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The map label for this gene is pgi

Identifier: 73541080

GI number: 73541080

Start: 1496548

End: 1498185

Strand: Reverse

Name: pgi

Synonym: Reut_A1386

Alternate gene names: 73541080

Gene position: 1498185-1496548 (Counterclockwise)

Preceding gene: 73541081

Following gene: 73541078

Centisome position: 39.36

GC content: 63.86

Gene sequence:

>1638_bases
ATGCCCACGAATCTTCACGCCTGGAACGCCCTTCAGCAGCATCACGACGCCATTCGCGATCACCAGATGGCGGATTGGTT
TGCCGAGAACGGCGCGGATCGTGTCAGGCAGTTTTCGCTGGAAGCCGCTGGCCTGTACCTGGACTACTCCAAGAACCGAA
TCACGCCGCAGACCATGCAGCTGTTGCTGCAACTTGCCGATGAGGCCGGCGTACCGGCACGTCGCGATGCGATGTTTGCC
GGCGAGCATATCAACGCAACGGAAGACCGGGCGGCGCTACACGTCGCATTGCGTGCCACAGCCGGTGCCGGTTTCAAGGT
TGACGGTGTCCCTGTCGTACCGGCTATCCAGAATGTGCTGGTACGCATGCGTGCCTTTTCCGAAGCCGTCCGCAGTGGCG
CGTGGACCGGCACGACCGGCGAGCGCATCACCGATGTCGTAAACATCGGCATTGGTGGCTCCGACCTCGGTCCGAAGATG
GTATGCCGCGCCCTGTCGCACCTTGCGCACGACGACGGCCACTCGGGCCCGCGCATGCACTTTGTGTCGAACGTCGACGG
CACGGAACTCGCCGAAGCGCTTGAACGGCTGGATCCGCGACGCACCCTGATGATCGTCTGCTCGAAGACCTTCACGACGC
TGGAGACCATGGCCAACGCGCACAGCGCGCGGCAATGGTATCTGGACAACGGCGTTGCCGAGGATCAGCTCGCCCGGCAT
TTCGTCGCGGTGTCGACCAATGTGGACGCCGTGCGTGCGTTCGGCATCGACCCGGCCAATATGTTCGAGTTCTGGGACTG
GATCGGCGGCCGCTTTTCGCTGTGGTCCTCGGTCGGCCTGTCGACCGCGCTGGCGGTCGGCTTCAATGCCTTCGCGGACC
TGCTTGCGGGCGGGCGCGCCATGGACGAGCACTTCCGTACAGCCCCGCTCGAACGCAACATGCCGGTGGTGCTTGGCATG
CTCGGCATTTGGTACCGCAACTTCTTCAACCTGCCCACCAGTTGCATGGCGCCCTACTCCACGTCGCTGGAGCTGTTCCC
CGCGTTCCTGCAGCAACTGGAAATGGAGAGCAACGGCAAGACAGTGCAGCTCAACGGACGCCGCGTGCGCACGCATACTT
CGCCGGTCGTGTGGGGTACCGCGGGCACCAACGGTCAGCATGCGTACTTCCAGATGATCCACCAGGGATCGCAGATCGTA
CCGGTCGATTTCGTGGCCCCGCTGGTGCCGCCGCGCGAGTTGCCGGGCCATCATGCCAAGCTGCTCGCCAATTGCTTTGC
ACAGGCCGAAGCGCTGATGCGCGGCCGATCCGCGGAGGAATTGCGCGCCGCCGGCATGACCGACGAGCTGCGCATTGCGC
ATATGGTCTTCGAAGGCAACCGCCCCAGCAATACGCTACTGATGGAAGACCTGACCCCGCACGTGCTGGGCGCGCTGATC
GCGCTCTACGAGCACAGGACGTTCGTGCAGGGCGTGGTCTGGAACATCAACTCATTCGACCAATGGGGCGTGGAACTAGG
CAAGATCCTCGCACGTCCGATCGAGTCGGAGCTGAACGGTGCCCAGGCGGGCTCGCACGACGCCTCTACGGCGGCCCTGA
TCGCACGCGCACGCGGCGTGCTGGCAAGGAACGGCTAG

Upstream 100 bases:

>100_bases
GGCACCCCGAGAAGCCGTGATCGACACCATACACGCCTTATACTTGCAAAGCCCGGGAAATATCCGGGCCTCGAGCTCCT
GAAACGAATCAGTGCCCCGC

Downstream 100 bases:

>100_bases
ACCTCGGTGGCCATCCACTCGTCGCTGGCCACGCGGCCGGCTTCGATGGTCAGGATGCGGTTGCAACGCGCCGCCACTGA
GCGGTCGTGCGTGACCAGTA

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI 1; Phosphoglucose isomerase 1; PGI 1; Phosphohexose isomerase 1; PHI 1

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MPTNLHAWNALQQHHDAIRDHQMADWFAENGADRVRQFSLEAAGLYLDYSKNRITPQTMQLLLQLADEAGVPARRDAMFA
GEHINATEDRAALHVALRATAGAGFKVDGVPVVPAIQNVLVRMRAFSEAVRSGAWTGTTGERITDVVNIGIGGSDLGPKM
VCRALSHLAHDDGHSGPRMHFVSNVDGTELAEALERLDPRRTLMIVCSKTFTTLETMANAHSARQWYLDNGVAEDQLARH
FVAVSTNVDAVRAFGIDPANMFEFWDWIGGRFSLWSSVGLSTALAVGFNAFADLLAGGRAMDEHFRTAPLERNMPVVLGM
LGIWYRNFFNLPTSCMAPYSTSLELFPAFLQQLEMESNGKTVQLNGRRVRTHTSPVVWGTAGTNGQHAYFQMIHQGSQIV
PVDFVAPLVPPRELPGHHAKLLANCFAQAEALMRGRSAEELRAAGMTDELRIAHMVFEGNRPSNTLLMEDLTPHVLGALI
ALYEHRTFVQGVVWNINSFDQWGVELGKILARPIESELNGAQAGSHDASTAALIARARGVLARNG

Sequences:

>Translated_545_residues
MPTNLHAWNALQQHHDAIRDHQMADWFAENGADRVRQFSLEAAGLYLDYSKNRITPQTMQLLLQLADEAGVPARRDAMFA
GEHINATEDRAALHVALRATAGAGFKVDGVPVVPAIQNVLVRMRAFSEAVRSGAWTGTTGERITDVVNIGIGGSDLGPKM
VCRALSHLAHDDGHSGPRMHFVSNVDGTELAEALERLDPRRTLMIVCSKTFTTLETMANAHSARQWYLDNGVAEDQLARH
FVAVSTNVDAVRAFGIDPANMFEFWDWIGGRFSLWSSVGLSTALAVGFNAFADLLAGGRAMDEHFRTAPLERNMPVVLGM
LGIWYRNFFNLPTSCMAPYSTSLELFPAFLQQLEMESNGKTVQLNGRRVRTHTSPVVWGTAGTNGQHAYFQMIHQGSQIV
PVDFVAPLVPPRELPGHHAKLLANCFAQAEALMRGRSAEELRAAGMTDELRIAHMVFEGNRPSNTLLMEDLTPHVLGALI
ALYEHRTFVQGVVWNINSFDQWGVELGKILARPIESELNGAQAGSHDASTAALIARARGVLARNG
>Mature_544_residues
PTNLHAWNALQQHHDAIRDHQMADWFAENGADRVRQFSLEAAGLYLDYSKNRITPQTMQLLLQLADEAGVPARRDAMFAG
EHINATEDRAALHVALRATAGAGFKVDGVPVVPAIQNVLVRMRAFSEAVRSGAWTGTTGERITDVVNIGIGGSDLGPKMV
CRALSHLAHDDGHSGPRMHFVSNVDGTELAEALERLDPRRTLMIVCSKTFTTLETMANAHSARQWYLDNGVAEDQLARHF
VAVSTNVDAVRAFGIDPANMFEFWDWIGGRFSLWSSVGLSTALAVGFNAFADLLAGGRAMDEHFRTAPLERNMPVVLGML
GIWYRNFFNLPTSCMAPYSTSLELFPAFLQQLEMESNGKTVQLNGRRVRTHTSPVVWGTAGTNGQHAYFQMIHQGSQIVP
VDFVAPLVPPRELPGHHAKLLANCFAQAEALMRGRSAEELRAAGMTDELRIAHMVFEGNRPSNTLLMEDLTPHVLGALIA
LYEHRTFVQGVVWNINSFDQWGVELGKILARPIESELNGAQAGSHDASTAALIARARGVLARNG

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=516, Percent_Identity=53.6821705426357, Blast_Score=557, Evalue=1e-158,
Organism=Homo sapiens, GI296080693, Length=516, Percent_Identity=49.6124031007752, Blast_Score=498, Evalue=1e-141,
Organism=Escherichia coli, GI1790457, Length=550, Percent_Identity=52.7272727272727, Blast_Score=575, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI71996708, Length=539, Percent_Identity=49.3506493506493, Blast_Score=533, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI71996703, Length=539, Percent_Identity=49.3506493506493, Blast_Score=532, Evalue=1e-151,
Organism=Saccharomyces cerevisiae, GI6319673, Length=547, Percent_Identity=47.7148080438757, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24651916, Length=544, Percent_Identity=49.6323529411765, Blast_Score=531, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24651914, Length=544, Percent_Identity=49.6323529411765, Blast_Score=531, Evalue=1e-151,
Organism=Drosophila melanogaster, GI17737445, Length=544, Percent_Identity=49.6323529411765, Blast_Score=531, Evalue=1e-151,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI1_CUPPJ (Q472C7)

Other databases:

- EMBL:   CP000090
- RefSeq:   YP_295600.1
- ProteinModelPortal:   Q472C7
- SMR:   Q472C7
- GeneID:   3611179
- GenomeReviews:   CP000090_GR
- KEGG:   reu:Reut_A1386
- NMPDR:   fig|264198.3.peg.2140
- HOGENOM:   HBG352954
- OMA:   GPKIVSQ
- ProtClustDB:   PRK00179
- BioCyc:   REUT264198:REUT_A1386-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 59756; Mature: 59624

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 356-356 ACT_SITE 387-387 ACT_SITE 508-508

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTNLHAWNALQQHHDAIRDHQMADWFAENGADRVRQFSLEAAGLYLDYSKNRITPQTMQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCEEEEECCCCCCCHHHHH
LLLQLADEAGVPARRDAMFAGEHINATEDRAALHVALRATAGAGFKVDGVPVVPAIQNVL
HHHHHHHHCCCCCHHHHHHCCCCCCCCHHHHHEEEEEEECCCCCEEECCCCCHHHHHHHH
VRMRAFSEAVRSGAWTGTTGERITDVVNIGIGGSDLGPKMVCRALSHLAHDDGHSGPRMH
HHHHHHHHHHHCCCCCCCCHHHHHHHHEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCEE
FVSNVDGTELAEALERLDPRRTLMIVCSKTFTTLETMANAHSARQWYLDNGVAEDQLARH
EECCCCHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
FVAVSTNVDAVRAFGIDPANMFEFWDWIGGRFSLWSSVGLSTALAVGFNAFADLLAGGRA
HHEEECCCHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
MDEHFRTAPLERNMPVVLGMLGIWYRNFFNLPTSCMAPYSTSLELFPAFLQQLEMESNGK
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHCCCCC
TVQLNGRRVRTHTSPVVWGTAGTNGQHAYFQMIHQGSQIVPVDFVAPLVPPRELPGHHAK
EEEECCEEEEEECCCEEEECCCCCCCHHHHHHHHCCCCEEEHHHHHCCCCCCCCCCHHHH
LLANCFAQAEALMRGRSAEELRAAGMTDELRIAHMVFEGNRPSNTLLMEDLTPHVLGALI
HHHHHHHHHHHHHCCCCHHHHHHCCCCHHHEEEEEEEECCCCCCCEEHHHCCHHHHHHHH
ALYEHRTFVQGVVWNINSFDQWGVELGKILARPIESELNGAQAGSHDASTAALIARARGV
HHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
LARNG
HHCCC
>Mature Secondary Structure 
PTNLHAWNALQQHHDAIRDHQMADWFAENGADRVRQFSLEAAGLYLDYSKNRITPQTMQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCEEEEECCCCCCCHHHHH
LLLQLADEAGVPARRDAMFAGEHINATEDRAALHVALRATAGAGFKVDGVPVVPAIQNVL
HHHHHHHHCCCCCHHHHHHCCCCCCCCHHHHHEEEEEEECCCCCEEECCCCCHHHHHHHH
VRMRAFSEAVRSGAWTGTTGERITDVVNIGIGGSDLGPKMVCRALSHLAHDDGHSGPRMH
HHHHHHHHHHHCCCCCCCCHHHHHHHHEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCEE
FVSNVDGTELAEALERLDPRRTLMIVCSKTFTTLETMANAHSARQWYLDNGVAEDQLARH
EECCCCHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
FVAVSTNVDAVRAFGIDPANMFEFWDWIGGRFSLWSSVGLSTALAVGFNAFADLLAGGRA
HHEEECCCHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
MDEHFRTAPLERNMPVVLGMLGIWYRNFFNLPTSCMAPYSTSLELFPAFLQQLEMESNGK
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHCCCCC
TVQLNGRRVRTHTSPVVWGTAGTNGQHAYFQMIHQGSQIVPVDFVAPLVPPRELPGHHAK
EEEECCEEEEEECCCEEEECCCCCCCHHHHHHHHCCCCEEEHHHHHCCCCCCCCCCHHHH
LLANCFAQAEALMRGRSAEELRAAGMTDELRIAHMVFEGNRPSNTLLMEDLTPHVLGALI
HHHHHHHHHHHHHCCCCHHHHHHCCCCHHHEEEEEEEECCCCCCCEEHHHCCHHHHHHHH
ALYEHRTFVQGVVWNINSFDQWGVELGKILARPIESELNGAQAGSHDASTAALIARARGV
HHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
LARNG
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA