position: 48.43

GC content: 60.81

Gene sequence:

>1161_bases
ATGGAGCAACTGCTAGTGGATTCGGTTGTATTCCTCGCAGCAGCGTTGATCGCTGTACCGTTGTCCGTACGCGCAGGCTT
TGGTTCTGTACTGGGATACCTTATCGCAGGCGTCGTCATCGGGCCCTGGGTTCTCAGGCTCGTAACGGATGTCGATTCCA
TCCTCGACATCTCCGAACTCGGCATTGTGCTGATGATGTTCATCATCGGCATTGAAATGGACCTCAAGAAGCTCTGGGCC
ATGCGCCGTGCCATCTTTGGCTATGGCGGCATCCAGGTCGCGCTATGCGCAGCGCTGCTTGCGGCGATCTTCACGATATT
CGGCGCGCCGTGGCGCGTCGGTGTCGCTGCCGGCTTCGCGCTATCCCTGTCATCGACCGCCATGGTGATTGCGATCCTGG
AGCAGAACCGCGAGATGGATACGCCGGTGGGCCAGACCTGCTTCGGCATCCTGCTGTTCCAGGACATCGCCGCAATACCG
ATGATCGCGCTGCTGCCGCTGCTTGCCCCGGCGCCGATCGAAGACAACGATCCCAGCGGCTGGTTGATGACGGCCAGGGC
ACTGGCCATGCTCGCCGCCGTGGTCTTTGGTGGCCGCTTTATCCTGCAGCATGCGCTGCGCATCATCCAGCGAAGCGGTA
CCCGCGAGATTTTCACCATCTTCGCGCTGCTTTGGGTCATCGGGATTGCGTTGTTGATGCATGTGGTGCACCTGTCCATG
TCTCTCGGCGCCTTCGTCGCCGGAATGCTGCTCGCCGGCTCCGAATCGCGTCACGAAATCGAAGCCGACATGGCACCGTT
CAAGGGCATCCTGCTCGGGCTGTTCTTCATTGCGGTGGGGATGTCGATCGACTTCCGCGTGCTGGCCGAACGGCCATGGC
TGGTCGCGATACTGGTCGTTGTGCTTGTCGGCGGCAAACTGCTGGCCTTGATGTTCCTGGCCAGCAAGATCAACCTGCCG
CGCGAACAACGCATCTACTTCGCAATCCTGCTGTCGCAGGGCGGCGAGTTTGCCTTTGTCGTGACGGCTGCGGCGCAGGC
CGCGCGACTGCTCGACAACGAGCAGTTGTCGATCGTCACGGTGGTGGTCGCGTTGTCGATGGCGACGACTCCGTTGCTGC
TTCTGGCATTTCGGAAGCTGATGGCGGTGCAGCCAGCTTGA

Upstream 100 bases:

>100_bases
CTTTTAAGTCGCACCGCGATGTGCTTGACTGTGACTGTCAACAGTACAAGCGCTGACCGGCATCAAATCCGATGCCTGGT
ATCGACTCCGGAGGACGATG

Downstream 100 bases:

>100_bases
TACGACTGGGGTACGACATTTCTTTTTGATTGGCCGATCTGAGACATCGATCCGGGTGGCAGGGCTTGGTGGCATGACGC
TCCCGTCGAAGTCCGCTAAC

Product: potassium efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MEQLLVDSVVFLAAALIAVPLSVRAGFGSVLGYLIAGVVIGPWVLRLVTDVDSILDISELGIVLMMFIIGIEMDLKKLWA
MRRAIFGYGGIQVALCAALLAAIFTIFGAPWRVGVAAGFALSLSSTAMVIAILEQNREMDTPVGQTCFGILLFQDIAAIP
MIALLPLLAPAPIEDNDPSGWLMTARALAMLAAVVFGGRFILQHALRIIQRSGTREIFTIFALLWVIGIALLMHVVHLSM
SLGAFVAGMLLAGSESRHEIEADMAPFKGILLGLFFIAVGMSIDFRVLAERPWLVAILVVVLVGGKLLALMFLASKINLP
REQRIYFAILLSQGGEFAFVVTAAAQAARLLDNEQLSIVTVVVALSMATTPLLLLAFRKLMAVQPA

Sequences:

>Translated_386_residues
MEQLLVDSVVFLAAALIAVPLSVRAGFGSVLGYLIAGVVIGPWVLRLVTDVDSILDISELGIVLMMFIIGIEMDLKKLWA
MRRAIFGYGGIQVALCAALLAAIFTIFGAPWRVGVAAGFALSLSSTAMVIAILEQNREMDTPVGQTCFGILLFQDIAAIP
MIALLPLLAPAPIEDNDPSGWLMTARALAMLAAVVFGGRFILQHALRIIQRSGTREIFTIFALLWVIGIALLMHVVHLSM
SLGAFVAGMLLAGSESRHEIEADMAPFKGILLGLFFIAVGMSIDFRVLAERPWLVAILVVVLVGGKLLALMFLASKINLP
REQRIYFAILLSQGGEFAFVVTAAAQAARLLDNEQLSIVTVVVALSMATTPLLLLAFRKLMAVQPA
>Mature_386_residues
MEQLLVDSVVFLAAALIAVPLSVRAGFGSVLGYLIAGVVIGPWVLRLVTDVDSILDISELGIVLMMFIIGIEMDLKKLWA
MRRAIFGYGGIQVALCAALLAAIFTIFGAPWRVGVAAGFALSLSSTAMVIAILEQNREMDTPVGQTCFGILLFQDIAAIP
MIALLPLLAPAPIEDNDPSGWLMTARALAMLAAVVFGGRFILQHALRIIQRSGTREIFTIFALLWVIGIALLMHVVHLSM
SLGAFVAGMLLAGSESRHEIEADMAPFKGILLGLFFIAVGMSIDFRVLAERPWLVAILVVVLVGGKLLALMFLASKINLP
REQRIYFAILLSQGGEFAFVVTAAAQAARLLDNEQLSIVTVVVALSMATTPLLLLAFRKLMAVQPA

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI1786232, Length=378, Percent_Identity=47.6190476190476, Blast_Score=334, Evalue=7e-93,
Organism=Escherichia coli, GI1789749, Length=382, Percent_Identity=47.3821989528796, Blast_Score=292, Evalue=2e-80,
Organism=Escherichia coli, GI1786685, Length=363, Percent_Identity=30.5785123966942, Blast_Score=129, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 41425; Mature: 41425

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQLLVDSVVFLAAALIAVPLSVRAGFGSVLGYLIAGVVIGPWVLRLVTDVDSILDISEL
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIVLMMFIIGIEMDLKKLWAMRRAIFGYGGIQVALCAALLAAIFTIFGAPWRVGVAAGFA
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LSLSSTAMVIAILEQNREMDTPVGQTCFGILLFQDIAAIPMIALLPLLAPAPIEDNDPSG
HHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
WLMTARALAMLAAVVFGGRFILQHALRIIQRSGTREIFTIFALLWVIGIALLMHVVHLSM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SLGAFVAGMLLAGSESRHEIEADMAPFKGILLGLFFIAVGMSIDFRVLAERPWLVAILVV
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHH
VLVGGKLLALMFLASKINLPREQRIYFAILLSQGGEFAFVVTAAAQAARLLDNEQLSIVT
HHHHHHHHHHHHHHHHCCCCHHHHEEEEEEECCCCCEEEEHHHHHHHHHHHCCCCHHHHH
VVVALSMATTPLLLLAFRKLMAVQPA
HHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEQLLVDSVVFLAAALIAVPLSVRAGFGSVLGYLIAGVVIGPWVLRLVTDVDSILDISEL
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIVLMMFIIGIEMDLKKLWAMRRAIFGYGGIQVALCAALLAAIFTIFGAPWRVGVAAGFA
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LSLSSTAMVIAILEQNREMDTPVGQTCFGILLFQDIAAIPMIALLPLLAPAPIEDNDPSG
HHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
WLMTARALAMLAAVVFGGRFILQHALRIIQRSGTREIFTIFALLWVIGIALLMHVVHLSM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SLGAFVAGMLLAGSESRHEIEADMAPFKGILLGLFFIAVGMSIDFRVLAERPWLVAILVV
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHH
VLVGGKLLALMFLASKINLPREQRIYFAILLSQGGEFAFVVTAAAQAARLLDNEQLSIVT
HHHHHHHHHHHHHHHHCCCCHHHHEEEEEEECCCCCEEEEHHHHHHHHHHHCCCCHHHHH
VVVALSMATTPLLLLAFRKLMAVQPA
HHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA