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The map label for this gene is lysP [H]

Identifier: 73541098

GI number: 73541098

Start: 1518112

End: 1519632

Strand: Reverse

Name: lysP [H]

Synonym: Reut_A1404

Alternate gene names: 73541098

Gene position: 1519632-1518112 (Counterclockwise)

Preceding gene: 73541111

Following gene: 73541090

Centisome position: 39.92

GC content: 63.58

Gene sequence:

>1521_bases
ATGTCTTCCCACTCCCATCCTCATCCTCACCAGCATCCGGTCGTCGAGCACGACGACCTTCAGCGCAAGCTCAAGGCGCG
CCATCTCACCATGATCGCAATCGGCGGCGCGGTTGGCACGGGGTTGTTCGTCGCATCCGGCGCCTCCATCGCACAGGCTG
GTCCCGGCGGCGCGCTTCTGATGTACGCCCTGCTTGGCTTCATGGTGTATTGCCTGATGACCAGCCTTGGCGAACTGGCC
GTCCACATGCCCGTGGCTGGCTCGTTCGTCACCTACAGCGCGCTCTATGTCGAGGAAGGTTTCGGCTTTGCGCTCGGCTG
GAATTACTGGTTCAGCCTGGCCGTGACCATCGCGGTGGAACTCACCGCCGCGCAACTGGTGATGCAGTTCTGGTTCCCCG
GCATGCCCGGCATGGTCTGGAGCGCGGGCTTCCTGCTGCTGATGTTCGCGCTCAACGCGTTCTCGGTGCGCGGCTTCGGC
GAAGCCGAGTACTGGTTCGCGCTGATCAAGGTGATCACGGTGATCGTGTTCCTGGGCGTGGGGCTGCTGATGATCTTCGG
CATCATGAAGGGCGGCCCGCAATCCGGCTGGCACAACTTCACGACCGGCGACGCGCCGTTCGTCGGCGGCATCCCTGCCA
TGATCGGCGTGGCGATGATCGCCGGGTTTTCGTTCCAAGGCACCGAGACCGTGGGCGTAGCTGCCGGCGAAGCGCAGGAT
CCGGCCAGAACGATCCCGCGCGCGATCCGCCAGACCTTCTGGCGCATCCTGCTGTTCTACGTGATCGCGATCCTGATCAT
CGGCGTGCTGATTCCCTATACCGATCCGAACCTGCTGCGCAATGATGTGACCGACGTCGGCGTGAGCCCGTTCGCCCTGG
TGTTCCGCCAGGCCGGGCTGGCCTTTGCCGCCGGCCTGATGAACGCCGTAGTGCTGACCGCGCTGCTGTCGGCGGGCACG
TCGAGCATGTACGTCTCCACGCGTATTCTCTACGGCCTGGCTGTGAGCGGACGCGCCCCGCGCTGGCTGGGCAAGCTGAC
CGTGAACGGCGTACCGTTCAATGCGCTGCTGGTCACCACCGCCGTCGGCGCGCTGTGCTTCTTCAGTTCGCTGTTCGGCG
ACAAGGCCGTGTACCTGTGGCTGCTGAACACATCGGCCATGACGGGCTTCTTCGCATGGTTCGGTATCGCCCTGAGCCAC
TACCGCTTCCGGCGCGGACTGGTCTATCAAGGCTATGACATCAACGCGCTGGCGTACCGCTCGCCGCTCTATCCGTTCGG
CCCAATCTTTGCGGGCGTGCTGTGCCTGGTGATCGTGGCGGGACAGAACTACCAGGCATTCGCGGACATTCCGAACCGCT
GGCCGGAAATCATTGCGACGTACATCGGGGTGCCGGTGTTCCTGGCGCTGTGGCTGGGGTACCGCATCGTCAGGAAGACG
CGGCTGATCGACTATGAGGATATGCCGTTCGAGTTGCCGAAGACGGCAAAAGTCATTGCCGGGCAAGCGGCACAAGTGTG
A

Upstream 100 bases:

>100_bases
GAGCGATCCGCTAAAAAAGACACGTTAGACTCGCGGCTTTTCATTTTTCGACCCCGGACATCCATAAGTTGTCCGGGCAG
GCGAAGTTCCAGCGACCCTG

Downstream 100 bases:

>100_bases
TGTCAGGCGCGTCCGCCCGGCACGGACGCAACCTGCGGCATTACACCTCCAGCCACTCCTTGCGCACCTGCGCATTGGCC
TTCAGTTCGGTCGGCGTTCC

Product: amino acid permease-associated region

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 506; Mature: 505

Protein sequence:

>506_residues
MSSHSHPHPHQHPVVEHDDLQRKLKARHLTMIAIGGAVGTGLFVASGASIAQAGPGGALLMYALLGFMVYCLMTSLGELA
VHMPVAGSFVTYSALYVEEGFGFALGWNYWFSLAVTIAVELTAAQLVMQFWFPGMPGMVWSAGFLLLMFALNAFSVRGFG
EAEYWFALIKVITVIVFLGVGLLMIFGIMKGGPQSGWHNFTTGDAPFVGGIPAMIGVAMIAGFSFQGTETVGVAAGEAQD
PARTIPRAIRQTFWRILLFYVIAILIIGVLIPYTDPNLLRNDVTDVGVSPFALVFRQAGLAFAAGLMNAVVLTALLSAGT
SSMYVSTRILYGLAVSGRAPRWLGKLTVNGVPFNALLVTTAVGALCFFSSLFGDKAVYLWLLNTSAMTGFFAWFGIALSH
YRFRRGLVYQGYDINALAYRSPLYPFGPIFAGVLCLVIVAGQNYQAFADIPNRWPEIIATYIGVPVFLALWLGYRIVRKT
RLIDYEDMPFELPKTAKVIAGQAAQV

Sequences:

>Translated_506_residues
MSSHSHPHPHQHPVVEHDDLQRKLKARHLTMIAIGGAVGTGLFVASGASIAQAGPGGALLMYALLGFMVYCLMTSLGELA
VHMPVAGSFVTYSALYVEEGFGFALGWNYWFSLAVTIAVELTAAQLVMQFWFPGMPGMVWSAGFLLLMFALNAFSVRGFG
EAEYWFALIKVITVIVFLGVGLLMIFGIMKGGPQSGWHNFTTGDAPFVGGIPAMIGVAMIAGFSFQGTETVGVAAGEAQD
PARTIPRAIRQTFWRILLFYVIAILIIGVLIPYTDPNLLRNDVTDVGVSPFALVFRQAGLAFAAGLMNAVVLTALLSAGT
SSMYVSTRILYGLAVSGRAPRWLGKLTVNGVPFNALLVTTAVGALCFFSSLFGDKAVYLWLLNTSAMTGFFAWFGIALSH
YRFRRGLVYQGYDINALAYRSPLYPFGPIFAGVLCLVIVAGQNYQAFADIPNRWPEIIATYIGVPVFLALWLGYRIVRKT
RLIDYEDMPFELPKTAKVIAGQAAQV
>Mature_505_residues
SSHSHPHPHQHPVVEHDDLQRKLKARHLTMIAIGGAVGTGLFVASGASIAQAGPGGALLMYALLGFMVYCLMTSLGELAV
HMPVAGSFVTYSALYVEEGFGFALGWNYWFSLAVTIAVELTAAQLVMQFWFPGMPGMVWSAGFLLLMFALNAFSVRGFGE
AEYWFALIKVITVIVFLGVGLLMIFGIMKGGPQSGWHNFTTGDAPFVGGIPAMIGVAMIAGFSFQGTETVGVAAGEAQDP
ARTIPRAIRQTFWRILLFYVIAILIIGVLIPYTDPNLLRNDVTDVGVSPFALVFRQAGLAFAAGLMNAVVLTALLSAGTS
SMYVSTRILYGLAVSGRAPRWLGKLTVNGVPFNALLVTTAVGALCFFSSLFGDKAVYLWLLNTSAMTGFFAWFGIALSHY
RFRRGLVYQGYDINALAYRSPLYPFGPIFAGVLCLVIVAGQNYQAFADIPNRWPEIIATYIGVPVFLALWLGYRIVRKTR
LIDYEDMPFELPKTAKVIAGQAAQV

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788480, Length=487, Percent_Identity=65.7084188911704, Blast_Score=652, Evalue=0.0,
Organism=Escherichia coli, GI87081708, Length=477, Percent_Identity=37.7358490566038, Blast_Score=301, Evalue=5e-83,
Organism=Escherichia coli, GI1786302, Length=425, Percent_Identity=38.1176470588235, Blast_Score=265, Evalue=6e-72,
Organism=Escherichia coli, GI1786789, Length=412, Percent_Identity=36.1650485436893, Blast_Score=264, Evalue=9e-72,
Organism=Escherichia coli, GI48994972, Length=429, Percent_Identity=36.8298368298368, Blast_Score=242, Evalue=5e-65,
Organism=Escherichia coli, GI87081915, Length=436, Percent_Identity=33.256880733945, Blast_Score=226, Evalue=4e-60,
Organism=Escherichia coli, GI1786602, Length=408, Percent_Identity=35.0490196078431, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI1789017, Length=426, Percent_Identity=31.924882629108, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1790653, Length=397, Percent_Identity=34.0050377833753, Blast_Score=204, Evalue=8e-54,
Organism=Escherichia coli, GI87081869, Length=240, Percent_Identity=28.75, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=481, Percent_Identity=37.8378378378378, Blast_Score=329, Evalue=7e-91,
Organism=Saccharomyces cerevisiae, GI6324061, Length=507, Percent_Identity=34.1222879684418, Blast_Score=303, Evalue=5e-83,
Organism=Saccharomyces cerevisiae, GI6324059, Length=486, Percent_Identity=36.2139917695473, Blast_Score=288, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6324990, Length=490, Percent_Identity=33.265306122449, Blast_Score=284, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6322892, Length=478, Percent_Identity=33.4728033472803, Blast_Score=273, Evalue=5e-74,
Organism=Saccharomyces cerevisiae, GI6324924, Length=500, Percent_Identity=31.8, Blast_Score=259, Evalue=9e-70,
Organism=Saccharomyces cerevisiae, GI6324553, Length=432, Percent_Identity=33.7962962962963, Blast_Score=252, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6322967, Length=511, Percent_Identity=30.3326810176125, Blast_Score=251, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6321629, Length=503, Percent_Identity=29.4234592445328, Blast_Score=245, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6320717, Length=481, Percent_Identity=28.0665280665281, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6324981, Length=471, Percent_Identity=33.3333333333333, Blast_Score=236, Evalue=8e-63,
Organism=Saccharomyces cerevisiae, GI6319824, Length=477, Percent_Identity=29.1404612159329, Blast_Score=234, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6321053, Length=511, Percent_Identity=29.7455968688845, Blast_Score=225, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6319542, Length=497, Percent_Identity=26.5593561368209, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6319543, Length=474, Percent_Identity=28.2700421940928, Blast_Score=216, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6320251, Length=477, Percent_Identity=24.9475890985325, Blast_Score=205, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6319608, Length=532, Percent_Identity=25, Blast_Score=199, Evalue=8e-52,
Organism=Saccharomyces cerevisiae, GI6320364, Length=552, Percent_Identity=27.3550724637681, Blast_Score=166, Evalue=7e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 54811; Mature: 54680

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSHSHPHPHQHPVVEHDDLQRKLKARHLTMIAIGGAVGTGLFVASGASIAQAGPGGALL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEECCHHHCCHHHCCCCCHHCCCCCHHHH
MYALLGFMVYCLMTSLGELAVHMPVAGSFVTYSALYVEEGFGFALGWNYWFSLAVTIAVE
HHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHEEECCCCEEEHHHHHHHHHHHHHHH
LTAAQLVMQFWFPGMPGMVWSAGFLLLMFALNAFSVRGFGEAEYWFALIKVITVIVFLGV
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GLLMIFGIMKGGPQSGWHNFTTGDAPFVGGIPAMIGVAMIAGFSFQGTETVGVAAGEAQD
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCC
PARTIPRAIRQTFWRILLFYVIAILIIGVLIPYTDPNLLRNDVTDVGVSPFALVFRQAGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHH
AFAAGLMNAVVLTALLSAGTSSMYVSTRILYGLAVSGRAPRWLGKLTVNGVPFNALLVTT
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEECCCCCCHHHEEEECCCCHHHHHHHH
AVGALCFFSSLFGDKAVYLWLLNTSAMTGFFAWFGIALSHYRFRRGLVYQGYDINALAYR
HHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEC
SPLYPFGPIFAGVLCLVIVAGQNYQAFADIPNRWPEIIATYIGVPVFLALWLGYRIVRKT
CCCCCCHHHHHHHHHHHHHCCCCCEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLIDYEDMPFELPKTAKVIAGQAAQV
HCCCCCCCCCCCCCHHHHHCCCCCCC
>Mature Secondary Structure 
SSHSHPHPHQHPVVEHDDLQRKLKARHLTMIAIGGAVGTGLFVASGASIAQAGPGGALL
CCCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEECCHHHCCHHHCCCCCHHCCCCCHHHH
MYALLGFMVYCLMTSLGELAVHMPVAGSFVTYSALYVEEGFGFALGWNYWFSLAVTIAVE
HHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHEEECCCCEEEHHHHHHHHHHHHHHH
LTAAQLVMQFWFPGMPGMVWSAGFLLLMFALNAFSVRGFGEAEYWFALIKVITVIVFLGV
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GLLMIFGIMKGGPQSGWHNFTTGDAPFVGGIPAMIGVAMIAGFSFQGTETVGVAAGEAQD
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCC
PARTIPRAIRQTFWRILLFYVIAILIIGVLIPYTDPNLLRNDVTDVGVSPFALVFRQAGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHH
AFAAGLMNAVVLTALLSAGTSSMYVSTRILYGLAVSGRAPRWLGKLTVNGVPFNALLVTT
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEECCCCCCHHHEEEECCCCHHHHHHHH
AVGALCFFSSLFGDKAVYLWLLNTSAMTGFFAWFGIALSHYRFRRGLVYQGYDINALAYR
HHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEC
SPLYPFGPIFAGVLCLVIVAGQNYQAFADIPNRWPEIIATYIGVPVFLALWLGYRIVRKT
CCCCCCHHHHHHHHHHHHHCCCCCEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLIDYEDMPFELPKTAKVIAGQAAQV
HCCCCCCCCCCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]