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The map label for this gene is ahpC [C]

Identifier: 73541059

GI number: 73541059

Start: 1468693

End: 1469241

Strand: Reverse

Name: ahpC [C]

Synonym: Reut_A1365

Alternate gene names: 73541059

Gene position: 1469241-1468693 (Counterclockwise)

Preceding gene: 73541060

Following gene: 73541058

Centisome position: 38.6

GC content: 58.29

Gene sequence:

>549_bases
ATGAAGACCGTTGGTGACAAGCTCGAAGCCTTCCACGTCGTTGGTGTCAAGCCGGGTTTCAACAACCATGAGGAAAACGG
CCAGTCGGCTTTCGAAGACATCACCGAAAAGTCGTTCGAAGGCAAGTGGAAGATCATCTACTTCTACCCGAAGGACTTCA
CGTTCGTATGCCCGACCGAAATCGTGGCATTCGCCAAGCTGAACGGCGATTTCGCTGACCGTGACGCCATCGTTCTGGGC
GGCTCGACCGACAACGAATTCGTGAAGCTGGCATGGCGCCGCGAGCACAAGGATCTGAACAAGCTGAACCAGTGGCAATT
TGCCGACGTGACCGGTTCGCTGATCGACCAGTTGGGCGTGCGTGACCAGGCCGCTGGCGTGGCTCTGCGCGCGACCTTCG
TGGTCGACCCGCACAATGTGATCCAGCACGTTTCGGTGAACAACCTGAACGTCGGCCGCAACCCGGACGAAGTGCTGCGT
ATTCTGGACGGTCTGCAAACGGACGAACTGTGCCCGTGCAACCGTGCCGTTGGCGGCGCAACGCTGTAA

Upstream 100 bases:

>100_bases
ATCTCCCCTTGTCGCGGCGCACCAAAGCGCTGGCTCCAGTCAGTGCCGACATTGCCCGCATTTGCACAAACTCTCTCTTC
AACCGTATCAGGAGAAGTCT

Downstream 100 bases:

>100_bases
TTGCTGCAAGGTTGCCGGTAACTACGGCGACTCGCGGAGGGCCCTGCCCCTCCGCCCCAAACCCGCAGAAGCGGGTTTTT
TGAGCCCTGATCGATAGGAG

Product: Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen

Products: NA

Alternate protein names: Peroxiredoxin; Thioredoxin peroxidase [H]

Number of amino acids: Translated: 182; Mature: 182

Protein sequence:

>182_residues
MKTVGDKLEAFHVVGVKPGFNNHEENGQSAFEDITEKSFEGKWKIIYFYPKDFTFVCPTEIVAFAKLNGDFADRDAIVLG
GSTDNEFVKLAWRREHKDLNKLNQWQFADVTGSLIDQLGVRDQAAGVALRATFVVDPHNVIQHVSVNNLNVGRNPDEVLR
ILDGLQTDELCPCNRAVGGATL

Sequences:

>Translated_182_residues
MKTVGDKLEAFHVVGVKPGFNNHEENGQSAFEDITEKSFEGKWKIIYFYPKDFTFVCPTEIVAFAKLNGDFADRDAIVLG
GSTDNEFVKLAWRREHKDLNKLNQWQFADVTGSLIDQLGVRDQAAGVALRATFVVDPHNVIQHVSVNNLNVGRNPDEVLR
ILDGLQTDELCPCNRAVGGATL
>Mature_182_residues
MKTVGDKLEAFHVVGVKPGFNNHEENGQSAFEDITEKSFEGKWKIIYFYPKDFTFVCPTEIVAFAKLNGDFADRDAIVLG
GSTDNEFVKLAWRREHKDLNKLNQWQFADVTGSLIDQLGVRDQAAGVALRATFVVDPHNVIQHVSVNNLNVGRNPDEVLR
ILDGLQTDELCPCNRAVGGATL

Specific function: Together with AhpD, DltA and Lpd constitutes an NADH- dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative str

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI5802974, Length=156, Percent_Identity=41.025641025641, Blast_Score=124, Evalue=6e-29,
Organism=Homo sapiens, GI32483377, Length=156, Percent_Identity=41.025641025641, Blast_Score=123, Evalue=7e-29,
Organism=Homo sapiens, GI32189392, Length=160, Percent_Identity=40.625, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI4505591, Length=172, Percent_Identity=33.7209302325581, Blast_Score=109, Evalue=1e-24,
Organism=Homo sapiens, GI32455266, Length=172, Percent_Identity=33.7209302325581, Blast_Score=109, Evalue=1e-24,
Organism=Homo sapiens, GI32455264, Length=172, Percent_Identity=33.7209302325581, Blast_Score=109, Evalue=1e-24,
Organism=Homo sapiens, GI5453549, Length=159, Percent_Identity=33.9622641509434, Blast_Score=101, Evalue=3e-22,
Organism=Homo sapiens, GI33188454, Length=66, Percent_Identity=45.4545454545455, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1786822, Length=172, Percent_Identity=36.6279069767442, Blast_Score=109, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI32565831, Length=159, Percent_Identity=36.4779874213836, Blast_Score=117, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI193204376, Length=159, Percent_Identity=36.4779874213836, Blast_Score=117, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17554494, Length=151, Percent_Identity=37.0860927152318, Blast_Score=116, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6323613, Length=159, Percent_Identity=41.5094339622642, Blast_Score=124, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6320661, Length=159, Percent_Identity=41.5094339622642, Blast_Score=124, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6319407, Length=160, Percent_Identity=30, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17157991, Length=159, Percent_Identity=37.1069182389937, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24641739, Length=159, Percent_Identity=37.1069182389937, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17738015, Length=153, Percent_Identity=37.2549019607843, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21357347, Length=159, Percent_Identity=34.5911949685535, Blast_Score=103, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24656348, Length=156, Percent_Identity=35.2564102564103, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17864676, Length=156, Percent_Identity=35.2564102564103, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24581278, Length=158, Percent_Identity=31.0126582278481, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 20247; Mature: 20247

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVGDKLEAFHVVGVKPGFNNHEENGQSAFEDITEKSFEGKWKIIYFYPKDFTFVCPTE
CCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCEEECHHH
IVAFAKLNGDFADRDAIVLGGSTDNEFVKLAWRREHKDLNKLNQWQFADVTGSLIDQLGV
HEEEHHCCCCCCCCCEEEECCCCCCCCEEEEHHHHHHHHHHHCCEEEHHHHHHHHHHHCC
RDQAAGVALRATFVVDPHNVIQHVSVNNLNVGRNPDEVLRILDGLQTDELCPCNRAVGGA
CCCCCCEEEEEEEEECHHHHHHEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
TL
CC
>Mature Secondary Structure
MKTVGDKLEAFHVVGVKPGFNNHEENGQSAFEDITEKSFEGKWKIIYFYPKDFTFVCPTE
CCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCEEECHHH
IVAFAKLNGDFADRDAIVLGGSTDNEFVKLAWRREHKDLNKLNQWQFADVTGSLIDQLGV
HEEEHHCCCCCCCCCEEEECCCCCCCCEEEEHHHHHHHHHHHCCEEEHHHHHHHHHHHCC
RDQAAGVALRATFVVDPHNVIQHVSVNNLNVGRNPDEVLRILDGLQTDELCPCNRAVGGA
CCCCCCEEEEEEEEECHHHHHHEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
TL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA